TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 250.252 | Formula: C15H10N2O2
H donors: 1 H acceptors: 3 LogP: 1.59 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=Cc1ccc2c(c1)c(=O)cc([nH]2)c1cccnc1
InChi: 1S/C15H10N2O2/c18-9-10-3-4-13-12(6-10)15(19)7-14(17-13)11-2-1-5-16-8-11/h1-9H,(H,17,19)
InChiKey: SOAMWAHKUJUYEU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.0602	0.7079	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0602	0.7079	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1251	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0839	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0602	0.7079	1
Onchocerca volvulus	Cathepsin L homolog	0.0602	0.7079	1
Giardia lamblia	Cathepsin B precursor	0.0349	0.3957	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0602	0.7079	0.7079
Brugia malayi	cathepsin L-like precursor	0.041	0.4716	0.4716
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0321	0.3614	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0602	0.7079	0.6661
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0602	0.7079	1
Entamoeba histolytica	cysteine proteinase, putative	0.0321	0.3614	0.4054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0602	0.7079	0.6661
Brugia malayi	Cathepsin L-like precursor	0.041	0.4716	0.4716
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Loa Loa (eye worm)	cysteine protease	0.0602	0.7079	0.7079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Brugia malayi	Cathepsin L-like precursor	0.0602	0.7079	0.7079
Plasmodium vivax	unspecified product	0.0192	0.2024	0.1327
Echinococcus multilocularis	cathepsin L cysteine protease	0.0602	0.7079	0.6661
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Leishmania major	cathepsin L-like protease	0.0602	0.7079	1
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0602	0.7079	0.6661
Echinococcus multilocularis	cathepsin L	0.0321	0.3614	0.27
Brugia malayi	cathepsin L precursor	0.0129	0.1251	0.1251
Trypanosoma cruzi	cysteine peptidase, putative	0.0602	0.7079	0.6661
Loa Loa (eye worm)	hypothetical protein	0.0602	0.7079	0.7079
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0129	0.1251	0.1251
Trypanosoma cruzi	cysteine proteinase, putative	0.0321	0.3614	0.27
Leishmania major	cathepsin L-like protease	0.0602	0.7079	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0839	1	1
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Echinococcus multilocularis	cysteine protease	0.0602	0.7079	0.6661
Entamoeba histolytica	cysteine proteinase, putative	0.0602	0.7079	1
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0839	1	1
Plasmodium vivax	vivapain-2	0.0602	0.7079	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0321	0.3614	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0602	0.7079	0.7079
Trypanosoma cruzi	cysteine peptidase, putative	0.0602	0.7079	0.6661
Entamoeba histolytica	cysteine protease, putative	0.0602	0.7079	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0192	0.2024	0.0884
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0602	0.7079	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Toxoplasma gondii	cathepsin B	0.0349	0.3957	0.4643
Brugia malayi	Papain family cysteine protease containing protein	0.0321	0.3614	0.3614
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Onchocerca volvulus		0.0602	0.7079	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0602	0.7079	1
Entamoeba histolytica	cysteine proteinase, putative	0.0321	0.3614	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.041	0.4716	0.396
Leishmania major	cathepsin L-like protease	0.0602	0.7079	1
Loa Loa (eye worm)	hypothetical protein	0.0192	0.2024	0.2024
Brugia malayi	Cathepsin L-like precursor	0.0602	0.7079	0.7079
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0349	0.3957	0.3093
Loa Loa (eye worm)	hypothetical protein	0.0192	0.2024	0.2024
Trypanosoma cruzi	cysteine peptidase, putative	0.0602	0.7079	0.6661
Echinococcus granulosus	cysteine protease	0.0321	0.3614	0.27
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0321	0.3614	0.27
Onchocerca volvulus		0.0602	0.7079	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0129	0.1251	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1251	0.1251
Plasmodium vivax	unspecified product	0.0321	0.3614	0.4054
Echinococcus multilocularis	cathepsin b	0.0839	1	1
Echinococcus multilocularis	cysteine protease	0.0602	0.7079	0.6661
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0602	0.7079	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0349	0.3957	0.4643
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0602	0.7079	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0839	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0602	0.7079	1
Echinococcus multilocularis	cathepsin b	0.0839	1	1
Brugia malayi	Cathepsin L-like precursor	0.0602	0.7079	0.7079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Onchocerca volvulus		0.0602	0.7079	1
Brugia malayi	Cathepsin L-like precursor	0.0602	0.7079	0.7079
Onchocerca volvulus	Cathepsin L homolog	0.0602	0.7079	1
Echinococcus granulosus	cathepsin l1	0.0602	0.7079	0.6661
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Leishmania major	cathepsin L-like protease	0.0602	0.7079	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Loa Loa (eye worm)	ctsf protein	0.0602	0.7079	0.7079
Onchocerca volvulus		0.0602	0.7079	1
Loa Loa (eye worm)	hypothetical protein	0.041	0.4716	0.4716
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0192	0.2024	0.2024
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0192	0.2024	0.0884
Onchocerca volvulus		0.0602	0.7079	1
Echinococcus granulosus	cathepsin b	0.0839	1	1
