Detailed information for compound 1462708

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 290.276 | Formula: C16H10N4O2
  • H donors: 0 H acceptors: 5 LogP: 1.86 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1c2n(nnc2C(=O)c2c1cccc2)Cc1ccccn1
  • InChi: 1S/C16H10N4O2/c21-15-11-6-1-2-7-12(11)16(22)14-13(15)18-19-20(14)9-10-5-3-4-8-17-10/h1-8H,9H2
  • InChiKey: CTLZYPQPXLGOIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0301
Echinococcus granulosus survival motor neuron protein 1 0.0172 0.2161 0.2154
Echinococcus multilocularis sterol regulatory element binding protein 0.0032 0.0258 0.025
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0069 0.0761 0.1781
Trypanosoma cruzi amidase, putative 0.0039 0.0362 0.0619
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0079 0.0168
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0223 0.2846 1
Plasmodium vivax PST-A protein 0.0223 0.2846 1
Brugia malayi jmjC domain containing protein 0.006 0.0645 0.1506
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0039 0.0362 0.0354
Onchocerca volvulus 0.0027 0.0192 0.1765
Giardia lamblia PHD finger protein 15 0.0018 0.0079 0.0942
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0039 0.0362 0.1247
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0136 0.0127
Leishmania major hypothetical protein, conserved 0.0039 0.0361 0.0617
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0136 0.0127
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0087 0.1013 0.1006
Loa Loa (eye worm) hypothetical protein 0.0172 0.2161 0.509
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.0659 0.1139
Plasmodium vivax acyl-CoA synthetase, putative 0.0013 0.001 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.007 0.024
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0003
Echinococcus granulosus sterol regulatory element binding protein 0.0032 0.0258 0.025
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0136 0.0127
Brugia malayi Eukaryotic aspartyl protease family protein 0.003 0.0239 0.0545
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0136 0.0301
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0136 0.0127
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0606 0.8029 0.8027
Schistosoma mansoni hypothetical protein 0.0751 1 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0039 0.0362 0.0354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0136 0.0301
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.2636 0.263
Schistosoma mansoni hypothetical protein 0.0087 0.1013 0.1006
Echinococcus granulosus fatty acid amide hydrolase 1 0.0039 0.0362 0.0354
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.007 0.0108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0136 0.0127
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0223 0.2846 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0239 0.0231
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0087 0.1013 0.1006
Plasmodium falciparum plasmepsin III 0.003 0.0239 0.0812
Plasmodium falciparum lysophospholipase, putative 0.0223 0.2846 1
Plasmodium falciparum plasmepsin IX 0.003 0.0239 0.0812
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.0435
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.001 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0027 0.0192 0.0184
Echinococcus multilocularis expressed conserved protein 0.0069 0.0766 0.0758
Mycobacterium ulcerans amidase 0.0039 0.0362 0.1209
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0015 0.0007
Mycobacterium ulcerans amidase 0.0039 0.0362 0.1209
Schistosoma mansoni kinase 0.0035 0.0304 0.0296
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0039 0.0362 0.1234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0136 0.0301
Brugia malayi hypothetical protein 0.0039 0.0361 0.0834
Schistosoma mansoni fatty-acid amide hydrolase 0.0326 0.4237 0.4232
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0027 0.0192 0.0435
Brugia malayi beta-lactamase family protein 0.0027 0.0192 0.0435
Entamoeba histolytica hypothetical protein 0.0078 0.0884 0.3085
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0192 0.0648
Onchocerca volvulus 0.0044 0.0428 0.5176
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0136 0.0127
Echinococcus multilocularis Niemann Pick C1 protein 0.0074 0.0826 0.0818
Onchocerca volvulus Serine\/threonine kinase homolog 0.0069 0.0761 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0645 0.0637
Toxoplasma gondii hypothetical protein 0.007 0.0781 0.4991
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0258 0.0879
Schistosoma mansoni cpg binding protein 0.0044 0.0428 0.042
Onchocerca volvulus 0.0027 0.0192 0.1765
Schistosoma mansoni memapsin-2 (A01 family) 0.003 0.0239 0.0231
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0027 0.0192 0.0655
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0239 0.0231
Onchocerca volvulus Alhambra homolog 0.0018 0.0079 0.013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0301
