Detailed information for compound 1462705

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 423.591 | Formula: C26H37N3O2
  • H donors: 0 H acceptors: 4 LogP: 8.99 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCCCn1nnc2c1C(=O)c1c(C2=O)cccc1
  • InChi: 1S/C26H37N3O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17-20-29-24-23(27-28-29)25(30)21-18-15-16-19-22(21)26(24)31/h15-16,18-19H,2-14,17,20H2,1H3
  • InChiKey: CBSDNEZFYOHXIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipE 0.0059 0.035 0.0629
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0256 0.0256
Schistosoma mansoni smad 0.0018 0.004 0.0022
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.0256 0.034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0256 0.0309
Brugia malayi beta-lactamase family protein 0.0059 0.035 0.0427
Plasmodium falciparum plasmepsin X 0.0028 0.0118 0.0165
Schistosoma mansoni opsin-like receptor 0.0047 0.0256 0.0309
Schistosoma mansoni memapsin-2 (A01 family) 0.0028 0.0118 0.0125
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0064 0.0947
Echinococcus multilocularis survival motor neuron protein 1 0.0162 0.1132 0.1132
Toxoplasma gondii aspartyl protease 0.0028 0.0118 0.1079
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0256 0.0256
Mycobacterium tuberculosis Conserved protein 0.0059 0.035 0.0629
Brugia malayi hypothetical protein 0.0037 0.0182 0.0205
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0256 0.0309
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0256 0.034
Echinococcus granulosus g protein coupled receptor 0.0047 0.0256 0.034
Trichomonas vaginalis D-aminoacylase, putative 0.0059 0.035 0.0444
Schistosoma mansoni hypothetical protein 0.0047 0.0256 0.0309
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0261 0.1875 0.249
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0394 0.0532
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0064 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0267 0.1922 0.2552
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.0079 0.0105
Echinococcus granulosus abhydrolase domain containing protein 13 0.0041 0.021 0.0279
Brugia malayi PHD-finger family protein 0.0017 0.0034 0.0006
Plasmodium vivax aspartyl protease, putative 0.0028 0.0118 0.0165
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0194 0.1375 0.2413
Echinococcus granulosus biogenic amine 5HT receptor 0.094 0.7015 0.9314
Onchocerca volvulus 0.0047 0.0256 0.6223
Onchocerca volvulus 0.0035 0.0166 0.3767
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0041 0.021 0.0165
Echinococcus multilocularis serotonin receptor 0.0561 0.4148 0.4148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.1698 0.223
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Schistosoma mansoni hypothetical protein 0.0029 0.012 0.0128
Mycobacterium ulcerans hypothetical protein 0.069 0.5123 1
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0394 0.0532
Onchocerca volvulus 0.0033 0.0153 0.3409
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0041 0.021 0.0347
Schistosoma mansoni kinase 0.0033 0.0152 0.0171
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.012 0.0813 0.108
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0064 0.0084
Plasmodium falciparum alpha/beta hydrolase, putative 0.0041 0.021 0.0347
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.004 0.004
Trypanosoma cruzi serine peptidase, putative 0.0041 0.021 0.0056
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0122 0.0823 0.1558
Plasmodium vivax unspecified product 0.0041 0.021 0.0347
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0256 0.0309
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0041 0.021 0.0056
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0256 0.034
Schistosoma mansoni jumonji domain containing protein 0.0045 0.0244 0.0293
Schistosoma mansoni fatty-acid amide hydrolase 0.0122 0.0823 0.1064
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.021 0.0165
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.0256 0.0303
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0256 0.034
Echinococcus multilocularis peregrin 0.0017 0.0034 0.0034
Echinococcus granulosus lysine specific demethylase 5A 0.0023 0.0079 0.0105
Schistosoma mansoni opsin-like receptor 0.0047 0.0256 0.0309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0256 0.0256
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0034 0.0045
Loa Loa (eye worm) hypothetical protein 0.0059 0.035 0.0464
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0033 0.0153 0.0166
Onchocerca volvulus 0.0047 0.0256 0.6223
Echinococcus granulosus geminin 0.0709 0.527 0.6998
Mycobacterium tuberculosis Probable lipase LipD 0.0059 0.035 0.0629
Leishmania major hypothetical protein, conserved 0.0041 0.021 0.0356
Echinococcus granulosus abhydrolase domain containing 3 0.0041 0.021 0.0279
Mycobacterium ulcerans amidase 0.0122 0.0823 0.1558
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0064 0.0064
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0256 0.034
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0064 0.0053
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Trichomonas vaginalis valacyclovir hydrolase, putative 0.069 0.5123 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0156
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0064 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.035 0.0338
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.0256 0.0256
Mycobacterium ulcerans esterase/lipase LipP 0.0059 0.035 0.0629
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0256 0.0256
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0064 0.0053
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0256 0.0309
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0256 0.0256
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.004 0.0053
Plasmodium vivax aspartyl protease, putative 0.0028 0.0118 0.0165
Mycobacterium ulcerans hypothetical protein 0.0216 0.1541 0.2968
