Detailed information for compound 14617

Basic information

Technical information
  • TDR Targets ID: 14617
  • Name: tert-butyl 7-chloro-4,4-dimethyl-5-[(3S,5R)-3 ,4,5-trimethylpiperazine-1-carbonyl]imidazo[1 ,5-a]quinoxaline-3-carboxylate
  • MW: 488.022 | Formula: C25H34ClN5O3
  • H donors: 0 H acceptors: 3 LogP: 3.72 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1[C@H](C)CN(C[C@@H]1C)C(=O)N1c2cc(Cl)ccc2n2c(C1(C)C)c(nc2)C(=O)OC(C)(C)C
  • InChi: 1S/C25H34ClN5O3/c1-15-12-29(13-16(2)28(15)8)23(33)31-19-11-17(26)9-10-18(19)30-14-27-20(21(30)25(31,6)7)22(32)34-24(3,4)5/h9-11,14-16H,12-13H2,1-8H3/t15-,16+
  • InChiKey: SONXYIDWJSRGDP-IYBDPMFKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-chloro-4,4-dimethyl-5-[oxo-[(3S,5R)-3,4,5-trimethyl-1-piperazinyl]methyl]-3-imidazo[1,5-a]quinoxalinecarboxylic acid tert-butyl ester
  • tert-butyl 7-chloro-4,4-dimethyl-5-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]carbonyl-imidazo[1,5-a]quinoxaline-3-carboxylate
  • 7-chloro-4,4-dimethyl-5-[(3S,5R)-3,4,5-trimethylpiperazine-1-carbonyl]imidazo[1,5-a]quinoxaline-3-carboxylic acid tert-butyl ester
  • tert-butyl 7-chloro-4,4-dimethyl-5-[(3S,5R)-3,4,5-trimethylpiperazine-1-carbonyl]imidazo[5,1-c]quinoxaline-3-carboxylate
  • 7-chloro-4,4-dimethyl-5-[oxo-[(3S,5R)-3,4,5-trimethyl-1-piperazinyl]methyl]-3-imidazo[5,1-c]quinoxalinecarboxylic acid tert-butyl ester
  • 7-chloro-4,4-dimethyl-5-[(3S,5R)-3,4,5-trimethylpiperazine-1-carbonyl]imidazo[5,1-c]quinoxaline-3-carboxylic acid tert-butyl ester
  • tert-butyl 7-chloro-4,4-dimethyl-5-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]carbonyl-imidazo[5,1-c]quinoxaline-3-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus GABA-A receptor; anion channel Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 454 aa 30.4 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative GABA-A receptor; anion channel   467 aa 384 aa 19.5 %
Onchocerca volvulus Large subunit GTPase 1 homolog GABA-A receptor; anion channel   467 aa 496 aa 26.0 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 446 aa 28.0 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 468 aa 28.6 %
Onchocerca volvulus Eukaryotic initiation factor 4A-III homolog GABA-A receptor; anion channel   467 aa 453 aa 26.9 %
Onchocerca volvulus Gamma-aminobutyric acid receptor subunit beta homolog GABA-A receptor; anion channel   467 aa 433 aa 34.6 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 446 aa 29.1 %
Echinococcus granulosus glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 494 aa 25.5 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 435 aa 29.7 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit GABA-A receptor; anion channel   467 aa 379 aa 19.3 %
Echinococcus multilocularis glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 478 aa 28.7 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 447 aa 25.7 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 434 aa 26.7 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 454 aa 29.5 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 375 aa 21.9 %
Schistosoma mansoni Cys-loop ligand gated ion channel subunit GABA-A receptor; anion channel   467 aa 479 aa 29.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog GABA-A receptor; anion channel   467 aa 418 aa 19.6 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 441 aa 33.8 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 461 aa 27.8 %
Echinococcus multilocularis glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Brugia malayi Cation transporter family protein GABA-A receptor; anion channel   467 aa 453 aa 28.5 %
Echinococcus granulosus glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 439 aa 29.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.9024 0.9024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.3437 0.3437
Echinococcus multilocularis serotonin receptor 0.0021 0.9024 0.9024
Brugia malayi steroid hormone receptor 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Schistosoma mansoni thyroid hormone receptor 0.0012 0.3437 0.3437
Brugia malayi Dopamine receptor protein 1 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.9024 0.9024
Schistosoma mansoni amine GPCR 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.0021 0.9024 0.9024
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.9024 0.9024
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.3437 0.1227
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus multilocularis allatostatin A receptor 0.0021 0.9024 0.9024
Brugia malayi G protein-coupled receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Schistosoma mansoni nAChR subunit 0.001 0.2539 0.2539
Schistosoma mansoni biogenic amine receptor 0.0021 0.9024 0.9024
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.9024 0.9024
Onchocerca volvulus 0.001 0.2539 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Schistosoma mansoni amine GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.9024 0.9024
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.3612 0.3612
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.9024 0.9024
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.2519 1
