TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 354.074 | Formula: C11H15BrCl2N4
H donors: 3 H acceptors: 0 LogP: 2.29 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NCC[C@H]1CNC(=N1)Nc1ccc(cc1Cl)Cl.Br
InChi: 1S/C11H14Cl2N4.BrH/c12-7-1-2-10(9(13)5-7)17-11-15-6-8(16-11)3-4-14;/h1-2,5,8H,3-4,6,14H2,(H2,15,16,17);1H/t8-;/m0./s1
InChiKey: SPIPNYXEBQQZBL-QRPNPIFTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Nischarin	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133208	All targets in OG5_133208
Echinococcus multilocularis	nischarin	Get druggable targets OG5_133208	All targets in OG5_133208
Brugia malayi	hypothetical protein	Get druggable targets OG5_133208	All targets in OG5_133208
Echinococcus granulosus	nischarin	Get druggable targets OG5_133208	All targets in OG5_133208
Onchocerca volvulus	Nischarin homolog	Get druggable targets OG5_133208	All targets in OG5_133208

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0096	0.0834	0.0834
Plasmodium falciparum	serine repeat antigen 6	0.0149	0.136	0.1887
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0687	0.6727	0.6727
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1863	0.1863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0367	0.3536	0.5176
Brugia malayi	nicalin	0.0096	0.0834	0.0834
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0149	0.136	0.136
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0149	0.136	0.136
Toxoplasma gondii	cathepsin B	0.0416	0.4032	0.5926
Plasmodium vivax	vivapain-2	0.0687	0.6727	1
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0023	0.0112	0.0112
Schistosoma mansoni	voltage-gated potassium channel	0.0046	0.0338	0.0338
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0149	0.136	0.1887
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0416	0.4032	0.5964
Loa Loa (eye worm)	hypothetical protein	0.0149	0.136	0.136
Plasmodium vivax	vivapain-2	0.0687	0.6727	1
Loa Loa (eye worm)	CYP4Cod1	0.0017	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0468	0.4551	0.4551
Toxoplasma gondii	peptidase, M28 family protein	0.0096	0.0834	0.1092
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0039	0.0272	0.0242
Schistosoma mansoni	nicalin (M28 family)	0.0096	0.0834	0.0834
Giardia lamblia	Cathepsin B precursor	0.0149	0.136	0.3184
Entamoeba histolytica	cysteine proteinase, putative	0.0687	0.6727	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0149	0.136	0.1887
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0687	0.6727	1
Schistosoma mansoni	glutaminyl-peptide cyclotransferase-related	0.0096	0.0834	0.0834
Schistosoma mansoni	cathepsin C	0.0149	0.136	0.136
Loa Loa (eye worm)	hypothetical protein	0.0149	0.136	0.136
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0687	0.6727	0.6727
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0367	0.3536	0.3536
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0149	0.136	0.1887
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0023	0.0112	0.0112
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0367	0.3536	0.3536
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Giardia lamblia	Cathepsin L precursor	0.0149	0.136	0.3184
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0023	0.0112	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0149	0.136	0.1887
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0162	0.0162
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0096	0.0834	0.0788
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0468	0.4551	0.4551
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0149	0.136	0.3184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Plasmodium falciparum	serine repeat antigen 2	0.0149	0.136	0.1887
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Giardia lamblia	Cathepsin L-like protease	0.0149	0.136	0.3184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0687	0.6727	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0367	0.3536	0.522
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0149	0.136	0.3184
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1015	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0687	0.6727	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0149	0.136	0.1887
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.005	0.005
Schistosoma mansoni	voltage-gated potassium channel	0.0046	0.0338	0.0338
Giardia lamblia	Cathepsin B precursor	0.0149	0.136	0.3184
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0023	0.0112	0.0092
Echinococcus multilocularis	cathepsin L cysteine protease	0.0687	0.6727	0.6727
Schistosoma mansoni	cathepsin F (C01 family)	0.0468	0.4551	0.4551
Onchocerca volvulus		0.0687	0.6727	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0149	0.136	0.1887
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0149	0.136	0.1887
Trypanosoma cruzi	cysteine proteinase, putative	0.0367	0.3536	0.3503
Brugia malayi	Cathepsin L-like precursor	0.0687	0.6727	0.6727
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0367	0.3536	0.3536
