TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 382.37 | Formula: C19H18N4O5
H donors: 0 H acceptors: 4 LogP: 2.46 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cn1)c1cccc(c1)CO[C@@H]1COc2n(C1)cc(n2)[N+](=O)[O-]
InChi: 1S/C19H18N4O5/c1-26-18-6-5-15(8-20-18)14-4-2-3-13(7-14)11-27-16-9-22-10-17(23(24)25)21-19(22)28-12-16/h2-8,10,16H,9,11-12H2,1H3/t16-/m0/s1
InChiKey: QIJDQLRGHKKXCN-INIZCTEOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	amine GPCR	0.0013	0.0049	0.0049
Brugia malayi	larval opioid receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	neuropeptide receptor A26	0.0013	0.0049	0.0049
Trypanosoma brucei	hexokinase	0.0184	1	0.5
Brugia malayi	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	neuropeptides capa receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Brugia malayi	Hexokinase family protein	0.0116	0.6014	0.6014
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.0049	0.0049
Trypanosoma cruzi	hexokinase, putative	0.0184	1	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0013	0.0049	0.0049
Plasmodium falciparum	hexokinase	0.0184	1	0.5
Echinococcus granulosus	g protein coupled receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0013	0.0049	0.0049
Brugia malayi	G-protein coupled receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0013	0.0049	0.0049
Brugia malayi	putative neuropeptide receptor NPR1	0.0013	0.0049	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0013	0.0049	0.0049
Onchocerca volvulus		0.0116	0.6014	0.5995
Echinococcus multilocularis	orexin receptor type 2	0.0013	0.0049	0.0049
Schistosoma mansoni	biogenic amine receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	amine GPCR	0.0013	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hexokinase type II	0.0184	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0049	0.0049
Echinococcus granulosus	dro:myosuppressin receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	melatonin receptor type 1A	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	amine GPCR	0.0013	0.0049	0.0049
Echinococcus multilocularis	neuropeptide receptor A26	0.0013	0.0049	0.0049
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0013	0.0049	0.0049
Echinococcus granulosus	hexokinase type 2	0.0184	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0013	0.0049	0.0049
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	sex peptide receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	7tm_1 domain containing protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0013	0.0049	0.0049
Onchocerca volvulus	Hexokinase homolog	0.0116	0.6014	0.5995
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2705	0.2705
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	neuropeptide receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	biogenic amine receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	hexokinase	0.0184	1	1
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0049	0.0049
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	neuropeptide F-like receptor	0.0013	0.0049	0.0049
Brugia malayi	Melatonin receptor type 1A	0.0013	0.0049	0.0049
Brugia malayi	neuropeptide F receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	neuropeptide receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hexokinase	0.0184	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0013	0.0049	0.0049
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	hexokinase type 2	0.0184	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0049	0.0049
Toxoplasma gondii	hexokinase	0.0184	1	0.5
Treponema pallidum	hexokinase (hxk)	0.0184	1	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.0049	0.0049
Leishmania major	hexokinase, putative	0.0184	1	0.5
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	growth hormone secretagogue receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	serotonin receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	opsin-like receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Brugia malayi	G-protein coupled receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	allatostatin A receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	neuropeptide Y receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2705	0.2705
Echinococcus granulosus	neuropeptide receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	dro:myosuppressin receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.1925	0.1925
Trypanosoma brucei	hexokinase, putative	0.0184	1	0.5
Brugia malayi	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	allatostatin A receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0049	0.0049
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0041	0.1705	0.1705
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	opsin-like receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	opsin-like receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0126	0.66	0.66
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0039	0.1547	0.5
Echinococcus multilocularis	sex peptide receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0049	0.0049
Brugia malayi	Dopamine receptor protein 1	0.0013	0.0049	0.0049
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.0049	0.0049
Brugia malayi	sulfakinin receptor protein	0.0013	0.0049	0.0049
Echinococcus granulosus	hexokinase	0.0184	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0013	0.0049	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0049	0.0049
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hexokinase	0.0184	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0013	0.0049	0.0049
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	neuropeptides capa receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	neuropeptide F-like receptor	0.0013	0.0049	0.0049
Brugia malayi	G protein-coupled receptor	0.0013	0.0049	0.0049
Onchocerca volvulus		0.0184	1	1
Leishmania major	hexokinase, putative	0.0184	1	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	g protein coupled receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Brugia malayi	Dopamine receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	amine GPCR	0.0013	0.0049	0.0049
