Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0043 | 0.1578 | 0.1578 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1578 | 0.4975 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1578 | 0.4975 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1468 | 0.4626 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3173 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0401 | 0.0401 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2387 | 0.2387 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3173 | 0.3173 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0401 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1468 | 0.1468 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0401 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2387 | 0.2387 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3173 | 0.3173 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1578 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2387 | 0.2387 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0401 | 0.0401 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1578 | 0.4975 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0401 | 0.1265 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1578 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1578 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1578 | 0.4975 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0401 | 0.1265 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1578 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0401 | 0.1265 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3173 | 0.3173 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3173 | 0.3173 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3173 | 0.3173 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1468 | 0.1468 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2387 | 0.2387 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.