Trypanosoma brucei monoglyceride lipase, putative 0.069 0.5123 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus granulosus fmrfamide receptor 0.0047 0.0256 0.034
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.069 0.5123 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.0256 0.034
Plasmodium falciparum plasmepsin III 0.0028 0.0118 0.0165
Schistosoma mansoni hypothetical protein 0.0082 0.0527 0.067
Echinococcus multilocularis smad 0.0018 0.004 0.004
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0058 0.034 0.0318
Brugia malayi Pepsin A precursor 0.0028 0.0118 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.1698 0.1698
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0256 0.0256
Plasmodium vivax hypothetical protein, conserved 0.0059 0.035 0.0621
Loa Loa (eye worm) amidase 0.0122 0.0823 0.1092
Echinococcus multilocularis Niemann Pick C1 protein 0.0069 0.0428 0.0428
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0064 0.0084
Mycobacterium ulcerans beta-lactamase 0.0059 0.035 0.0629
Brugia malayi hypothetical protein 0.0047 0.0256 0.0303
Echinococcus granulosus Phospholipase carboxylesterase 0.0041 0.021 0.0279
Schistosoma mansoni hypothetical protein 0.0709 0.527 0.6988
Schistosoma mansoni cathepsin D (A01 family) 0.012 0.0813 0.1052
Echinococcus multilocularis somatostatin receptor 0.0047 0.0256 0.0256
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0527 0.0699
Schistosoma mansoni hypothetical protein 0.0047 0.0256 0.0309
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0256 0.034
Toxoplasma gondii hypothetical protein 0.0041 0.021 0.2263
Brugia malayi Serotonin receptor 0.0047 0.0256 0.0303
Plasmodium vivax PST-A protein 0.0041 0.021 0.0347
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0064 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0064 0.0046
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus granulosus fatty acid amide hydrolase 1 0.1008 0.7532 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0256 0.0309
Brugia malayi CHE-14 protein 0.003 0.0128 0.0132
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0256 0.0309
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0041 0.021 0.0056
Toxoplasma gondii hypothetical protein 0.0041 0.021 0.2263
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.021 0.0165
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0194 0.1375 0.2413
Brugia malayi neuropeptide F receptor 0.0047 0.0256 0.0303
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0256 0.6223
Echinococcus multilocularis jumonji domain containing protein 0.0024 0.0085 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0256 0.0256
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0256 0.0309
Plasmodium vivax PST-A protein 0.0041 0.021 0.0347
Leishmania major hypothetical protein, conserved 0.0037 0.0182 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0394 0.0532
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0041 0.021 0.0165
Schistosoma mansoni jumonji/arid domain-containing protein 0.0023 0.0079 0.0074
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.0256 0.034
Loa Loa (eye worm) hypothetical protein 0.0041 0.021 0.0279
Mycobacterium ulcerans lysophospholipase 0.069 0.5123 1
Brugia malayi hypothetical protein 0.0047 0.0256 0.0303
Echinococcus granulosus GPCR family 2 0.0082 0.0527 0.0699
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.1008 0.7532 1
Plasmodium falciparum epoxide hydrolase 2 0.0041 0.021 0.0347
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0173 0.023
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus multilocularis geminin 0.0709 0.527 0.527
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.069 0.5123 1
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0041 0.021 0.0056
Loa Loa (eye worm) amidase 0.0122 0.0823 0.1092
Echinococcus granulosus hypothetical protein 0.0047 0.0256 0.034
Schistosoma mansoni neuropeptide receptor 0.0047 0.0256 0.0309
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0118 0.0125
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0256 0.0256
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0256 0.0309
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus multilocularis serotonin receptor 0.0561 0.4148 0.4148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0064 0.0084
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0064 0.0064
Toxoplasma gondii hypothetical protein 0.0041 0.021 0.2263
Echinococcus multilocularis abhydrolase domain containing 3 0.0041 0.021 0.021
Plasmodium vivax PST-A protein 0.0041 0.021 0.0347
Leishmania major hypothetical protein, conserved 0.0041 0.021 0.0356
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0084
Echinococcus multilocularis biogenic amine (5HT) receptor 0.094 0.7015 0.7015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0064 0.0046
Echinococcus multilocularis allatostatin A receptor 0.0047 0.0256 0.0256
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.003 0.0128 0.017
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0064 0.0053
Echinococcus granulosus PHD finger protein rhinoceros 0.0017 0.0034 0.0045
Entamoeba histolytica serine/threonine protein kinase, putative 0.0065 0.0394 0.0716
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.0256 0.0256
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0122 0.0823 0.1558
Plasmodium falciparum BEM46-like protein, putative 0.0041 0.021 0.0347
Mycobacterium tuberculosis Possible lysophospholipase 0.069 0.5123 1
Onchocerca volvulus 0.0047 0.0256 0.6223
Entamoeba histolytica hypothetical protein 0.0041 0.021 0.0356
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0118 0.0125
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.0256 0.0256
Schistosoma mansoni hypothetical protein 0.0029 0.012 0.0128
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0042 0.0017
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.0256 0.0256
Brugia malayi jmjC domain containing protein 0.0023 0.0079 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0256 0.0309
Schistosoma mansoni hypothetical protein 0.0271 0.1956 0.2573
