Detailed information for compound 1462838

Basic information

Technical information
  • TDR Targets ID: 1462838
  • Name: tetralithium [(2R,3S,4R,5R)-5-(2-amino-6-oxo- 3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methy l (dioxidophosphinothioyloxy-oxidophosphoryl) phosphate
  • MW: 562.978 | Formula: C10H12Li4N5O13P3S
  • H donors: 8 H acceptors: 10 LogP: -4.85 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=S)([O-])[O-])[O-])[O-])O[C@H]([C@@H]1O)n1cnc2c1nc(N)[nH]c2=O.[Li+].[Li+].[Li+].[Li+]
  • InChi: 1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1
  • InChiKey: AMQXJFWJOAWCPV-ZVQJTLEUSA-J  


Substructure search Similarity search

Network

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Synonyms

  • tetralithium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl (dioxidophosphinothioyloxy-oxido-phosphoryl) phosphate
  • tetralithium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl (dioxidophosphinothioyloxy-oxidophosphoryl) phosphate
  • tetralithium [(2R,3S,4R,5R)-5-(2-amino-6-keto-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl (dioxidothiophosphoryloxy-oxido-phosphoryl) phosphate
  • tetralithium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl (dioxidophosphinothioyloxy-oxido-phosphoryl) phosphate
  • G8634_SIGMA
  • GTP-gamma-S-Li4
  • Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt
  • Guanosine 5′-[gamma-thio]triphosphate tetralithium salt

