Detailed information for compound 146089

Basic information

Technical information
  • TDR Targets ID: 146089
  • Name: 1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5 -yl]pyrimidine-2,4-dione
  • MW: 230.241 | Formula: C8H10N2O4S
  • H donors: 2 H acceptors: 3 LogP: -0.87 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](CS1)n1ccc(=O)[nH]c1=O
  • InChi: 1S/C8H10N2O4S/c11-3-7-14-6(4-15-7)10-2-1-5(12)9-8(10)13/h1-2,6-7,11H,3-4H2,(H,9,12,13)/t6-,7+/m1/s1
  • InChiKey: BNVOMPQTQUUYHU-RQJHMYQMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[(2S,5R)-2-methylol-1,3-oxathiolan-5-yl]pyrimidine-2,4-quinone
  • 149819-44-3
  • 149819-45-4
  • 131086-26-5
  • (+)-(2S,5R)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]uracil
  • 2,4(1H,3H)-Pyrimidinedione, 1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-cis)-
  • AIDS-005666
  • 2,4(1H,3H)-Pyrimidinedione, 1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, cis-
  • OxathiolanU-(+).b.
  • AIDS002621
  • Cis-2-Hydroxymethyl-5-(uracil-N-1'-yl)-1,3-oxathiolane
  • SddU
  • AIDS005666
  • 2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, cis-
  • AIDS-002621
  • (-)-(2S,5S)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]uracil
  • 2,4(1H,3H)-Pyrimidinedione, 1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-trans)-
  • AIDS-005667
  • AIDS005667
  • OxathiolanU-(-).a.
  • (+)-(2S,5R)-1-(2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)uracil
  • 2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2S-cis)-
  • OxathiolanU-(+)-beta
  • (-)-(2S,5S)-1-(2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)uracil
  • 2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2S-trans)-
  • OxathiolanU-(-)-alpha

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0116 0.0405 0.095
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0052 0.0075
Entamoeba histolytica hypothetical protein 0.0739 0.2818 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0042
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0026 0.0474
Brugia malayi MH2 domain containing protein 0.0177 0.0641 0.0641
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0023 0.0057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0256 0.0474
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0128 0.0127
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0831 0.3176 0.5953
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0041 0.0041
Loa Loa (eye worm) histone methyltransferase 0.002 0.0035 0.0034
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0116 0.0405 0.7333
Leishmania major hypothetical protein, conserved 0.0077 0.0256 0.0587
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0262 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0011 0.002
Brugia malayi RNA binding protein 0.0654 0.249 0.249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0128 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0133 0.0246
Onchocerca volvulus 0.0017 0.0023 0.0057
Loa Loa (eye worm) hypothetical protein 0.0154 0.0552 0.0552
Toxoplasma gondii hypothetical protein 0.0027 0.0062 0.1122
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0024 0.0024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.0778 0.0777
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0157 0.0295
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0023 0.0023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0011 0.002
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0256 0.1318
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0023 0.0043
Schistosoma mansoni cpg binding protein 0.0062 0.0195 0.0361
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0023 0.0023
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0062 0.112
Echinococcus granulosus zinc finger protein 0.0023 0.0045 0.0084
Schistosoma mansoni transcription factor LCR-F1 0.0739 0.2818 0.5221
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0023 0.0043
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.086 0.1613
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0023 0.0042
Loa Loa (eye worm) MH2 domain-containing protein 0.0177 0.0641 0.0641
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0256 0.0593
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0053 0.0162 0.0361
Schistosoma mansoni histamine h1 receptor 0.0017 0.0023 0.0042
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0026 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0097 0.0179
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0294 0.0552
Loa Loa (eye worm) Smad1 0.0177 0.0641 0.0641
Loa Loa (eye worm) transcription factor SMAD2 0.2593 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0077 0.0256 0.0255
Loa Loa (eye worm) FYVE zinc finger family protein 0.0053 0.0162 0.0161
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0023 0.0042
Onchocerca volvulus 0.0077 0.0256 0.0965
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0198 0.0372
Trypanosoma brucei PAB1-binding protein , putative 0.0154 0.0552 0.1293
Echinococcus multilocularis cpg binding protein 0.0067 0.0216 0.0405
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0023 0.0042
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0116 0.0405 0.0944
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0053 0.0162 0.0628
Onchocerca volvulus Serine\/threonine kinase homolog 0.0675 0.2573 1
Schistosoma mansoni biogenic amine receptor 0.0017 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0098 0.0335 0.0335
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Loa Loa (eye worm) glutaminase 2 0.1405 0.5398 0.5398
Echinococcus granulosus tar DNA binding protein 0.0654 0.249 0.4668
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0116 0.0405 0.0759
Schistosoma mansoni hypothetical protein 0.1244 0.4775 0.8846
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0023 0.0042
Trichomonas vaginalis ras GTP exchange factor, putative 0.0013 0.0008 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0052 0.0092
Echinococcus granulosus microtubule associated protein 2 0.1389 0.5335 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Schistosoma mansoni amine GPCR 0.0017 0.0023 0.0042
Loa Loa (eye worm) RNA binding protein 0.0654 0.249 0.249
Echinococcus multilocularis citrate lyase subunit beta protein 0.0126 0.0443 0.0831
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0023 0.0043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0035 0.0065
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0126 0.0443 0.1042
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0029 0.0102
Brugia malayi Calcitonin receptor-like protein seb-1 0.1087 0.4167 0.4167
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0023 0.0043
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0023 0.0043
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0056 0.0104
Mycobacterium tuberculosis Conserved protein 0.0126 0.0443 0.2328
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0023 0.0043
Echinococcus granulosus bloom syndrome protein 0.0027 0.0062 0.0117