Echinococcus granulosus sex peptide receptor 0.0047 0.0256 0.034
Echinococcus multilocularis tumor protein p63 0.0238 0.1706 0.1706
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0084
Schistosoma mansoni cpg binding protein 0.0044 0.0236 0.0282
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0064 0.0064
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0256 0.034
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.069 0.5123 1
Brugia malayi hypothetical protein 0.0162 0.1132 0.1471
Brugia malayi hypothetical protein 0.0073 0.0458 0.0572
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0256 0.034
Onchocerca volvulus 0.0047 0.0256 0.6223
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0122 0.0823 0.155
Schistosoma mansoni amine GPCR 0.0047 0.0256 0.0309
Brugia malayi Dopamine receptor protein 1 0.0047 0.0256 0.0303
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0411 0.3013 0.5729
Plasmodium falciparum esterase, putative 0.069 0.5123 1
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0041 0.021 0.0165
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0084
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.0256 0.0256
Schistosoma mansoni smad1 5 8 and 0.0018 0.004 0.0022
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0256 0.0256
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0064 0.0084
Plasmodium vivax PST-A protein 0.0041 0.021 0.0347
Echinococcus granulosus Protein patched homolog 1 0.003 0.0128 0.017
Mycobacterium ulcerans lipase LipD 0.0059 0.035 0.0629
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0458 0.0458
Plasmodium falciparum plasmepsin VI 0.012 0.0813 0.1532
Plasmodium vivax lysophospholipase, putative 0.0041 0.021 0.0347
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0059 0.035 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0064 0.0084
Echinococcus granulosus beta LACTamase domain containing family member 0.0059 0.035 0.0464
Schistosoma mansoni adenoreceptor 0.0047 0.0256 0.0309
Echinococcus multilocularis beta LACTamase domain containing family member 0.0059 0.035 0.035
Echinococcus granulosus sterol regulatory element binding protein 0.003 0.0128 0.017
Echinococcus granulosus fatty acid amide hydrolase 1 0.1008 0.7532 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.021 0.0165
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0064 0.0053
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0256 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.021 0.0165
Brugia malayi larval opioid receptor 0.0047 0.0256 0.0303
Onchocerca volvulus 0.0047 0.0256 0.6223
Brugia malayi CXXC zinc finger family protein 0.0042 0.0218 0.0252
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0038
Trypanosoma brucei polo-like protein kinase 0.0065 0.0394 0.0428
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0064 0.0084
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.012 0.0813 1
Schistosoma mansoni hypothetical protein 0.0073 0.0458 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.021 0.0165
Plasmodium falciparum exported lipase 2 0.0041 0.021 0.0347
Brugia malayi Serotonin receptor 0.0047 0.0256 0.0303
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0118 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0064 0.0046
Mycobacterium tuberculosis Probable esterase LipL 0.0059 0.035 0.0629
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.0256 0.0256
Onchocerca volvulus 0.0028 0.0118 0.2436
Onchocerca volvulus 0.0047 0.0256 0.6223
Entamoeba histolytica hypothetical protein 0.0073 0.0458 0.0843
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Brugia malayi Amidase family protein 0.0122 0.0823 0.1058
Loa Loa (eye worm) hypothetical protein 0.0261 0.1875 0.249
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0256 0.0256
Brugia malayi hypothetical protein 0.0047 0.0256 0.0303
Loa Loa (eye worm) hypothetical protein 0.012 0.0813 0.108
Toxoplasma gondii aspartyl protease ASP1 0.012 0.0813 1
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0256 0.0303
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0041 0.021 0.0356
Echinococcus multilocularis lysine specific demethylase 5A 0.0021 0.0061 0.0061
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0256 0.034
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.069 0.5123 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0041 0.021 0.0165
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0527 0.0663
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0038
Onchocerca volvulus 0.0047 0.0256 0.6223
Echinococcus granulosus g protein coupled receptor 0.0047 0.0256 0.034
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0064 0.0046
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0065 0.0394 0.0523
Plasmodium falciparum ataxin-2 like protein, putative 0.0037 0.0182 0.0292
Plasmodium vivax hypothetical protein, conserved 0.0041 0.021 0.0347
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0394 0.0532
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0041 0.021 0.0165
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0059 0.035 0.0427
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0256 0.0256
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.1251 0.1629
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.034 0.0318
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0064 0.0947
Onchocerca volvulus Serine\/threonine kinase homolog 0.0065 0.0394 1
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0041 0.021 0.0356
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0028 0.0118 0.0156
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0065 0.0394 0.0394
Echinococcus multilocularis sex peptide receptor 0.0047 0.0256 0.0256
Plasmodium vivax hypothetical protein, conserved 0.0041 0.021 0.0347
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0084
Echinococcus multilocularis dnaJ subfamily B 0.0271 0.1956 0.1956
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0064 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.0059 0.035 0.0338