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0122 0.2815 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0528 0.0479
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0014
Leishmania major prostaglandin f synthase, putative 0.042 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.042 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0471 0.0431
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0052 0.0052
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0052 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0128 0.0128
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0127 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0128 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0052 0.0023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0041 0.00000000010001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0128 0.0128
Loa Loa (eye worm) oxidoreductase 0.042 1 1
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0182 0.0182
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0127 0.0119
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0445 0.0441
Echinococcus multilocularis GPCR, family 2 0.0032 0.0649 0.0649
Trypanosoma brucei unspecified product 0.0027 0.0528 0.0479
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0817 0.0809
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0128 0.0128
Onchocerca volvulus 0.042 1 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0127 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0175 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0452 0.0452
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0128 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0817 0.0809
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0309 0.1085
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0198 0.0194
Loa Loa (eye worm) hypothetical protein 0.001 0.0127 0.0127
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.001 0.0128 0.0128
Echinococcus granulosus aldo keto reductase 0.042 1 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0127 0.0127
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0128 0.0128
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0452 0.0402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0128 0.0128
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0128 0.0128
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0175 0.0607
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0098 0.0098
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0175 0.0175
Onchocerca volvulus 0.042 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0128 0.0128
Echinococcus granulosus aldo keto reductase family 1 member B4 0.042 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0041 0.00000000010001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0572 0.0572
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.1426 0.1419
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0052 0.0023
Echinococcus multilocularis voltage gated potassium channel subunit 0.0122 0.2815 0.2815
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0052 0.0052
Entamoeba histolytica aldose reductase, putative 0.042 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.2297 0.2297
Loa Loa (eye worm) hypothetical protein 0.0012 0.0179 0.0179
Entamoeba histolytica aldose reductase, putative 0.042 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.042 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0198 0.0158
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0128 0.0128
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0277 0.0268
Loa Loa (eye worm) hypothetical protein 0.0024 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.001 0.0128 0.0128
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0445 0.0395
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0452 0.0425
Echinococcus granulosus aldo keto reductase family 1 member B4 0.042 1 1
Loa Loa (eye worm) oxidoreductase 0.042 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0128 0.0128
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.2815 0.2786
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0817 0.0779
Leishmania major hypothetical protein, conserved 0.0012 0.0182 0.0131
Schistosoma mansoni hypothetical protein 0.0032 0.0649 0.0649
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0175 0.0123
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0182 0.0182
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0649 0.0649
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0052 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0052 0.0052
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0175 0.0123
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0005 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0528 0.0479
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0817 0.0769
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0817 0.0769
Brugia malayi nuclear receptor NHR-88 0.001 0.0128 0.0128
Onchocerca volvulus 0.0122 0.2815 0.2815
Giardia lamblia Aldose reductase 0.042 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0128 0.0128
Echinococcus granulosus aldehyde reductase 0.0298 0.707 0.707
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0012 0.0182 0.0182
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0052 0.0043
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0445 0.0395
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0052 0.0011
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0122 0.2815 0.2815
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0182 0.0142
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0452 0.0449
Trichomonas vaginalis aldo-keto reductase, putative 0.0122 0.2815 0.2786
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1342 0.1342
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0452 0.0449
Trichomonas vaginalis aldo-keto reductase, putative 0.0122 0.2815 0.2786
Schistosoma mansoni coup transcription factor 0.001 0.0128 0.0128
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.1873 0.1873
Echinococcus multilocularis aldo keto reductase 0.042 1 1
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0817 0.0817
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0052 0.0048
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0014 0.0014
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0175 0.0444
Onchocerca volvulus 0.042 1 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0052 0.0023
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.1873 0.1873
Onchocerca volvulus 0.0007 0.0052 0.0052
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0471 0.0431
Mycobacterium ulcerans oxidoreductase 0.042 1 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0445 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0128 0.0128
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0128 0.0128
Mycobacterium leprae Conserved hypothetical protein 0.0298 0.707 0.7055
Brugia malayi polk-prov protein 0.0012 0.0175 0.0175
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0817 0.0779
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0128 0.0128
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0127 0.0127
Entamoeba histolytica alcohol dehydrogenase, putative 0.0122 0.2815 0.2812
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0452 0.0402
Brugia malayi nuclear hormone receptor 0.001 0.0128 0.0128
Echinococcus granulosus aldo keto reductase family 1 member B4 0.042 1 1
Echinococcus multilocularis cpg binding protein 0.003 0.0611 0.0611
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0052 0.0052
Toxoplasma gondii aldose reductase, putative 0.042 1 1
Schistosoma mansoni hypothetical protein 0.0032 0.0649 0.0649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0032 0.0649 0.0649
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0286 0.0258
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0309 0.0281
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0041 0.00000000010001
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0817 0.0769
Loa Loa (eye worm) hypothetical protein 0.001 0.0128 0.0128
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0309 0.0258
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0817 0.0817
Schistosoma mansoni hypothetical protein 0.0068 0.1534 0.1534
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0052 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0286 0.0258
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0128 0.0128
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0452 0.0402
Loa Loa (eye worm) hypothetical protein 0.0007 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0182 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0128 0.0128
Trypanosoma brucei unspecified product 0.0027 0.0528 0.0479
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.042 1 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0572 0.0572
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0817 0.0817
Trichomonas vaginalis aldo/keto reductase, putative 0.042 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.042 1 1
Trypanosoma brucei prostaglandin f synthase 0.042 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0445 0.0417
