Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0297 | 0.5184 | 0.5184 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0047 | 0.0296 | 0.0296 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0146 | 0.2241 | 0.2241 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1699 | 0.1699 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0116 | 0.1646 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0035 | 0.0074 | 0.0074 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0035 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0035 | 0.0074 | 0.0074 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.3441 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0146 | 0.2241 | 0.2241 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0285 | 0.4938 | 0.4938 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0035 | 0.0074 | 0.0074 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0035 | 0.0074 | 0.0074 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0035 | 0.0074 | 0.0074 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0047 | 0.0296 | 0.0296 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.3441 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.3441 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.3441 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0035 | 0.0074 | 0.0074 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0135 | 0.2019 | 0.2019 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0035 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0135 | 0.2019 | 0.2019 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0047 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0296 | 0.0296 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0035 | 0.0074 | 0.0074 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0208 | 0.3441 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0047 | 0.0296 | 0.0296 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0544 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0297 | 0.5184 | 0.5184 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0135 | 0.2019 | 0.2019 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0297 | 0.5184 | 0.5184 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0297 | 0.5184 | 0.5184 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.5184 | 0.5184 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0116 | 0.1646 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0035 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0035 | 0.0074 | 0.0074 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0035 | 0.0074 | 0.0074 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0296 | 0.0296 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0297 | 0.5184 | 0.5184 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0035 | 0.0074 | 0.0074 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0035 | 0.0074 | 0.0074 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0135 | 0.2019 | 0.2019 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0544 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0297 | 0.5184 | 0.5184 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0035 | 0.0074 | 0.0074 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0035 | 0.0074 | 0.0074 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.3441 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0296 | 0.0296 |
Brugia malayi | Dihydrofolate reductase | 0.0544 | 1 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0035 | 0.0074 | 0.0074 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0035 | 0.0074 | 0.0074 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0035 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0544 | 1 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0035 | 0.0074 | 0.0074 |
Schistosoma mansoni | dihydrofolate reductase | 0.0544 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0544 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0544 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0544 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0047 | 0.0296 | 0.0296 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0544 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.