Brugia malayi RasGEF domain containing protein 0.0013 0.0008 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0023 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0344 0.1289 0.1289
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0023 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.002 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.038 0.1428 0.5536
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0013 0.0008 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0256 0.0474
Loa Loa (eye worm) hypothetical protein 0.038 0.1428 0.1428
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0659 0.251 0.465
Echinococcus granulosus g protein coupled receptor 0.0017 0.0023 0.0043
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0177 0.0641 0.1201
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0013 0.0008 0.0015
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0013 0.0005
Onchocerca volvulus 0.0017 0.0023 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0016 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0088 0.0162
Echinococcus multilocularis mothers against decapentaplegic 6 0.0079 0.0262 0.0492
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0026 0.0602
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0116 0.0405 0.2121
Schistosoma mansoni glutaminase 0.1405 0.5398 1
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0053 0.0162 0.0299
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0029 0.0054
Brugia malayi RasGEF domain containing protein 0.0013 0.0008 0.0008
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.0414 0.2173
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0029 0.0049
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0023 0.0042
Schistosoma mansoni ap endonuclease 0.0019 0.0029 0.0053
Loa Loa (eye worm) hypothetical protein 0.0344 0.1289 0.1289
Brugia malayi Bromodomain containing protein 0.0038 0.0103 0.0103
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.004 0.0112 0.0112
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0029 0.0053
Toxoplasma gondii isocitrate dehydrogenase 0.0116 0.0405 0.7333
Schistosoma mansoni cpg binding protein 0.0067 0.0216 0.04
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0344 0.1289 0.2416
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0053 0.0162 0.0303
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.0077 0.0256 0.0255
Echinococcus multilocularis son of sevenless 1 0.0013 0.0008 0.0015
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0262 0.4754
Schistosoma mansoni opsin-like receptor 0.0017 0.0023 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0088 0.0162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0079 0.0146
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0659 0.251 0.4704
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0133 0.0249
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Trypanosoma brucei polo-like protein kinase 0.0675 0.2573 0.614
Onchocerca volvulus 0.0077 0.0256 0.0965
Schistosoma mansoni hypothetical protein 0.0344 0.1289 0.2388
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Schistosoma mansoni isocitrate dehydrogenase 0.0014 0.0011 0.002
Schistosoma mansoni neuropeptide receptor 0.0017 0.0023 0.0042
Schistosoma mansoni hypothetical protein 0.0344 0.1289 0.2388
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0256 0.1318
Brugia malayi AKH receptor 0.0017 0.0023 0.0023
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0256 0.1318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0062 0.0115
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0029 0.0028
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0053 0.0162 0.0303
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0097 0.0201
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0023 0.0043
Echinococcus granulosus mothers against decapentaplegic 5 0.0177 0.0641 0.1201
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0023 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0144 0.0267
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0053 0.0162 0.0367
Brugia malayi Probable isocitrate dehydrogenase 0.0014 0.0011 0.0011
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0029 0.0111
Loa Loa (eye worm) pip kinase 2 0.0659 0.251 0.2509
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0053 0.0162 0.0303
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0013 0.0006 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0256 0.0474
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0654 0.249 0.4614
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0026 0.0043
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0133 0.0287
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0294 0.0294
Echinococcus multilocularis GPCR, family 2 0.0344 0.1289 0.2416
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0126 0.0443 0.1036
Brugia malayi Probable ClpP-like protease 0.0079 0.0262 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0088 0.0162
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0023 0.0042
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0029 0.0054
Brugia malayi Latrophilin receptor protein 2 0.0344 0.1289 0.1289
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0195 0.0195
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0029 0.0049
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0023 0.0043
Schistosoma mansoni zinc finger protein 0.0015 0.0015 0.0028
Echinococcus granulosus cpg binding protein 0.0067 0.0216 0.0405
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0126 0.0443 0.0821
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.0466 0.2448
Schistosoma mansoni serine/threonine protein kinase 0.0675 0.2573 0.4766
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0023 0.0043
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0262 0.0492
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0062 0.1515
Brugia malayi glutaminase DH11.1 0.1405 0.5398 0.5398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Brugia malayi neuropeptide F receptor 0.0017 0.0023 0.0023
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0023 0.0043
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0256 0.5383
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0256 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0062 0.0115
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0344 0.1289 0.2416
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0094 0.0176
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0008 0.0007
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0262 0.4754
Brugia malayi larval opioid receptor 0.0017 0.0023 0.0023
Schistosoma mansoni DNA helicase recq1 0.0011 0 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0154 0.0552 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0023 0.0043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0023 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0334 0.1252 0.2319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0052 0.0096
Schistosoma mansoni hypothetical protein 0.1244 0.4775 0.8846