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0147
Brugia malayi beta-lactamase 0.0027 0.0192 0.0435
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0128 0.1557 0.5456
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0192 0.0322
Echinococcus multilocularis geminin 0.0751 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0171 0.2141 0.7296
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0239 0.0231
Plasmodium falciparum lysophospholipase, putative 0.0223 0.2846 1
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0039 0.0362 0.5
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0015 0.0017
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0018 0.0069 0.006
Toxoplasma gondii ABC1 family protein 0.0027 0.0192 0.1188
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0013 0.001 0.0038
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.0435
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0018 0.007 0.0212
Mycobacterium ulcerans lysophospholipase 0.0223 0.2846 0.9698
Schistosoma mansoni hypothetical protein 0.0035 0.0306 0.0298
Schistosoma mansoni hypothetical protein 0.003 0.0242 0.0234
Echinococcus multilocularis cpg binding protein 0.0047 0.0462 0.0454
Loa Loa (eye worm) latrophilin receptor protein 2 0.0087 0.1013 0.2376
Brugia malayi steroid hormone receptor 0.0023 0.0136 0.0301
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.007 0.0108
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0128 0.1557 1
Schistosoma mansoni hypothetical protein 0.0018 0.0079 0.0071
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0136 0.0127
Mycobacterium tuberculosis Conserved hypothetical protein 0.0013 0.0008 0.0029
Brugia malayi Pepsin A precursor 0.003 0.0239 0.0545
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.001 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0192 0.0648
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0136 0.0127
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0884 0.0876
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0136 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0207 0.2636 0.263
Plasmodium falciparum phd finger protein, putative 0.0018 0.0079 0.025
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0136 0.0127
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0239 0.0231
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0094 0.0203
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0645 0.0637
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0291 0.0997
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0206 0.262 0.4569
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.0435
Mycobacterium ulcerans hypothetical protein 0.0229 0.2935 1
Brugia malayi nuclear receptor NHR-88 0.0023 0.0136 0.0301
Plasmodium falciparum ataxin-2 like protein, putative 0.0039 0.0361 0.1243
Brugia malayi Bromodomain containing protein 0.0018 0.0079 0.0168
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0136 0.0127
Echinococcus granulosus dnaJ subfamily B 0.0287 0.3721 0.3715
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0761 0.2654
Echinococcus granulosus Niemann Pick C1 protein 0.0074 0.0826 0.0818
Brugia malayi latrophilin 2 splice variant baaae 0.0189 0.2385 0.5621
Mycobacterium tuberculosis Conserved protein 0.0027 0.0192 0.0655
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0069 0.0761 0.0754
Trypanosoma cruzi monoglyceride lipase, putative 0.0223 0.2846 0.4965
Loa Loa (eye worm) CXXC zinc finger family protein 0.0044 0.0428 0.0992
Brugia malayi AMP-binding enzyme family protein 0.0018 0.007 0.0147
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0039 0.0362 0.1209
Loa Loa (eye worm) beta-lactamase 0.0027 0.0192 0.0435
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0136 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0761 0.2654
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0136 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0136 0.0301
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0018 0.007 0.024
Onchocerca volvulus 0.0037 0.0331 0.3767
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0136 0.0301
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0223 0.2846 1
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.003 0.0239 0.1488
Brugia malayi hypothetical protein 0.003 0.0239 0.0545
Brugia malayi putative amidase 0.0039 0.0362 0.0837
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0015 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.1557 0.155
Entamoeba histolytica acyl-coA synthetase, putative 0.0018 0.007 0.0218
Schistosoma mansoni jumonji domain containing protein 0.0048 0.0478 0.047
Trypanosoma brucei PAB1-binding protein , putative 0.0039 0.0361 0.0617
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0192 0.0322
Mycobacterium ulcerans esterase/lipase LipP 0.0027 0.0192 0.0628
Plasmodium vivax aspartyl protease, putative 0.003 0.0239 0.0812
