Detailed information for compound 1462715

Basic information

Technical information
  • TDR Targets ID: 1462715
  • Name: N'-[4-(4-methylphenyl)-1,3-thiazol-2-yl]aceto hydrazide
  • MW: 247.316 | Formula: C12H13N3OS
  • H donors: 2 H acceptors: 2 LogP: 2.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NNc1scc(n1)c1ccc(cc1)C
  • InChi: 1S/C12H13N3OS/c1-8-3-5-10(6-4-8)11-7-17-12(13-11)15-14-9(2)16/h3-7H,1-2H3,(H,13,15)(H,14,16)
  • InChiKey: PNUVJUCQHOTCCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[4-(4-methylphenyl)thiazol-2-yl]acetohydrazide
  • N'-[4-(4-methylphenyl)-2-thiazolyl]acetohydrazide
  • N'-[4-(4-methylphenyl)-1,3-thiazol-2-yl]ethanehydrazide
  • ZINC01466431
  • T0500-9586

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei aldo/keto reductase, putative 0.0157 0.2735 0.2391
Trypanosoma brucei monoglyceride lipase, putative 0.0204 0.3626 0.3324
Loa Loa (eye worm) oxidoreductase 0.0542 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0542 1 1
Loa Loa (eye worm) oxidoreductase 0.0542 1 1
Echinococcus multilocularis ankyrin repeat protein 0.0158 0.2758 0.2415
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0542 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0542 1 1
Toxoplasma gondii aldose reductase, putative 0.0542 1 1
Echinococcus multilocularis aldo keto reductase 0.0542 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0158 0.2758 0.2415
Trichomonas vaginalis aldo/keto reductase, putative 0.0542 1 1
Brugia malayi amidase 0.0298 0.5403 0.5186
Loa Loa (eye worm) hypothetical protein 0.0542 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0542 1 1
Trypanosoma brucei monoglyceride lipase, putative 0.0204 0.3626 0.3324
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0157 0.2735 0.2391
Mycobacterium leprae Possible oxidoreductase 0.0157 0.2735 0.2391
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0542 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0158 0.2762 0.242
Trichomonas vaginalis aldo/keto reductase, putative 0.0542 1 1
Mycobacterium tuberculosis Possible lysophospholipase 0.0204 0.3626 0.3324
Schistosoma mansoni aldo-keto reductase 0.0542 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.3626 0.1226
Entamoeba histolytica aldose reductase, putative 0.0542 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Onchocerca volvulus 0.0542 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0542 1 1
Loa Loa (eye worm) oxidoreductase 0.0542 1 1
Plasmodium falciparum lysophospholipase, putative 0.0204 0.3626 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0542 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Onchocerca volvulus 0.0542 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0542 1 1
Entamoeba histolytica aldose reductase, putative 0.0542 1 1
Loa Loa (eye worm) hypothetical protein 0.0298 0.5403 0.5186
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0036 0.0452 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0204 0.3626 0.1226
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0204 0.3626 0.1226
Leishmania major aldo-keto reductase-like protein 0.0542 1 1
Echinococcus granulosus hypothetical protein 0.0542 1 1
Mycobacterium ulcerans hypothetical protein 0.0157 0.2735 0.2391
Echinococcus multilocularis aldo keto reductase 0.0542 1 1
Onchocerca volvulus 0.0542 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0542 1 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0542 1 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0298 0.5403 0.5186
Echinococcus granulosus fatty acid amide hydrolase 1 0.0298 0.5403 0.5186
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Plasmodium falciparum lysophospholipase, putative 0.0204 0.3626 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0542 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0542 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0204 0.3626 0.1226
Trypanosoma cruzi aldo-keto reductase 0.0542 1 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0298 0.5403 0.5186
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.3626 0.1226
Plasmodium falciparum aldo-keto reductase, putative 0.0157 0.2735 0.7194
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0542 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0542 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0542 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0542 1 1
Echinococcus multilocularis aldo keto reductase 0.0542 1 1
Echinococcus granulosus aldo keto reductase 0.0542 1 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0157 0.2735 0.2735
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Mycobacterium ulcerans oxidoreductase 0.0542 1 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0157 0.2735 0.2391
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0036 0.0452 0.5
Giardia lamblia Aldose reductase 0.0542 1 0.5
Mycobacterium ulcerans lysophospholipase 0.0204 0.3626 0.3324
Schistosoma mansoni amidase 0.0298 0.5403 0.5186
Leishmania major prostaglandin f synthase, putative 0.0542 1 1
Loa Loa (eye worm) oxidoreductase 0.0542 1 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0204 0.3626 0.1226
Echinococcus granulosus fatty acid amide hydrolase 1 0.0298 0.5403 0.5186
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0157 0.2735 0.7194
Echinococcus granulosus aldo keto reductase 0.0542 1 1
Plasmodium vivax PST-A protein 0.0204 0.3626 1
Echinococcus granulosus aldehyde reductase 0.0385 0.7038 0.6897
Mycobacterium ulcerans hypothetical protein 0.0204 0.3626 0.3324
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0158 0.2758 0.2415
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0204 0.3626 0.3324
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0204 0.3626 0.1226
Mycobacterium tuberculosis Conserved protein 0.0157 0.2735 0.2391
Leishmania major monoglyceride lipase, putative 0.0204 0.3626 0.3626
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0204 0.3626 0.1226
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0542 1 1
Trypanosoma cruzi monoglyceride lipase, putative 0.0204 0.3626 0.3324
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Echinococcus multilocularis aldehyde reductase 0.0385 0.7038 0.6897
Brugia malayi NADH-dependent xylose reductase 0.0157 0.2735 0.2391
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0204 0.3626 0.1226
Leishmania major hypothetical protein, conserved 0.0036 0.0452 0.0452
Plasmodium falciparum esterase, putative 0.0204 0.3626 1
Echinococcus multilocularis aldo keto reductase 0.0542 1 1
Schistosoma mansoni potassium channel beta 0.0157 0.2735 0.2391
Echinococcus granulosus ankyrin repeat protein 0.0158 0.2758 0.2415
Onchocerca volvulus 0.0542 1 1
Trypanosoma brucei aldo-keto reductase, putative 0.0542 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0542 1 1
Plasmodium falciparum aldehyde reductase, putative 0.0157 0.2735 0.7194
Onchocerca volvulus 0.0542 1 1
Entamoeba histolytica aldose reductase, putative 0.0542 1 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0204 0.3626 0.1226
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Schistosoma mansoni aldo-keto reductase 0.0542 1 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0298 0.5403 0.5186
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0036 0.0452 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0542 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0157 0.2735 0.2391
Onchocerca volvulus 0.0542 1 1
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0157 0.2735 0.2391
Echinococcus granulosus aldo keto reductase 0.0542 1 1
Trypanosoma brucei prostaglandin f synthase 0.0542 1 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.0157 0.2735 0.2391
Trichomonas vaginalis aldo-keto reductase, putative 0.0542 1 1
Schistosoma mansoni pol-related 0.0542 1 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0542 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0542 1 1
Plasmodium falciparum lysophospholipase, putative 0.0204 0.3626 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0542 1 1
Giardia lamblia Aldose reductase 0.0542 1 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0385 0.7038 0.6897
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0157 0.2735 0.2391
Plasmodium vivax aldehyde reductase, putative 0.0157 0.2735 0.7194
Loa Loa (eye worm) oxidoreductase 0.0542 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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