Detailed information for compound 1460911

Basic information

Technical information
  • TDR Targets ID: 1460911
  • Name: 7-(2-ethoxyethyl)-1,3-dimethyl-8-pyrrolidin-1 -ylpurine-2,6-dione
  • MW: 321.375 | Formula: C15H23N5O3
  • H donors: 0 H acceptors: 3 LogP: 0.67 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCCn1c(nc2c1c(=O)n(C)c(=O)n2C)N1CCCC1
  • InChi: 1S/C15H23N5O3/c1-4-23-10-9-20-11-12(16-14(20)19-7-5-6-8-19)17(2)15(22)18(3)13(11)21/h4-10H2,1-3H3
  • InChiKey: MYOMGYBWLLCHFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-(2-ethoxyethyl)-1,3-dimethyl-8-pyrrolidin-1-yl-purine-2,6-dione
  • 7-(2-ethoxyethyl)-1,3-dimethyl-8-1-pyrrolidinylpurine-2,6-dione
  • 7-(2-ethoxyethyl)-1,3-dimethyl-8-pyrrolidin-1-yl-xanthine
  • 7-(2-Ethoxy-ethyl)-1,3-dimethyl-8-pyrrolidin-1-yl-3,7-dihydro-purine-2,6-dione
  • BAS 08333457
  • STOCK4S-74116
  • ZINC02425279

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus integrin alpha ps 0.0074 0.0566 0.0566
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) CUTiclin-Like family member 0.0034 0.0124 0.0134
Schistosoma mansoni cathepsin D (A01 family) 0.0731 0.7842 0.7842
Brugia malayi GCC2 and GCC3 family protein 0.0059 0.0397 0.0429
Echinococcus multilocularis G-protein coupled receptor, putative 0.0076 0.0594 0.0594
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0162 0.1543 0.1667
Loa Loa (eye worm) melatonin receptor type 1A 0.0076 0.0594 0.0642
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0594 0.0594
Schistosoma mansoni adenoreceptor 0.0076 0.0594 0.0594
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0085 0.0689 0.2375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Toxoplasma gondii microneme protein MIC2 0.0034 0.0124 0.0349
Loa Loa (eye worm) hypothetical protein 0.0064 0.0458 0.0494
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0076 0.0594 0.0594
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0073 0.0551 0.0551
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0594 0.0594
Echinococcus granulosus voltage dependent calcium channel subunit 0.0034 0.0124 0.0124
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0594 0.0594
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0162 0.1543 0.1543
Trypanosoma brucei mitotic cyclin 6 0.0044 0.0233 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Brugia malayi hypothetical protein 0.0059 0.0397 0.0429
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0587 0.6246 0.6246
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0162 0.1543 0.1667
Loa Loa (eye worm) hypothetical protein 0.0087 0.0714 0.0772
Loa Loa (eye worm) hypothetical protein 0.0059 0.0397 0.0429
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0075 0.0575 0.0622
Plasmodium falciparum plasmepsin VIII, putative 0.0073 0.0551 0.192
Echinococcus multilocularis glycine receptor subunit beta 0.0162 0.1543 0.1543
Toxoplasma gondii rhoptry neck protein RON1 0.0059 0.0397 0.1354
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0087 0.0714 0.0772
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Brugia malayi Cation transporter family protein 0.0162 0.1543 0.1667
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0126 0.4744
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0897 0.3123
Brugia malayi AKH receptor 0.0076 0.0594 0.0642
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0594 0.0594
Entamoeba histolytica cyclin, putative 0.0044 0.0233 0.2978
Echinococcus multilocularis neuroendocrine convertase 2 0.0276 0.2808 0.2808
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Onchocerca volvulus 0.0059 0.0397 0.0636
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0034 0.0124 0.0134
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0076 0.0594 0.0594
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0073 0.0551 0.0551
Schistosoma mansoni hypothetical protein 0.0034 0.0124 0.0124
Leishmania major cyclin 0.0044 0.0233 1
Giardia lamblia High cysteine membrane protein Group 2 0.0163 0.1557 1
Onchocerca volvulus 0.0076 0.0594 0.0951
Onchocerca volvulus 0.0162 0.1543 0.247
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0075 0.0575 0.0575
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Plasmodium vivax thrombospondin-related anonymous protein 0.0034 0.0124 0.0349
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0023
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.0025 0.0029 0.0029
Loa Loa (eye worm) endoprotease bli-4 0.044 0.4617 0.4988
Echinococcus granulosus serotonin receptor 0.0076 0.0594 0.0594
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0267 0.2707 0.9633
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0594 0.0594
Plasmodium falciparum plasmepsin III 0.0073 0.0551 0.192
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0162 0.1543 0.1667
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0162 0.1543 0.1667
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Onchocerca volvulus 0.0276 0.2809 0.4498
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0076 0.0594 0.0642
Echinococcus multilocularis serotonin receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0271 0.2747 0.2968
Echinococcus multilocularis nAChR subunit 0.0162 0.1543 0.1543
Onchocerca volvulus 0.0076 0.0594 0.0951