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0136 0.0127
Echinococcus multilocularis jumonji domain containing protein 0.0026 0.0177 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0761 0.2654
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0061 0.0659 0.1139
Schistosoma mansoni coup transcription factor 0.0023 0.0136 0.0127
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0003
Trypanosoma cruzi amidase, putative 0.0039 0.0362 0.0619
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0035 0.0306 0.0704
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0087 0.1013 0.1006
Brugia malayi Amidase family protein 0.0039 0.0362 0.0837
Mycobacterium tuberculosis Probable esterase LipL 0.0027 0.0192 0.0655
Toxoplasma gondii aspartyl protease ASP3 0.003 0.0239 0.1488
Brugia malayi aspartic protease BmAsp-1, identical 0.003 0.0239 0.0545
Schistosoma mansoni hypothetical protein 0.0087 0.1013 0.1006
Trypanosoma cruzi polo-like protein kinase, putative 0.0069 0.0761 0.1318
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0136 0.0301
Entamoeba histolytica serine/threonine protein kinase, putative 0.0069 0.0761 0.2654
Loa Loa (eye worm) hypothetical protein 0.0018 0.0079 0.0168
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.007 0.0212
Plasmodium vivax aspartyl protease, putative 0.003 0.0239 0.0812
Echinococcus granulosus PHD finger protein rhinoceros 0.0018 0.0079 0.0071
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0192 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.0435
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0039 0.0362 0.1234
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0079 0.025
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0069 0.0761 0.1318
Schistosoma mansoni hypothetical protein 0.0087 0.1013 0.1006
Loa Loa (eye worm) amidase 0.0039 0.0362 0.0837
Plasmodium falciparum lysophospholipase, putative 0.0223 0.2846 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0074 0.0826 0.1933
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0147
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0223 0.2846 1
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0136 0.0947
Echinococcus granulosus cpg binding protein 0.0047 0.0462 0.0454
Plasmodium falciparum plasmepsin II 0.0128 0.1557 0.5456
Onchocerca volvulus 0.003 0.0239 0.2436
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0207 0.2636 0.263
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0027 0.0192 0.0655
Echinococcus granulosus expressed conserved protein 0.0069 0.0766 0.0758
Mycobacterium ulcerans lipase LipD 0.0027 0.0192 0.0628
Plasmodium falciparum plasmepsin V 0.003 0.0239 0.0812
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0166 0.0372
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0136 0.0301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.2636 0.263
Mycobacterium tuberculosis Probable hydrolase 0.0027 0.0192 0.0655
Trypanosoma brucei monoglyceride lipase, putative 0.0223 0.2846 0.4965
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0136 0.0301
Brugia malayi CHE-14 protein 0.0032 0.0258 0.059
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0239 0.0231
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0018 0.0069 0.006
Plasmodium vivax aspartyl proteinase, putative 0.0128 0.1557 0.5456
Plasmodium falciparum esterase, putative 0.0223 0.2846 1
Mycobacterium tuberculosis Conserved protein 0.0027 0.0192 0.0655
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0326 0.4237 0.4232
Mycobacterium ulcerans hypothetical protein 0.0223 0.2846 0.9698
Schistosoma mansoni hypothetical protein 0.003 0.0242 0.0234
Plasmodium falciparum plasmepsin VIII, putative 0.003 0.0239 0.0812
Brugia malayi hypothetical protein 0.0025 0.0173 0.039
Echinococcus multilocularis beta LACTamase domain containing family member 0.0027 0.0192 0.0184
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0128 0.1557 0.155
Mycobacterium ulcerans amidase 0.0039 0.0362 0.1209
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0039 0.0362 0.1051
Trypanosoma brucei polo-like protein kinase 0.0069 0.0761 0.1318
Loa Loa (eye worm) hypothetical protein 0.0087 0.1013 0.2376
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.007 0.0212
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.1253 0.1246
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0761 0.2654
Brugia malayi jmjC domain containing protein 0.0025 0.0166 0.0372
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0094 0.1098 0.109
Echinococcus multilocularis PHD finger protein rhinoceros 0.0018 0.0079 0.0071
Schistosoma mansoni hypothetical protein 0.0751 1 1
Brugia malayi PHD-finger family protein 0.0018 0.0079 0.0168
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0136 0.0301
Plasmodium falciparum plasmepsin IV 0.0128 0.1557 0.5456
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0136 0.0127