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0064 0.0064
Schistosoma mansoni biogenic amine receptor 0.0047 0.0256 0.0309
Onchocerca volvulus 0.0059 0.035 0.8788
Mycobacterium ulcerans peptide amidase, GatA 0.0122 0.0823 0.1558
Onchocerca volvulus 0.0059 0.035 0.8788
Brugia malayi Calcitonin receptor-like protein seb-1 0.0261 0.1875 0.2461
Loa Loa (eye worm) hypothetical protein 0.0041 0.021 0.0279
Brugia malayi putative amidase 0.0122 0.0823 0.1058
Entamoeba histolytica hypothetical protein 0.0073 0.0458 0.0843
Plasmodium vivax PST-A protein 0.069 0.5123 1
Toxoplasma gondii LsmAD domain-containing protein 0.0037 0.0182 0.1908
Brugia malayi ORL1-like opioid receptor 0.0047 0.0256 0.0303
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Plasmodium falciparum lysophospholipase, putative 0.0041 0.021 0.0347
Echinococcus multilocularis sterol regulatory element binding protein 0.003 0.0128 0.0128
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0256 0.034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0179 0.0237
Schistosoma mansoni biogenic amine receptor 0.0047 0.0256 0.0309
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Brugia malayi aspartic protease BmAsp-1, identical 0.0028 0.0118 0.0118
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0017 0.0028 0.0037
Schistosoma mansoni hypothetical protein 0.0082 0.0527 0.067
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0064 0.0947
Brugia malayi MH2 domain containing protein 0.0267 0.1922 0.2524
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0377 0.2759 0.5359
Onchocerca volvulus 0.0047 0.0256 0.6223
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0064 0.0084
Plasmodium vivax lysophospholipase, putative 0.0041 0.021 0.0347
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0064 0.0053
Plasmodium falciparum plasmepsin II 0.012 0.0813 0.1532
Onchocerca volvulus 0.0042 0.0218 0.5176
Echinococcus granulosus neuropeptide receptor 0.0047 0.0256 0.034
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.004 0.0053
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.0256 0.034
Plasmodium falciparum lysophospholipase, putative 0.069 0.5123 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0064 0.0046
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.069 0.5123 1
Brugia malayi MH1 domain containing protein 0.0018 0.004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus granulosus biogenic amine 5HT receptor 0.0561 0.4148 0.5507
Schistosoma mansoni hypothetical protein 0.0178 0.1251 0.1635
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0059 0.035 0.0629
Plasmodium falciparum alpha/beta hydrolase, putative 0.0041 0.021 0.0347
Loa Loa (eye worm) hypothetical protein 0.0037 0.0182 0.0242
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0237 0.1698 0.2255
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0256 0.0256
Schistosoma mansoni biogenic amine receptor 0.0047 0.0256 0.0309
Plasmodium falciparum esterase, putative 0.0041 0.021 0.0347
Toxoplasma gondii phospholipase/carboxylesterase 0.0041 0.021 0.2263
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0256 0.0256
Schistosoma mansoni cellular tumor antigen P53 0.0035 0.0166 0.019
Brugia malayi Melatonin receptor type 1A 0.0047 0.0256 0.0303
Brugia malayi Dopamine receptor protein 2 0.0047 0.0256 0.0303
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0256 0.034
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0394 0.0532
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.0256 0.0309
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.069 0.5123 1
Echinococcus granulosus smad 0.0018 0.004 0.0053
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0064 0.0084
Schistosoma mansoni hypothetical protein 0.0017 0.0028 0.0006
Loa Loa (eye worm) hypothetical protein 0.0059 0.035 0.0464
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0122 0.0823 0.155
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0013
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0256 0.034
Onchocerca volvulus 0.0028 0.0118 0.2436
Echinococcus granulosus expressed conserved protein 0.0065 0.0396 0.0526
Schistosoma mansoni hypothetical protein 0.0029 0.012 0.0128
Trichomonas vaginalis esterase, putative 0.0059 0.035 0.0444
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0256 0.034
Toxoplasma gondii hypothetical protein 0.0066 0.0404 0.475
Echinococcus granulosus peregrin 0.0017 0.0034 0.0045
Plasmodium falciparum alpha/beta hydrolase, putative 0.0041 0.021 0.0347
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0064 0.0084
Schistosoma mansoni amine GPCR 0.0047 0.0256 0.0309
Echinococcus granulosus somatostatin receptor 0.0047 0.0256 0.034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0064 0.0046
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.0256 0.0256
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0394 0.0532
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0256 0.0309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0256 0.0256
Onchocerca volvulus 0.0059 0.035 0.8788
Brugia malayi hypothetical protein 0.0028 0.0118 0.0118
Brugia malayi hypothetical protein 0.0047 0.0256 0.0303
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0118 0.0125
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0017 0.0034 0.0013
Brugia malayi Smad1 0.0018 0.004 0.0015
Plasmodium falciparum lysophospholipase, putative 0.069 0.5123 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0064 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0038
Loa Loa (eye worm) CXXC zinc finger family protein 0.0042 0.0218 0.0289
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0084
Echinococcus granulosus cpg binding protein 0.0044 0.0236 0.0313
Echinococcus multilocularis Phospholipase carboxylesterase 0.0041 0.021 0.021
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0256 0.0309
Echinococcus granulosus neuropeptide receptor 0.0047 0.0256 0.034
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0059 0.035 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.021 0.0165