Brugia malayi G protein-coupled receptor 0.0076 0.0594 0.0642
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0594 0.0594
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0233 0.0252
Onchocerca volvulus 0.0076 0.0594 0.0951
Echinococcus granulosus G protein coupled receptor kinase 1 0.0085 0.0692 0.0692
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0076 0.0594 0.0594
Loa Loa (eye worm) integrin alpha pat-2 0.0254 0.2564 0.277
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0198 0.8294
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Echinococcus granulosus G protein coupled receptor 139 0.0076 0.0594 0.0594
Echinococcus granulosus C type lectin domian containing protein 0.0059 0.0397 0.0397
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0162 0.1543 0.1667
Brugia malayi neuropeptide F receptor 0.0076 0.0594 0.0642
Brugia malayi von Willebrand factor type A domain containing protein 0.0034 0.0124 0.0134
Schistosoma mansoni integrin alpha 0.0165 0.1574 0.1574
Loa Loa (eye worm) hypothetical protein 0.0038 0.0174 0.0188
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0271 0.2747 0.2747
Loa Loa (eye worm) hypothetical protein 0.0304 0.3112 0.3362
Schistosoma mansoni nAChR subunit 0.0162 0.1543 0.1543
Schistosoma mansoni hypothetical protein 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.003
Trichomonas vaginalis cyclins, putative 0.0044 0.0233 0.0734
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0076 0.0594 0.0642
Loa Loa (eye worm) TYRA-2 protein 0.0076 0.0594 0.0642
Schistosoma mansoni nAChR subunit 0.0162 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Brugia malayi Protein set-1 0.0064 0.0458 0.0494
Brugia malayi Cation transporter family protein 0.0304 0.3112 0.3362
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Schistosoma mansoni opsin-like receptor 0.0076 0.0594 0.0594
Echinococcus granulosus sex peptide receptor 0.0076 0.0594 0.0594
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0034 0.0124 0.0349
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0614 0.0614
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0594 0.0594
Echinococcus granulosus glycine receptor subunit beta 0.0162 0.1543 0.1543
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0073 0.0551 0.0551
Echinococcus multilocularis neuropeptide FF receptor 2 0.0076 0.0594 0.0594
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0271 0.2747 1
Echinococcus granulosus somatostatin receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0025 0.0021 0.0021
Plasmodium falciparum SET domain protein, putative 0.0064 0.0458 0.1577
Onchocerca volvulus 0.0034 0.0124 0.0199
Echinococcus granulosus hypothetical protein 0.0076 0.0594 0.0594
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0594 0.0594
Echinococcus granulosus alpha 1A adrenergic receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0091 0.0755 0.0816
Echinococcus granulosus neuropeptide receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0714 0.0714
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.0025 0.0029 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0594 0.0594
Toxoplasma gondii aspartyl protease ASP3 0.0151 0.1424 0.5131
Brugia malayi larval opioid receptor 0.0076 0.0594 0.0642
Brugia malayi hypothetical protein 0.0076 0.0594 0.0642
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0594 0.0594
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0076 0.0594 0.0951
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0059 0.0397 0.0429
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0304 0.3112 0.4982
Schistosoma mansoni neuropeptide receptor 0.0076 0.0594 0.0594
Schistosoma mansoni thyroid hormone receptor 0.0148 0.1383 0.1383
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0034 0.0124 0.0124
Brugia malayi polk-prov protein 0.0031 0.0089 0.0096
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.1383 0.1383
Loa Loa (eye worm) CUTiclin family member 0.0034 0.0124 0.0134
Brugia malayi hypothetical protein 0.0076 0.0594 0.0642
Onchocerca volvulus 0.0087 0.0714 0.1144
Onchocerca volvulus 0.0076 0.0594 0.0951
Schistosoma mansoni alpha-1 adrenergic receptor 0.0076 0.0594 0.0594
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0162 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0104 0.0897 0.0897
Plasmodium falciparum plasmepsin V 0.0073 0.0551 0.192
Loa Loa (eye worm) hypothetical protein 0.0059 0.0397 0.0429
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0064 0.0458 0.0458
Echinococcus granulosus nAChR subunit 0.0087 0.0714 0.0714
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0594 0.0594
Echinococcus multilocularis sex peptide receptor 0.0076 0.0594 0.0594
Schistosoma mansoni hypothetical protein 0.0078 0.0614 0.0614
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0594 0.0594
Echinococcus multilocularis c4b binding protein beta chain 0.0059 0.0397 0.0397
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0044 0.0233 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0233 0.0252
Brugia malayi Dopamine receptor protein 1 0.0076 0.0594 0.0642
Schistosoma mansoni hypothetical protein 0.0035 0.014 0.014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0594 0.0594
Trichomonas vaginalis cyclin B, putative 0.0044 0.0233 0.0734