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0175 0.0166
Mycobacterium ulcerans hypothetical protein 0.0122 0.2815 0.2778
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0128 0.0128
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0052 0.0043
Echinococcus multilocularis aldo keto reductase 0.042 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.042 1 1
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0012 0.0182 0.0131
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0817 0.0817
Trichomonas vaginalis dullard protein, putative 0.0012 0.0182 0.0142
Echinococcus granulosus aldo keto reductase family 1 member B4 0.042 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0128 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0128 0.0128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0041 0.00000000010001
Onchocerca volvulus 0.001 0.0128 0.0128
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0175 0.0166
Mycobacterium ulcerans hypothetical protein 0.0012 0.0175 0.0123
Loa Loa (eye worm) hypothetical protein 0.0122 0.2831 0.2831
Loa Loa (eye worm) RecQ helicase 0.0024 0.0471 0.0471
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0182 0.0174
Brugia malayi NADH-dependent xylose reductase 0.0122 0.2815 0.2815
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0128 0.0128
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0452 0.0402
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0041 0.00000000010001
Leishmania major DNA polymerase eta, putative 0.0064 0.1426 0.1381
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0445 0.0395
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0064 0.1426 0.1426
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0052 0.0052
Plasmodium falciparum aldehyde reductase, putative 0.0122 0.2815 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0817 0.0817
Echinococcus granulosus cpg binding protein 0.003 0.0611 0.0611
Brugia malayi steroid hormone receptor 0.001 0.0128 0.0128
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0452 0.0402
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0127 0.0127
Giardia lamblia DNA damage repair protein 0.0012 0.0175 0.0048
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0014 0.0014
Trichomonas vaginalis dullard protein, putative 0.0012 0.0182 0.0142
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0281 0.0986
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Schistosoma mansoni hypothetical protein 0.0032 0.0649 0.0649
Echinococcus granulosus aldo keto reductase family 1 member B4 0.042 1 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0452 0.0452
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0182 0.0142
Echinococcus granulosus aldo keto reductase 0.042 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0452 0.0402
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0128 0.0128
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0127 0.0272
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0175 0.0166
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.1873 0.1873
Trypanosoma brucei aldo/keto reductase, putative 0.0122 0.2815 0.2778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0128 0.0128
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0052 0.0043
Schistosoma mansoni DNA helicase recq5 0.001 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.01 0.2297 0.2297
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0452 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0175 0.0123
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0817 0.0769
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0452 0.0402
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0128 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0128 0.0128
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Giardia lamblia Aldose reductase 0.042 1 1
Brugia malayi hypothetical protein 0.0005 0.0014 0.0014
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0052 0.0023
Echinococcus multilocularis aldo keto reductase 0.042 1 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.0009 0.0009
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0198 0.0147
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0098 0.0098
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0122 0.2815 0.2809
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0182 0.0182
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0052 0.0043
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0128 0.0128
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0452 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.1426 0.1426
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0041 0.00000000010001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0649 0.0649
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0122 0.2815 0.2815
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0128 0.0128
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0445 0.0395
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0817 0.0809
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0128 0.0128
Echinococcus granulosus bloom syndrome protein 0.0024 0.0471 0.0471
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0041 0.00000000010001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0309 0.0309
Onchocerca volvulus 0.042 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.2297 0.2297
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0128 0.0128
Echinococcus multilocularis aldo keto reductase 0.042 1 1
Onchocerca volvulus 0.0024 0.0452 0.0452
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0198 0.0147
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.042 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0128 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Schistosoma mansoni thyroid hormone receptor 0.001 0.0128 0.0128
Trichomonas vaginalis aldo/keto reductase, putative 0.042 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.042 1 1
Echinococcus granulosus GPCR family 2 0.0032 0.0649 0.0649
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0452 0.0425
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0052 0.0023
Onchocerca volvulus 0.042 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0128 0.0128
Trypanosoma brucei unspecified product 0.0039 0.0817 0.0769
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.001 0.0128 0.0128
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0445 0.1421
Echinococcus granulosus dnaJ subfamily B 0.0406 0.9663 0.9663
Mycobacterium ulcerans hypothetical protein 0.0024 0.0452 0.0402
Toxoplasma gondii aldo-keto reductase 0.0122 0.2815 0.2809
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0128 0.0128
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0182 0.0182
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0452 0.0449
Echinococcus granulosus aldo keto reductase family 1 member B4 0.042 1 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0052 0.0043
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0056 0.0056
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0128 0.0128
Echinococcus granulosus aldo keto reductase family 1 member B4 0.042 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Plasmodium vivax aldehyde reductase, putative 0.0122 0.2815 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0286 0.0258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0309 0.0309
Schistosoma mansoni hypothetical protein 0.0406 0.9663 0.9663
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0309 0.0309
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0041 0.00000000010001
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0182 0.0634
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0175 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0128 0.0128
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.1873 0.1873
Loa Loa (eye worm) hypothetical protein 0.001 0.0128 0.0128
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0128 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0128 0.0128
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0052 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0128 0.0128
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0309 0.093
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Echinococcus granulosus FTZ F1 alpha 0.001 0.0128 0.0128
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0182 0.0142
Loa Loa (eye worm) oxidoreductase 0.042 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0128 0.0128
Giardia lamblia DINP protein human, muc B family 0.0039 0.0817 0.0699
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0817 0.0817
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0009 0.0005
Schistosoma mansoni cpg binding protein 0.0028 0.0572 0.0572
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0052 0.0023
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.04 0.1258
Loa Loa (eye worm) hypothetical protein 0.001 0.0128 0.0128
Trichomonas vaginalis aldo-keto reductase, putative 0.0122 0.2815 0.2786
Echinococcus multilocularis aldehyde reductase 0.0298 0.707 0.707
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0817 0.0809
Onchocerca volvulus 0.0007 0.0052 0.0052