Schistosoma mansoni survival motor neuron protein 0.0033 0.0153 0.0173
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0064 0.0084
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0041 0.021 0.0165
Schistosoma mansoni coup transcription factor 0.0021 0.0064 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.021 0.0165
Trypanosoma cruzi amidase, putative 0.0122 0.0823 0.1296
Schistosoma mansoni histamine h1 receptor 0.0047 0.0256 0.0309
Brugia malayi MGC79044 protein 0.0041 0.021 0.0242
Plasmodium vivax aspartyl proteinase, putative 0.012 0.0813 0.1532
Schistosoma mansoni hypothetical protein 0.0033 0.0153 0.0173
Mycobacterium ulcerans hypothetical protein 0.0041 0.021 0.0356
Brugia malayi hypothetical protein 0.0028 0.0118 0.0118
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0256 0.0303
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Schistosoma mansoni neuropeptide receptor 0.0047 0.0256 0.0309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0256 0.0256
Plasmodium vivax PST-A protein 0.0041 0.021 0.0347
Plasmodium falciparum esterase, putative 0.0041 0.021 0.0347
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0064 0.0053
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0256 0.0309
Giardia lamblia Kinase, PLK 0.0065 0.0394 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1008 0.7532 0.7532
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.021 0.0165
Brugia malayi MH1 domain containing protein 0.0018 0.004 0.0015
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.0256 0.0256
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0256 0.0309
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0256 0.0309
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0458 0.0579
Echinococcus granulosus g protein coupled receptor 0.0047 0.0256 0.034
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0041 0.021 0.0347
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0332 0.0332
Entamoeba histolytica hypothetical protein 0.0041 0.021 0.0356
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0411 0.3013 0.5729
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0059 0.035 0.0629
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0256 0.0303
Brugia malayi neuropeptide F receptor 0.0047 0.0256 0.0303
Brugia malayi RE15519p 0.0047 0.0256 0.0303
Brugia malayi beta-lactamase 0.0059 0.035 0.0427
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0084
Leishmania major monoglyceride lipase, putative 0.069 0.5123 1
Plasmodium vivax alpha/beta hydrolase, putative 0.0041 0.021 0.0347
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0256 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0064 0.0084
Plasmodium falciparum plasmepsin V 0.0028 0.0118 0.0165
Brugia malayi Niemann-Pick C1 protein precursor 0.0069 0.0428 0.0532
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0064 0.0053
Loa Loa (eye worm) hypothetical protein 0.0059 0.035 0.0464
Trypanosoma cruzi polo-like protein kinase, putative 0.0065 0.0394 0.0428
Brugia malayi hypothetical protein 0.0047 0.0256 0.0303
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0059 0.035 0.0629
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.1698 0.2255
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0256 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.021 0.0165
Trypanosoma cruzi monoglyceride lipase, putative 0.069 0.5123 1
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0041 0.021 0.0279
Mycobacterium ulcerans hypothetical protein 0.0059 0.035 0.0629
Schistosoma mansoni niemann-pick C1 (NPC1) 0.007 0.0436 0.0549
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.0256 0.0256
Schistosoma mansoni hypothetical protein 0.0709 0.527 0.6988
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.0256 0.0309
Brugia malayi GnHR receptor homolog 0.0047 0.0256 0.0303
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1008 0.7532 0.7532
Trichomonas vaginalis D-aminoacylase, putative 0.0059 0.035 0.0444
Trypanosoma cruzi serine peptidase, putative 0.0041 0.021 0.0056
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0058 0.034 0.0318
Schistosoma mansoni hypothetical protein 0.0082 0.0527 0.067
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0122 0.0823 0.0823
Schistosoma mansoni amine GPCR 0.0047 0.0256 0.0309
Plasmodium vivax alpha/beta hydrolase, putative 0.0041 0.021 0.0347
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0156
Onchocerca volvulus 0.0047 0.0256 0.6223
Plasmodium falciparum plasmepsin I 0.012 0.0813 0.1532
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.0256 0.0256
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0064 0.0064
Schistosoma mansoni cathepsin D (A01 family) 0.012 0.0813 0.1052
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0041 0.021 0.4901
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0064 0.0064
Mycobacterium leprae conserved hypothetical protein 0.0059 0.035 0.0629
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0028 0.0118 0.1079
Brugia malayi steroid hormone receptor 0.0021 0.0064 0.0046
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.0256 0.0256
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0059 0.035 0.0434
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0065 0.0394 0.0716
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0256 0.034
Brugia malayi ecdysteroid receptor 0.0021 0.0064 0.0046
Brugia malayi serine/threonine-protein kinase plk-2 0.0065 0.0394 0.0486
Loa Loa (eye worm) hypothetical protein 0.0035 0.0166 0.0221
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0394 0.0493
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0122 0.0823 0.1296
Plasmodium vivax ataxin-2 like protein, putative 0.0037 0.0182 0.0292
Onchocerca volvulus 0.0047 0.0256 0.6223
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0041 0.021 0.021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.012 0.0813 0.1052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0045
