Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | furin (paired basic amino acid cleaving enzyme) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.0539 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0206 | 0.291 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0539 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0539 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0539 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0539 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0539 | 1 | 1 |
Brugia malayi | celfurPC protein | 0.0143 | 0.1562 | 0.0737 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0539 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0539 | 1 | 0.5 |
Echinococcus multilocularis | 0.0143 | 0.1562 | 0.0816 | |
Brugia malayi | endoprotease bli-4 precursor | 0.0177 | 0.2292 | 0.1538 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0177 | 0.2292 | 0.2165 |
Echinococcus granulosus | furin | 0.0177 | 0.2292 | 0.161 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0108 | 0.0813 | 0.5 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0177 | 0.2292 | 0.2292 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0206 | 0.291 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0539 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0206 | 0.291 | 0.5 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0111 | 0.0891 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.2292 | 0.2292 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0206 | 0.291 | 0.5 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0111 | 0.0891 | 0.0085 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0108 | 0.0813 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0206 | 0.291 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0206 | 0.291 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.04 uM | Inhibition of human recombinant furin by fluorescence plate reader analysis | ChEMBL. | 21168329 |
Ki (binding) | = 1000 uM | Inhibition of thrombin | ChEMBL. | 21168329 |
Ki (binding) | = 1000 uM | Inhibition of factor 10a | ChEMBL. | 21168329 |
Ki (binding) | = 1000 uM | Inhibition of plasmin | ChEMBL. | 21168329 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.