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0034 0.0124 0.0342
Brugia malayi GnHR receptor homolog 0.0076 0.0594 0.0642
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0594 0.0594
Brugia malayi Dopamine receptor 0.0076 0.0594 0.0642
Schistosoma mansoni growth hormone secretagogue receptor 0.0076 0.0594 0.0594
Trichomonas vaginalis cyclins, putative 0.0044 0.0233 0.0734
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0034 0.0124 0.0134
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0162 0.1543 0.1667
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0162 0.1543 0.1543
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0087 0.0714 0.0714
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0594 0.0594
Brugia malayi von Willebrand factor type A domain containing protein 0.0034 0.0124 0.0134
Schistosoma mansoni hypothetical protein 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0034 0.0124 0.0199
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0198 0.5
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Schistosoma mansoni neuropeptide receptor 0.0076 0.0594 0.0594
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0162 0.1543 0.1543
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0073 0.0551 0.0551
Echinococcus granulosus dro:myosuppressin receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus multilocularis integrin alpha 3 0.0126 0.1148 0.1148
Echinococcus multilocularis C type lectin domian containing protein 0.0059 0.0397 0.0397
Onchocerca volvulus 0.0059 0.0397 0.0636
Brugia malayi celfurPC protein 0.0355 0.3675 0.3971
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0034 0.0124 0.0124
Plasmodium vivax aspartyl protease, putative 0.0151 0.1424 0.5131
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Loa Loa (eye worm) hypothetical protein 0.0059 0.0397 0.0429
Brugia malayi Will die slowly protein 0.0276 0.2809 0.3035
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0594 0.0594
Schistosoma mansoni nAChR subunit 0.0162 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0087 0.0714 0.0772
Schistosoma mansoni integrin alpha-ps 0.0074 0.0566 0.0566
Onchocerca volvulus 0.0162 0.1543 0.247
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0594 0.0594
Brugia malayi von Willebrand factor type A domain containing protein 0.0034 0.0124 0.0134
Loa Loa (eye worm) hypothetical protein 0.0044 0.0233 0.0252
Echinococcus granulosus c4b binding protein beta chain 0.0059 0.0397 0.0397
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0073 0.0551 0.192
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0025 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0162 0.1543 0.1667
Onchocerca volvulus 0.0076 0.0594 0.0951
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0162 0.1543 0.1667
Echinococcus granulosus fmrfamide receptor 0.0076 0.0594 0.0594
Onchocerca volvulus Neuropeptide F receptor homolog 0.0076 0.0594 0.0951
Schistosoma mansoni hypothetical protein 0.0078 0.0614 0.0614
Entamoeba histolytica hypothetical protein 0.0087 0.0714 1
Brugia malayi hypothetical protein 0.0059 0.0397 0.0429
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0075 0.0575 0.0622
Onchocerca volvulus 0.0059 0.0397 0.0636
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Brugia malayi hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0087 0.0714 0.0772
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Schistosoma mansoni cyclin B 0.0044 0.0233 0.0233
Giardia lamblia G2/mitotic-specific cyclin B 0.0044 0.0233 0.1336
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Brugia malayi Pepsin A precursor 0.0073 0.0551 0.0595
Echinococcus granulosus glycine receptor subunit beta 0.0162 0.1543 0.1543
Echinococcus granulosus protein will die slowly 0.0276 0.2809 0.2809
Brugia malayi Zona pellucida-like domain containing protein 0.0034 0.0124 0.0134
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0198 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Echinococcus granulosus peptide allatostatin:somatostatin 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0162 0.1543 0.1667
Brugia malayi hypothetical protein 0.0075 0.0575 0.0622
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0075 0.0575 0.0622
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0897 0.3123
Plasmodium vivax aspartyl proteinase, putative 0.0073 0.0551 0.192
Echinococcus multilocularis 0.0034 0.0129 0.0129
Brugia malayi hypothetical protein 0.0076 0.0594 0.0642
Echinococcus granulosus GPCR family 2 0.0078 0.0614 0.0614
Brugia malayi Dopamine receptor protein 2 0.0076 0.0594 0.0642
Brugia malayi G-protein coupled receptor 0.0076 0.0594 0.0642
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0025 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0033
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0059 0.0397 0.0636
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0162 0.1543 0.1543
Echinococcus granulosus tachykinin peptides receptor 99D 0.0076 0.0594 0.0594
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0247 0.2488 0.2688
Onchocerca volvulus 0.0076 0.0594 0.0951
Echinococcus granulosus glycine receptor subunit alpha 1 0.0162 0.1543 0.1543
Brugia malayi von Willebrand factor type A domain containing protein 0.0034 0.0124 0.0134