Brugia malayi	cathepsin F-like cysteine proteinase	0.0149	0.136	0.136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Brugia malayi	Papain family cysteine protease containing protein	0.0149	0.136	0.136
Giardia lamblia	Cathepsin B precursor	0.0149	0.136	0.3184
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0042	0.0299	0.0299
Echinococcus granulosus	cysteine protease	0.0367	0.3536	0.3536
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0687	0.6727	1
Trichomonas vaginalis	conserved hypothetical protein	0.0149	0.136	0.1887
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0687	0.6727	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0244	0.0244
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0149	0.136	0.1887
Giardia lamblia	Encystation-specific protease	0.0149	0.136	0.3184
Trypanosoma cruzi	cysteine peptidase, putative	0.0687	0.6727	0.6711
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0039	0.0272	0.0242
Mycobacterium ulcerans	hypothetical protein	0.0096	0.0834	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0468	0.4551	0.6711
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0149	0.136	0.1887
Echinococcus granulosus	nischarin	0.017	0.1573	0.1573
Loa Loa (eye worm)	hypothetical protein	0.0166	0.1535	0.1535
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0162	0.0162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Trypanosoma brucei	glutaminyl cyclase, putative	0.0096	0.0834	0.1175
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0149	0.136	0.136
Plasmodium falciparum	serine repeat antigen 9	0.0149	0.136	0.1887
Plasmodium falciparum	serine repeat antigen 4	0.0149	0.136	0.1887
Trypanosoma cruzi	cysteine protease, putative	0.0367	0.3536	0.3503
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.136	0.136
Onchocerca volvulus		0.0468	0.4551	0.6307
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0112	0.0112
Echinococcus multilocularis	cysteine protease	0.0687	0.6727	0.6727
Brugia malayi	fibroinase precursor	0.0149	0.136	0.136
Leishmania major	geranylgeranyltransferase, putative	0.0023	0.0112	0.0092
Leishmania major	cathepsin L-like protease	0.0687	0.6727	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0149	0.136	0.1887
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0416	0.4032	0.4032
Leishmania major	cathepsin L-like protease	0.0687	0.6727	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0149	0.136	0.1887
Leishmania major	hypothetical protein, conserved	0.0096	0.0834	0.1175
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Loa Loa (eye worm)	hypothetical protein	0.0218	0.2054	0.2054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0687	0.6727	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0687	0.6727	0.6727
Onchocerca volvulus		0.0687	0.6727	1
Entamoeba histolytica	cysteine protease, putative	0.0149	0.136	0.1887
Loa Loa (eye worm)	cathepsin B	0.0416	0.4032	0.4032
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0149	0.136	0.136
Plasmodium falciparum	serine repeat antigen 5	0.0149	0.136	0.1887
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Echinococcus granulosus	cathepsin b	0.1015	1	1
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0023	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0112	0.0112
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Entamoeba histolytica	cysteine proteinase, putative	0.0687	0.6727	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0149	0.136	0.1887
Onchocerca volvulus		0.0687	0.6727	1
Leishmania major	cathepsin L-like protease	0.0687	0.6727	1
Brugia malayi	Cytochrome P450 family protein	0.0017	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0149	0.136	0.136
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0149	0.136	0.1887
Giardia lamblia	Hypothetical protein	0.0149	0.136	0.3184
Giardia lamblia	Hypothetical protein	0.0149	0.136	0.3184
Schistosoma mansoni	glutaminyl cyclase (M28 family)	0.0199	0.1863	0.1863
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0149	0.136	0.1887
Echinococcus multilocularis	nischarin	0.017	0.1573	0.1573
Entamoeba histolytica	cysteine proteinase, putative	0.0367	0.3536	0.5176
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.0834	0.1092
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0367	0.3536	0.5176
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0367	0.3536	0.5176
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1015	1	1
Brugia malayi	leucyl aminopeptidase	0.0096	0.0834	0.0834
Leishmania major	cathepsin L-like protease	0.0687	0.6727	1
Mycobacterium ulcerans	lipoprotein aminopeptidase LpqL	0.0096	0.0834	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0149	0.136	0.1887
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0096	0.0834	0.0834
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0149	0.136	0.1887
Trypanosoma cruzi	major cysteine proteinase, putative	0.0149	0.136	0.1316
Plasmodium vivax	vivapain-1	0.0367	0.3536	0.5176
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0149	0.136	0.1887
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0149	0.136	0.3184
