Detailed information for compound 1462709

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.565 | Formula: C22H41NO4
  • H donors: 2 H acceptors: 4 LogP: 7.52 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCC(=O)C(=O)N[C@H](C(=O)O)CC(C)C
  • InChi: 1S/C22H41NO4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)21(25)23-19(22(26)27)17-18(2)3/h18-19H,4-17H2,1-3H3,(H,23,25)(H,26,27)/t19-/m0/s1
  • InChiKey: QTCPFCYZZJFWOO-IBGZPJMESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus phospholipase A2, group V Starlite/ChEMBL References
Homo sapiens phospholipase A2, group IIA (platelets, synovial fluid) Starlite/ChEMBL References
Mus musculus phospholipase A2, group IIA (platelets, synovial fluid) Starlite/ChEMBL References
Homo sapiens phospholipase A2, group V Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Phospholipase A2 family protein phospholipase A2, group V 137 aa 125 aa 28.8 %
Brugia malayi Phospholipase A2 family protein phospholipase A2, group V 138 aa 125 aa 30.4 %
Leishmania major hypothetical protein, conserved phospholipase A2, group IIA (platelets, synovial fluid) 146 aa 144 aa 22.9 %
Brugia malayi Phospholipase A2 family protein phospholipase A2, group IIA (platelets, synovial fluid) 144 aa 125 aa 28.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved hypothetical protein 0.0252 0.1685 0.2709
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0073
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0238 0.1582 0.2416
Onchocerca volvulus Phospholipase A2 homolog 0.1055 0.738 1
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Plasmodium vivax PST-A protein 0.0053 0.0269 0.0433
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Onchocerca volvulus Phospholipase A2 homolog 0.0556 0.3839 0.5179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0073 0.0073
Echinococcus granulosus voltage gated potassium channel subunit 0.0069 0.0385 0.0382
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0019 0.0035 0.0056
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0891 0.6219 1
Brugia malayi PHD-finger family protein 0.002 0.004 0.0005
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0172 0.1115 0.1794
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0073 0.0038
Onchocerca volvulus Alhambra homolog 0.002 0.004 0.0007
Loa Loa (eye worm) oxidoreductase 0.0238 0.1582 0.1582
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0073 0.0044
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0073 0.0051
Plasmodium falciparum lysophospholipase, putative 0.0053 0.0269 0.0433
Entamoeba histolytica hypothetical protein 0.0086 0.0504 0.0758
Onchocerca volvulus 0.0033 0.0132 0.0132
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0053 0.0269 0.0269
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0578 0.0575
Trichomonas vaginalis aldo-keto reductase, putative 0.0069 0.0385 0.0458
Schistosoma mansoni aldo-keto reductase 0.0238 0.1582 0.1558
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.014 0.0891 0.0888
Plasmodium falciparum plasmepsin VII 0.0033 0.0132 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0073 0.0038
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0132 0.0103
Mycobacterium ulcerans hypothetical protein 0.0053 0.0269 0.0433
Echinococcus multilocularis GPCR, family 2 0.0096 0.0578 0.0575
Loa Loa (eye worm) aspartyl protease 6 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0053 0.0269 0.0269
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0172 0.1115 1
Toxoplasma gondii aspartyl protease ASP1 0.014 0.0891 0.5518
Plasmodium falciparum lysophospholipase, putative 0.0891 0.6219 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0043 0.0202 0.0159
Plasmodium vivax aspartyl proteinase, putative 0.014 0.0891 0.1433
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0132 0.0103
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0033 0.0132 0.0595
Plasmodium vivax aspartyl protease, putative 0.0033 0.0132 0.0212
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0891 0.6219 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0076 0.0433 0.0644
Mycobacterium ulcerans lysophospholipase 0.0891 0.6219 1
Leishmania major hypothetical protein, conserved 0.0053 0.0269 0.0379
Trypanosoma brucei polo-like protein kinase 0.0076 0.0433 0.0536
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0035 0.0056
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0053 0.0269 0.0379
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0086 0.0504 0.05
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0228 0.1513 0.1483
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Plasmodium falciparum plasmepsin I 0.014 0.0891 0.1433
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0132 0.0103
Echinococcus multilocularis aldo keto reductase 0.0238 0.1582 0.158
Schistosoma mansoni hypothetical protein 0.0033 0.0134 0.0105
Brugia malayi beta-lactamase 0.0029 0.0105 0.007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.0105 0.0102
Loa Loa (eye worm) hypothetical protein 0.0053 0.0269 0.0269
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0238 0.1582 0.158
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0073 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0073 0.0073