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0124 0.1386
Plasmodium vivax apical sushi protein, putative 0.0059 0.0397 0.1354
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0085 0.0692 0.0692
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus multilocularis GPCR, family 2 0.0078 0.0614 0.0614
Brugia malayi hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0095 0.0801 0.0866
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0587 0.6246 0.6246
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Echinococcus granulosus neuropeptide s receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0125 0.1129 0.122
Loa Loa (eye worm) aspartyl protease 6 0.0073 0.0551 0.0595
Echinococcus granulosus orexin receptor type 2 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0087 0.0714 0.1144
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0075 0.0575 0.0575
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0162 0.1543 0.1543
Loa Loa (eye worm) proprotein convertase 2 0.0104 0.0897 0.097
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Onchocerca volvulus 0.0034 0.0124 0.0199
Echinococcus granulosus 7tm_1 domain containing protein 0.0076 0.0594 0.0594
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0198 0.0609
Echinococcus granulosus g-protein coupled receptor 0.0076 0.0594 0.0594
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0801 0.0801
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0897 0.3123
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0594 0.0594
Brugia malayi hypothetical protein 0.0059 0.0397 0.0429
Brugia malayi Serotonin receptor 0.0076 0.0594 0.0642
Schistosoma mansoni amine GPCR 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0587 0.6246 0.6748
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0594 0.0594
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0076 0.0594 0.0594
Brugia malayi Calcitonin receptor-like protein seb-1 0.0247 0.2488 0.2688
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0075 0.0575 0.0921
Plasmodium falciparum thrombospondin-related anonymous protein 0.0034 0.0124 0.0349
Echinococcus granulosus collagen alpha 1VII chain 0.0034 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0059 0.0397 0.0429
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0087 0.0714 0.0772
Loa Loa (eye worm) GABA receptor subunit 0.0087 0.0714 0.0772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0594 0.0594
Echinococcus multilocularis integrin alpha ps 0.0074 0.0566 0.0566
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0162 0.1543 0.1667
Toxoplasma gondii aspartyl protease 0.0073 0.0551 0.192
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0073 0.0551 0.0595
Echinococcus granulosus integrin alpha ps 0.0035 0.014 0.014
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0076 0.0594 0.0594
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0786 0.8452 0.8452
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Onchocerca volvulus 0.0059 0.0397 0.0636
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0059 0.0397 0.0429
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Schistosoma mansoni hypothetical protein 0.0125 0.113 0.113
Schistosoma mansoni nAChR subunit 0.0075 0.0575 0.0575
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0087 0.0714 0.0772
Loa Loa (eye worm) hypothetical protein 0.0271 0.2747 0.2968
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0271 0.2747 0.2747
Onchocerca volvulus 0.0034 0.0124 0.0199
Echinococcus granulosus g protein coupled receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0059 0.0397 0.0429
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0034 0.0124 0.0134
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0162 0.1543 0.1543
Trypanosoma cruzi cyclin 6, putative 0.0044 0.0233 1
Brugia malayi hypothetical protein 0.0076 0.0594 0.0642
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0594 0.0594
Loa Loa (eye worm) acetylcholine receptor protein 0.0075 0.0575 0.0622
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0162 0.1543 0.1543
Treponema pallidum 76K protein 0.0034 0.0124 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0124 0.0134
Toxoplasma gondii histone lysine methyltransferase SET8 0.0064 0.0458 0.1577
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0076 0.0594 0.0642
Plasmodium falciparum plasmepsin IV 0.0271 0.2747 1
Schistosoma mansoni thyroid hormone receptor 0.0148 0.1383 0.1383
Brugia malayi von Willebrand factor type A domain containing protein 0.0034 0.0124 0.0134
Schistosoma mansoni memapsin-2 (A01 family) 0.0073 0.0551 0.0551
Brugia malayi hypothetical protein 0.0073 0.0551 0.0595
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Echinococcus granulosus 7TM GPCR rhodopsin 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0594 0.0594
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0162 0.1543 0.1543
Schistosoma mansoni neuropeptide f receptor 76f 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0059 0.0397 0.0429
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0076 0.0594 0.0642
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0076 0.0594 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0076 0.0594 0.0594
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0085 0.0689 0.2375
