Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Loa Loa (eye worm) | cysteine protease | 0.0742 | 0.7208 | 0.7208 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0395 | 0.3694 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0742 | 0.7208 | 0.6791 |
Brugia malayi | Cathepsin L-like precursor | 0.0505 | 0.4812 | 0.4812 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0742 | 0.7208 | 0.7208 |
Giardia lamblia | Cathepsin B precursor | 0.0424 | 0.3989 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0742 | 0.7208 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0505 | 0.4812 | 0.4812 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0742 | 0.7208 | 0.6791 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0395 | 0.3694 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Leishmania major | cathepsin L-like protease | 0.0742 | 0.7208 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1298 | 0.1298 |
Onchocerca volvulus | Cathepsin F homolog | 0.0742 | 0.7208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1017 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Plasmodium vivax | vivapain-2 | 0.0742 | 0.7208 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1017 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1017 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0742 | 0.7208 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0742 | 0.7208 | 0.6791 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0742 | 0.7208 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0742 | 0.7208 | 0.6791 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0742 | 0.7208 | 1 |
Brugia malayi | cathepsin L precursor | 0.0159 | 0.1298 | 0.1298 |
Echinococcus multilocularis | cathepsin L | 0.0395 | 0.3694 | 0.2753 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0159 | 0.1298 | 0.1298 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0742 | 0.7208 | 0.6791 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 0.7208 | 0.7208 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0395 | 0.3694 | 0.2753 |
Brugia malayi | Cathepsin L-like precursor | 0.0742 | 0.7208 | 0.7208 |
Plasmodium vivax | unspecified product | 0.0236 | 0.2087 | 0.1336 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0742 | 0.7208 | 0.6791 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0424 | 0.3989 | 0.3093 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2087 | 0.2087 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0742 | 0.7208 | 0.6791 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0395 | 0.3694 | 0.2753 |
Echinococcus granulosus | cysteine protease | 0.0395 | 0.3694 | 0.2753 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Onchocerca volvulus | 0.0742 | 0.7208 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0505 | 0.4812 | 0.4038 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0395 | 0.3694 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0742 | 0.7208 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0742 | 0.7208 | 0.7208 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2087 | 0.2087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0395 | 0.3694 | 0.3694 |
Toxoplasma gondii | cathepsin B | 0.0424 | 0.3989 | 0.4554 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Onchocerca volvulus | 0.0742 | 0.7208 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0395 | 0.3694 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0742 | 0.7208 | 0.6791 |
Brugia malayi | Cathepsin L-like precursor | 0.0742 | 0.7208 | 0.7208 |
Entamoeba histolytica | cysteine protease, putative | 0.0742 | 0.7208 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0742 | 0.7208 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0236 | 0.2087 | 0.0907 |
Brugia malayi | Cathepsin L-like precursor | 0.0742 | 0.7208 | 0.7208 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Onchocerca volvulus | 0.0742 | 0.7208 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0742 | 0.7208 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0742 | 0.7208 | 0.6791 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Leishmania major | cathepsin L-like protease | 0.0742 | 0.7208 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1017 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1017 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0742 | 0.7208 | 0.7208 |
Echinococcus multilocularis | cysteine protease | 0.0742 | 0.7208 | 0.6791 |
Echinococcus multilocularis | cathepsin b | 0.1017 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0424 | 0.3989 | 0.4554 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0159 | 0.1298 | 0.1298 |
Plasmodium vivax | unspecified product | 0.0395 | 0.3694 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1298 | 0.1298 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1017 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0424 | 0.3989 | 0.0841 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0395 | 0.3694 | 0.2753 |
Brugia malayi | Cathepsin L-like precursor | 0.0505 | 0.4812 | 0.4812 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0395 | 0.3694 | 0.2753 |
Leishmania major | cathepsin L-like protease | 0.0742 | 0.7208 | 1 |
Leishmania major | cathepsin L-like protease | 0.0742 | 0.7208 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0742 | 0.7208 | 0.7208 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0395 | 0.3694 | 0.2753 |
