Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine protease, putative | 0.07 | 0.7029 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0223 | 0.2027 | 0.0873 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.07 | 0.7029 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0373 | 0.3602 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.07 | 0.7029 | 0.7029 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.07 | 0.7029 | 0.6599 |
Onchocerca volvulus | 0.07 | 0.7029 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Toxoplasma gondii | cathepsin B | 0.0408 | 0.3966 | 0.4687 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0373 | 0.3602 | 0.3602 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Leishmania major | cathepsin L-like protease | 0.07 | 0.7029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.2027 | 0.2027 |
Brugia malayi | Cathepsin L-like precursor | 0.07 | 0.7029 | 0.7029 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0373 | 0.3602 | 0.4054 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0477 | 0.4692 | 0.3924 |
Echinococcus granulosus | cysteine protease | 0.0373 | 0.3602 | 0.2675 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0373 | 0.3602 | 0.2675 |
Onchocerca volvulus | 0.07 | 0.7029 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.2027 | 0.2027 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0408 | 0.3966 | 0.3093 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.07 | 0.7029 | 0.6599 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1264 | 0.1264 |
Plasmodium vivax | unspecified product | 0.0373 | 0.3602 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.015 | 0.1264 | 0.1264 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0983 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.07 | 0.7029 | 0.6599 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0408 | 0.3966 | 0.4687 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0983 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0983 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.07 | 0.7029 | 0.7029 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Leishmania major | cathepsin L-like protease | 0.07 | 0.7029 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Onchocerca volvulus | 0.07 | 0.7029 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.07 | 0.7029 | 0.7029 |
Echinococcus granulosus | cathepsin l1 | 0.07 | 0.7029 | 0.6599 |
Onchocerca volvulus | Cathepsin L homolog | 0.07 | 0.7029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1264 | 0.1264 |
Loa Loa (eye worm) | hypothetical protein | 0.0983 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.07 | 0.7029 | 1 |
Leishmania major | cathepsin L-like protease | 0.07 | 0.7029 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0373 | 0.3602 | 0.4054 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.07 | 0.7029 | 0.6599 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0408 | 0.3966 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.07 | 0.7029 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.07 | 0.7029 | 0.7029 |
Brugia malayi | cathepsin L-like precursor | 0.0477 | 0.4692 | 0.4692 |
Brugia malayi | Cathepsin L-like precursor | 0.0477 | 0.4692 | 0.4692 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.07 | 0.7029 | 0.6599 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0373 | 0.3602 | 0.4054 |
Loa Loa (eye worm) | cysteine protease | 0.07 | 0.7029 | 0.7029 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.07 | 0.7029 | 0.6599 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Plasmodium vivax | unspecified product | 0.0223 | 0.2027 | 0.1322 |
Brugia malayi | Cathepsin L-like precursor | 0.07 | 0.7029 | 0.7029 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 0.7029 | 0.7029 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.07 | 0.7029 | 0.6599 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.015 | 0.1264 | 0.1264 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0373 | 0.3602 | 0.2675 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.07 | 0.7029 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.07 | 0.7029 | 0.6599 |
Echinococcus multilocularis | cathepsin L | 0.0373 | 0.3602 | 0.2675 |
Brugia malayi | cathepsin L precursor | 0.015 | 0.1264 | 0.1264 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.07 | 0.7029 | 1 |
Echinococcus multilocularis | cysteine protease | 0.07 | 0.7029 | 0.6599 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.07 | 0.7029 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0983 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0983 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.07 | 0.7029 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.07 | 0.7029 | 0.6599 |
Entamoeba histolytica | cysteine proteinase, putative | 0.07 | 0.7029 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0477 | 0.4692 | 0.5946 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0408 | 0.3966 | 0.3093 |
Echinococcus granulosus | cathepsin b | 0.0983 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0373 | 0.3602 | 0.2675 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0477 | 0.4692 | 0.5946 |
Brugia malayi | Papain family cysteine protease containing protein | 0.015 | 0.1264 | 0.1264 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.4692 | 0.4692 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0408 | 0.3966 | 0.3966 |