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0122 0.0823 0.1558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0256 0.0309
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0122 0.0823 0.5
Brugia malayi hypothetical protein 0.0047 0.0256 0.0303
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0527 0.0527
Schistosoma mansoni smad1 5 8 and 0.0018 0.004 0.0022
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.0256 0.034
Loa Loa (eye worm) aspartyl protease 6 0.0028 0.0118 0.0156
Brugia malayi Amidase family protein 0.0122 0.0823 0.1058
Mycobacterium ulcerans amidase 0.0122 0.0823 0.1558
Onchocerca volvulus 0.0047 0.0256 0.6223
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0256 0.0256
Echinococcus multilocularis PHD finger protein rhinoceros 0.0017 0.0034 0.0034
Echinococcus granulosus allatostatin A receptor 0.0047 0.0256 0.034
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0653 0.0653
Plasmodium falciparum alpha/beta hydrolase, putative 0.0041 0.021 0.0347
Trypanosoma brucei monoglyceride lipase, putative 0.069 0.5123 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.0256 0.034
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0146 0.0036
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0059 0.035 0.0464
Toxoplasma gondii peptidase S15, putative 0.0041 0.021 0.2263
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0256 0.0309
Brugia malayi hypothetical protein 0.0047 0.0256 0.0303
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0146 0.0036
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.0256 0.0256
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0256 0.0256
Schistosoma mansoni smad1 5 8 and 0.0018 0.004 0.0022
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.0256 0.034
Plasmodium falciparum exported lipase 1 0.0041 0.021 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0064 0.0084
Leishmania major hypothetical protein, conserved 0.0122 0.0823 0.1558
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.0256 0.034
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0122 0.0823 0.5
Plasmodium vivax unspecified product 0.0041 0.021 0.0347
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0118 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.1698 0.223
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0256 0.0303
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0194 0.1375 0.2641
Entamoeba histolytica ;Alias 0.0041 0.021 0.0356
Mycobacterium ulcerans amidase 0.0122 0.0823 0.1558
Brugia malayi Bromodomain containing protein 0.0017 0.0034 0.0006
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0122 0.0823 0.1558
Schistosoma mansoni amidase 0.1008 0.7532 1
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0256 0.0309
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0527 0.0663
Trypanosoma cruzi amidase, putative 0.0122 0.0823 0.1296
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0256 0.0309
Onchocerca volvulus 0.0021 0.0064 0.0947
Brugia malayi G protein-coupled receptor 0.0047 0.0256 0.0303
Plasmodium vivax lysophospholipase, putative 0.0041 0.021 0.0347
Loa Loa (eye worm) hypothetical protein 0.0059 0.035 0.0464
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0256 0.034
Loa Loa (eye worm) beta-lactamase 0.0059 0.035 0.0464
Brugia malayi AKH receptor 0.0047 0.0256 0.0303
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0256 0.0256
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0261 0.1875 0.2461
Echinococcus granulosus neuropeptide s receptor 0.0047 0.0256 0.034
Loa Loa (eye worm) hypothetical protein 0.0178 0.1251 0.1661
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.069 0.5123 1
Brugia malayi beta-lactamase family protein 0.0059 0.035 0.0427
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0069 0.0428 0.0783
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0256 0.0309
Brugia malayi jmjC domain containing protein 0.0057 0.0332 0.0404
Brugia malayi putative neuropeptide receptor 0.0047 0.0256 0.0303
Brugia malayi sulfakinin receptor protein 0.0047 0.0256 0.0303
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0041 0.021 0.2263
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.0256 0.034
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0256 0.0309
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0041 0.021 0.0056
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0256 0.034
Schistosoma mansoni patched 1 0.003 0.0128 0.0139
Brugia malayi MH2 domain containing protein 0.0018 0.004 0.0015
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.069 0.5123 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Toxoplasma gondii ABC1 family protein 0.0059 0.035 0.405
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.0256 0.034
Mycobacterium tuberculosis Conserved protein 0.0059 0.035 0.0629
Schistosoma mansoni neuropeptide receptor 0.0047 0.0256 0.0309
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0064 0.0053
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0064 0.0053
Onchocerca volvulus 0.0047 0.0256 0.6223
Loa Loa (eye worm) hypothetical protein 0.0041 0.021 0.0279
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0041 0.021 0.2263
Brugia malayi Protein C20orf22 0.0041 0.021 0.0242
Plasmodium vivax hypothetical protein, conserved 0.0041 0.021 0.0347
Plasmodium vivax aspartyl proteinase, putative 0.0028 0.0118 0.0165
Brugia malayi nuclear receptor NHR-88 0.0021 0.0064 0.0046
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0122 0.0823 0.1558
Trichomonas vaginalis penicillin-binding protein, putative 0.0059 0.035 0.0444
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0065 0.0394 0.0523
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0256 0.034
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0256 0.0256
Brugia malayi aspartic protease BmAsp-2, identical 0.0028 0.0118 0.0118
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0041 0.021 0.2263
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.035 0.0338
Echinococcus granulosus serotonin receptor 0.0047 0.0256 0.034
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0122 0.0823 0.1558