Giardia lamblia | Cathepsin B precursor | 0.0424 | 0.3989 | 1 |
Echinococcus granulosus | cathepsin L | 0.0395 | 0.3694 | 0.2753 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0395 | 0.3694 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1298 | 0.1298 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0395 | 0.3694 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0159 | 0.1298 | 0.1298 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0236 | 0.2087 | 0.2087 |
Brugia malayi | fibroinase precursor | 0.0159 | 0.1298 | 0.1298 |
Onchocerca volvulus | 0.0742 | 0.7208 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.4812 | 0.4812 |
Loa Loa (eye worm) | ctsf protein | 0.0742 | 0.7208 | 0.7208 |
Onchocerca volvulus | 0.0742 | 0.7208 | 1 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0236 | 0.2087 | 0.0907 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0236 | 0.2087 | 0.2087 |
Onchocerca volvulus | 0.0742 | 0.7208 | 1 | |
Schistosoma mansoni | cathepsin s | 0.0236 | 0.2087 | 0.0907 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0395 | 0.3694 | 0.2753 |
Echinococcus granulosus | cathepsin b | 0.1017 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.0742 | 0.7208 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0742 | 0.7208 | 0.7208 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0395 | 0.3694 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0505 | 0.4812 | 0.5946 |
Brugia malayi | cahepsin L-like non-peptiedase homolog | 0.0159 | 0.1298 | 0.1298 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0742 | 0.7208 | 0.7208 |
Toxoplasma gondii | cathepsin CPL | 0.0742 | 0.7208 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Onchocerca volvulus | 0.0742 | 0.7208 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1298 | 0.1298 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0742 | 0.7208 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1017 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0742 | 0.7208 | 0.6791 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0159 | 0.1298 | 0.1298 |
Trypanosoma cruzi | cysteine protease, putative | 0.0395 | 0.3694 | 0.2753 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0742 | 0.7208 | 0.6791 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0742 | 0.7208 | 0.6791 |
Echinococcus granulosus | cathepsin l1 | 0.0505 | 0.4812 | 0.4038 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0236 | 0.2087 | 0.2087 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0159 | 0.1298 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1298 | 0.1298 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0424 | 0.3989 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0505 | 0.4812 | 0.4812 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0395 | 0.3694 | 0.3694 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0395 | 0.3694 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0159 | 0.1298 | 0.1298 |
Brugia malayi | cathepsin L-like cysteine proteinase | 0.0159 | 0.1298 | 0.1298 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.4812 | 0.4812 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0159 | 0.1298 | 0.1298 |
Plasmodium vivax | vivapain-3 | 0.0395 | 0.3694 | 0.4054 |
Loa Loa (eye worm) | cathepsin B | 0.0424 | 0.3989 | 0.3989 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0395 | 0.3694 | 0.2753 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0505 | 0.4812 | 0.5946 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0424 | 0.3989 | 0.3093 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0505 | 0.4812 | 0.5946 |
Echinococcus granulosus | cathepsin b | 0.1017 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0742 | 0.7208 | 0.6791 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0742 | 0.7208 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0742 | 0.7208 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0742 | 0.7208 | 0.6791 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0742 | 0.7208 | 0.6791 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0159 | 0.1298 | 0.1298 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0742 | 0.7208 | 0.7208 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0159 | 0.1298 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.4812 | 0.4812 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0742 | 0.7208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2087 | 0.2087 |
Onchocerca volvulus | 0.0505 | 0.4812 | 0.5946 | |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1298 | 0.1298 |
Brugia malayi | Cathepsin L-like precursor | 0.0236 | 0.2087 | 0.2087 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0505 | 0.4812 | 0.4038 |
Entamoeba histolytica | cysteine protease, putative | 0.0395 | 0.3694 | 0.4054 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0395 | 0.3694 | 0.2753 |
Plasmodium vivax | vivapain-1 | 0.0395 | 0.3694 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0395 | 0.3694 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0742 | 0.7208 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0742 | 0.7208 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0742 | 0.7208 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Toxicity in Saccharomyces cerevisiae after 24 hrs by microdilution method | ChEMBL. | 21109444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.