Schistosoma mansoni dep domain containing protein 0.0019 0.0029 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0133 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0052 0.0096
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0262 0.0467
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0675 0.2573 0.6142
Brugia malayi sulfakinin receptor protein 0.0017 0.0023 0.0023
Echinococcus multilocularis smad 0.0177 0.0641 0.1201
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0013 0.0008 0.0015
Mycobacterium ulcerans lipase LipD 0.0077 0.0256 0.0454
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0013 0.0008 0.0015
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0262 0.4754
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0026 0.0474
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0014 0.0011 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis dnaJ subfamily B 0.0877 0.3353 0.6284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0004 0.0007
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0023 0.0043
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0157 0.3212
Schistosoma mansoni tar DNA-binding protein 0.0654 0.249 0.4614
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0029 0.0054
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0026 0.0043
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0116 0.0405 0.0759
Echinococcus granulosus mothers against decapentaplegic 2 0.0079 0.0262 0.0492
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0023 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0128 0.0237
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0013 0.0047
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0126 0.0443 0.0802
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0026 0.0474
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0 0.0001
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0053 0.0162 0.0161
Brugia malayi N-terminal motif family protein 0.038 0.1428 0.1428
Echinococcus multilocularis somatostatin receptor 0.0017 0.0023 0.0043
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.002 0.0038
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0013 0.0008 0.0015
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0052 0.0097
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0157 0.0787
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0023 0.0043
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0053 0.0162 0.2926
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0029 0.0053
Schistosoma mansoni hypothetical protein 0.0344 0.1289 0.2388
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0654 0.249 0.249
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0029 0.0054
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0053 0.0162 0.0356
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Onchocerca volvulus 0.0659 0.251 0.9754
Plasmodium falciparum glutathione reductase 0.0018 0.0026 0.0474
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Onchocerca volvulus 0.0017 0.0023 0.0057
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0026 0.0048
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0014 0.0011 0.0021
Schistosoma mansoni smad 0.0079 0.0262 0.0486
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0052 0.0892
Schistosoma mansoni myosin xvIII 0.0017 0.0023 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0256 0.4632
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0133 0.0292
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.0466 0.2448
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0023 0.0042
Schistosoma mansoni Smad4 0.0177 0.0641 0.1187
Brugia malayi MH1 domain containing protein 0.0098 0.0335 0.0335
Schistosoma mansoni ap endonuclease 0.0019 0.0029 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0022 0.0041
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0029 0.0081
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.004 0.0064
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0053 0.0162 0.2926
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0739 0.2818 0.5221
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0116 0.0405 0.075
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0262 1
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0014 0.0011 0.0021
Brugia malayi hypothetical protein 0.0739 0.2818 0.2818
Schistosoma mansoni survival motor neuron protein 0.0048 0.0141 0.0261
Loa Loa (eye worm) glutathione reductase 0.0052 0.0157 0.0157
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0029 0.0029
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0053 0.0162 0.0299
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0023 0.0042
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0133 0.0246
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0053 0.0162 0.0361
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0016 0.0029
Schistosoma mansoni smad1 5 8 and 0.0177 0.0641 0.1187
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0026 0.0474
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0023 0.0043
Brugia malayi GnHR receptor homolog 0.0017 0.0023 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0023 0.0023
Brugia malayi beta-lactamase family protein 0.0077 0.0256 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0097 0.0179
Loa Loa (eye worm) latrophilin receptor protein 2 0.0344 0.1289 0.1289
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0023 0.0043
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0042
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0053 0.0162 0.0299
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0023 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Plasmodium vivax glutathione reductase, putative 0.0052 0.0157 0.285
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0023 0.0043
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0023 0.0043
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0053 0.0162 0.0361
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0256 0.1318
Trypanosoma cruzi ISWI complex protein 0.0015 0.0015 0.0016
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0029 0.0033
Plasmodium falciparum thioredoxin reductase 0.0052 0.0157 0.285
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0026 0.0081
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0026 0.0031
Brugia malayi RasGEF domain containing protein 0.0013 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.0077 0.0256 0.0255
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0256 0.0479
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0467 0.0865
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0023 0.0043
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0062 0.1122
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0023 0.0043
Echinococcus granulosus ras GTP exchange factor 0.0013 0.0008 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0016 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0061 0.0113
Brugia malayi Thioredoxin reductase 0.0052 0.0157 0.0157