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0053 0.0269 0.0266
Trypanosoma cruzi PAB1-binding protein , putative 0.0043 0.0202 0.0159
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0053 0.0269 0.0269
Schistosoma mansoni cathepsin D (A01 family) 0.014 0.0891 0.0864
Plasmodium vivax hypothetical protein, conserved 0.002 0.004 0.0064
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0053 0.0269 0.0241
Plasmodium vivax unspecified product 0.0053 0.0269 0.0433
Trypanosoma cruzi monoglyceride lipase, putative 0.0891 0.6219 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0891 0.0891
Schistosoma mansoni jumonji/arid domain-containing protein 0.0027 0.009 0.0061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0073
Echinococcus granulosus hypothetical protein 0.0238 0.1582 0.158
Mycobacterium tuberculosis Conserved protein 0.0069 0.0385 0.0619
Echinococcus multilocularis sterol regulatory element binding protein 0.0035 0.0143 0.014
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0226 0.1503 0.2287
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0269 0.0269
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0891 0.6219 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1424 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0132
Trichomonas vaginalis aldo-keto reductase, putative 0.0069 0.0385 0.0458
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0073 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0073 0.0069
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0891 0.6219 1
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0073 0.0044
Plasmodium falciparum lysophospholipase, putative 0.0891 0.6219 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0238 0.1582 0.2544
Loa Loa (eye worm) hypothetical protein 0.0053 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0132
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0053 0.0269 0.0269
Plasmodium vivax plasmepsin V, putative 0.0033 0.0132 0.0212
Plasmodium vivax aspartyl protease, putative 0.0033 0.0132 0.0212
Toxoplasma gondii aspartyl protease ASP3 0.0033 0.0132 0.0595
Loa Loa (eye worm) hypothetical protein 0.0556 0.3839 0.3839
Mycobacterium ulcerans hypothetical protein 0.0053 0.0269 0.0433
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.0105 0.0169
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0105 0.0076
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0172 0.1115 0.1113
Onchocerca volvulus 0.0238 0.1582 0.2107
Plasmodium falciparum lysophospholipase, putative 0.0891 0.6219 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0238 0.1582 0.2416
Brugia malayi ecdysteroid receptor 0.0025 0.0073 0.0038
Trypanosoma cruzi amidase, putative 0.0172 0.1115 0.1653
Plasmodium falciparum lysophospholipase, putative 0.0053 0.0269 0.0433
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0132 0.0103
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.0269 0.0433
Loa Loa (eye worm) hypothetical protein 0.0043 0.0202 0.0202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.1513 0.1488
Schistosoma mansoni jumonji/arid domain-containing protein 0.0027 0.009 0.0061
Toxoplasma gondii hypothetical protein 0.0053 0.0269 0.1487
Brugia malayi beta-lactamase family protein 0.0029 0.0105 0.007
Trypanosoma cruzi polo-like protein kinase, putative 0.0076 0.0433 0.0536
Brugia malayi Phospholipase A2 family protein 0.1055 0.738 0.7371
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0132 0.0103
Onchocerca volvulus 0.0039 0.0171 0.0185
Echinococcus granulosus PHD finger protein rhinoceros 0.002 0.004 0.0037
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0073 0.0044
Mycobacterium leprae Probable lipase LipE 0.0029 0.0105 0.0114
Echinococcus multilocularis aldo keto reductase 0.0238 0.1582 0.158
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0073 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0269 0.0269
Echinococcus granulosus abhydrolase domain containing 3 0.0053 0.0269 0.0266
Brugia malayi Protein C20orf22 0.0053 0.0269 0.0235
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0172 0.1115 0.1794
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0073 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0073 0.0069
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0069 0.0385 0.0619
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0073 0.0044
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0053 0.0269 0.0379
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.0105 0.0169
Echinococcus granulosus Niemann Pick C1 protein 0.0081 0.047 0.0467
Schistosoma mansoni memapsin-2 (A01 family) 0.0033 0.0132 0.0103
Onchocerca volvulus 0.0238 0.1582 0.2107
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0269 0.0433
Toxoplasma gondii phospholipase 0.0053 0.0269 0.1487
Echinococcus granulosus dnaJ subfamily B 0.0316 0.2138 0.2135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0073 0.0073
Trypanosoma brucei monoglyceride lipase, putative 0.0891 0.6219 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0053 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0105
Plasmodium falciparum plasmepsin X 0.0033 0.0132 0.0212
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Plasmodium falciparum plasmepsin VI 0.014 0.0891 0.1433