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0149	0.136	0.1887
Leishmania major	farnesyltransferase beta subunit	0.0023	0.0112	0.0092
Schistosoma mansoni	Fxna peptidase (M28 family)	0.0096	0.0834	0.0834
Schistosoma mansoni	cathepsin F (C01 family)	0.0687	0.6727	0.6727
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0149	0.136	0.1887
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0042	0.0299	0.0299
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0096	0.0834	0.0834
Onchocerca volvulus		0.0687	0.6727	1
Brugia malayi	Cathepsin L-like precursor	0.0687	0.6727	0.6727
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0149	0.136	0.1887
Entamoeba histolytica	cysteine protease, putative	0.0149	0.136	0.1887
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0468	0.4551	0.6711
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0416	0.4032	0.4002
Entamoeba histolytica	cysteine protease, putative	0.0149	0.136	0.1887
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0687	0.6727	1
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Giardia lamblia	Cysteine protease	0.0149	0.136	0.3184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Echinococcus multilocularis	cathepsin b	0.1015	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0149	0.136	0.1887
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0149	0.136	0.1887
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0023	0.0112	0.0112
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0023	0.0112	0.0112
Brugia malayi	Cathepsin L-like precursor	0.0687	0.6727	0.6727
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0023	0.0112	0.0112
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.136	0.136
Onchocerca volvulus		0.0687	0.6727	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0042	0.0299	0.0299
Schistosoma mansoni	cathepsin B (C01 family)	0.0149	0.136	0.136
Giardia lamblia	Cathepsin L precursor	0.0149	0.136	0.3184
Entamoeba histolytica	cysteine proteinase, putative	0.0367	0.3536	0.5176
Trypanosoma brucei	lanosterol synthase	0.0171	0.1586	0.23
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0023	0.0112	0.0112
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0149	0.136	0.1887
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0149	0.136	0.1887
Toxoplasma gondii	hypothetical protein	0.0096	0.0834	0.1092
Entamoeba histolytica	cysteine protease, putative	0.0149	0.136	0.1887
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Brugia malayi	Cathepsin L-like precursor	0.0687	0.6727	0.6727
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0468	0.4551	0.4524
Giardia lamblia	Cathepsin B precursor	0.0416	0.4032	1
Brugia malayi	hypothetical protein	0.0166	0.1535	0.1535
Trypanosoma cruzi	cysteine peptidase, putative	0.0687	0.6727	0.6711
Giardia lamblia	Cysteine protease	0.0149	0.136	0.3184
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0112	0.0062
Echinococcus multilocularis	cathepsin b	0.1015	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.136	0.136
Echinococcus granulosus	cathepsin l1	0.0468	0.4551	0.4551
Giardia lamblia	Cathepsin L-like protease	0.0149	0.136	0.3184
Plasmodium vivax	serine-repeat antigen (SERA)	0.0149	0.136	0.1887
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0834	0.0834
Leishmania major	glutaminyl cyclase, putative	0.0096	0.0834	0.1175
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0149	0.136	0.1887
Loa Loa (eye worm)	ctsf protein	0.0687	0.6727	0.6727
Entamoeba histolytica	hypothetical protein	0.0149	0.136	0.1887
Entamoeba histolytica	cysteine proteinase, putative	0.0367	0.3536	0.5176
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	0.0199	0.1863	0.1863
Plasmodium vivax	unspecified product	0.0149	0.136	0.1887
Brugia malayi	Cathepsin L-like precursor	0.0468	0.4551	0.4551
Toxoplasma gondii	cathepsin CPC2	0.0149	0.136	0.1887
Giardia lamblia	Cathepsin B precursor	0.0149	0.136	0.3184
Entamoeba histolytica	cysteine proteinase 2	0.0367	0.3536	0.5176
Loa Loa (eye worm)	hypothetical protein	0.0468	0.4551	0.4551
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0218	0.2054	0.2054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Plasmodium falciparum	serine repeat antigen 3	0.0149	0.136	0.1887
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0149	0.136	0.136
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0149	0.136	0.3184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Brugia malayi	Cytochrome P450 family protein	0.0017	0.005	0.005
Plasmodium vivax	serine-repeat antigen (SERA)	0.0149	0.136	0.1887
Onchocerca volvulus	Glutaminyl cyclase homolog	0.0199	0.1863	0.1746
Plasmodium vivax	unspecified product	0.0218	0.2054	0.2936
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Onchocerca volvulus	Cathepsin F homolog	0.0687	0.6727	1
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0023	0.0112	0.0092
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Entamoeba histolytica	cysteine protease, putative	0.0149	0.136	0.1887