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0262 0.0486
Echinococcus granulosus geminin 0.1244 0.4775 0.8949
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0026 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.1091 0.4182 1
Schistosoma mansoni tar DNA-binding protein 0.0654 0.249 0.4614
Echinococcus multilocularis sex peptide receptor 0.0017 0.0023 0.0043
Trichomonas vaginalis esterase, putative 0.0077 0.0256 0.0474
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0011 0.002
Trichomonas vaginalis ras GTP exchange factor, putative 0.0013 0.0008 0.0015
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0126 0.0443 0.0802
Onchocerca volvulus 0.0017 0.0023 0.0057
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0079 0.1428
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0011 0.002
Onchocerca volvulus 0.0241 0.089 0.344
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0023 0.0043
Brugia malayi hypothetical protein 0.0019 0.0029 0.0029
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.0414 0.8876
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0023 0.0043
Leishmania major hypothetical protein, conserved 0.1091 0.4182 1
Echinococcus multilocularis serotonin receptor 0.0017 0.0023 0.0043
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0013 0.0008 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0675 0.2573 0.4766
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0026 0.0049
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0097 0.0212
Schistosoma mansoni unc-13 (munc13) 0.0014 0.0011 0.002
Schistosoma mansoni microtubule-associated protein tau 0.1389 0.5335 0.9884
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0026 0.0043
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0023 0.0042
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0094 0.0176
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0133 0.0133
Schistosoma mansoni amine GPCR 0.0017 0.0023 0.0042
Brugia malayi RE15519p 0.0017 0.0023 0.0023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0048 0.0144 0.0144
Echinococcus multilocularis tar DNA binding protein 0.0654 0.249 0.4668
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0026 0.0049
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0 0.0005
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.007 0.0227 0.0227
Echinococcus multilocularis isocitrate dehydrogenase 0.0116 0.0405 0.0759
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0023 0.0043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.002 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0011 0.002
Brugia malayi CXXC zinc finger family protein 0.0062 0.0195 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0061 0.0113
Onchocerca volvulus 0.0017 0.0023 0.0057
Echinococcus granulosus allatostatin A receptor 0.0017 0.0023 0.0043
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0052 0.0935
Schistosoma mansoni Smad4 0.0079 0.0262 0.0486
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0023 0.0043
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0023 0.0042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0344 0.1289 0.2416
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0256 0.0454
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0069 0.013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0023 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0011 0.002
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0177 0.0641 0.1187
Echinococcus multilocularis mothers against decapentaplegic 2 0.0079 0.0262 0.0492
Entamoeba histolytica tartrate dehydrogenase, putative 0.0014 0.0011 0.0039
Loa Loa (eye worm) RasGEF domain-containing protein 0.0013 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Brugia malayi hypothetical protein 0.0305 0.1138 0.1138
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0027 0.0495
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0262 0.4754
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Echinococcus granulosus TGF beta signal transducer SmadC 0.0177 0.0641 0.1201
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0116 0.0405 0.0759
Brugia malayi serine/threonine-protein kinase plk-2 0.0675 0.2573 0.2573
Onchocerca volvulus 0.0017 0.0023 0.0057
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0 0.0005
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0023 0.0023
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0062 0.1122
Schistosoma mansoni cpg binding protein 0.0067 0.0216 0.04
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0029 0.0029
Brugia malayi RNA recognition motif domain containing protein 0.0654 0.249 0.249
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0029
Echinococcus granulosus Smad4 0.0177 0.0641 0.1201
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0035 0.0065
Loa Loa (eye worm) RasGEF domain-containing protein 0.0013 0.0008 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0344 0.1289 0.2416
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0262 1
Loa Loa (eye worm) MH2 domain-containing protein 0.2593 1 1
Brugia malayi PHD-finger family protein 0.0028 0.0065 0.0065
Echinococcus granulosus neuropeptide receptor 0.0017 0.0023 0.0043
Plasmodium vivax SET domain protein, putative 0.0032 0.0079 0.1428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.003 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0103 0.0103
Toxoplasma gondii exonuclease III APE 0.0019 0.0029 0.0517
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0141 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0052 0.0096
Brugia malayi TAR-binding protein 0.0654 0.249 0.249
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0157 0.0357
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.1091 0.4182 1
Schistosoma mansoni hypothetical protein 0.0048 0.0141 0.0261
Loa Loa (eye worm) RasGEF domain-containing protein 0.0013 0.0008 0.0008
Echinococcus granulosus hypothetical protein 0.0017 0.0023 0.0043
Onchocerca volvulus 0.0017 0.0023 0.0057
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0026 0.0474
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0023 0.0043
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0023 0.0023
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0133 0.0471
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0659 0.251 0.4704
Trichomonas vaginalis CAMK family protein kinase 0.0675 0.2573 0.4766
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0023 0.0043
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0053 0.0162 0.0367
Onchocerca volvulus 0.0017 0.0023 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0097 0.0179
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0023 0.0043
Schistosoma mansoni neuropeptide receptor 0.0017 0.0023 0.0042
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus granulosus mothers against decapentaplegic 6 0.0079 0.0262 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0097 0.0179
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0029 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0128 0.0239
Trypanosoma cruzi ISWI complex protein 0.0015 0.0015 0.0016