Echinococcus granulosus survival motor neuron protein 1 0.0189 0.1239 0.1236
Echinococcus multilocularis aldehyde reductase 0.0169 0.1094 0.1091
Trypanosoma cruzi aldo/keto reductase, putative 0.0238 0.1582 0.2416
Brugia malayi jmjC domain containing protein 0.0027 0.009 0.0055
Mycobacterium leprae Conserved hypothetical protein 0.0169 0.1094 0.1713
Schistosoma mansoni cathepsin D (A01 family) 0.014 0.0891 0.0864
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0433 0.0405
Echinococcus multilocularis protein dispatched 1 0.004 0.0178 0.0174
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0019 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.1424 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.0105 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0073 0.0069
Brugia malayi Pepsin A precursor 0.0033 0.0132 0.0097
Loa Loa (eye worm) hypothetical protein 0.1055 0.738 0.738
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0172 0.1115 0.1113
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Plasmodium falciparum plasmepsin III 0.0033 0.0132 0.0212
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0073
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0891 0.6219 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0053 0.0269 0.0269
Toxoplasma gondii hypothetical protein 0.0053 0.0269 0.1487
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0053 0.0269 0.0269
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0035 0.0056
Echinococcus multilocularis tumor protein p63 0.0277 0.1865 0.1862
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0132 0.0103
Entamoeba histolytica aldose reductase, putative 0.0238 0.1582 0.2502
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0269 0.0269
Echinococcus multilocularis voltage gated potassium channel subunit 0.0069 0.0385 0.0382
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.0105 0.0169
Trypanosoma brucei monoglyceride lipase, putative 0.0891 0.6219 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0238 0.1582 0.158
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0188 0.1228 0.1974
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.1513 0.151
Plasmodium falciparum alpha/beta hydrolase, putative 0.0053 0.0269 0.0433
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0053 0.0269 0.0269
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0172 0.1115 0.1747
Mycobacterium leprae conserved hypothetical protein 0.0029 0.0105 0.0114
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0073 0.0069
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.0716 0.0713
Brugia malayi Amidase family protein 0.0172 0.1115 0.1084
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0073 0.0073
Plasmodium falciparum prodrug activation and resistance esterase 0.0053 0.0269 0.0433
Trichomonas vaginalis aldo/keto reductase, putative 0.0238 0.1582 0.2416
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0073 0.0069
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0172 0.1115 0.1653
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0086 0.0504 0.05
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0172 0.1115 0.1794
Toxoplasma gondii protein c14orf29, putative 0.0053 0.0269 0.1487
Onchocerca volvulus 0.0029 0.0105 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0269 0.0269
Plasmodium vivax lysophospholipase, putative 0.0053 0.0269 0.0433
Mycobacterium ulcerans amidase 0.0172 0.1115 0.1794
Loa Loa (eye worm) transcription factor SMAD2 0.018 0.1174 0.1174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0073 0.0038
Entamoeba histolytica ;Alias 0.0053 0.0269 0.0379
Echinococcus granulosus aldo keto reductase 0.0238 0.1582 0.158
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0269 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0073 0.0038
Plasmodium falciparum plasmepsin II 0.014 0.0891 0.1433
Plasmodium vivax PST-A protein 0.0053 0.0269 0.0433
Loa Loa (eye worm) hypothetical protein 0.0207 0.1369 0.1369
Echinococcus multilocularis Niemann Pick C1 protein 0.0081 0.047 0.0467
Plasmodium vivax PST-A protein 0.0053 0.0269 0.0433
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0019 0.0035 0.0056
Entamoeba histolytica aldose reductase, putative 0.0238 0.1582 0.2502
Plasmodium falciparum exported lipase 1 0.0053 0.0269 0.0433
Loa Loa (eye worm) oxidoreductase 0.0238 0.1582 0.1582
Trypanosoma brucei aldo-keto reductase, putative 0.0238 0.1582 0.2416
Leishmania major prostaglandin f synthase, putative 0.0238 0.1582 0.2502
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0053 0.0269 0.0433
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0053 0.0269 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0073 0.0038
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0073 0.0038
Mycobacterium ulcerans hypothetical protein 0.0891 0.6219 1
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0385 0.0458
Brugia malayi Bromodomain containing protein 0.002 0.004 0.0005
Mycobacterium ulcerans hypothetical protein 0.0069 0.0385 0.0619
Echinococcus multilocularis lysine specific demethylase 5A 0.0024 0.007 0.0067
Leishmania major hypothetical protein, conserved 0.0043 0.0202 0.0271