Echinococcus granulosus neuroendocrine convertase 2 0.0276 0.2808 0.2808
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0304 0.3112 0.3362
Onchocerca volvulus 0.0076 0.0594 0.0951
Plasmodium falciparum plasmepsin VI 0.0271 0.2747 1
Onchocerca volvulus 0.0304 0.3112 0.4982
Schistosoma mansoni neuropeptide receptor 0.0926 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0714 0.0772
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0096
Onchocerca volvulus 0.0076 0.0594 0.0951
Onchocerca volvulus 0.0059 0.0397 0.0636
Trichomonas vaginalis cyclins, putative 0.003 0.008 0.0182
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Schistosoma mansoni c4b-binding protein beta chain 0.0059 0.0397 0.0397
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0034 0.0129 0.0129
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0075 0.0575 0.0622
Echinococcus multilocularis glycine receptor subunit beta 0.0162 0.1543 0.1543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Schistosoma mansoni cathepsin D (A01 family) 0.0731 0.7842 0.7842
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0267 0.2707 0.2707
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Loa Loa (eye worm) hypothetical protein 0.0087 0.0714 0.0772
Echinococcus granulosus nAChR subunit 0.0162 0.1543 0.1543
Brugia malayi Melatonin receptor type 1A 0.0076 0.0594 0.0642
Brugia malayi ORL1-like opioid receptor 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus granulosus allatostatin A receptor 0.0076 0.0594 0.0594
Brugia malayi hypothetical protein 0.0076 0.0594 0.0642
Schistosoma mansoni myosin xvIII 0.0076 0.0594 0.0594
Brugia malayi G-protein coupled receptor 0.0076 0.0594 0.0642
Schistosoma mansoni hypothetical protein 0.0034 0.0124 0.0124
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0162 0.1543 0.1667
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0073 0.0551 0.0551
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.8654 0.8654
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Loa Loa (eye worm) hypothetical protein 0.0858 0.9256 1
Brugia malayi putative neuropeptide receptor 0.0076 0.0594 0.0642
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0034 0.0124 0.0349
Brugia malayi hypothetical protein 0.0075 0.0575 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0304 0.3112 0.3112
Schistosoma mansoni amine GPCR 0.0076 0.0594 0.0594
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0076 0.0594 0.0642
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0271 0.2747 0.2747
Trypanosoma cruzi cyclin, putative 0.0044 0.0233 1
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0025 0.0021 0.0021
Brugia malayi hypothetical protein 0.0059 0.0397 0.0429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0075 0.0575 0.0921
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0594 0.0594
Plasmodium falciparum plasmepsin I 0.0271 0.2747 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Schistosoma mansoni nAChR subunit 0.0162 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0587 0.6246 0.6246
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0162 0.1543 0.1667
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0267 0.2707 0.2707
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0897 0.3123
Brugia malayi endoprotease bli-4 precursor 0.044 0.4617 0.4988
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0151
Brugia malayi hypothetical protein 0.0059 0.0397 0.0429
Onchocerca volvulus 0.0059 0.0397 0.0636
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Echinococcus granulosus g protein coupled receptor 0.0076 0.0594 0.0594
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0064 0.0458 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Trypanosoma brucei unspecified product 0.0034 0.0126 0.4744
Echinococcus multilocularis integrin alpha ps 0.0074 0.0566 0.0566
Brugia malayi hypothetical protein 0.0075 0.0575 0.0622
Loa Loa (eye worm) ube2i2 protein 0.0025 0.0029 0.0031
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0075 0.0575 0.0575
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0714 0.0772
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0034 0.0124 0.0349
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0587 0.6246 0.6246
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.044 0.4617 0.4617
Loa Loa (eye worm) hypothetical protein 0.0229 0.2284 0.2467
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Onchocerca volvulus 0.0076 0.0594 0.0951
Trichomonas vaginalis cyclin B, putative 0.0044 0.0233 0.0734
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0075 0.0575 0.0622
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0059 0.0397 0.0636
Trypanosoma cruzi CYC2-like cyclin, putative 0.0044 0.0233 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0162 0.1543 0.1667
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Echinococcus multilocularis 0.0355 0.3675 0.3675
Plasmodium vivax SET domain protein, putative 0.0064 0.0458 0.1577
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Brugia malayi hypothetical protein 0.0076 0.0594 0.0642
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0034 0.0124 0.0124
Plasmodium vivax plasmepsin IV, putative 0.0271 0.2747 1
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.0025 0.0029 0.0029
