TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 538.615 | Formula: C24H27N4NaO5S2
H donors: 2 H acceptors: 6 LogP: 4.86 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCC(=O)[N-]S(=O)(=O)c1ccc(cc1)C(C(=O)Nc1nc2c(s1)nc(cc2)OC)CC1CCCC1.[Na+]
InChi: 1S/C24H28N4O5S2.Na/c1-3-20(29)28-35(31,32)17-10-8-16(9-11-17)18(14-15-6-4-5-7-15)22(30)27-24-25-19-12-13-21(33-2)26-23(19)34-24;/h8-13,15,18H,3-7,14H2,1-2H3,(H2,25,27,28,29,30);/q;+1/p-1
InChiKey: OZXOODMHBLWQNO-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0066	0.0046
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0037	0.0311
Schistosoma mansoni	hypothetical protein	0.0183	0.1181	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.0341	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0037	0.0173
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.0403	0.2739	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0037	0.0173
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0216	0.0942
Brugia malayi	hypothetical protein	0.0314	0.2114	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.01
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0037	0.0173
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0021	0.0612
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0037	0.0173
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0037	0.016
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0341	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0037	0.0173
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.0727	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0037	0.0173
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.0341	0.1614
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0037	0.016
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0021	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0037	0.0173
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0073	0.0345
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0037	0.016
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0092	0.0434
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0216	0.0942
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0037	0.0173
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0037	0.0311
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0037	0.016
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.0727	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0037	0.0173
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0066	0.0093
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0242	0.1144
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0216	0.102
Onchocerca volvulus		0.0314	0.2114	1
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0037	0.0173
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0021	0.0612
Brugia malayi	MH2 domain containing protein	0.0119	0.0727	0.3441
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0037	0.016
Onchocerca volvulus	Dual oxidase homolog	0.0026	0.0073	0.0174
Loa Loa (eye worm)	blistered cuticle protein 3	0.0026	0.0073	0.0345
Schistosoma mansoni	hypothetical protein	0.0183	0.1181	1
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.015	0.0657
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0037	0.0173
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0029	0.0096	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Loa Loa (eye worm)	pax transcription factor protein 2	0.0241	0.1597	0.7556
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1428	1	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0037	0.0173
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0037	0.016
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0216	0.0942
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0073	0.0345
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0037	0.0311
Echinococcus granulosus	peroxidasin	0.0026	0.0073	0.0319
Brugia malayi	Blistered cuticle protein 3	0.0026	0.0073	0.0345
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0037	0.016
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0014	0.0019
Onchocerca volvulus	Chorion peroxidase homolog	0.0026	0.0073	0.0174
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0037	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0037	0.0173
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0037	0.016
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0029	0.0095	0.1049
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0037	0.016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0037	0.0173
Onchocerca volvulus		0.005	0.0239	0.0974
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0037	0.0173
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0029	0.0095	0.1049
Onchocerca volvulus		0.0241	0.1597	0.7513
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0037	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.01
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0066	0.0046
Onchocerca volvulus	Peroxidasin homolog	0.0026	0.0073	0.0174
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0037	0.016
Schistosoma mansoni	peroxidasin	0.0026	0.0073	0.0617
Brugia malayi	Pax transcription factor protein 2	0.0241	0.1597	0.7556
Loa Loa (eye worm)	hypothetical protein	0.005	0.0239	0.1131
Echinococcus multilocularis	peroxidasin	0.0026	0.0073	0.0319
Schistosoma mansoni	hypothetical protein	0.0034	0.013	0.11
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.0341	0.1491
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0073	0.0345
Brugia malayi	Peroxidasin	0.0026	0.0073	0.0345
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0037	0.0311
Trichomonas vaginalis	MYB, putative	0.0029	0.0096	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0037	0.0173
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0037	0.016
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0216	0.1826
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0066	0.1945
Onchocerca volvulus		0.0026	0.0073	0.0174
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0014	0.0019
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0037	0.016
Brugia malayi	steroid hormone receptor	0.0021	0.0037	0.0173
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0066	0.0314
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0037	0.0311
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0037	0.0173
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0216	0.102
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0021	0.0099
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.013	0.0614
Onchocerca volvulus		0.0026	0.0073	0.0174
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0037	0.0311
Onchocerca volvulus		0.0025	0.0066	0.0143
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0037	0.016
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0029	0.0095	0.1049
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0066	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0037	0.0173
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0066	0.1945
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0037	0.0173
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0066	0.1945
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0066	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0066	0.0046
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0021	0.003
Brugia malayi	ecdysteroid receptor	0.0021	0.0037	0.0173
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0239	0.2025
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0073	0.0345
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0037	0.0173
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0037	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0066	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.01
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0341	1
Mycobacterium leprae	PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA	0.1026	0.7149	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0037	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0314	0.2114	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0216	0.1826
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0037	0.0311
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0037	0.0173
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0066	0.0046
Echinococcus multilocularis	tumor protein p63	0.0339	0.2288	1
Onchocerca volvulus	Peroxidasin homolog	0.0026	0.0073	0.0174
Echinococcus granulosus	tumor protein p63	0.0339	0.2288	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Onchocerca volvulus		0.0026	0.0073	0.0174
Chlamydia trachomatis	phosphoshikimate 1-carboxyl vinyltransferase	0.0403	0.2739	0.2723
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0037	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0037	0.0173
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.0341	0.1491
Loa Loa (eye worm)	hypothetical protein	0.005	0.0242	0.1144
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0021	0.0099
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0242	0.1144
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.0403	0.2739	0.3773
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.0341	1
Toxoplasma gondii	Myb family DNA-binding domain-containing protein	0.0029	0.0096	0.0351
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0014	0.0019
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0092	0.0434
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0021	0.0612
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0073	0.0345
Brugia malayi	nuclear hormone receptor	0.0021	0.0037	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.01
Echinococcus granulosus	geminin	0.0183	0.1181	0.516
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0029	0.0096	1
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0073	0.0345
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0037	0.0173
Echinococcus multilocularis	geminin	0.0183	0.1181	0.516
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.0341	0.1614
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0037	0.0173
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0037	0.0311
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0066	0.0046
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0216	0.0942
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0021	0.0099
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0021	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0037	0.0173
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0216	0.1826
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0021	1
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0073	0.0345
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0029	0.0095	0.1049
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0037	0.0173
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0029	0.0095	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0037	0.0173
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0066	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0037	0.0173
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0066	0.0314
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0242	0.1144
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0341	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0037	0.0173
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0037	0.016
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA	0.1026	0.7149	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0037	0.016
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Onchocerca volvulus	Peroxidase homolog	0.0026	0.0073	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.01
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0037	0.0311
Schistosoma mansoni	coup transcription factor	0.0021	0.0037	0.0311
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1428	1	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0037	0.0311
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.0403	0.2739	0.2723
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0021	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Onchocerca volvulus	Peroxidase homolog	0.0026	0.0073	0.0174
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0073	0.0345
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0037	0.016
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0066	0.0314
Brugia malayi	hypothetical protein	0.0026	0.0073	0.0345
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0066	0.0046
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.015	0.0657
Giardia lamblia	Myb 1-like protein	0.0029	0.0096	0.5
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0073	0.0345
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0066	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0034	0.013	0.0614
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.0341	0.289
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0037	0.016
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0037	0.016
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0345
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1428	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0037	0.0311
Leishmania major	cytochrome p450-like protein	0.0019	0.0021	0.0612
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0014	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0066	0.0314
Schistosoma mansoni	peroxidasin	0.0026	0.0073	0.0617

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1627112

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1462451