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0149	0.136	0.136
Brugia malayi	cathepsin L-like precursor	0.0468	0.4551	0.4551
Schistosoma mansoni	cathepsin S (C01 family)	0.0149	0.136	0.136
Trypanosoma cruzi	cruzipain precursor, putative	0.0218	0.2054	0.2014
Leishmania major	cathepsin L-like protease	0.0687	0.6727	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.136	0.136
Onchocerca volvulus		0.0687	0.6727	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Giardia lamblia	Cathepsin B precursor	0.0416	0.4032	1
Brugia malayi	Papain family cysteine protease containing protein	0.0149	0.136	0.136
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0416	0.4032	0.5964
Entamoeba histolytica	cysteine proteinase, putative	0.0367	0.3536	0.5176
Trypanosoma cruzi	cysteine peptidase, putative	0.0687	0.6727	0.6711
Giardia lamblia	Cathepsin L precursor	0.0149	0.136	0.3184
Mycobacterium tuberculosis	Probable lipoprotein aminopeptidase LpqL	0.0096	0.0834	1
Giardia lamblia	Cysteine protease	0.0149	0.136	0.3184
Onchocerca volvulus	Cathepsin L homolog	0.0149	0.136	0.0892
Brugia malayi	Cathepsin L-like precursor	0.0468	0.4551	0.4551
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0416	0.4032	0.5926
Brugia malayi	Cathepsin L-like precursor	0.0687	0.6727	0.6727
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0687	0.6727	0.6727
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0834	0.0834
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0149	0.136	0.136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0096	0.0834	0.0834
Leishmania major	cathepsin L-like protease	0.0687	0.6727	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1015	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0367	0.3536	0.5176
Brugia malayi	cathepsin F-like cysteine proteinase	0.0218	0.2054	0.2054
Brugia malayi	FXNA	0.0096	0.0834	0.0834
Brugia malayi	Cathepsin L-like precursor	0.0218	0.2054	0.2054
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0023	0.0112	0.0112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0687	0.6727	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0218	0.2054	0.2014
Trypanosoma cruzi	lanosterol synthase, putative	0.0171	0.1586	0.1543
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0218	0.2054	0.2054
Schistosoma mansoni	cathepsin s	0.0218	0.2054	0.2054
Brugia malayi	Papain family cysteine protease containing protein	0.0367	0.3536	0.3536
Giardia lamblia	Cathepsin L precursor	0.0149	0.136	0.3184
Leishmania major	lanosterol synthase, putative	0.0148	0.1352	0.195
Trypanosoma cruzi	lanosterol synthase, putative	0.0171	0.1586	0.1543
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0096	0.0834	0.0834
Giardia lamblia	Cysteine protease	0.0149	0.136	0.3184
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0687	0.6727	1
Onchocerca volvulus	Nischarin homolog	0.0166	0.1533	0.1186
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Loa Loa (eye worm)	hypothetical protein	0.1015	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0687	0.6727	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0149	0.136	0.1887
Loa Loa (eye worm)	hypothetical protein	0.0149	0.136	0.136
Trypanosoma cruzi	cysteine proteinase, putative	0.0367	0.3536	0.3503
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Loa Loa (eye worm)	fibroinase	0.0687	0.6727	0.6727
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0687	0.6727	1
Onchocerca volvulus	Cathepsin L homolog	0.0687	0.6727	1
Giardia lamblia	Cathepsin B precursor	0.0149	0.136	0.3184
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0149	0.136	0.1887
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Trypanosoma cruzi	cysteine peptidase, putative	0.0367	0.3536	0.3503
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0096	0.0834	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0468	0.4551	0.4551
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0687	0.6727	0.6727
Echinococcus granulosus	cathepsin L	0.0149	0.136	0.136
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.136	0.136
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0023	0.0112	0.0112
Trypanosoma cruzi	major cysteine proteinase, putative	0.0149	0.136	0.1316
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Loa Loa (eye worm)	hypothetical protein	0.0218	0.2054	0.2054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0834	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0218	0.2054	0.2054
Onchocerca volvulus	Cathepsin L homolog	0.0687	0.6727	1
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0023	0.0112	0.0112
Leishmania major	cysteine peptidase A (CPA)	0.0687	0.6727	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0687	0.6727	0.6727
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.0834	0.1092
Plasmodium vivax	vivapain-3	0.0367	0.3536	0.5176
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0149	0.136	0.136
Echinococcus multilocularis	cathepsin L	0.0149	0.136	0.136
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0023	0.0112	0.0112
Plasmodium vivax	unspecified product	0.0367	0.3536	0.5176