Echinococcus granulosus aldo keto reductase family 1 member B4 0.042 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0098 0.0098
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0452 0.0402
Schistosoma mansoni hypothetical protein 0.0012 0.0179 0.0179
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0122 0.2815 0.2809
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0128 0.0128
Trypanosoma brucei aldo-keto reductase, putative 0.042 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0445 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Onchocerca volvulus 0.0028 0.0572 0.0572
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0452 0.0402
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Trypanosoma cruzi aldo-keto reductase 0.042 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0649 0.0649
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0817 0.0769
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0649 0.0649
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0182 0.0634
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0127 0.0127
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Leishmania major DNA damage repair protein, putative 0.0012 0.0175 0.0123
Schistosoma mansoni pol-related 0.042 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Schistosoma mansoni cpg binding protein 0.003 0.0611 0.0611
Trichomonas vaginalis aldo-keto reductase, putative 0.042 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0128 0.0128
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0817 0.0814
Loa Loa (eye worm) hypothetical protein 0.0024 0.0452 0.0452
Entamoeba histolytica aldose reductase, putative 0.042 1 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0052 0.0052
Echinococcus granulosus dna polymerase kappa 0.0039 0.0817 0.0817
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0817 0.0769
Onchocerca volvulus 0.0007 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0309 0.0309
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0056 0.0056
Trichomonas vaginalis dullard protein, putative 0.0012 0.0182 0.0142
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0052 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0052 0.0052
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0182 0.0142
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0122 0.2815 0.2815
Schistosoma mansoni potassium channel beta 0.0122 0.2815 0.2815
Mycobacterium tuberculosis Conserved protein 0.0122 0.2815 0.2794
Loa Loa (eye worm) hypothetical protein 0.0068 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0082 0.1873 0.1873
Schistosoma mansoni thyroid hormone receptor 0.001 0.0128 0.0128
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.042 1 1
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0182 0.0178
Loa Loa (eye worm) hypothetical protein 0.042 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.042 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0198 0.019
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.9663 0.9663
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1534 0.1534
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0175 0.0123
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0175 0.0123
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0128 0.0128
Loa Loa (eye worm) oxidoreductase 0.042 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0128 0.0128
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0122 0.2815 0.2786
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0471 0.0471
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0452 0.0402
Onchocerca volvulus 0.0007 0.0052 0.0052
Echinococcus granulosus aldo keto reductase 0.042 1 1
Onchocerca volvulus 0.0082 0.1873 0.1873
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.042 1 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0128 0.0128
Echinococcus multilocularis dna polymerase eta 0.0064 0.1426 0.1426
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.042 1 1
Leishmania major DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Loa Loa (eye worm) oxidoreductase 0.042 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0014 0.0014
Leishmania major DNA polymerase eta, putative 0.0037 0.0784 0.0736
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0127 0.0127
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0817 0.0791
Mycobacterium leprae Possible oxidoreductase 0.0122 0.2815 0.2778
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0052 0.0043
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0052 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0128 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0128 0.0128
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0784 0.0776
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0784 0.0776
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0175 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0817 0.0769
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0649 0.0649
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0014 0.0014
Echinococcus granulosus hypothetical protein 0.042 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0817 0.0817
Plasmodium falciparum aldo-keto reductase, putative 0.0122 0.2815 1
Brugia malayi hypothetical protein 0.0005 0.0014 0.0014
Brugia malayi nuclear receptor RXR 0.0005 0.0014 0.0014
Schistosoma mansoni aldo-keto reductase 0.042 1 1
Brugia malayi ecdysteroid receptor 0.001 0.0128 0.0128
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0018 0.0309 0.0309
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0052 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0649 0.0649
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0452 0.0402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0286 0.0258
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.001 0.0128 0.0128
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.042 1 1
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0012 0.0182 0.0471
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0128 0.0128
Onchocerca volvulus 0.042 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.1426 0.1381
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0817 0.0791
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0007 0.0052 0.0052
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0056 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0052 0.0052
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0348 0.0348
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0122 0.2815 0.2778
Echinococcus multilocularis 0.0012 0.0182 0.0182
Schistosoma mansoni DNA helicase recq1 0.001 0.0127 0.0127
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0445 0.0395
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0452 0.0452
Schistosoma mansoni cpg binding protein 0.003 0.0611 0.0611
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.042 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0014 0.0014
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0128 0.0128
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0052 0.0171
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0095 0.0095
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0175 0.0166
Schistosoma mansoni aldo-keto reductase 0.042 1 1
Echinococcus granulosus dna polymerase eta 0.0064 0.1426 0.1426
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0014 0.0014
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0052 0.0023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.2297 0.2297
Entamoeba histolytica alcohol dehydrogenase, putative 0.0122 0.2815 0.2812
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0012 0.0182 0.0056
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0445 0.1567
Leishmania major aldo-keto reductase-like protein 0.042 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0128 0.0128
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0128 0.0128
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0128 0.0128
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0445 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0528 0.0479
Trichomonas vaginalis aldo/keto reductase, putative 0.042 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0122 0.2815 0.2809
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0445 0.0436
Leishmania major DNA polymerase kappa, putative 0.0012 0.0175 0.0123
Loa Loa (eye worm) oxidoreductase 0.0007 0.0052 0.0052
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0445 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1186 0.1179
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0175 0.0123
Schistosoma mansoni DNA polymerase eta 0.0064 0.1426 0.1426
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0052 0.0011
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0175 0.0166
Echinococcus granulosus voltage gated potassium channel subunit 0.0122 0.2815 0.2815
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0649 0.0649

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 4.8 pM Antagonist activity at kappa opioid receptor expressed in HEK293 cells assessed as inhibition of compound 16-induced [35S]GTPgammaS binding ChEMBL. 19683449

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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