Chlamydia trachomatis hydrolase 0.0053 0.0269 0.2416
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0035 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.1513 0.151
Brugia malayi Calcitonin receptor-like protein seb-1 0.0303 0.205 0.2022
Echinococcus granulosus Phospholipase carboxylesterase 0.0053 0.0269 0.0266
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0067 0.0374 0.044
Mycobacterium ulcerans hypothetical protein 0.0252 0.1685 0.2709
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0076 0.0433 0.0536
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.0105 0.0169
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0053 0.0269 0.0269
Echinococcus granulosus geminin 0.0826 0.5755 0.5753
Trichomonas vaginalis CAMK family protein kinase 0.0076 0.0433 0.0536
Leishmania major hypothetical protein, conserved 0.0053 0.0269 0.0379
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0891 0.6219 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0478 0.3291 0.5212
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Entamoeba histolytica hypothetical protein 0.0086 0.0504 0.0758
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0303 0.205 0.2022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0073 0.0069
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0172 0.1115 0.1794
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0238 0.1582 0.158
Echinococcus granulosus aldehyde reductase 0.0169 0.1094 0.1091
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0162 0.0093
Echinococcus multilocularis aldo keto reductase 0.0238 0.1582 0.158
Brugia malayi hypothetical protein 0.0086 0.0504 0.047
Schistosoma mansoni pol-related 0.0238 0.1582 0.1558
Brugia malayi hypothetical protein 0.0189 0.1239 0.1208
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.0105 0.0169
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0891 0.6219 1
Brugia malayi nuclear receptor NHR-88 0.0025 0.0073 0.0038
Plasmodium vivax ataxin-2 like protein, putative 0.0043 0.0202 0.0326
Toxoplasma gondii hypothetical protein 0.0077 0.0444 0.2621
Loa Loa (eye worm) hypothetical protein 0.0041 0.0185 0.0185
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0073 0.0069
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0073 0.0069
Plasmodium vivax aspartyl protease, putative 0.0033 0.0132 0.0212
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0069 0.0385 0.2237
Plasmodium vivax lysophospholipase, putative 0.0053 0.0269 0.0433
Brugia malayi Eukaryotic aspartyl protease family protein 0.0033 0.0132 0.0097
Plasmodium falciparum plasmepsin IV 0.014 0.0891 0.1433
Schistosoma mansoni patched 1 0.0035 0.0143 0.0114
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0172 0.1115 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0269 0.0269
Schistosoma mansoni hypothetical protein 0.0826 0.5755 0.5742
Mycobacterium tuberculosis Conserved protein 0.0029 0.0105 0.0169
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.0105 0.0169
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0073 0.0044
Brugia malayi nuclear hormone receptor 0.0025 0.0073 0.0038
Plasmodium vivax aspartyl proteinase, putative 0.0033 0.0132 0.0212
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0073 0.0069
Schistosoma mansoni cpg binding protein 0.0048 0.0241 0.0212
Giardia lamblia Aldose reductase 0.0238 0.1582 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0105
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0049 0.0014
Plasmodium falciparum exported lipase 2 0.0053 0.0269 0.0433
Plasmodium falciparum alpha/beta hydrolase, putative 0.0053 0.0269 0.0433
Giardia lamblia Kinase, PLK 0.0076 0.0433 0.2548
Toxoplasma gondii aspartyl protease 0.0033 0.0132 0.0595
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0269 0.0269
Brugia malayi hypothetical protein 0.0043 0.0202 0.0168
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0666 0.462 0.4618
Mycobacterium ulcerans amidase 0.0172 0.1115 0.1794
Schistosoma mansoni hypothetical protein 0.0096 0.0578 0.055
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0238 0.1582 0.158
Schistosoma mansoni hypothetical protein 0.0019 0.0034 0.0005
Loa Loa (eye worm) amidase 0.0172 0.1115 0.1115
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0132 0.0103
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0172 0.1115 0.1747
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0067 0.0374 0.044
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0172 0.1115 0.109
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0143 0.0062
Plasmodium vivax lysophospholipase, putative 0.0053 0.0269 0.0433
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0105
Brugia malayi steroid hormone receptor 0.0025 0.0073 0.0038
Trypanosoma cruzi polo-like protein kinase, putative 0.0076 0.0433 0.0536
Echinococcus granulosus Protein patched homolog 1 0.0035 0.0143 0.014
Plasmodium falciparum ataxin-2 like protein, putative 0.0043 0.0202 0.0326
Leishmania major hypothetical protein, conserved 0.0172 0.1115 0.1747
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0073 0.0044
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1424 1 1
Echinococcus multilocularis cpg binding protein 0.0051 0.0261 0.0257