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0026 0.0474
Schistosoma mansoni neuropeptide receptor 0.0017 0.0023 0.0042
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0157 0.0788
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0023 0.0043
Brugia malayi G protein-coupled receptor 0.0017 0.0023 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0026 0.0043
Schistosoma mansoni amine GPCR 0.0017 0.0023 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0088 0.0162
Brugia malayi Pip kinase protein 1 0.0053 0.0162 0.0161
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0654 0.249 0.249
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0023 0.0023
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0294 0.0552
Schistosoma mansoni dishevelled 0.0019 0.0029 0.0054
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0023 0.0043
Brugia malayi MH1 domain containing protein 0.0177 0.0641 0.0641
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1087 0.4167 0.4167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0023 0.0042
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0116 0.0405 0.0939
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0052 0.0935
Echinococcus granulosus Protein son of sevenless 0.0013 0.0008 0.0015
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0053 0.0162 0.0367
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0029 0.0054
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0023 0.0043
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0023 0.0042
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0659 0.251 0.465
Onchocerca volvulus 0.0062 0.0195 0.0729
Echinococcus granulosus fmrfamide receptor 0.0017 0.0023 0.0043
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0029 0.0094
Brugia malayi DIX domain containing protein 0.0019 0.0029 0.0029
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0016 0.0006
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0053 0.0162 0.0299
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0029 0.0054
Mycobacterium tuberculosis Probable reductase 0.0118 0.0414 0.2173
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0056 0.0106
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0 0.0005
Mycobacterium ulcerans beta-lactamase 0.0077 0.0256 0.0454
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0023 0.0043
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0062 0.0117
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0042
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0023 0.0023
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0069 0.0224 0.0419
Schistosoma mansoni Smad4 0.0079 0.0262 0.0486
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0023 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0011 0.002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1087 0.4167 0.4167
Brugia malayi MH1 domain containing protein 0.0098 0.0335 0.0335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0088 0.1588
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0056 0.0106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0128 0.0239
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.005 0.0898
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0026 0.0036
Schistosoma mansoni smad 0.0177 0.0641 0.1187
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0029 0.0054
Echinococcus granulosus sex peptide receptor 0.0017 0.0023 0.0043
Plasmodium falciparum thioredoxin reductase 0.0018 0.0026 0.0474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Trypanosoma brucei hypothetical protein, conserved 0.1091 0.4182 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0133 0.0471
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0026 0.0026
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0023 0.0023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0256 0.1318
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0023 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0052 0.0096
Brugia malayi neuropeptide F receptor 0.0017 0.0023 0.0023
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0029 0.0029
Brugia malayi Melatonin receptor type 1A 0.0017 0.0023 0.0023
Echinococcus multilocularis Smad4 0.0177 0.0641 0.1201
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0052 0.0935
Brugia malayi hypothetical protein 0.0233 0.086 0.086
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0294 0.0545
Schistosoma mansoni neuropeptide receptor 0.0017 0.0023 0.0042
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.0154 0.0552 0.1303
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0079 0.0262 0.0991
Echinococcus granulosus g protein coupled receptor 0.0017 0.0023 0.0043
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0016 0.0015
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0053 0.0162 0.0367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0128 0.0237
Onchocerca volvulus 0.0017 0.0023 0.0057
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0053 0.0162 0.2926
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0743 0.2835 0.2835
Loa Loa (eye worm) nuclear factor I 0.0098 0.0335 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0107 0.0198
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0023 0.0042
Schistosoma mansoni amine GPCR 0.0017 0.0023 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0079 0.0146
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0014 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0079 0.0262 0.0262
Brugia malayi N-terminal motif family protein 0.0013 0.0008 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0011 0.002
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0014 0.0011 0.002
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Schistosoma mansoni opsin-like receptor 0.0017 0.0023 0.0042
Onchocerca volvulus 0.0077 0.0256 0.0965
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0466 0.2448
Schistosoma mansoni hypothetical protein 0.0069 0.0224 0.0414
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0062 0.0116
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0052 0.1077
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0023 0.0043
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0053 0.0162 0.0361
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0042
Brugia malayi Pre-SET motif family protein 0.0212 0.0778 0.0777
Schistosoma mansoni hypothetical protein 0.0344 0.1289 0.2388
Onchocerca volvulus 0.0017 0.0023 0.0057
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0026 0.0048
Echinococcus multilocularis mothers against decapentaplegic 5 0.0177 0.0641 0.1201
Echinococcus granulosus smad 0.0177 0.0641 0.1201
Loa Loa (eye worm) hypothetical protein 0.0743 0.2835 0.2835
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0023 0.0042
Loa Loa (eye worm) pip kinase 1 0.0053 0.0162 0.0161
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0015
Leishmania major trypanothione reductase 0.0052 0.0157 0.0351
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0256 0.0474
Toxoplasma gondii thioredoxin reductase 0.0052 0.0157 0.285