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.1253 0.1246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0136 0.0301
Loa Loa (eye worm) MH2 domain-containing protein 0.0164 0.2048 0.4823
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0128 0.1557 0.3661
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0192 0.0184
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0301
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0239 0.0231
Entamoeba histolytica hypothetical protein 0.0078 0.0884 0.3085
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0192 0.0439
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0061 0.0659 0.1139
Trypanosoma cruzi PAB1-binding protein , putative 0.0039 0.0361 0.0617
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0128 0.1557 0.155
Brugia malayi hypothetical protein 0.0078 0.0884 0.207
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0039 0.0362 0.0354
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0326 0.4237 0.4232
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0018 0.007 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0761 0.0754
Schistosoma mansoni jumonji/arid domain-containing protein 0.0025 0.0166 0.0157
Brugia malayi Latrophilin receptor protein 2 0.0087 0.1013 0.2376
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0039 0.0362 0.0354
Plasmodium vivax plasmepsin V, putative 0.003 0.0239 0.0812
Brugia malayi aspartic protease BmAsp-2, identical 0.003 0.0239 0.0545
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0435 0.5723 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.007 0.0108
Loa Loa (eye worm) hypothetical protein 0.0189 0.2385 0.5621
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.007 0.0218
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0301
Brugia malayi serine/threonine-protein kinase plk-2 0.0069 0.0761 0.1781
Toxoplasma gondii PHD-finger domain-containing protein 0.0018 0.0079 0.0458
Leishmania major hypothetical protein, conserved 0.0027 0.0192 0.0322
Onchocerca volvulus 0.0027 0.0192 0.1765
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0136 0.0301
Echinococcus granulosus peregrin 0.0018 0.0079 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0136 0.0301
Schistosoma mansoni jumonji/arid domain-containing protein 0.0025 0.0166 0.0157
Schistosoma mansoni hypothetical protein 0.003 0.0242 0.0234
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0301
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0223 0.2846 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0013 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0301
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0018 0.0079 0.0071
Mycobacterium tuberculosis Probable lipase LipE 0.0027 0.0192 0.0655
Mycobacterium ulcerans beta-lactamase 0.0027 0.0192 0.0628
Plasmodium vivax aspartyl protease, putative 0.003 0.0239 0.0812
Schistosoma mansoni survival motor neuron protein 0.0035 0.0306 0.0298
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0301
Leishmania major mitochondrial DNA polymerase beta 0.0435 0.5723 1
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.2846 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0136 0.0127
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0039 0.0362 0.1234
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0061 0.0659 0.1139
Plasmodium falciparum ataxin-2 like protein, putative 0.0039 0.0361 0.1243
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0018 0.007 0.0212
Schistosoma mansoni cathepsin D (A01 family) 0.0128 0.1557 0.155
Echinococcus granulosus fatty acid amide hydrolase 1 0.0326 0.4237 0.4232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.2636 0.263
Leishmania major monoglyceride lipase, putative 0.0223 0.2846 0.4965
Toxoplasma gondii aspartyl protease ASP1 0.0128 0.1557 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0192 0.0648
Loa Loa (eye worm) hypothetical protein 0.0276 0.3568 0.8417
Onchocerca volvulus 0.003 0.0239 0.2436
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0136 0.0301
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0206 0.262 0.4569
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0207 0.2636 0.6213
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0136 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0136 0.0301
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0136 0.0127
Schistosoma mansoni cpg binding protein 0.0047 0.0462 0.0454
Loa Loa (eye worm) hypothetical protein 0.0032 0.0257 0.0588
Loa Loa (eye worm) hypothetical protein 0.0128 0.1557 0.3661
Trypanosoma cruzi PAB1-binding protein , putative 0.0039 0.0361 0.0617
Mycobacterium ulcerans hypothetical protein 0.0027 0.0192 0.0628
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0087 0.1013 0.1006
Echinococcus granulosus tumor protein p63 0.0252 0.3247 0.3241
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0027 0.0192 0.0435
Loa Loa (eye worm) aspartic protease BmAsp-1 0.003 0.0239 0.0545