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0076 0.0433 0.043
Onchocerca volvulus 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0053 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0189 0.1239 0.1239
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0081 0.047 0.0704
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0073 0.0038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0073 0.0069
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.0716 0.0713
Loa Loa (eye worm) hypothetical protein 0.0303 0.205 0.205
Trypanosoma cruzi aldo/keto reductase, putative 0.0069 0.0385 0.0458
Toxoplasma gondii hypothetical protein 0.0053 0.0269 0.1487
Onchocerca volvulus 0.0029 0.0105 0.0096
Brugia malayi aspartic protease BmAsp-1, identical 0.0033 0.0132 0.0097
Loa Loa (eye worm) hypothetical protein 0.0081 0.047 0.047
Entamoeba histolytica alcohol dehydrogenase, putative 0.0069 0.0385 0.0566
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0578 0.0575
Echinococcus multilocularis PHD finger protein rhinoceros 0.002 0.004 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0073 0.0073
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0238 0.1582 0.2502
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0069 0.0385 0.0382
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0073 0.0044
Mycobacterium ulcerans oxidoreductase 0.0238 0.1582 0.2544
Mycobacterium tuberculosis Conserved protein 0.0029 0.0105 0.0169
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.002 0.004 0.0011
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0053 0.0269 0.0269
Entamoeba histolytica hypothetical protein 0.0053 0.0269 0.0379
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.0105 0.0105
Schistosoma mansoni hypothetical protein 0.0033 0.0134 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0891 0.6219 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0053 0.0269 0.0433
Plasmodium vivax aldehyde reductase, putative 0.0069 0.0385 0.0619
Schistosoma mansoni fatty-acid amide hydrolase 0.1424 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0578 0.0575
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0073 0.0044
Schistosoma mansoni hypothetical protein 0.0086 0.0504 0.0476
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0069 0.0385 0.0566
Schistosoma mansoni aldo-keto reductase 0.0238 0.1582 0.1558
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.1513 0.151
Echinococcus granulosus lysine specific demethylase 5A 0.0027 0.009 0.0087
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0035 0.0056
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0053 0.0269 0.0269
Trypanosoma brucei prostaglandin f synthase 0.0238 0.1582 0.2416
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0053 0.0269 0.0266
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0238 0.1582 0.2416
Plasmodium vivax alpha/beta hydrolase, putative 0.0053 0.0269 0.0433
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0578 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0269 0.0269
Plasmodium vivax PST-A protein 0.0891 0.6219 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.009 0.009
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0053 0.0269 0.0269
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0172 0.1115 0.1794
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0269 0.0269
Schistosoma mansoni fatty-acid amide hydrolase 0.0172 0.1115 0.109
Schistosoma mansoni hypothetical protein 0.0096 0.0578 0.055
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0238 0.1582 0.1553
Echinococcus multilocularis Phospholipase carboxylesterase 0.0053 0.0269 0.0266
Echinococcus granulosus GPCR family 2 0.0096 0.0578 0.0575
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0073 0.0069
Echinococcus multilocularis geminin 0.0826 0.5755 0.5753
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0172 0.1115 0.1794
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0073
Brugia malayi MH2 domain containing protein 0.018 0.1174 0.1143
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0067 0.0374 0.044
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Toxoplasma gondii phospholipase/carboxylesterase 0.0053 0.0269 0.1487
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0238 0.1582 0.158
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0053 0.0269 0.0269
Plasmodium falciparum aldehyde reductase, putative 0.0069 0.0385 0.0619
Onchocerca volvulus 0.0025 0.0073 0.0051
Loa Loa (eye worm) oxidoreductase 0.0238 0.1582 0.1582
Mycobacterium tuberculosis Possible lysophospholipase 0.0891 0.6219 1
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0053 0.0269 0.1487
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.014 0.0891 0.0888
Echinococcus multilocularis peregrin 0.002 0.004 0.0037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0042 0.0198 0.0198
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0193 0.0193
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0053 0.0269 0.1487
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0053 0.0269 0.0269
Echinococcus granulosus peregrin 0.002 0.004 0.0037
Plasmodium falciparum esterase, putative 0.0053 0.0269 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0073 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0578 0.0575