Schistosoma mansoni nAChR subunit 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.001 0.2539 0.2539
Schistosoma mansoni hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Brugia malayi ecdysteroid receptor 0.0012 0.3437 0.3437
Brugia malayi hypothetical protein 0.0021 0.9024 0.9024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.9024 0.9024
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.2519 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.3437 0.3437
Echinococcus multilocularis somatostatin receptor 0.0021 0.9024 0.9024
Schistosoma mansoni hypothetical protein 0.0021 0.9024 0.9024
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.2519 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.9024 0.9024
Echinococcus granulosus glycine receptor subunit beta 0.0023 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.2519 0.2519
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0023 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.9024 0.9024
Echinococcus multilocularis orexin receptor type 2 0.0021 0.9024 0.9024
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.9024 0.9024
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.2519 1
Echinococcus granulosus orexin receptor type 2 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.001 0.2539 0.2539
Onchocerca volvulus 0.0021 0.9024 0.8695
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.9024 0.9024
Loa Loa (eye worm) GABA receptor subunit 0.0012 0.3612 0.3612
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus granulosus allatostatin A receptor 0.0021 0.9024 0.9024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 1 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0023 1 1
Echinococcus multilocularis fmrfamide receptor 0.0021 0.9024 0.9024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.3437 0.3437
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Brugia malayi follicle stimulating hormone receptor 0.0021 0.9024 0.9024
Brugia malayi neuropeptide F receptor 0.0021 0.9024 0.9024
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0023 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.3437 0.3437
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.2519 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.2519 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.2519 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.3437 0.3437
Schistosoma mansoni nuclear hormone receptor 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.9024 0.9024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0012 0.3437 0.3437
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.3437 0.1227
Onchocerca volvulus 0.0021 0.9024 0.8695
Loa Loa (eye worm) hypothetical protein 0.001 0.245 0.245
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.001 0.2519 0.5
Echinococcus granulosus hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus granulosus g-protein coupled receptor 0.0021 0.9024 0.9024
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.9024 0.9024
Onchocerca volvulus 0.001 0.2539 0.0027
Echinococcus multilocularis nAChR subunit 0.0012 0.3612 0.3612
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0023 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.9024 0.9024
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.2519 1
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.245 0.245
Schistosoma mansoni biogenic amine receptor 0.0021 0.9024 0.9024
Echinococcus granulosus somatostatin receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Brugia malayi ABC transporter family protein 0.001 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.9024 0.9024
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.9024 0.9024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0012 0.3437 0.3437
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0023 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.2519 0.2519
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.9024 0.9024
Schistosoma mansoni hypothetical protein 0.0021 0.9024 0.9024
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.9024 0.9024
Schistosoma mansoni amine GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.3437 0.3437
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Onchocerca volvulus 0.0021 0.9024 0.8695
Echinococcus granulosus g protein coupled receptor 0.0021 0.9024 0.9024
Trichomonas vaginalis ABC transporter, putative 0.001 0.2519 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.001 0.2519 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.9024 0.9024
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.2519 1
Echinococcus granulosus serotonin receptor 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.001 0.2539 0.2539
Onchocerca volvulus 0.0021 0.9024 0.8695
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.9024 0.9024
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.001 0.2539 0.2539
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.245 0.245
Brugia malayi hypothetical protein 0.001 0.2539 0.2539
Schistosoma mansoni neuropeptide receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis multidrug resistance protein 1 0.0007 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.2519 1