Schistosoma mansoni	cathepsin s	0.0192	0.2024	0.0884
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0321	0.3614	0.27
Onchocerca volvulus		0.0602	0.7079	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1251	0.1251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Brugia malayi	Papain family cysteine protease containing protein	0.0129	0.1251	0.1251
Entamoeba histolytica	cysteine proteinase 2	0.0321	0.3614	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0192	0.2024	0.2024
Brugia malayi	fibroinase precursor	0.0129	0.1251	0.1251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0321	0.3614	0.27
Leishmania major	cathepsin L-like protease	0.0602	0.7079	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Leishmania major	cathepsin L-like protease	0.0602	0.7079	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Loa Loa (eye worm)	fibroinase	0.0602	0.7079	0.7079
Giardia lamblia	Cathepsin B precursor	0.0349	0.3957	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0321	0.3614	0.4054
Echinococcus granulosus	cathepsin L	0.0321	0.3614	0.27
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0321	0.3614	0.27
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0321	0.3614	0.27
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0602	0.7079	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0349	0.3957	0.0991
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0602	0.7079	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0839	1	1
Brugia malayi	Cathepsin L-like precursor	0.041	0.4716	0.4716
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0129	0.1251	0.1251
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1251	0.1251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0602	0.7079	0.6661
Echinococcus granulosus	cathepsin l1	0.041	0.4716	0.396
Trypanosoma cruzi	cysteine peptidase, putative	0.0602	0.7079	0.6661
Brugia malayi	cathepsin F-like cysteine proteinase	0.0192	0.2024	0.2024
Onchocerca volvulus		0.0602	0.7079	1
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1251	0.1251
Trypanosoma cruzi	cysteine protease, putative	0.0321	0.3614	0.27
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0129	0.1251	0.1251
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0839	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0602	0.7079	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0602	0.7079	0.6661
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Plasmodium vivax	vivapain-2	0.0602	0.7079	1
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0602	0.7079	0.7079
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0129	0.1251	0.1251
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Entamoeba histolytica	cysteine proteinase, putative	0.0321	0.3614	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.041	0.4716	0.5946
Toxoplasma gondii	cathepsin CPL	0.0602	0.7079	1
Brugia malayi	Papain family cysteine protease containing protein	0.0602	0.7079	0.7079
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0349	0.3957	0.3093
Entamoeba histolytica	cysteine proteinase, putative	0.041	0.4716	0.5946
Echinococcus granulosus	cathepsin b	0.0839	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0602	0.7079	0.6661
Entamoeba histolytica	cysteine proteinase, putative	0.0602	0.7079	1
Brugia malayi	Papain family cysteine protease containing protein	0.0129	0.1251	0.1251
Loa Loa (eye worm)	hypothetical protein	0.041	0.4716	0.4716
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0602	0.7079	1
Loa Loa (eye worm)	cathepsin B	0.0349	0.3957	0.3957
Plasmodium vivax	vivapain-3	0.0321	0.3614	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0321	0.3614	0.27
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.041	0.4716	0.5946
Brugia malayi	Cathepsin L-like cysteine proteinase	0.041	0.4716	0.4716
Giardia lamblia	Cathepsin B precursor	0.0349	0.3957	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0129	0.1251	0.1251
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0602	0.7079	1
Entamoeba histolytica	cysteine proteinase, putative	0.0321	0.3614	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0602	0.7079	1
Brugia malayi	Papain family cysteine protease containing protein	0.0321	0.3614	0.3614
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0129	0.1251	0.1251
Plasmodium vivax	vivapain-1	0.0321	0.3614	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0321	0.3614	0.27
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0321	0.3614	0.4054
Leishmania major	cathepsin L-like protease	0.0602	0.7079	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0602	0.7079	1
Leishmania major	cysteine peptidase A (CPA)	0.0602	0.7079	1
Onchocerca volvulus		0.041	0.4716	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1251	0.1251
Entamoeba histolytica	cysteine protease, putative	0.0321	0.3614	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0192	0.2024	0.2024
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.041	0.4716	0.396
Loa Loa (eye worm)	hypothetical protein	0.041	0.4716	0.4716
Loa Loa (eye worm)	hypothetical protein	0.0192	0.2024	0.2024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.7079	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0602	0.7079	0.6661
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0602	0.7079	1
Brugia malayi	Papain family cysteine protease containing protein	0.0129	0.1251	0.1251
Trypanosoma cruzi	cruzipain precursor, putative	0.0602	0.7079	0.6661
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0602	0.7079	0.7079
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0129	0.1251	0.1251

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1645500

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1461492