Trichomonas vaginalis cyclin B, putative 0.0044 0.0233 0.0734
Brugia malayi aspartic protease BmAsp-2, identical 0.0073 0.0551 0.0595
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0076 0.0594 0.0594
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0594 0.0594
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0034 0.0124 0.0349
Brugia malayi follicle stimulating hormone receptor 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0087 0.0714 0.0772
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Trichomonas vaginalis hypothetical protein 0.0085 0.0689 0.2375
Loa Loa (eye worm) hypothetical protein 0.0059 0.0397 0.0429
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0162 0.1543 0.1667
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0162 0.1543 0.1543
Echinococcus granulosus neuropeptide FF receptor 2 0.0076 0.0594 0.0594
Schistosoma mansoni biogenic amine receptor 0.0076 0.0594 0.0594
Echinococcus multilocularis nAChR subunit 0.0087 0.0714 0.0714
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0076 0.0594 0.0594
Plasmodium falciparum plasmepsin X 0.0151 0.1424 0.5131
Schistosoma mansoni hypothetical protein 0.0169 0.1621 0.1621
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus multilocularis orexin receptor type 2 0.0076 0.0594 0.0594
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0689 0.7383 0.7383
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0076 0.0594 0.0642
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0162 0.1543 0.1543
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0587 0.6246 0.6246
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0169 0.1621 0.1751
Loa Loa (eye worm) hypothetical protein 0.0087 0.0714 0.0772
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) LGC-31 protein 0.0162 0.1543 0.1667
Brugia malayi von Willebrand factor type A domain containing protein 0.0034 0.0124 0.0134
Entamoeba histolytica hypothetical protein 0.0034 0.0124 0.1386
Echinococcus granulosus glycine receptor subunit alpha 1 0.0162 0.1543 0.1543
Brugia malayi proprotein convertase 2 0.0276 0.2808 0.3033
Schistosoma mansoni amine GPCR 0.0076 0.0594 0.0594
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0897 0.3123
Treponema pallidum hypothetical protein 0.0034 0.0124 0.5
Echinococcus granulosus glycine receptor subunit alpha 1 0.0162 0.1543 0.1543
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0162 0.1543 0.1667
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0162 0.1543 0.1667
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus granulosus Furin 1 0.0104 0.0897 0.0897
Echinococcus multilocularis beta adrenergic receptor kinase 0.0095 0.0801 0.0801
Brugia malayi hypothetical protein 0.0073 0.0551 0.0595
Brugia malayi Zona pellucida-like domain containing protein 0.0034 0.0124 0.0134
Plasmodium vivax aspartyl protease, putative 0.0151 0.1424 0.5131
Schistosoma mansoni hypothetical protein 0.0078 0.0614 0.0614
Echinococcus granulosus cyclin B 0.0044 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0078 0.0614 0.0664
Schistosoma mansoni nAChR subunit 0.0162 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0025 0.0021 0.0021
Echinococcus multilocularis allatostatin A receptor 0.0076 0.0594 0.0594
Trichomonas vaginalis cyclins, putative 0.0044 0.0233 0.0734
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) ACC-1 protein 0.0162 0.1543 0.1667
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0034 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Loa Loa (eye worm) ACC-1 protein 0.0162 0.1543 0.1667
Loa Loa (eye worm) hypothetical protein 0.0059 0.0397 0.0429
Onchocerca volvulus 0.0076 0.0594 0.0951
Onchocerca volvulus 0.0044 0.0233 0.0373
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0034 0.0124 0.0349
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.113 0.113
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0089 0.2923
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0594 0.0594
Schistosoma mansoni opsin-like receptor 0.0076 0.0594 0.0594
Brugia malayi Sushi domain 0.0059 0.0397 0.0429
Schistosoma mansoni histamine h1 receptor 0.0076 0.0594 0.0594
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0124 0.1386
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0614 0.0614
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0124 0.0349
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0075 0.0575 0.0921
Onchocerca volvulus 0.0076 0.0594 0.0951
Schistosoma mansoni biogenic amine receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0858 0.9256 1
Onchocerca volvulus 0.0073 0.0551 0.0882
Brugia malayi hypothetical protein 0.0034 0.0124 0.0134
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0075 0.0575 0.0575
Onchocerca volvulus 0.0034 0.0124 0.0199
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0025 0.0021 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0689 0.7383 0.7383
Brugia malayi Cation transporter family protein 0.0162 0.1543 0.1667
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0198 0.8294
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0075 0.0575 0.0622
Brugia malayi aspartic protease BmAsp-1, identical 0.0073 0.0551 0.0595
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0594 0.0594
Schistosoma mansoni nAChR subunit 0.0075 0.0575 0.0575
