Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 0.0339 | 0.8047 | 0.8047 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0401 | 0.9856 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0351 | 0.8404 | 0.1827 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0339 | 0.8047 | 0.8047 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Echinococcus multilocularis | neuropeptide receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0339 | 0.8047 | 0.8047 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0339 | 0.8047 | 0.8047 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0401 | 0.9856 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0339 | 0.8047 | 0.8047 |
Schistosoma mansoni | immunophilin | 0.0406 | 1 | 1 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0339 | 0.8047 | 0.8047 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0401 | 0.9856 | 0.5 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | sex peptide receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | fmrfamide receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0339 | 0.8047 | 0.8047 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.8261 | 0.1179 |
Echinococcus multilocularis | g protein coupled receptor | 0.0339 | 0.8047 | 0.8047 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0401 | 0.9856 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0339 | 0.8047 | 0.8047 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0406 | 1 | 0.5 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0401 | 0.9856 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0339 | 0.8047 | 0.8047 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0401 | 0.9856 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0339 | 0.8047 | 0.5 |
Echinococcus multilocularis | somatostatin receptor | 0.0339 | 0.8047 | 0.8047 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0401 | 0.9856 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0401 | 0.9856 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0339 | 0.8047 | 0.8047 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0406 | 1 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0339 | 0.8047 | 0.8047 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0401 | 0.9856 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.0401 | 0.9856 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0351 | 0.8404 | 0.8404 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0339 | 0.8047 | 0.8047 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0401 | 0.9856 | 0.9264 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0339 | 0.8047 | 0.8047 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Echinococcus multilocularis | g protein coupled receptor | 0.0339 | 0.8047 | 0.8047 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0401 | 0.9856 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0401 | 0.9856 | 1 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0339 | 0.8047 | 0.8047 |
Leishmania major | fk506-binding protein 1-like protein | 0.0401 | 0.9856 | 0.5 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | neuropeptide receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0339 | 0.8047 | 0.8047 |
Trichomonas vaginalis | immunophilin, putative | 0.0401 | 0.9856 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0406 | 1 | 1 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0339 | 0.8047 | 0.8047 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0339 | 0.8047 | 0.8047 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0401 | 0.9856 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0401 | 0.9856 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0401 | 0.9856 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0339 | 0.8047 | 0.8047 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0401 | 0.9856 | 0.5 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0401 | 0.9856 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0401 | 0.9856 | 0.5 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0401 | 0.9856 | 0.5 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | serotonin receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0339 | 0.8047 | 0.8047 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0401 | 0.9856 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0406 | 1 | 1 |
Onchocerca volvulus | 0.0339 | 0.8047 | 0.5 | |
Echinococcus multilocularis | fk506 binding protein | 0.0401 | 0.9856 | 0.9856 |
Echinococcus multilocularis | fmrfamide receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | g protein coupled receptor | 0.0339 | 0.8047 | 0.8047 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0339 | 0.8047 | 0.5 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0339 | 0.8047 | 0.8047 |
Schistosoma mansoni | immunophilin | 0.0351 | 0.8404 | 0.1827 |
Echinococcus multilocularis | allatostatin A receptor | 0.0339 | 0.8047 | 0.8047 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0339 | 0.8047 | 0.8047 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0401 | 0.9856 | 0.9264 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of HIV1 YU2 gp120 binding to CD4 expressing Cf2Th-CD4/CCR5 cells assessed as inhibition of viral infection after 48 hrs | ChEMBL. | 21169023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.