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0017 0.0028 0.0028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0256 0.034
Schistosoma mansoni opsin-like receptor 0.0047 0.0256 0.0309
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0256 0.0309
Plasmodium falciparum lysophospholipase, putative 0.069 0.5123 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0256 0.034
Echinococcus granulosus jumonji domain containing protein 0.0024 0.0085 0.0113
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0118 0.0125
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Schistosoma mansoni amine GPCR 0.0047 0.0256 0.0309
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.1698 0.1698
Leishmania major mitochondrial DNA polymerase beta 0.0411 0.3013 0.5858
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0256 0.034
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0256 0.0303
Mycobacterium tuberculosis Conserved hypothetical protein 0.0216 0.1541 0.2968
Echinococcus granulosus dnaJ subfamily B 0.0271 0.1956 0.2597
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0527 0.0699
Loa Loa (eye worm) hypothetical protein 0.0059 0.035 0.0464
Echinococcus multilocularis cpg binding protein 0.0044 0.0236 0.0236
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.004 0.0053
Plasmodium vivax plasmepsin IV, putative 0.012 0.0813 0.1532
Plasmodium falciparum lysophospholipase, putative 0.0041 0.021 0.0347
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.0256 0.034
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0256 0.0303
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0411 0.3013 0.5729
Toxoplasma gondii phospholipase 0.0041 0.021 0.2263
Mycobacterium ulcerans hydrolase 0.0041 0.021 0.0356
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.021 0.0356
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0041 0.021 0.0056
Mycobacterium ulcerans hypothetical protein 0.0041 0.021 0.0356
Echinococcus multilocularis orexin receptor type 2 0.0047 0.0256 0.0256
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0256 0.0256
Echinococcus granulosus tumor protein p63 0.0238 0.1706 0.2265
Trichomonas vaginalis D-aminoacylase, putative 0.0059 0.035 0.0444
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0256 0.0256
Toxoplasma gondii aspartyl protease ASP3 0.0028 0.0118 0.1079
Loa Loa (eye worm) hypothetical protein 0.0041 0.021 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.069 0.5123 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0064 0.0084
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0237 0.1698 0.2225
Leishmania major hypothetical protein, conserved 0.0059 0.035 0.0629
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0256 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0064 0.0046
Plasmodium falciparum plasmepsin VII 0.0028 0.0118 0.0165
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.004 0.0022
Plasmodium falciparum plasmepsin IX 0.0028 0.0118 0.0165
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0169
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0653 0.0867
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0256 0.0309
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0118 0.0125
Plasmodium falciparum plasmepsin VIII, putative 0.0028 0.0118 0.0165
Echinococcus multilocularis Smad4 0.0018 0.004 0.004
Mycobacterium ulcerans amidase 0.0122 0.0823 0.1558
Schistosoma mansoni hypothetical protein 0.0047 0.0256 0.0309
Schistosoma mansoni neuropeptide receptor 0.0047 0.0256 0.0309
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Loa Loa (eye worm) hypothetical protein 0.0561 0.4148 0.5507
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0041 0.021 0.0248
Entamoeba histolytica hypothetical protein 0.0073 0.0458 0.0843
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.012 0.0813 0.0813
Brugia malayi hypothetical protein 0.0047 0.0256 0.0303
Echinococcus multilocularis GPCR, family 2 0.0082 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0064 0.0084
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0041 0.021 0.0165
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0256 0.0309
Loa Loa (eye worm) hypothetical protein 0.0082 0.0527 0.0699
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0527 0.0699
Onchocerca volvulus 0.0047 0.0256 0.6223
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.004 0.0053
Echinococcus granulosus fatty acid amide hydrolase 1 0.0122 0.0823 0.1092
Echinococcus multilocularis protein patched 0.003 0.0128 0.0128
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0256 0.034
Echinococcus granulosus g-protein coupled receptor 0.0047 0.0256 0.034
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0332 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0064 0.0046
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.0256 0.034
Plasmodium falciparum ataxin-2 like protein, putative 0.0037 0.0182 0.0292
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0256 0.0309
Loa Loa (eye worm) hypothetical protein 0.0041 0.021 0.0279
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0084
Brugia malayi Eukaryotic aspartyl protease family protein 0.0028 0.0118 0.0118
Mycobacterium tuberculosis Probable hydrolase 0.0059 0.035 0.0629
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0064 0.0046
Trypanosoma cruzi polo-like protein kinase, putative 0.0065 0.0394 0.0428
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0122 0.0823 0.1064
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0041 0.021 0.0056
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0122 0.0823 0.0823
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0122 0.0823 0.1558
Brugia malayi hypothetical protein 0.0047 0.0256 0.0303
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0064 0.0064
Plasmodium falciparum plasmepsin IV 0.012 0.0813 0.1532
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0122 0.0823 0.1558
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0041 0.021 0.0165
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0064 0.0046