Echinococcus granulosus integrin alpha 3 0.0126 0.1148 0.1148
Toxoplasma gondii aspartyl protease ASP1 0.0271 0.2747 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0162 0.1543 0.1543
Plasmodium falciparum plasmepsin II 0.0271 0.2747 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0075 0.0575 0.0575
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0594 0.0642
Plasmodium falciparum plasmepsin IX 0.0151 0.1424 0.5131
Brugia malayi hypothetical protein 0.0075 0.0575 0.0622
Schistosoma mansoni amine GPCR 0.0076 0.0594 0.0594
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0125 0.1129 0.122
Schistosoma mansoni acetylcholine receptor subunit beta 0.0075 0.0575 0.0575
Schistosoma mansoni biogenic amine receptor 0.0076 0.0594 0.0594
Schistosoma mansoni integrin alpha-ps 0.0038 0.0174 0.0174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0073 0.0551 0.0882
Echinococcus multilocularis G protein coupled receptor 139 0.0926 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0089 0.2923
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0594 0.0594
Echinococcus granulosus beta-adrenergic receptor kinase 0.0095 0.0801 0.0801
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Schistosoma mansoni neuropeptide receptor 0.0076 0.0594 0.0594
Brugia malayi latrophilin 2 splice variant baaae 0.0169 0.1621 0.1751
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0594 0.0594
Echinococcus multilocularis protein will die slowly 0.0276 0.2809 0.2809
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0059 0.0397 0.0636
Loa Loa (eye worm) hypothetical protein 0.0073 0.0551 0.0595
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Onchocerca volvulus 0.0076 0.0594 0.0951
Onchocerca volvulus 0.0076 0.0594 0.0951
Brugia malayi sulfakinin receptor protein 0.0076 0.0594 0.0642
Echinococcus granulosus furin 0.044 0.4617 0.4617
Brugia malayi pregnancy-associated plasma protein-A 0.0059 0.0397 0.0429
Brugia malayi Serotonin receptor 0.0076 0.0594 0.0642
Brugia malayi von Willebrand factor type A domain containing protein 0.0034 0.0124 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Schistosoma mansoni amine GPCR 0.0076 0.0594 0.0594
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0162 0.1543 0.1667
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0034 0.0124 0.0199
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0162 0.1543 0.1667
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0076 0.0594 0.0594
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0073 0.0551 0.0551
Schistosoma mansoni hypothetical protein 0.0085 0.0689 0.0689
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0614 0.0664
Onchocerca volvulus 0.0076 0.0594 0.0951
Brugia malayi von Willebrand Factor 0.0034 0.0124 0.0134
Schistosoma mansoni neurotransmitter gated ion channel 0.0087 0.0714 0.0714
Brugia malayi hypothetical protein 0.0076 0.0594 0.0642
Giardia lamblia Furin precursor putative serine protease 0.0085 0.0689 0.4321
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0786 0.8452 0.8452
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0073 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0044 0.0233 0.0252
Trichomonas vaginalis cyclins, putative 0.0044 0.0233 0.0734
Loa Loa (eye worm) hypothetical protein 0.044 0.4617 0.4988
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0614 0.0664
Loa Loa (eye worm) hypothetical protein 0.0129 0.1182 0.1277
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Echinococcus multilocularis g-protein coupled receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Echinococcus multilocularis Furin 1 0.0104 0.0897 0.0897
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0162 0.1543 0.1543
Schistosoma mansoni hypothetical protein 0.0276 0.2809 0.2809
Schistosoma mansoni furin-1 (S08 family) 0.0191 0.1866 0.1866
Echinococcus multilocularis somatostatin receptor 0.0076 0.0594 0.0594
Brugia malayi excitatory GABA receptor EXP-1A 0.0162 0.1543 0.1667
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0594 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0034 0.0124 0.0349
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0271 0.2747 0.9776
Brugia malayi hypothetical protein 0.0076 0.0594 0.0642
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0587 0.6246 0.6246
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0786 0.8452 0.8452
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0162 0.1543 0.1543
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0162 0.1543 0.1543
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Toxoplasma gondii rhoptry neck protein RON9 0.0059 0.0397 0.1354
Brugia malayi Integrin alpha pat-2 precursor 0.0165 0.1574 0.1701
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.113 0.113
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0073 0.0551 0.0551
Onchocerca volvulus 0.0034 0.0124 0.0199
Schistosoma mansoni nAChR subunit 0.0162 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0801 0.0801
Loa Loa (eye worm) WD40 repeat protein 0.0276 0.2809 0.3035
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Schistosoma mansoni hypothetical protein 0.0078 0.0614 0.0614
Onchocerca volvulus 0.0162 0.1543 0.247
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0594 0.0594