Echinococcus granulosus multidrug resistance protein 1 0.0007 0.0596 0.0596
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.2539 0.2539
Entamoeba histolytica hypothetical protein 0.0012 0.3612 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.2539 0.2539
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.3437 0.3437
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.9024 0.9024
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.9024 0.9024
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0023 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.9024 0.9024
Brugia malayi GnHR receptor homolog 0.0021 0.9024 0.9024
Brugia malayi multidrug resistance protein 3 0.001 0.2519 0.2519
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0012 0.3612 0.3612
Brugia malayi RE15519p 0.0021 0.9024 0.9024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Schistosoma mansoni neuropeptide receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0012 0.3612 0.3612
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0012 0.3437 0.3437
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Onchocerca volvulus 0.0021 0.9024 0.8695
Echinococcus multilocularis g protein coupled receptor 0.0021 0.9024 0.9024
Onchocerca volvulus 0.0021 0.9024 0.8695
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.2519 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.3437 0.3437
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0023 1 1
Onchocerca volvulus 0.0021 0.9024 0.8695
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.3612 0.3612
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.9024 0.9024
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0023 1 1
Echinococcus granulosus neuropeptide receptor 0.0021 0.9024 0.9024
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.9024 0.9024
Onchocerca volvulus 0.0023 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.9024 0.9024
Brugia malayi larval opioid receptor 0.0021 0.9024 0.9024
Brugia malayi Dopamine receptor 0.0021 0.9024 0.9024
Schistosoma mansoni adenoreceptor 0.0021 0.9024 0.9024
Echinococcus granulosus neuropeptide s receptor 0.0021 0.9024 0.9024
Echinococcus granulosus fmrfamide receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Echinococcus granulosus g protein coupled receptor 0.0021 0.9024 0.9024
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.9024 0.9024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.3437 0.3437
Schistosoma mansoni nAChR subunit 0.0023 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.9024 0.9024
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.001 0.2539 0.2539
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 1 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.001 0.2539 0.2539
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.2519 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.2519 0.2519
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.3612 0.3612
Schistosoma mansoni hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.3437 0.3437
Brugia malayi G-protein coupled receptor 0.0021 0.9024 0.9024
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.2519 0.2519
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.9024 0.9024
Schistosoma mansoni thyroid hormone receptor 0.0012 0.3437 0.3437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.2519 0.2519
Onchocerca volvulus 0.0021 0.9024 0.8695
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.9024 0.9024
Echinococcus granulosus multidrug resistance protein 1 0.001 0.2519 0.2519
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.3437 0.3437
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.2519 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.9024 0.9024
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.9024 0.9024
Leishmania major p-glycoprotein 0.001 0.2519 0.5
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.2519 0.2519
Onchocerca volvulus 0.0021 0.9024 0.8695
Echinococcus multilocularis g protein coupled receptor 0.0021 0.9024 0.9024
Schistosoma mansoni neuropeptide receptor 0.0021 0.9024 0.9024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.3437 0.3437
Echinococcus multilocularis neuropeptide receptor 0.0021 0.9024 0.9024
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.3437 0.3437
Echinococcus multilocularis serotonin receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.001 0.2539 0.2539
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0007 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.2519 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.2519 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0023 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.2519 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.3437 0.3437
Plasmodium vivax multidrug resistance protein 1, putative 0.001 0.2519 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.9024 0.9024
Schistosoma mansoni amine GPCR 0.0021 0.9024 0.9024
Onchocerca volvulus 0.0012 0.3437 0.1227
Trichomonas vaginalis abcb9, putative 0.001 0.2519 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0023 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.3437 0.3437
