Detailed information for compound 1460882

Basic information

Technical information
  • TDR Targets ID: 1460882
  • Name: [3-[5-[(2,4-dioxo-1H-pyrimidin-5-yl)carbamoyl ]-1,3-dioxoisoindol-2-yl]phenyl] acetate
  • MW: 434.358 | Formula: C21H14N4O7
  • H donors: 3 H acceptors: 8 LogP: 1.28 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1cccc(c1)N1C(=O)c2c(C1=O)cc(cc2)C(=O)Nc1cnc(nc1O)O
  • InChi: 1S/C21H14N4O7/c1-10(26)32-13-4-2-3-12(8-13)25-19(29)14-6-5-11(7-15(14)20(25)30)17(27)23-16-9-22-21(31)24-18(16)28/h2-9H,1H3,(H,23,27)(H2,22,24,28,31)
  • InChiKey: KXJLPMKPWNUJQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [3-[5-[(2,4-dioxo-1H-pyrimidin-5-yl)carbamoyl]-1,3-dioxo-isoindolin-2-yl]phenyl] acetate
  • acetic acid [3-[5-[[(2,4-dioxo-1H-pyrimidin-5-yl)amino]-oxomethyl]-1,3-dioxo-2-isoindolinyl]phenyl] ester
  • acetic acid [3-[5-[(2,4-diketo-1H-pyrimidin-5-yl)carbamoyl]-1,3-diketo-isoindolin-2-yl]phenyl] ester
  • [3-[5-[(2,4-dioxo-1H-pyrimidin-5-yl)carbamoyl]-1,3-dioxo-isoindol-2-yl]phenyl] ethanoate
  • CBMicro_032921
  • BIM-0032675.P001
  • 3-(5-{[(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino]carbonyl}-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)phenyl acetate
  • MLS000685698
  • SMR000312662
  • ZINC02934393
  • STK057963
  • Oprea1_630760

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis para nitrobenzyl esterase 0.1215 0.1663 0.1663
Plasmodium falciparum glutathione reductase 0.0046 0.0032 1
Loa Loa (eye worm) carboxylesterase 0.719 1 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.1215 0.1663 0.1663
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.1215 0.1663 1
Echinococcus multilocularis neuroligin 0.1215 0.1663 0.1663
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1215 0.1663 0.1663
Brugia malayi Muscleblind-like protein 0.018 0.022 0.022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Mycobacterium tuberculosis Carboxylesterase LipT 0.1215 0.1663 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1215 0.1663 1
Loa Loa (eye worm) hypothetical protein 0.1215 0.1663 0.1663
Loa Loa (eye worm) glutathione reductase 0.0046 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.719 1 1
Echinococcus multilocularis acetylcholinesterase 0.719 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.013 1
Brugia malayi Carboxylesterase family protein 0.1215 0.1663 0.1663
Brugia malayi Carboxylesterase family protein 0.719 1 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.1215 0.1663 0.1663
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0114 0.0684
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0114 0.0684
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0032 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.013 0.0781
Schistosoma mansoni neuroligin 3 (S09 family) 0.1215 0.1663 0.1663
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.719 1 1
Mycobacterium ulcerans carboxylesterase, LipT 0.1215 0.1663 1
Trypanosoma brucei trypanothione reductase 0.0046 0.0032 1
Echinococcus granulosus para nitrobenzyl esterase 0.1215 0.1663 0.1663
Echinococcus granulosus muscleblind protein 0.018 0.022 0.022
Loa Loa (eye worm) carboxylesterase 0.1215 0.1663 0.1663
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0 0.5
Echinococcus multilocularis acetylcholinesterase 0.719 1 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0032 1
Loa Loa (eye worm) hypothetical protein 0.1215 0.1663 0.1663
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0033 0.0033
Brugia malayi Carboxylesterase family protein 0.1215 0.1663 0.1663
Echinococcus granulosus acetylcholinesterase 0.719 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0114 0.0684
Trichomonas vaginalis spcc417.12 protein, putative 0.1215 0.1663 1
Loa Loa (eye worm) hypothetical protein 0.018 0.022 0.022
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.013 0.0781
Loa Loa (eye worm) hypothetical protein 0.1215 0.1663 0.1663
Echinococcus granulosus BC026374 protein S09 family 0.1215 0.1663 0.1663
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0 0.5
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0032 1
Onchocerca volvulus 0.1215 0.1663 0.5
Loa Loa (eye worm) hypothetical protein 0.1215 0.1663 0.1663
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0 0.5
Onchocerca volvulus 0.1215 0.1663 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1215 0.1663 0.1663
Echinococcus granulosus carboxylesterase 5A 0.719 1 1
Brugia malayi Carboxylesterase family protein 0.1215 0.1663 0.1663
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1215 0.1663 1
Brugia malayi Carboxylesterase family protein 0.1215 0.1663 0.1663
Brugia malayi Thioredoxin reductase 0.0046 0.0032 0.0032
Onchocerca volvulus 0.1215 0.1663 0.5
Loa Loa (eye worm) hypothetical protein 0.1215 0.1663 0.1663
Loa Loa (eye worm) acetylcholinesterase 1 0.719 1 1
Onchocerca volvulus 0.1215 0.1663 0.5
Echinococcus multilocularis carboxylesterase 5A 0.719 1 1
Mycobacterium tuberculosis Probable reductase 0.0104 0.0114 0.0684
Schistosoma mansoni acetylcholinesterase 0.1215 0.1663 0.1663
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0114 0.0684
Schistosoma mansoni gliotactin 0.1215 0.1663 0.1663
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.1215 0.1663 0.1663
Onchocerca volvulus 0.1215 0.1663 0.5
Loa Loa (eye worm) hypothetical protein 0.1215 0.1663 0.1663
Loa Loa (eye worm) hypothetical protein 0.1215 0.1663 0.1663
Plasmodium falciparum thioredoxin reductase 0.0046 0.0032 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1215 0.1663 0.1663
Schistosoma mansoni BC026374 protein (S09 family) 0.1215 0.1663 0.1663
Brugia malayi glutathione reductase 0.0046 0.0032 0.0032
Loa Loa (eye worm) carboxylesterase 0.1215 0.1663 0.1663
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0032 0.0193
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0033 0.0033
Leishmania major trypanothione reductase 0.0046 0.0032 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0114 0.0684
Echinococcus multilocularis muscleblind protein 0.018 0.022 0.022
Echinococcus granulosus acetylcholinesterase 0.719 1 1
Loa Loa (eye worm) hypothetical protein 0.719 1 1
Loa Loa (eye worm) hypothetical protein 0.018 0.022 0.022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.013 0.0781
Plasmodium vivax glutathione reductase, putative 0.0046 0.0032 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0032 0.0032
Brugia malayi hypothetical protein 0.1215 0.1663 0.1663
Echinococcus multilocularis muscleblind protein 1 0.018 0.022 0.022
Echinococcus granulosus neuroligin 0.1215 0.1663 0.1663

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 1.9953 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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