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0069 0.0385 0.0458
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0172 0.1115 0.5
Plasmodium falciparum esterase, putative 0.0053 0.0269 0.0433
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.014 0.0891 0.1286
Mycobacterium ulcerans peptide amidase, GatA 0.0172 0.1115 0.1794
Schistosoma mansoni hypothetical protein 0.002 0.004 0.0011
Trypanosoma cruzi amidase, putative 0.0172 0.1115 0.1653
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0073 0.0038
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0053 0.0269 0.1487
Leishmania major aldo-keto reductase-like protein 0.0238 0.1582 0.2502
Onchocerca volvulus 0.0029 0.0105 0.0096
Loa Loa (eye worm) oxidoreductase 0.0238 0.1582 0.1582
Echinococcus multilocularis protein patched 0.0035 0.0143 0.014
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0238 0.1582 0.2502
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.1513 0.1488
Plasmodium falciparum alpha/beta hydrolase, putative 0.0053 0.0269 0.0433
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.014 0.0891 0.5518
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0105 0.0169
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0053 0.0269 0.0433
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0103 0.0627 0.0599
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0076 0.0433 0.0644
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0132 0.0103
Entamoeba histolytica hypothetical protein 0.0086 0.0504 0.0758
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0238 0.1582 0.1553
Giardia lamblia Aldose reductase 0.0238 0.1582 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0053 0.0269 0.0269
Leishmania major monoglyceride lipase, putative 0.0891 0.6219 1
Mycobacterium ulcerans amidase 0.0172 0.1115 0.1794
Schistosoma mansoni cellular tumor antigen P53 0.0041 0.0185 0.0156
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0082 0.0479 0.0611
Plasmodium falciparum plasmepsin VIII, putative 0.0033 0.0132 0.0212
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0053 0.0269 0.0269
Brugia malayi MGC83647 protein 0.0053 0.0269 0.0235
Toxoplasma gondii ABC1 family protein 0.0029 0.0105 0.0422
Brugia malayi jmjC domain containing protein 0.0066 0.0366 0.0332
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0039 0.0171 0.0136
Brugia malayi NADH-dependent xylose reductase 0.0069 0.0385 0.0351
Trypanosoma cruzi serine peptidase, putative 0.0053 0.0269 0.0269
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0073 0.0069
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Echinococcus multilocularis expressed conserved protein 0.0076 0.0435 0.0432
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0073 0.0069
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0053 0.0269 0.0269
Loa Loa (eye worm) oxidoreductase 0.0238 0.1582 0.1582
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0238 0.1582 0.2502
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0073 0.0069
Onchocerca volvulus 0.0048 0.0241 0.0281
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0238 0.1582 0.2416
Onchocerca volvulus 0.0238 0.1582 0.2107
Onchocerca volvulus 0.0238 0.1582 0.2107
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0073 0.0069
Plasmodium falciparum ataxin-2 like protein, putative 0.0043 0.0202 0.0326
Echinococcus granulosus fatty acid amide hydrolase 1 0.1424 1 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0226 0.1503 0.2375
Onchocerca volvulus 0.0238 0.1582 0.2107
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0076 0.0433 0.043
Plasmodium falciparum epoxide hydrolase 2 0.0053 0.0269 0.0433
Mycobacterium ulcerans hypothetical protein 0.0019 0.0035 0.0056
Brugia malayi hypothetical protein 0.0033 0.0132 0.0097
Schistosoma mansoni potassium channel beta 0.0069 0.0385 0.0357
Brugia malayi beta-lactamase family protein 0.0029 0.0105 0.007
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0172 0.1115 0.1794
Loa Loa (eye worm) hypothetical protein 0.0238 0.1582 0.1582
Brugia malayi hypothetical protein 0.0033 0.0132 0.0097
Toxoplasma gondii LsmAD domain-containing protein 0.0043 0.0202 0.1053
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0891 0.6219 1
Schistosoma mansoni kinase 0.0038 0.0169 0.0141
Trichomonas vaginalis CAMK family protein kinase 0.0076 0.0433 0.0536
Echinococcus granulosus expressed conserved protein 0.0076 0.0435 0.0432
Trypanosoma cruzi serine peptidase, putative 0.0053 0.0269 0.0269
Mycobacterium ulcerans hydrolase 0.0053 0.0269 0.0433
Schistosoma mansoni hypothetical protein 0.0316 0.2138 0.2115
Echinococcus granulosus aldo keto reductase 0.0238 0.1582 0.158
Plasmodium vivax unspecified product 0.0053 0.0269 0.0433
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0303 0.205 0.205
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Mycobacterium ulcerans beta-lactamase 0.0029 0.0105 0.0169
Toxoplasma gondii histone lysine methyltransferase SET1 0.0092 0.0549 0.3298
Plasmodium falciparum esterase, putative 0.0891 0.6219 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0142
Plasmodium falciparum BEM46-like protein, putative 0.0053 0.0269 0.0433