Schistosoma mansoni nAChR subunit 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Schistosoma mansoni multidrug resistance protein 0.001 0.2519 0.2519
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.9024 0.9024
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.9024 0.9024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.3612 0.3612
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.9024 0.9024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.2539 0.2539
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.9024 0.9024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.3437 0.3437
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.2539 0.2539
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Brugia malayi Cation transporter family protein 0.0023 1 1
Loa Loa (eye worm) acetylcholine receptor protein 0.001 0.2539 0.2539
Brugia malayi sulfakinin receptor protein 0.0021 0.9024 0.9024
Schistosoma mansoni smdr2 0.001 0.2519 0.2519
Onchocerca volvulus Putative nachr subunit 0.0023 1 1
Echinococcus multilocularis glycine receptor subunit beta 0.0023 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.2519 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.9024 0.9024
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.001 0.2539 0.2539
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.001 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.9024 0.9024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.9024 0.9024
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.3437 0.3437
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.2519 0.2519
Schistosoma mansoni nAChR subunit 0.0023 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.9024 0.9024
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.9024 0.9024
Trichomonas vaginalis ABC transporter, putative 0.001 0.2519 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.2519 0.2519
Brugia malayi hypothetical protein 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.0021 0.9024 0.9024
Plasmodium falciparum multidrug resistance protein 1 0.001 0.2519 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.0021 0.9024 0.9024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.9024 0.9024
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Echinococcus granulosus sex peptide receptor 0.0021 0.9024 0.9024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.3437 0.3437
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0023 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.9024 0.9024
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.2519 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.3437 0.3437
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.9024 0.9024
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.9024 0.9024
Onchocerca volvulus 0.0023 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.9024 0.9024
Brugia malayi Serotonin receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.3437 0.3437
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.9024 0.9024
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.001 0.2519 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.3437 0.3437
Schistosoma mansoni opsin-like receptor 0.0021 0.9024 0.9024
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.9024 0.8695
Schistosoma mansoni histamine h1 receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0023 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.3437 0.3437
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.3437 0.3437
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.3437 0.3437
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 1 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.001 0.2539 0.2539
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0023 1 1
Trichomonas vaginalis ABC transporter, putative 0.001 0.2519 1
Schistosoma mansoni myosin xvIII 0.0021 0.9024 0.9024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.3437 0.3437
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0023 1 1
Onchocerca volvulus 0.0021 0.9024 0.8695
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0012 0.3612 0.3612
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis nAChR subunit 0.0023 1 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0023 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.3437 0.3437
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0023 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.3612 0.3612
Brugia malayi Serotonin receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis glycine receptor subunit beta 0.0023 1 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.001 0.2539 0.2539
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.3437 0.3437
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0012 0.3437 0.3437
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.001 0.2539 0.2539
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.3437 0.3437
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.3437 0.3437
Loa Loa (eye worm) ACC-1 protein 0.0023 1 1
Echinococcus granulosus nAChR subunit 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Trichomonas vaginalis ABC transporter, putative 0.001 0.2519 1