Loa Loa (eye worm) hypothetical protein 0.0077 0.0256 0.0255
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0493 0.1868 1
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0053 0.0162 0.0356
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0256 0.0255
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.086 0.1613
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0739 0.2818 0.5283
Brugia malayi MH1 domain containing protein 0.0177 0.0641 0.0641
Entamoeba histolytica hypothetical protein 0.0739 0.2818 1
Schistosoma mansoni smad1 5 8 and 0.0177 0.0641 0.1187
Loa Loa (eye worm) hypothetical protein 0.0046 0.0133 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0654 0.249 0.4614
Brugia malayi Isocitrate dehydrogenase 0.0116 0.0405 0.0404
Schistosoma mansoni opsin-like receptor 0.0017 0.0023 0.0042
Loa Loa (eye worm) RecQ helicase 0.0027 0.0062 0.0062
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0022 0.0041
Entamoeba histolytica hypothetical protein 0.0025 0.0052 0.0183
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0013 0.0008 0.0015
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0116 0.0405 0.095
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.0414 0.2173
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0014 0.0011 0.0021
Brugia malayi isocitrate dehydrogenase 0.0116 0.0405 0.0404
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0133 0.0298
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0029 0.0054
Mycobacterium ulcerans glutaminase 0.1405 0.5398 1
Echinococcus granulosus g protein coupled receptor 0.0017 0.0023 0.0043
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Schistosoma mansoni dishevelled 0.0019 0.0029 0.0054
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0029 0.0517
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0014 0.0011 0.002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis ras GTP exchange factor 0.0013 0.0008 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0675 0.2573 0.4766
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0023 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0052 0.0096
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0023 0.0043
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0069 0.0224 0.0419
Schistosoma mansoni hypothetical protein 0.0743 0.2835 0.5252
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0022 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0128 0.0237
Toxoplasma gondii isocitrate dehydrogenase 0.0116 0.0405 0.7333
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0052 0.0218
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0052 0.1613
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0023 0.0043
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0256 0.0582
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0133 0.0249
Echinococcus multilocularis zinc finger protein 0.0023 0.0045 0.0084
Onchocerca volvulus 0.0017 0.0023 0.0057
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.0422 0.764
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0011 0.002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0023 0.0023
Echinococcus granulosus orexin receptor type 2 0.0017 0.0023 0.0043
Brugia malayi hypothetical protein 0.0019 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0138 0.0489 0.0489
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0116 0.0405 0.7333
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0029 0.0029
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0022 0.004
Mycobacterium tuberculosis Conserved protein 0.0077 0.0256 0.1318
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0062 0.0116
Onchocerca volvulus 0.0305 0.1138 0.4407
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0053 0.0162 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0088 0.0162
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0739 0.2818 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0133 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0675 0.2573 0.4766
Toxoplasma gondii LsmAD domain-containing protein 0.0154 0.0552 1
Mycobacterium tuberculosis Conserved protein 0.0077 0.0256 0.1318
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0053 0.0162 0.0299
Echinococcus multilocularis Protein son of sevenless 0.0013 0.0008 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0128 0.0127
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0029 0.0054
Schistosoma mansoni ras GTP exchange factor 0.0013 0.0008 0.0015
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0016 0.0018
Loa Loa (eye worm) hypothetical protein 0.1087 0.4167 0.4167
Schistosoma mansoni zinc finger protein 0.0023 0.0045 0.0083
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0029 0.0042
Giardia lamblia Kinase, PLK 0.0675 0.2573 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0026 0.0031
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0029 0.0101
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0029 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0026 0.0043
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.0414 0.2173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0128 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0011 0.002
Echinococcus granulosus son of sevenless 1 0.0013 0.0008 0.0015
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0026 0.0036
Echinococcus multilocularis serotonin receptor 0.0017 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Onchocerca volvulus 0.0017 0.0023 0.0057
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0023 0.0023
Schistosoma mansoni biogenic amine receptor 0.0017 0.0023 0.0042
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0116 0.0405 0.0759
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0023 0.0043
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0256 0.0454
Giardia lamblia GTOR 0.0045 0.0133 0.0516
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0023 0.0043
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.0466 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0016 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0011 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0023 0.0043
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0014 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0015 0.0015 0.001
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0157 0.0294
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0023 0.0043
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0675 0.2573 0.4822
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Brugia malayi glutathione reductase 0.0052 0.0157 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0256 0.0474
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.0414 0.2173
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0029 0.0054
Onchocerca volvulus 0.0019 0.0029 0.0081
Echinococcus multilocularis microtubule associated protein 2 0.1389 0.5335 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0023 0.0043
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0014 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0088 0.0162