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0162 0.1543 0.1543
Onchocerca volvulus 0.0304 0.3112 0.4982
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Echinococcus multilocularis neuropeptide receptor A26 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0076 0.0594 0.0951
Echinococcus multilocularis neuropeptide receptor 0.0926 1 1
Plasmodium vivax aspartyl proteinase, putative 0.0271 0.2747 1
Trichomonas vaginalis cyclin A, putative 0.0044 0.0233 0.0734
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0594 0.0642
Schistosoma mansoni opsin-like receptor 0.0076 0.0594 0.0594
Brugia malayi neuropeptide F receptor 0.0076 0.0594 0.0642
Trichomonas vaginalis cyclin B, putative 0.0044 0.0233 0.0734
Loa Loa (eye worm) hypothetical protein 0.0172 0.1657 0.1791
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0198 0.8294
Echinococcus granulosus dna polymerase kappa 0.0041 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0076 0.0594 0.0594
Onchocerca volvulus Putative nachr subunit 0.0587 0.6246 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0614 0.0664
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0897 0.3123
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0085 0.0689 0.2375
Echinococcus multilocularis neuropeptide s receptor 0.0076 0.0594 0.0594
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0075 0.0575 0.0575
Echinococcus multilocularis integrin alpha ps 0.0035 0.014 0.014
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0076 0.0594 0.0594
Echinococcus granulosus g protein coupled receptor 0.0076 0.0594 0.0594
Onchocerca volvulus 0.0076 0.0594 0.0951
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0162 0.1543 0.1667
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0587 0.6246 0.6748
Trichomonas vaginalis WD repeat domain, putative 0.0276 0.2809 1
Echinococcus granulosus neuropeptide receptor A26 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0076 0.0594 0.0642
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0075 0.0575 0.0622
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0587 0.6246 0.6748
Brugia malayi ube2i2 protein 0.0025 0.0029 0.0031
Schistosoma mansoni nAChR subunit 0.0162 0.1543 0.1543
Plasmodium vivax plasmepsin V, putative 0.0073 0.0551 0.192
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Echinococcus multilocularis serotonin receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Echinococcus multilocularis dro:myosuppressin receptor 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Plasmodium falciparum apical sushi protein 0.0059 0.0397 0.1354
Brugia malayi Eukaryotic aspartyl protease family protein 0.0073 0.0551 0.0595
Loa Loa (eye worm) hypothetical protein 0.0073 0.0551 0.0595
Schistosoma mansoni acetylcholine receptor-related 0.0075 0.0575 0.0575
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0198 0.0609
Plasmodium vivax aspartyl protease, putative 0.0073 0.0551 0.192
Entamoeba histolytica elongation factor-2 kinase, putative 0.0034 0.0124 0.1386
Loa Loa (eye worm) hypothetical protein 0.0075 0.0575 0.0622
Brugia malayi von Willebrand factor type A domain containing protein 0.0034 0.0124 0.0134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0594 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0075 0.0575 0.0622
Schistosoma mansoni neurotransmitter gated ion channel 0.0075 0.0575 0.0575
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0714 0.0772
Brugia malayi hypothetical protein 0.0059 0.0397 0.0429
Brugia malayi Tachykinin-like peptides receptor 99D 0.0076 0.0594 0.0642
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0064 0.0458 0.0458
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0594 0.0594
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Onchocerca volvulus 0.0076 0.0594 0.0951
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Brugia malayi PDZ domain containing protein 0.0025 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0162 0.1543 0.1667
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Loa Loa (eye worm) hypothetical protein 0.0162 0.1543 0.1667
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0076 0.0594 0.0594
Plasmodium falciparum plasmepsin VII 0.0073 0.0551 0.192
Brugia malayi neuroendocrine convertase 1 precursor 0.0276 0.2808 0.3033
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0304 0.3112 0.3112
Schistosoma mansoni hypothetical protein 0.0076 0.0594 0.0594
Brugia malayi G protein-coupled receptor F59B2.13 0.0076 0.0594 0.0642
Trypanosoma cruzi cyclin, putative 0.0044 0.0233 1
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0689 0.2375
Brugia malayi RE15519p 0.0076 0.0594 0.0642
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0134
Brugia malayi putative neuropeptide receptor NPR1 0.0076 0.0594 0.0642
Echinococcus multilocularis cyclin B 0.0044 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0076 0.0594 0.0642
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0594 0.0594
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0267 0.2707 0.9633
Onchocerca volvulus 0.0059 0.0397 0.0636
Brugia malayi hypothetical protein 0.0075 0.0575 0.0622
Brugia malayi hypothetical protein 0.0059 0.0397 0.0429

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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