Schistosoma mansoni transcription factor LCR-F1 0.0086 0.0504 0.0476
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0162 0.0093
Loa Loa (eye worm) aspartic protease BmAsp-2 0.014 0.0891 0.0891
Echinococcus multilocularis abhydrolase domain containing 3 0.0053 0.0269 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0073 0.0038
Leishmania major hypothetical protein, conserved 0.0029 0.0105 0.0114
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0073 0.0051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0105 0.0076
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0238 0.1582 0.158
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0069 0.0385 0.0385
Brugia malayi Amidase family protein 0.0172 0.1115 0.1084
Loa Loa (eye worm) hypothetical protein 0.0096 0.0578 0.0578
Trichomonas vaginalis aldo/keto reductase, putative 0.0238 0.1582 0.2416
Loa Loa (eye worm) PHD-finger family protein 0.002 0.004 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0076 0.0433 0.0536
Plasmodium falciparum aldo-keto reductase, putative 0.0069 0.0385 0.0619
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0238 0.1582 0.1553
Brugia malayi CHE-14 protein 0.0035 0.0143 0.0108
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0076 0.0433 0.0536
Leishmania major mitochondrial DNA polymerase beta 0.0478 0.3291 0.5266
Trichomonas vaginalis aldo-keto reductase, putative 0.0069 0.0385 0.0458
Plasmodium falciparum plasmepsin V 0.0033 0.0132 0.0212
Brugia malayi hypothetical protein 0.0028 0.0094 0.0059
Echinococcus multilocularis survival motor neuron protein 1 0.0189 0.1239 0.1236
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0073 0.0069
Onchocerca volvulus 0.0069 0.0385 0.0477
Schistosoma mansoni cpg binding protein 0.0051 0.0261 0.0232
Echinococcus multilocularis dnaJ subfamily B 0.0316 0.2138 0.2135
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0105
Mycobacterium tuberculosis Conserved protein 0.0029 0.0105 0.0169
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0073 0.0051
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0073 0.0044
Mycobacterium ulcerans hypothetical protein 0.0029 0.0105 0.0169
Schistosoma mansoni peptidase 0.0053 0.0269 0.0241
Brugia malayi CXXC zinc finger family protein 0.0048 0.0241 0.0207
Entamoeba histolytica aldose reductase, putative 0.0238 0.1582 0.2502
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0578 0.0545
Echinococcus granulosus cpg binding protein 0.0051 0.0261 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0035 0.0056
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.0105 0.0169
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0891 0.6219 1
Echinococcus granulosus aldo keto reductase 0.0238 0.1582 0.158
Schistosoma mansoni cpg binding protein 0.0051 0.0261 0.0232
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0172 0.1115 0.1794
Plasmodium vivax plasmepsin IV, putative 0.014 0.0891 0.1433
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0172 0.1115 0.1113
Toxoplasma gondii aldose reductase, putative 0.0238 0.1582 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0073 0.0069
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0238 0.1582 0.158
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Toxoplasma gondii hypothetical protein 0.0053 0.0269 0.1487
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0238 0.1582 0.158
Chlamydia trachomatis acyltransferase family protein 0.0053 0.0269 0.2416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0033 0.0134 0.0105
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.0105 0.0169
Toxoplasma gondii aldo-keto reductase 0.0069 0.0385 0.2237
Trichomonas vaginalis CAMK family protein kinase 0.0076 0.0433 0.0536
Loa Loa (eye worm) CXXC zinc finger family protein 0.0048 0.0241 0.0241
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.0105 0.0102
Schistosoma mansoni hypothetical protein 0.0096 0.0578 0.055
Toxoplasma gondii peptidase S15, putative 0.0053 0.0269 0.1487
Trypanosoma cruzi aldo-keto reductase 0.0238 0.1582 0.2416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.1513 0.151
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0069 0.0385 0.0351
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0073 0.0038
Loa Loa (eye worm) hypothetical protein 0.0053 0.0269 0.0269
Onchocerca volvulus 0.0041 0.0185 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.1513 0.1488
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0033 0.0132 0.0132
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Brugia malayi MGC79044 protein 0.0053 0.0269 0.0235
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0019 0.0035 0.0056
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0082 0.0479 0.0451
Brugia malayi Niemann-Pick C1 protein precursor 0.0081 0.047 0.0437
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0067 0.0374 0.044
Trypanosoma brucei aldo/keto reductase, putative 0.0069 0.0385 0.0458
Entamoeba histolytica alcohol dehydrogenase, putative 0.0069 0.0385 0.0566
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0073 0.0038
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.0105 0.0169
Echinococcus granulosus fatty acid amide hydrolase 1 0.0172 0.1115 0.1113
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0228 0.1513 0.1513