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0027 0.0192 0.0655
Echinococcus granulosus fatty acid amide hydrolase 1 0.0326 0.4237 0.4232
Trypanosoma brucei monoglyceride lipase, putative 0.0223 0.2846 0.4965
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0276 0.3568 0.8417
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0136 0.0127
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0039 0.0362 0.1234
Schistosoma mansoni hypothetical protein 0.0087 0.1013 0.1006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.006 0.0052
Mycobacterium ulcerans amidase 0.0039 0.0362 0.1209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0207 0.2636 0.263
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0075 0.0841 0.0834
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0039 0.0362 0.1247
Loa Loa (eye worm) transcription factor SMAD2 0.0164 0.2048 0.4823
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0136 0.0127
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0206 0.262 0.4569
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0039 0.0362 1
Schistosoma mansoni cpg binding protein 0.0047 0.0462 0.0454
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0223 0.2846 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0136 0.0301
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0435 0.5723 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0018 0.0079 0.0458
Plasmodium falciparum plasmepsin X 0.003 0.0239 0.0812
Loa Loa (eye worm) aspartyl protease 6 0.003 0.0239 0.0545
Loa Loa (eye worm) hypothetical protein 0.0039 0.0361 0.0834
Giardia lamblia Kinase, PLK 0.0069 0.0761 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0354 0.0817
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0223 0.2846 1
Mycobacterium tuberculosis Possible lysophospholipase 0.0223 0.2846 0.9699
Toxoplasma gondii LsmAD domain-containing protein 0.0039 0.0361 0.2279
Brugia malayi beta-lactamase family protein 0.0027 0.0192 0.0435
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0136 0.0127
Plasmodium falciparum plasmepsin I 0.0128 0.1557 0.5456
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0136 0.0127
Plasmodium vivax aspartyl proteinase, putative 0.003 0.0239 0.0812
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0136 0.0947
Brugia malayi hypothetical protein 0.003 0.0239 0.0545
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0239 0.0231
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.007 0.0218
Mycobacterium tuberculosis Conserved hypothetical protein 0.0229 0.2935 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.007 0.0212
Brugia malayi ecdysteroid receptor 0.0023 0.0136 0.0301
Entamoeba histolytica hypothetical protein 0.0078 0.0884 0.3085
Echinococcus multilocularis survival motor neuron protein 1 0.0172 0.2161 0.2154
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0032 0.0258 0.059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0136 0.0127
Echinococcus granulosus jumonji domain containing protein 0.0026 0.0177 0.0168
Echinococcus multilocularis protein patched 0.0032 0.0258 0.025
Brugia malayi nuclear hormone receptor 0.0023 0.0136 0.0301
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0039 0.0362 0.0619
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0039 0.0362 0.5
Brugia malayi CXXC zinc finger family protein 0.0044 0.0428 0.0992
Plasmodium vivax ataxin-2 like protein, putative 0.0039 0.0361 0.1243
Mycobacterium ulcerans amidase 0.0039 0.0362 0.1209
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0207 0.2636 0.263
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.2846 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0136 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.0239 0.0545
Onchocerca volvulus 0.0023 0.0136 0.0947
Echinococcus granulosus Protein patched homolog 1 0.0032 0.0258 0.025
Loa Loa (eye worm) hypothetical protein 0.003 0.0239 0.0545
Brugia malayi AMP-binding enzyme family protein 0.0018 0.007 0.0147
Echinococcus granulosus lysine specific demethylase 5A 0.0025 0.0166 0.0157
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0136 0.0127
Plasmodium falciparum plasmepsin VII 0.003 0.0239 0.0812
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0136 0.0301
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0039 0.0362 0.1051
Echinococcus multilocularis tumor protein p63 0.0252 0.3247 0.3241
Plasmodium vivax plasmepsin IV, putative 0.0128 0.1557 0.5456
Mycobacterium leprae Probable lipase LipE 0.0027 0.0192 0.0439
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0761 0.2654
Leishmania major hypothetical protein, conserved 0.0039 0.0362 0.0619
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0192 0.0648
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0276 0.3568 0.8417
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0223 0.2846 1
Brugia malayi hypothetical protein 0.0172 0.2161 0.509
