Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0756 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0128 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1553 | 0.1553 |
Echinococcus granulosus | acetylcholinesterase | 0.0756 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0756 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0128 | 0.1553 | 0.1553 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0128 | 0.1553 | 0.1553 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0128 | 0.1553 | 0.1553 |
Onchocerca volvulus | 0.0128 | 0.1553 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.0128 | 0.1553 | 0.1553 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0128 | 0.1553 | 0.1553 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0128 | 0.1553 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0128 | 0.1553 | 0.1553 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0128 | 0.1553 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0128 | 0.1553 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0128 | 0.1553 | 0.1553 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0128 | 0.1553 | 0.1553 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0756 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0128 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1553 | 0.1553 |
Brugia malayi | hypothetical protein | 0.0128 | 0.1553 | 0.1553 |
Brugia malayi | Carboxylesterase family protein | 0.0128 | 0.1553 | 0.1553 |
Schistosoma mansoni | gliotactin | 0.0128 | 0.1553 | 0.1553 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0128 | 0.1553 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.1553 | 1 | |
Onchocerca volvulus | 0.0128 | 0.1553 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0128 | 0.1553 | 0.1553 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0128 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0756 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0128 | 0.1553 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1553 | 0.1553 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0128 | 0.1553 | 0.1553 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0756 | 1 | 1 |
Onchocerca volvulus | 0.0128 | 0.1553 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0756 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0128 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | carboxylesterase | 0.0756 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0756 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0128 | 0.1553 | 0.1553 |
Brugia malayi | Carboxylesterase family protein | 0.0128 | 0.1553 | 0.1553 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0128 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1553 | 0.1553 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0128 | 0.1553 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0756 | 1 | 1 |
Onchocerca volvulus | 0.0128 | 0.1553 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0756 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0128 | 0.1553 | 0.1553 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0128 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1553 | 0.1553 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.