Brugia malayi	Papain family cysteine protease containing protein	0.0687	0.6727	0.6727
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0149	0.136	0.1887
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0149	0.136	0.136
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0687	0.6727	0.6727
Entamoeba histolytica	cysteine protease, putative	0.0149	0.136	0.1887
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0687	0.6727	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.136	0.136
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0023	0.0112	0.0112
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0687	0.6727	0.6727
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0149	0.136	0.1887
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1015	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0149	0.136	0.1887
Echinococcus multilocularis	cysteine protease	0.0687	0.6727	0.6727
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0149	0.136	0.136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Loa Loa (eye worm)	cysteine protease	0.0687	0.6727	0.6727
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0023	0.0112	0.0062
Plasmodium falciparum	serine repeat antigen 1	0.0149	0.136	0.1887
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0687	0.6727	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0149	0.136	0.1887
Trypanosoma cruzi	cruzipain precursor, putative	0.0687	0.6727	0.6711
Giardia lamblia	Cathepsin B precursor	0.0416	0.4032	1
Trichomonas vaginalis	Clan MH, family M28, aminopeptidase S-like metallopeptidase	0.0096	0.0834	0.1092
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0023	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0687	0.6727	0.6727
Loa Loa (eye worm)	leucyl aminopeptidase	0.0096	0.0834	0.0834
Giardia lamblia	Cathepsin L precursor	0.0149	0.136	0.3184
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0112	0.0062
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0149	0.136	0.1887
Toxoplasma gondii	cathepsin CPL	0.0687	0.6727	1
Plasmodium falciparum	serine repeat antigen 8	0.0149	0.136	0.1887
Entamoeba histolytica	cysteine proteinase, putative	0.0468	0.4551	0.6711
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Mycobacterium tuberculosis	Conserved protein	0.0096	0.0834	1
Brugia malayi	Papain family cysteine protease containing protein	0.0149	0.136	0.136
Brugia malayi	Papain family cysteine protease containing protein	0.0367	0.3536	0.3536
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0834	0.0834
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0042	0.0299	0.0299
Trypanosoma cruzi	cysteine peptidase, putative	0.0687	0.6727	0.6711
Brugia malayi	cathepsin L precursor	0.0149	0.136	0.136
Loa Loa (eye worm)	hypothetical protein	0.0149	0.136	0.136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0687	0.6727	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1015	1	1
Onchocerca volvulus		0.0687	0.6727	1
Echinococcus granulosus	glutaminyl peptide cyclotransferase	0.0199	0.1863	0.1863
Toxoplasma gondii	cathepsin CPC1	0.0149	0.136	0.1887
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.0834	0.1092
Leishmania major	cathepsin L-like protease	0.0687	0.6727	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0367	0.3536	0.3503
Onchocerca volvulus		0.0149	0.136	0.0892
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0096	0.0834	0.0834
Giardia lamblia	Cathepsin L precursor	0.0149	0.136	0.3184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0367	0.3536	0.522
Entamoeba histolytica	cysteine protease, putative	0.0367	0.3536	0.5176
Entamoeba histolytica	cysteine protease, putative	0.0687	0.6727	1
Echinococcus granulosus	cathepsin l1	0.0687	0.6727	0.6727
Plasmodium falciparum	serine repeat antigen 7	0.0149	0.136	0.1887
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.005	0.005
Echinococcus granulosus	cathepsin b	0.1015	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0687	0.6727	1
Echinococcus multilocularis	cathepsin L	0.0367	0.3536	0.3536
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0149	0.136	0.1887
Brugia malayi	cathepsin L-like cysteine proteinase	0.0149	0.136	0.136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0687	0.6727	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0149	0.136	0.1887
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0023	0.0112	0.0062
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0023	0.0112	0.0062
Echinococcus granulosus	cathepsin L	0.0367	0.3536	0.3536
Echinococcus granulosus	cathepsin L cysteine protease	0.0367	0.3536	0.3536
Leishmania major	cathepsin L-like protease	0.0687	0.6727	1
Brugia malayi	Cathepsin L-like precursor	0.0687	0.6727	0.6727
Brugia malayi	Peptidase family M28 containing protein	0.0199	0.1863	0.1863

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1482 nM	Inhibition of Sprague-Dawley rat imidazoline I1 receptor	ChEMBL.	21159515

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1644496

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1461489