Plasmodium vivax | vivapain-3 | 0.0373 | 0.3602 | 0.4054 |
Brugia malayi | cathepsin L-like cysteine proteinase | 0.015 | 0.1264 | 0.1264 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0477 | 0.4692 | 0.4692 |
Giardia lamblia | Cathepsin B precursor | 0.0408 | 0.3966 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.015 | 0.1264 | 0.1264 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0373 | 0.3602 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0373 | 0.3602 | 0.3602 |
Leishmania major | cathepsin L-like protease | 0.07 | 0.7029 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.07 | 0.7029 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.07 | 0.7029 | 1 |
Plasmodium vivax | vivapain-1 | 0.0373 | 0.3602 | 0.4054 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0373 | 0.3602 | 0.2675 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0373 | 0.3602 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1264 | 0.1264 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0223 | 0.2027 | 0.2027 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0477 | 0.4692 | 0.3924 |
Onchocerca volvulus | 0.0477 | 0.4692 | 0.5946 | |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.2027 | 0.2027 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.4692 | 0.4692 |
Brugia malayi | Papain family cysteine protease containing protein | 0.015 | 0.1264 | 0.1264 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.07 | 0.7029 | 0.6599 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.07 | 0.7029 | 0.7029 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.015 | 0.1264 | 0.1264 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.07 | 0.7029 | 0.6599 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0223 | 0.2027 | 0.2027 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0223 | 0.2027 | 0.0873 |
Onchocerca volvulus | 0.07 | 0.7029 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0983 | 1 | 1 |
Schistosoma mansoni | cathepsin s | 0.0223 | 0.2027 | 0.0873 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0373 | 0.3602 | 0.2675 |
Onchocerca volvulus | 0.07 | 0.7029 | 1 | |
Loa Loa (eye worm) | ctsf protein | 0.07 | 0.7029 | 0.7029 |
Onchocerca volvulus | 0.07 | 0.7029 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.4692 | 0.4692 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0373 | 0.3602 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.015 | 0.1264 | 0.1264 |
Brugia malayi | fibroinase precursor | 0.015 | 0.1264 | 0.1264 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0223 | 0.2027 | 0.2027 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1264 | 0.1264 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Loa Loa (eye worm) | fibroinase | 0.07 | 0.7029 | 0.7029 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0373 | 0.3602 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0408 | 0.3966 | 1 |
Echinococcus granulosus | cathepsin L | 0.0373 | 0.3602 | 0.2675 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0373 | 0.3602 | 0.2675 |
Leishmania major | cathepsin L-like protease | 0.07 | 0.7029 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0373 | 0.3602 | 0.2675 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Leishmania major | cathepsin L-like protease | 0.07 | 0.7029 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0408 | 0.3966 | 0.1064 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0373 | 0.3602 | 0.2675 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0983 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0477 | 0.4692 | 0.4692 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.015 | 0.1264 | 0.1264 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1264 | 0.1264 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0223 | 0.2027 | 0.2027 |
Echinococcus granulosus | cathepsin l1 | 0.0477 | 0.4692 | 0.3924 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.07 | 0.7029 | 0.6599 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.07 | 0.7029 | 0.6599 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.015 | 0.1264 | 0.1264 |
Trypanosoma cruzi | cysteine protease, putative | 0.0373 | 0.3602 | 0.2675 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.07 | 0.7029 | 0.6599 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.07 | 0.7029 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0983 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.07 | 0.7029 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Onchocerca volvulus | 0.07 | 0.7029 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1264 | 0.1264 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.07 | 0.7029 | 1 |
Brugia malayi | cahepsin L-like non-peptiedase homolog | 0.015 | 0.1264 | 0.1264 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0373 | 0.3602 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0477 | 0.4692 | 0.5946 |
Toxoplasma gondii | cathepsin CPL | 0.07 | 0.7029 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.07 | 0.7029 | 0.7029 |
Entamoeba histolytica | cysteine protease, putative | 0.0373 | 0.3602 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.07 | 0.7029 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.07 | 0.7029 | 0.7029 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000000 nM | Inhibition of Sprague-Dawley rat imidazoline I1 receptor | ChEMBL. | 21159515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.