Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | growth factor receptor-bound protein | 0.0058 | 0.2385 | 0.2385 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0123 | 1 | 1 |
Echinococcus multilocularis | NCK adaptor protein | 0.0058 | 0.2385 | 0.2385 |
Schistosoma mansoni | tyrosine kinase | 0.0123 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0066 | 0.335 | 0.335 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0123 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0066 | 0.335 | 0.335 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0058 | 0.2385 | 0.2385 |
Brugia malayi | Variant SH3 domain containing protein | 0.0058 | 0.2385 | 0.2385 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0066 | 0.335 | 0.335 |
Echinococcus granulosus | tyrosine kinase | 0.0095 | 0.665 | 0.665 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0066 | 0.335 | 0.335 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0123 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0123 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0123 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0066 | 0.335 | 0.335 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0123 | 1 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0058 | 0.2385 | 0.2385 |
Schistosoma mansoni | tyrosine kinase | 0.0066 | 0.335 | 0.335 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0123 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0095 | 0.665 | 0.665 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0058 | 0.2385 | 0.2385 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2385 | 0.2385 |
Brugia malayi | Variant SH3 domain containing protein | 0.0058 | 0.2385 | 0.2385 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0065 | 0.3215 | 0.3215 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0058 | 0.2385 | 0.2385 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0095 | 0.665 | 0.665 |
Schistosoma mansoni | tyrosine kinase | 0.0066 | 0.335 | 0.335 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0058 | 0.2385 | 0.2385 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0058 | 0.2385 | 0.2385 |
Schistosoma mansoni | tyrosine kinase | 0.0123 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0066 | 0.335 | 0.335 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0065 | 0.3215 | 0.3215 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0123 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0123 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0123 | 1 | 1 |
Echinococcus granulosus | NCK adaptor protein | 0.0058 | 0.2385 | 0.2385 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0123 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0123 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0095 | 0.665 | 0.665 |
Brugia malayi | protein-tyrosine kinase | 0.0095 | 0.665 | 0.665 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0123 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0095 | 0.665 | 0.665 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0086 | 0.5686 | 0.5686 |
Schistosoma mansoni | adapter molecule crk | 0.0058 | 0.2385 | 0.2385 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0095 | 0.665 | 0.665 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0065 | 0.3215 | 0.3215 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0123 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0065 | 0.3215 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0123 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0066 | 0.335 | 0.335 |
Loa Loa (eye worm) | TK protein kinase | 0.0095 | 0.665 | 0.665 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0086 | 0.5686 | 0.5686 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0123 | 1 | 1 |
Schistosoma mansoni | nck2/grb4 | 0.0058 | 0.2385 | 0.2385 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0123 | 1 | 1 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0058 | 0.2385 | 0.2385 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | ChEMBL. | 20971532 |
IC50 (functional) | > 100 uM | Cytotoxicity against human SF295 cells after 72 hrs by MTT assay | ChEMBL. | 20971532 |
IC50 (functional) | > 100 uM | Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay | ChEMBL. | 20971532 |
IC50 (functional) | > 100 uM | Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay | ChEMBL. | 20971532 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.