Loa Loa (eye worm) LGC-31 protein 0.0023 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.001 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.3612 0.3612
Brugia malayi Melatonin receptor type 1A 0.0021 0.9024 0.9024
Trichomonas vaginalis abcb9, putative 0.001 0.2519 1
Echinococcus granulosus g protein coupled receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.3437 0.3437
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.2539 0.2539
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.3437 0.3437
Echinococcus multilocularis fmrfamide receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.2519 0.2519
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.3437 0.3437
Schistosoma mansoni opsin-like receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0012 0.3437 0.3437
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.3437 0.3437
Brugia malayi nuclear receptor NHR-88 0.0012 0.3437 0.3437
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.0021 0.9024 0.9024
Onchocerca volvulus 0.0021 0.9024 0.8695
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.2519 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.2519 1
Onchocerca volvulus 0.0012 0.3612 0.1461
Brugia malayi neuropeptide F receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Schistosoma mansoni nAChR subunit 0.0023 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.2539 0.2539
Onchocerca volvulus 0.0021 0.9024 0.8695
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.9024 0.9024
Onchocerca volvulus 0.0021 0.9024 0.8695
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.9024 0.9024
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.2519 0.2519
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.9024 0.9024
Schistosoma mansoni amine GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus granulosus glycine receptor subunit beta 0.0023 1 1
Echinococcus granulosus nAChR subunit 0.0012 0.3612 0.3612
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.9024 0.9024
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.9024 0.9024
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.9024 0.9024
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.3612 0.3612
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.2519 1
Brugia malayi AKH receptor 0.0021 0.9024 0.9024
Schistosoma mansoni opsin-like receptor 0.0021 0.9024 0.9024
Schistosoma mansoni neuropeptide receptor 0.0021 0.9024 0.9024
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.9024 0.9024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.3437 0.3437
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.9024 0.9024
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.001 0.2519 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Trichomonas vaginalis taga, putative 0.001 0.2519 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.2519 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Schistosoma mansoni nAChR subunit 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Onchocerca volvulus 0.001 0.2539 0.0027
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 1 1
Onchocerca volvulus 0.0021 0.9024 0.8695
Schistosoma mansoni nAChR subunit 0.0023 1 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0023 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.9024 0.8695
Brugia malayi Dopamine receptor protein 2 0.0021 0.9024 0.9024
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.2519 0.2519
Schistosoma mansoni coup transcription factor 0.0012 0.3437 0.3437
Onchocerca volvulus 0.0012 0.3612 0.1461
Onchocerca volvulus 0.0023 1 1
Schistosoma mansoni acetylcholine receptor-related 0.001 0.2539 0.2539
Onchocerca volvulus 0.0021 0.9024 0.8695
Echinococcus granulosus multidrug resistance protein 1 0.001 0.2519 0.2519
Trichomonas vaginalis abcb9, putative 0.001 0.2519 1
Brugia malayi ORL1-like opioid receptor 0.0021 0.9024 0.9024
Onchocerca volvulus 0.0021 0.9024 0.8695
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Echinococcus multilocularis neuropeptide receptor 0.0021 0.9024 0.9024
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.3437 0.3437
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.9024 0.9024
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.9024 0.9024
Onchocerca volvulus 0.0023 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0023 1 1
Onchocerca volvulus 0.0023 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.3437 0.3437
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.3437 0.3437
Brugia malayi hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.001 0.2539 0.2539
Loa Loa (eye worm) hypothetical protein 0.0012 0.3612 0.3612
Brugia malayi putative neuropeptide receptor 0.0021 0.9024 0.9024
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.9024 0.9024
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) ACC-1 protein 0.0023 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.3437 0.3437
Brugia malayi Cation transporter family protein 0.0023 1 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.3612 0.3612
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.3437 0.1227
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.9024 0.9024