Loa Loa (eye worm) hypothetical protein 0.0659 0.251 0.2509
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0029 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0097 0.0179
Brugia malayi beta-lactamase 0.0077 0.0256 0.0255
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0042
Echinococcus granulosus neuropeptide receptor 0.0017 0.0023 0.0043
Schistosoma mansoni hypothetical protein 0.0015 0.0015 0.0028
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0016 0.0011
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0053 0.0162 0.0367
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0023 0.0043
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0023 0.0043
Schistosoma mansoni bromodomain containing protein 0.0066 0.0212 0.0393
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0016 0.0006
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0256 0.1318
Trichomonas vaginalis CAMK family protein kinase 0.0334 0.1252 0.2319
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0053 0.0162 0.0367
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0023 0.0043
Brugia malayi MH2 domain containing protein 0.0177 0.0641 0.0641
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0062 0.0062
Leishmania major hypothetical protein, conserved 0.0154 0.0552 0.1297
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0016 0.0029
Onchocerca volvulus 0.0017 0.0023 0.0057
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0133 0.0298
Mycobacterium tuberculosis Conserved protein 0.0077 0.0256 0.1318
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0157 0.285
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0023 0.0057
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0053 0.0162 0.0356
Brugia malayi G-protein coupled receptor 0.0017 0.0023 0.0023
Brugia malayi Dopamine receptor 0.0017 0.0023 0.0023
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0256 0.0479
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0126 0.0443 0.2328
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0053 0.0162 0.2926
Schistosoma mansoni adenoreceptor 0.0017 0.0023 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0042
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Loa Loa (eye worm) MH1 domain-containing protein 0.0079 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Brugia malayi Smad1 0.0177 0.0641 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0011 0.002
Schistosoma mansoni smad1 5 8 and 0.0177 0.0641 0.1187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0088 0.0162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Brugia malayi mothers against decapentaplegic homolog 3 0.0079 0.0262 0.0262
Trypanosoma cruzi polo-like protein kinase, putative 0.0675 0.2573 0.6145
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0675 0.2573 0.4822
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.0079 0.0262 0.0262
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0026 0.0028
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0026 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0011 0.002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0157 0.0787
Onchocerca volvulus 0.0017 0.0023 0.0057
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0126 0.0443 0.0802
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0026 0.0028
Trypanosoma brucei trypanothione reductase 0.0052 0.0157 0.0346
Trichomonas vaginalis set domain proteins, putative 0.0241 0.089 0.165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0062 0.0115
Schistosoma mansoni hypothetical protein 0.0877 0.3353 0.6212
Onchocerca volvulus 0.0087 0.0294 0.1116
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0013 0.0012
Entamoeba histolytica hypothetical protein 0.0739 0.2818 1
Brugia malayi Serotonin receptor 0.0017 0.0023 0.0023
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0116 0.0405 0.0759
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0013 0.0008 0.0015
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Brugia malayi hypothetical protein 0.0099 0.0341 0.0341
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0023 0.0043
Loa Loa (eye worm) beta-lactamase 0.0077 0.0256 0.0255
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.0414 0.2173
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0052 0.0075
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0157 0.0294
Loa Loa (eye worm) MH1 domain-containing protein 0.0177 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0011 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0029
Echinococcus granulosus serotonin receptor 0.0017 0.0023 0.0043
Brugia malayi Probable isocitrate dehydrogenase 0.0014 0.0011 0.0011
Mycobacterium leprae Probable lipase LipE 0.0077 0.0256 0.5383
Brugia malayi Pip kinase protein 2 0.0659 0.251 0.2509
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0079 0.0262 0.0262
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.002 0.0038
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0133 0.0133
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0026 0.0048
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0053 0.0162 0.0303
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0087 0.0294 0.0294
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0126 0.0443 0.1042
Entamoeba histolytica serine/threonine protein kinase, putative 0.0675 0.2573 0.9129
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0023 0.0043
Trichomonas vaginalis glutaminase, putative 0.1405 0.5398 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0053 0.0162 0.0161
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0144 0.027
Trypanosoma cruzi polo-like protein kinase, putative 0.0675 0.2573 0.6145
Echinococcus granulosus somatostatin receptor 0.0017 0.0023 0.0043
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0023 0.0043
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0023 0.0043
Toxoplasma gondii ABC1 family protein 0.0077 0.0256 0.4632
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0026 0.0602
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0026 0.0043
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0256 0.0474
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0026 0.0028
Brugia malayi Dopamine receptor protein 2 0.0017 0.0023 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0675 0.2573 0.4766
Onchocerca volvulus 0.0017 0.0023 0.0057
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.002 0.0038
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0256 0.0255
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0256 0.0593
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0013 0.0024
Brugia malayi MH2 domain containing protein 0.0079 0.0262 0.0262
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0011 0.002
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0256 0.1318
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0144 0.0267
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0262 0.0467
Brugia malayi Serotonin receptor 0.0017 0.0023 0.0023