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0066 0.0366 0.0363
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0073 0.0044
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.014 0.0891 0.0864
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0019 0.0035 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0073 0.0038
Schistosoma mansoni hypothetical protein 0.0039 0.0171 0.0142
Mycobacterium ulcerans amidase 0.0172 0.1115 0.1794
Schistosoma mansoni hypothetical protein 0.0033 0.0134 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0076 0.0433 0.0536
Brugia malayi aspartic protease BmAsp-2, identical 0.0033 0.0132 0.0097
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0076 0.0433 0.0433
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0238 0.1582 0.158
Brugia malayi serine/threonine-protein kinase plk-2 0.0076 0.0433 0.0399
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0478 0.3291 0.5212
Plasmodium falciparum plasmepsin IX 0.0033 0.0132 0.0212
Schistosoma mansoni hypothetical protein 0.0096 0.0578 0.055
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0226 0.1503 0.2287
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Echinococcus granulosus tumor protein p63 0.0277 0.1865 0.1862
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0578 0.0578
Mycobacterium ulcerans amidase 0.0172 0.1115 0.1794
Schistosoma mansoni amidase 0.1424 1 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.1424 1 1
Plasmodium vivax PST-A protein 0.0053 0.0269 0.0433
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0478 0.3291 0.5212
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0073 0.0044
Mycobacterium ulcerans lipase LipD 0.0029 0.0105 0.0169
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0073
Loa Loa (eye worm) histone methyltransferase 0.0015 0.0003 0.0003
Plasmodium falciparum phd finger protein, putative 0.002 0.004 0.0064
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Echinococcus granulosus abhydrolase domain containing protein 13 0.0053 0.0269 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0073 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0269 0.0433
Schistosoma mansoni coup transcription factor 0.0025 0.0073 0.0044
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0053 0.0269 0.0241
Schistosoma mansoni jumonji domain containing protein 0.0053 0.027 0.0241
Schistosoma mansoni hypothetical protein 0.0207 0.1369 0.1343
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0053 0.0269 0.1487
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Schistosoma mansoni survival motor neuron protein 0.0039 0.0171 0.0142
Echinococcus multilocularis jumonji domain containing protein 0.0028 0.0096 0.0093
Plasmodium vivax PST-A protein 0.0053 0.0269 0.0433
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0066 0.0366 0.0363
Echinococcus granulosus jumonji domain containing protein 0.0028 0.0096 0.0093
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0035 0.0143 0.0143
Echinococcus granulosus sterol regulatory element binding protein 0.0035 0.0143 0.014
Mycobacterium leprae Possible oxidoreductase 0.0069 0.0385 0.0566
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0019 0.0034 0.0031
Schistosoma mansoni hypothetical protein 0.0826 0.5755 0.5742
Onchocerca volvulus Serine\/threonine kinase homolog 0.0076 0.0433 0.0542
Echinococcus multilocularis aldo keto reductase 0.0238 0.1582 0.158
Entamoeba histolytica hypothetical protein 0.0053 0.0269 0.0379
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0238 0.1582 0.1553
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0238 0.1582 0.158
Loa Loa (eye worm) amidase 0.0172 0.1115 0.1115
Plasmodium vivax alpha/beta hydrolase, putative 0.0053 0.0269 0.0433
Trypanosoma brucei PAB1-binding protein , putative 0.0043 0.0202 0.0159
Entamoeba histolytica hypothetical protein 0.0086 0.0504 0.0758
Plasmodium falciparum alpha/beta hydrolase, putative 0.0053 0.0269 0.0433
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0069 0.0385 0.2237
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0891 0.6219 1
Brugia malayi putative amidase 0.0172 0.1115 0.1084
Loa Loa (eye worm) beta-lactamase 0.0029 0.0105 0.0105
Brugia malayi latrophilin 2 splice variant baaae 0.0207 0.1369 0.1338
Trichomonas vaginalis aldo-keto reductase, putative 0.0238 0.1582 0.2416
Onchocerca volvulus 0.0238 0.1582 0.2107
Loa Loa (eye worm) MH2 domain-containing protein 0.018 0.1174 0.1174

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.18 uM Inhibition of mouse group 2A sPLA2 by fluorescence assay ChEMBL. 21216150
IC50 (binding) = 0.3 uM Inhibition of human group 2A sPLA2 by fluorescence assay ChEMBL. 21216150
IC50 (binding) = 0.44 uM Inhibition of human group 5 sPLA2 by fluorescence assay ChEMBL. 21216150
IC50 (binding) = 2.6 uM Inhibition of mouse group 5 sPLA2 by fluorescence assay ChEMBL. 21216150
Inhibition (binding) = 50 % Inhibition of human group 10 sPLA2 at 16.6 uM by fluorescence assay ChEMBL. 21216150
Inhibition (binding) = 58 % Inhibition of mouse group 10 sPLA2 by fluorescence assay ChEMBL. 21216150

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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