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Schistosoma mansoni cpg binding protein 0.0042 0.0218 0.0259
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0256 0.6223
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0256 0.034
Brugia malayi G-protein coupled receptor 0.0047 0.0256 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0064 0.0046
Toxoplasma gondii protein c14orf29, putative 0.0041 0.021 0.2263
Mycobacterium leprae Probable lipase LipE 0.0059 0.035 0.0629
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0256 0.034
Mycobacterium tuberculosis Conserved protein 0.0059 0.035 0.0629
Brugia malayi nuclear hormone receptor 0.0021 0.0064 0.0046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0527 0.0527
Trichomonas vaginalis penicillin-binding protein, putative 0.0059 0.035 0.0444
Loa Loa (eye worm) transcription factor SMAD2 0.0267 0.1922 0.2552
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0122 0.0823 0.1092
Schistosoma mansoni fatty-acid amide hydrolase 0.1008 0.7532 1
Echinococcus granulosus Niemann Pick C1 protein 0.0069 0.0428 0.0568
Brugia malayi amidase 0.1008 0.7532 1
Brugia malayi hypothetical protein 0.0024 0.0083 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0064 0.0084
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0256 0.0303
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0088 0.0571 0.0729
Schistosoma mansoni cpg binding protein 0.0044 0.0236 0.0282
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0041 0.021 0.0056
Schistosoma mansoni biogenic amine (5HT) receptor 0.0561 0.4148 0.5493
Echinococcus multilocularis protein dispatched 1 0.0034 0.016 0.016
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0041 0.021 0.0165
Plasmodium vivax aspartyl protease, putative 0.0028 0.0118 0.0165
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.004 0.004
Plasmodium falciparum prodrug activation and resistance esterase 0.0041 0.021 0.0347
Onchocerca volvulus 0.0047 0.0256 0.6223
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.1698 0.2255
Brugia malayi hypothetical protein 0.0047 0.0256 0.0303
Brugia malayi Dopamine receptor 0.0047 0.0256 0.0303
Brugia malayi MGC83647 protein 0.0041 0.021 0.0242
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.0256 0.0256
Toxoplasma gondii histone lysine methyltransferase SET1 0.0079 0.05 0.5978
Echinococcus granulosus Smad4 0.0018 0.004 0.0053
Schistosoma mansoni hypothetical protein 0.0082 0.0527 0.067
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0394 0.0532
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0064 0.0046
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0041 0.021 0.0056
Loa Loa (eye worm) hypothetical protein 0.0059 0.035 0.0464
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0064 0.0046
Onchocerca volvulus Alhambra homolog 0.0017 0.0034 0.013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0084
Plasmodium falciparum alpha/beta hydrolase, putative 0.0041 0.021 0.0347
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Loa Loa (eye worm) hypothetical protein 0.0069 0.0428 0.0568
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0256 0.0309
Plasmodium vivax plasmepsin V, putative 0.0028 0.0118 0.0165
Schistosoma mansoni amine GPCR 0.0047 0.0256 0.0309
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Schistosoma mansoni hypothetical protein 0.0047 0.0256 0.0309
Mycobacterium ulcerans amidase 0.0122 0.0823 0.1558
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0064 0.0046
Loa Loa (eye worm) hypothetical protein 0.0561 0.4148 0.5507
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.007 0.0435 0.0512
Brugia malayi G-protein coupled receptor 0.0047 0.0256 0.0303
Onchocerca volvulus 0.0047 0.0256 0.6223
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0058 0.034 0.0318
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0256 0.034
Schistosoma mansoni biogenic amine (5HT) receptor 0.094 0.7015 0.9311
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0256 0.034
Loa Loa (eye worm) Smad1 0.0018 0.004 0.0053
Toxoplasma gondii hypothetical protein 0.0041 0.021 0.2263
Echinococcus multilocularis expressed conserved protein 0.0065 0.0396 0.0396
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0064 0.0053
Brugia malayi MH2 domain containing protein 0.0018 0.004 0.0015
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.012 0.0813 0.1372
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0458 0.0609
Entamoeba histolytica hypothetical protein 0.0073 0.0458 0.0843
Loa Loa (eye worm) aspartic protease BmAsp-2 0.012 0.0813 0.108
Onchocerca volvulus 0.0047 0.0256 0.6223
Echinococcus granulosus survival motor neuron protein 1 0.0162 0.1132 0.1503
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0041 0.021 0.0248
Schistosoma mansoni myosin xvIII 0.0047 0.0256 0.0309
Onchocerca volvulus 0.0047 0.0256 0.6223
Schistosoma mansoni jumonji/arid domain-containing protein 0.0023 0.0079 0.0074
Echinococcus granulosus orexin receptor type 2 0.0047 0.0256 0.034
Schistosoma mansoni peptidase 0.0041 0.021 0.0248
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0256 0.034
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.034
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0256 0.034
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0118 0.0125
Schistosoma mansoni hypothetical protein 0.0029 0.012 0.0128
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.069 0.5123 1
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0256 0.034
Schistosoma mansoni Smad4 0.0018 0.004 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.1698 0.223
Loa Loa (eye worm) hypothetical protein 0.0162 0.1132 0.1503
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0122 0.0823 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0064 0.0046

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Escherichia coli ATCC 25922 by agar diffusion assay ChEMBL. 21111625

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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