Echinococcus multilocularis	hexokinase	0.0184	1	1
Schistosoma mansoni	myosin xvIII	0.0013	0.0049	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0013	0.0049	0.0049
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0013	0.0049	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hexokinase	0.0057	0.2614	0.2614
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0049	0.0049
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.0049	0.0049
Brugia malayi	hexokinase type II	0.0059	0.2705	0.2705
Echinococcus multilocularis	neuropeptides capa receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Echinococcus granulosus	serotonin receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1388	0.1388
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Echinococcus granulosus	fmrfamide receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	G protein coupled receptor 139	0.0013	0.0049	0.0049
Echinococcus granulosus	g-protein coupled receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Brugia malayi	GnHR receptor homolog	0.0013	0.0049	0.0049
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	TYRA-2 protein	0.0013	0.0049	0.0049
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0013	0.0049	0.0049
Echinococcus multilocularis	fmrfamide receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	amine GPCR	0.0013	0.0049	0.0049
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0013	0.0049	0.0049
Echinococcus multilocularis	hexokinase	0.0184	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0013	0.0049	0.0049
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0041	0.1705	0.1705
Trypanosoma cruzi	hexokinase, putative	0.0184	1	0.5
Brugia malayi	Hexokinase family protein	0.0184	1	1
Brugia malayi	AKH receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	g protein coupled receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0013	0.0049	0.0049
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0013	0.0049	0.0049
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0013	0.0049	0.0049
Brugia malayi	Serotonin receptor	0.0013	0.0049	0.0049
Entamoeba histolytica	hexokinase 1	0.0184	1	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.1925	0.1925
Echinococcus granulosus	neuropeptide FF receptor 2	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0013	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0013	0.0049	0.0049
Trypanosoma brucei	hexokinase	0.0184	1	0.5
Loa Loa (eye worm)	hexokinase	0.0116	0.6014	0.6014
Brugia malayi	putative neuropeptide receptor	0.0013	0.0049	0.0049
Brugia malayi	RE15519p	0.0013	0.0049	0.0049
Brugia malayi	Serotonin receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0049	0.0049
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	adenoreceptor	0.0013	0.0049	0.0049
Echinococcus granulosus	neuropeptides capa receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	neuropeptide Y receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	somatostatin receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	fmrfamide receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.0049	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Brugia malayi	neuropeptide F receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0041	0.1705	0.1705
Plasmodium vivax	hexokinase, putative	0.0184	1	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	neuropeptide s receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.0049	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	neuropeptide s receptor	0.0013	0.0049	0.0049
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0041	0.1705	0.1705
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	orexin receptor type 2	0.0013	0.0049	0.0049
Schistosoma mansoni	histamine h1 receptor	0.0013	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus multilocularis	somatostatin receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	neuropeptide f receptor 76f	0.0013	0.0049	0.0049
Brugia malayi	G protein-coupled receptor F59B2.13	0.0013	0.0049	0.0049
Echinococcus multilocularis	hexokinase	0.0184	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.0049	0.0049
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.0049	0.0049
Schistosoma mansoni	biogenic amine receptor	0.0013	0.0049	0.0049
Brugia malayi	Dopamine receptor protein 2	0.0013	0.0049	0.0049
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	neuropeptide receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0013	0.0049	0.0049
Onchocerca volvulus		0.0184	1	1
Brugia malayi	Hexokinase family protein	0.0057	0.2614	0.2614
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Brugia malayi	ORL1-like opioid receptor	0.0013	0.0049	0.0049
Schistosoma mansoni	hexokinase	0.0184	1	1
Echinococcus multilocularis	g-protein coupled receptor	0.0013	0.0049	0.0049
Onchocerca volvulus		0.0184	1	1
Echinococcus multilocularis	serotonin receptor	0.0013	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	G protein coupled receptor 139	0.0013	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	biogenic amine 5HT receptor	0.0013	0.0049	0.0049
Echinococcus granulosus	hexokinase	0.0184	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Echinococcus granulosus	neuropeptide Y receptor	0.0013	0.0049	0.0049
Entamoeba histolytica	hexokinase 2	0.0184	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0049
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0039	0.1547	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0013	0.0049	0.0049
Echinococcus multilocularis	neuropeptide Y receptor	0.0013	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0013	0.0049	0.0049

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 0.4 uM	Antitubercular activity against Mycobacterium tuberculosis H37Rv by MABA method	ChEMBL.	21069962
MIC (functional)	= 1.7 uM	Antitubercular activity against Mycobacterium tuberculosis H37Rv by LORA method	ChEMBL.	21069962

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1631953

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1462082