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0675 0.2573 0.2573
Schistosoma mansoni tar DNA-binding protein 0.0654 0.249 0.4614
Schistosoma mansoni kinase 0.0343 0.1286 0.2383
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.0154 0.0552 0.1303
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0079 0.0148
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0116 0.0405 0.0939
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0053 0.0162 0.0356
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0052 0.1077
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0053 0.0162 0.0573
Brugia malayi ORL1-like opioid receptor 0.0017 0.0023 0.0023
Toxoplasma gondii hypothetical protein 0.0019 0.0029 0.0526
Giardia lamblia Hypothetical protein 0.0053 0.0162 0.0628
Mycobacterium ulcerans hypothetical protein 0.0126 0.0443 0.0802
Echinococcus granulosus citrate lyase subunit beta protein 0.0126 0.0443 0.0831
Loa Loa (eye worm) glutaminase 0.1405 0.5398 0.5398
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0029 0.0037
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0157 0.0295
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus granulosus GPCR family 2 0.0344 0.1289 0.2416
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0023 0.0023
Onchocerca volvulus 0.0048 0.0141 0.0518
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0016 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0016 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0071 0.0131
Mycobacterium ulcerans hypothetical protein 0.0077 0.0256 0.0454
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Loa Loa (eye worm) hypothetical protein 0.0305 0.1138 0.1138
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0162 0.2926
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0023 0.0043
Plasmodium vivax ataxin-2 like protein, putative 0.0154 0.0552 1
Schistosoma mansoni amine GPCR 0.0017 0.0023 0.0042
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0133 0.0287
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0026 0.0036
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0013 0.0008 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0075 0.0139
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0675 0.2573 0.4766
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Schistosoma mansoni DNA helicase recq5 0.0011 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0029
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.004 0.0074
Brugia malayi putative neuropeptide receptor 0.0017 0.0023 0.0023
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0029 0.0054
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0016 0.0029
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0014 0.0011 0.0011
Brugia malayi Pre-SET motif family protein 0.0032 0.0079 0.0079
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0028 0.051
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0023 0.0023
Trichomonas vaginalis helicase, putative 0.0014 0.0011 0.002
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0675 0.2573 0.4766
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0262 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0008 0.0029
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0144 0.027
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0052 0.0935
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0053 0.0162 0.0299
Schistosoma mansoni biogenic amine receptor 0.0017 0.0023 0.0042
Trypanosoma brucei ISWI complex protein 0.0015 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0077 0.0256 0.0255
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0042
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0016 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0043
Brugia malayi N-terminal motif family protein 0.0013 0.0008 0.0008
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0262 0.553
Brugia malayi hypothetical protein 0.0154 0.0552 0.0552
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0029 0.0054
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0023 0.0043
Loa Loa (eye worm) isocitrate dehydrogenase 0.0116 0.0405 0.0404
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0026 0.0043
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0097 0.0206
Entamoeba histolytica hypothetical protein 0.0013 0.0008 0.0029
Brugia malayi Dopamine receptor protein 1 0.0017 0.0023 0.0023
Brugia malayi G-protein coupled receptor 0.0017 0.0023 0.0023
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0262 0.0492
Entamoeba histolytica phosphoinositide kinase, putative 0.0053 0.0162 0.0573
Loa Loa (eye worm) hypothetical protein 0.0077 0.0256 0.0255
Loa Loa (eye worm) hypothetical protein 0.0077 0.0256 0.0255
Mycobacterium ulcerans hypothetical protein 0.0126 0.0443 0.0802
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0029 0.0517
Echinococcus granulosus dnaJ subfamily B 0.0877 0.3353 0.6284
Brugia malayi Bromodomain containing protein 0.0078 0.0257 0.0257
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0133 0.0292
Plasmodium falciparum glutathione reductase 0.0052 0.0157 0.285
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0053 0.0162 0.0367
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0023 0.0042
Onchocerca volvulus 0.0017 0.0023 0.0057
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0016 0.0011
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0053 0.0162 0.2926
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0023 0.0043
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0739 0.2818 0.5283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0052 0.0096
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0023 0.0023
Onchocerca volvulus 0.0017 0.0023 0.0057
Plasmodium falciparum ataxin-2 like protein, putative 0.0154 0.0552 1
Onchocerca volvulus 0.0032 0.0079 0.0275
Echinococcus multilocularis geminin 0.1244 0.4775 0.8949
Loa Loa (eye worm) hypothetical protein 0.0233 0.086 0.086
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0023 0.0043
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0026 0.0031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0198 0.0372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0052 0.0096
Schistosoma mansoni hypothetical protein 0.002 0.0035 0.0066

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 94.7 uM Concentration required for antiviral activity in PBMC (human peripheral blood mononuclear cells) infected with HIV-1 strain LAV ChEMBL. 8410975
EC50 (functional) > 200 uM Compound was tested for its anti-HIV activity in acutely infected MT-4 cells ChEMBL. No reference
IC50 (functional) > 100 uM Inhibition of cell growth against HIV-1 infected PBM (Human peripheral blood mononuclear) cells ChEMBL. 8410975
IC50 (functional) > 100 uM Inhibition of cell growth in vero cells ChEMBL. 8410975
Inhibition (functional) = 0 % Percent inhibition of the compound was tested for its anti-HBV activity in infected HepG2(2.2.15) cells at concentration of 25 microM ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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