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0136 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0136 0.0301
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0074 0.0826 0.2881
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0075 0.0841 0.1456
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0136 0.0301
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0435 0.5723 1
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0291 0.0997
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0136 0.0127
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0027 0.0192 0.0628
Brugia malayi amidase 0.0326 0.4237 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0207 0.2636 0.6213
Schistosoma mansoni amidase 0.0326 0.4237 0.4232
Schistosoma mansoni cathepsin D (A01 family) 0.0128 0.1557 0.155
Trypanosoma cruzi polo-like protein kinase, putative 0.0069 0.0761 0.1318
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.0435
Plasmodium falciparum plasmepsin VI 0.0128 0.1557 0.5456
Schistosoma mansoni hypothetical protein 0.003 0.0242 0.0234
Loa Loa (eye worm) amidase 0.0039 0.0362 0.0837
Entamoeba histolytica hypothetical protein 0.0078 0.0884 0.3085
Loa Loa (eye worm) hypothetical protein 0.0326 0.4237 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0136 0.0301
Brugia malayi Amidase family protein 0.0039 0.0362 0.0837
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0136 0.0127
Mycobacterium ulcerans peptide amidase, GatA 0.0039 0.0362 0.1209
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0136 0.0127
Onchocerca volvulus 0.0035 0.0306 0.3409
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0884 0.0876
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0147
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0761 0.2654
Toxoplasma gondii histone lysine methyltransferase SET1 0.0084 0.0962 0.6162
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.0435
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0003
Echinococcus multilocularis GPCR, family 2 0.0087 0.1013 0.1006
Loa Loa (eye worm) hypothetical protein 0.0074 0.0826 0.1933
Schistosoma mansoni patched 1 0.0032 0.0258 0.025
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0884 0.0876
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.006
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0136 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0136 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0136 0.0301
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.0762
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0039 0.0362 0.0354
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0192 0.0648
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0192 0.0648
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0087 0.1013 0.2376
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0069 0.0761 0.0754
Toxoplasma gondii aspartyl protease 0.003 0.0239 0.1488
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0136 0.0301
Echinococcus multilocularis protein dispatched 1 0.0036 0.0318 0.031
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0192 0.0322
Echinococcus multilocularis dnaJ subfamily B 0.0287 0.3721 0.3715
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0239 0.0231
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0761 0.2654
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0136 0.0127
Schistosoma mansoni cellular tumor antigen P53 0.0037 0.0331 0.0323
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0136 0.0127
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0301
Echinococcus multilocularis peregrin 0.0018 0.0079 0.0071
Schistosoma mansoni hypothetical protein 0.0189 0.2385 0.2379
Mycobacterium ulcerans hypothetical protein 0.0018 0.007 0.0212
Schistosoma mansoni hypothetical protein 0.0078 0.0884 0.0876
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0039 0.0362 0.1234
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.007 0.0212
Mycobacterium tuberculosis Conserved protein 0.0027 0.0192 0.0655
Schistosoma mansoni hypothetical protein 0.0287 0.3721 0.3715
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0344 0.0794
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0136 0.0301
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0223 0.2846 1
Mycobacterium tuberculosis Probable lipase LipD 0.0027 0.0192 0.0655
Trichomonas vaginalis esterase, putative 0.0027 0.0192 0.0648
Brugia malayi Calcitonin receptor-like protein seb-1 0.0276 0.3568 0.8417
Echinococcus multilocularis lysine specific demethylase 5A 0.0022 0.0132 0.0123
Echinococcus granulosus GPCR family 2 0.0087 0.1013 0.1006
Brugia malayi AMP-binding enzyme family protein 0.0018 0.007 0.0147
Brugia malayi MH2 domain containing protein 0.0164 0.2048 0.4823

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Escherichia coli ATCC 25922 by agar diffusion assay ChEMBL. 21111625

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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