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.9024 0.9024
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0023 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.0021 0.9024 0.9024
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.001 0.2539 0.2539
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.2519 1
Echinococcus multilocularis g protein coupled receptor 0.0021 0.9024 0.9024
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0012 0.3612 0.3612
Echinococcus multilocularis sex peptide receptor 0.0021 0.9024 0.9024
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.9024 0.9024
Schistosoma mansoni multidrug resistance protein 0.001 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0012 0.3612 0.3612
Onchocerca volvulus 0.0023 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.9024 0.9024
Echinococcus granulosus neuropeptide receptor 0.0021 0.9024 0.9024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 1 1
Echinococcus granulosus multidrug resistance protein 1 0.001 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0012 0.3612 0.3612
Schistosoma mansoni multidrug resistance protein 0.001 0.2519 0.2519
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0023 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.001 0.2539 0.2539
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 1 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.3437 0.3437
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0012 0.3612 0.3612
Schistosoma mansoni biogenic amine receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.0021 0.9024 0.9024
Brugia malayi Cation transporter family protein 0.0023 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.9024 0.9024
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.9024 0.9024
Brugia malayi nuclear hormone receptor 0.0012 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Onchocerca volvulus 0.0021 0.9024 0.8695
Schistosoma mansoni nAChR subunit 0.001 0.2539 0.2539
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.2519 0.2519
Brugia malayi G-protein coupled receptor 0.0021 0.9024 0.9024
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0023 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.9024 0.9024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.9024 0.9024
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.9024 0.9024
Loa Loa (eye worm) hypothetical protein 0.0023 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.9024 0.9024
Brugia malayi hypothetical protein 0.001 0.2539 0.2539

Activities

Activity type Activity value Assay description Source Reference
Acute electroshock activity (functional) 0 In vivo acute electroshock physical dependence activity of the compound in mice; Active ChEMBL. 10197957
Change in Cl- current (functional) = 0.68 In vitro GABA-mediated chloride current in A293 cells expressing GABA-A benzodiazepine receptor alpha3-beta2-gamma2 subunits at 5 uM ChEMBL. 10197957
Change in Cl- current (functional) = 2.6 In vitro GABA-mediated chloride current in A293 cells expressing GABA-A benzodiazepine receptor alpha1-beta2-gamma2 subunits at 5 uM ChEMBL. 10197957
Change in Cl- current (functional) = 0.68 In vitro GABA-mediated chloride current in A293 cells expressing GABA-A benzodiazepine receptor alpha3-beta2-gamma2 subunits at 5 uM ChEMBL. 10197957
Change in Cl- current (functional) = 2.6 In vitro GABA-mediated chloride current in A293 cells expressing GABA-A benzodiazepine receptor alpha1-beta2-gamma2 subunits at 5 uM ChEMBL. 10197957
Control (functional) = 0.38 % In vivo efficacy of the compound is evaluated by percent control of cerebellar GMP levels in (drug+stress) treated mice/mice under stress ChEMBL. 10197957
Control (functional) = 0.38 % In vivo efficacy of the compound is evaluated by percent control of cerebellar GMP levels in (drug+stress) treated mice/mice under stress ChEMBL. 10197957
ED50 (functional) = 0.6 mg kg-1 In vivo efficacy evaluated for ability to antagonize metrazole induced clonic convulsions in rat after ip injection ChEMBL. 10197957
ED50 (functional) > 30 mg kg-1 Ability to antagonize the muscle relaxation effect in mice caused by a benzodiazepine full agonist, triazolam. ChEMBL. 10197957
ED50 (functional) > 30 mg kg-1 Ability to antagonize the muscle relaxation effect in mice caused by a benzodiazepine full agonist, triazolam. ChEMBL. 10197957
Inhibition (binding) = 84 % Displacement of [3H]-flunitrazepam from GABA-A benzodiazepine receptor of rat cortical membranes ChEMBL. 10197957
Inhibition (binding) = 84 % Displacement of [3H]-flunitrazepam from GABA-A benzodiazepine receptor of rat cortical membranes ChEMBL. 10197957
Ki (binding) = 39.75 nM Displacement of [3H]-flunitrazepam from GABA-A benzodiazepine receptor of rat cortical membranes ChEMBL. 10197957
Ki (binding) = 39.75 nM Displacement of [3H]-flunitrazepam from GABA-A benzodiazepine receptor of rat cortical membranes ChEMBL. 10197957
Shift (binding) = 1.43 Shift in [35S]-TBPS binding to GABA-A Benzodiazepine receptor of rat brain membrane ChEMBL. 10197957

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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