Detailed information for compound 1462870

Basic information

Technical information
  • TDR Targets ID: 1462870
  • Name: [(5-nitrofuran-2-yl)methylideneamino]thiourea
  • MW: 214.202 | Formula: C6H6N4O3S
  • H donors: 2 H acceptors: 2 LogP: 0.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(o1)/C=N/NC(=S)N
  • InChi: 1S/C6H6N4O3S/c7-6(14)9-8-3-4-1-2-5(13-4)10(11)12/h1-3H,(H3,7,9,14)/b8-3+
  • InChiKey: XWUHTDIIQSYUDH-FPYGCLRLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(5-nitro-2-furyl)methyleneamino]thiourea
  • 831-71-0
  • AH-034/32845015
  • ARONIS023171
  • Hydrazinecarbothioamide, 2-((5-nitro-2-furanyl)methylene)- (9CI)
  • STK032034
  • NSC 6458
  • 2-Furaldehyde, 5-nitro-, thiosemicarbazone
  • 5-Nitro-2-furaldehyde thiosemicarbazone
  • 5-Nitro-2-furfural thiosemicarbazone
  • 5-Nitro-2-furfurylidene thiosemicarbazone
  • 5-Nitrofurfural thiosemicarbazone
  • Benzazon vii
  • Benzazone-VII
  • Hydrazinecarbothioamide, 2-[(5-nitro-2-furanyl)methylene]-
  • NSC6458
  • SHCH-49
  • Usaf ea-14
  • WLN: T5OJ BNW E1UNMYZUS
  • AI3-62410

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0138795 0.0613003 0.111811
Loa Loa (eye worm) hypothetical protein 0.00624902 0.00238053 0.00238053
Loa Loa (eye worm) TK/ROR protein kinase 0.00699511 0.00814149 0.00814149
Echinococcus multilocularis neuropeptide FF receptor 2 0.0385848 0.252065 0.287099
Echinococcus granulosus cathepsin l cysteine peptidase 0.0192923 0.103096 0.117425
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0351333 0.225414 0.256743
Echinococcus granulosus cathepsin b 0.0769428 0.548251 0.624451
Echinococcus granulosus neuropeptide FF receptor 2 0.0385848 0.252065 0.287099
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0113535 0.0417957 0.0476047
Loa Loa (eye worm) hypothetical protein 0.00624902 0.00238053 0.00238053
Loa Loa (eye worm) hypothetical protein 0.0178264 0.0917765 0.0917765
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Brugia malayi hypothetical protein 0.00624902 0.00238053 0.00238053
Echinococcus multilocularis cysteine protease 0.0192923 0.103096 0.117425
Echinococcus granulosus glutamate receptor 2 0.00718473 0.00960567 0.0109407
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0192923 0.103096 0.457363
Echinococcus granulosus cathepsin l1 0.0138795 0.0613003 0.0698202
Loa Loa (eye worm) hypothetical protein 0.00624902 0.00238053 0.00238053
Onchocerca volvulus Heterochromatin protein 1 homolog 0.00624902 0.00238053 0.02271
Brugia malayi Glutamate receptor 2 precursor 0.00671045 0.00594349 0.00594349
Echinococcus multilocularis cathepsin b 0.0769428 0.548251 0.624451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Entamoeba histolytica cysteine proteinase, putative 0.0192923 0.103096 1
Brugia malayi SWIRM domain containing protein 0.019516 0.104823 0.104823
Brugia malayi Cathepsin L-like precursor 0.0192923 0.103096 0.103096
Brugia malayi Protein cec-1. 0.00624902 0.00238053 0.00238053
Plasmodium vivax unspecified product 0.0113535 0.0417957 0.405405
Leishmania major cathepsin L-like protease 0.0192923 0.103096 0.43703
Trypanosoma cruzi cysteine peptidase, putative 0.0192923 0.103096 0.188045
Echinococcus granulosus glutamate receptor 2 0.00625957 0.00246195 0.00280413
Brugia malayi Cathepsin L-like precursor 0.0138795 0.0613003 0.0613003
Trichomonas vaginalis hypothetical protein 0.00624902 0.00238053 0.0105607
Onchocerca volvulus 0.0192923 0.103096 0.983526
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.00624902 0.00238053 0.0105607
Loa Loa (eye worm) hypothetical protein 0.00699511 0.00814149 0.00814149
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.00624902 0.00238053 0.0105607
Entamoeba histolytica cysteine proteinase 1, putative 0.0113535 0.0417957 0.405405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192923 0.103096 0.457363
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.00624902 0.00238053 0.0105607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192923 0.103096 0.457363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.00624902 0.00238053 0.0105607
Loa Loa (eye worm) matrixin family protein 0.0101832 0.0327587 0.0327587
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.00624902 0.00238053 0.0105607
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.00624902 0.00238053 0.0105607
Echinococcus multilocularis integrin beta 2 0.0519524 0.355285 0.404665
Plasmodium falciparum cysteine proteinase falcipain 3 0.0192923 0.103096 1
Loa Loa (eye worm) hypothetical protein 0.00834242 0.0185449 0.0185449
Loa Loa (eye worm) helicase 0.00624902 0.00238053 0.00238053
Entamoeba histolytica hypothetical protein 0.00624902 0.00238053 0.0230904
Loa Loa (eye worm) cathepsin B 0.0351333 0.225414 0.225414
Brugia malayi Papain family cysteine protease containing protein 0.0192923 0.103096 0.103096
Loa Loa (eye worm) hypothetical protein 0.0138795 0.0613003 0.0613003
Loa Loa (eye worm) hypothetical protein 0.0178264 0.0917765 0.0917765
Echinococcus granulosus cathepsin L 0.0113535 0.0417957 0.0476047
Loa Loa (eye worm) aminopeptidase N 0.00702284 0.00835565 0.00835565
Trypanosoma cruzi Aminopeptidase M1, putative 0.00702284 0.00835565 0.0152406
Entamoeba histolytica cysteine protease, putative 0.0192923 0.103096 1
Loa Loa (eye worm) hypothetical protein 0.00624902 0.00238053 0.00238053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192923 0.103096 0.457363
Giardia lamblia Cathepsin B precursor 0.0351333 0.225414 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138795 0.0613003 0.271946
Plasmodium vivax vivapain-3 0.0113535 0.0417957 0.405405
Echinococcus multilocularis chromobox protein 1 0.00624902 0.00238053 0.00271139
Loa Loa (eye worm) hypothetical protein 0.00624902 0.00238053 0.00238053
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Schistosoma mansoni chromobox protein 0.119644 0.877974 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Leishmania major cathepsin L-like protease 0.0192923 0.103096 0.43703
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.00624902 0.00238053 0.0230904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Brugia malayi Cathepsin L-like precursor 0.0192923 0.103096 0.103096
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.00702284 0.00835565 0.000985686
Onchocerca volvulus 0.0192923 0.103096 0.983526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Brugia malayi Hemopexin family protein 0.00651 0.00439568 0.00439568
Loa Loa (eye worm) glutamate receptor 1 0.00671045 0.00594349 0.00594349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Echinococcus multilocularis chromobox protein 2 0.119644 0.877974 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0192923 0.103096 0.117425
Echinococcus multilocularis Chromo domain 0.00624902 0.00238053 0.00271139
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0113535 0.0417957 0.0762345
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Echinococcus granulosus cathepsin b 0.0769428 0.548251 0.624451
Plasmodium falciparum heterochromatin protein 1 0.00624902 0.00238053 0.0230904
Loa Loa (eye worm) hypothetical protein 0.0138795 0.0613003 0.0613003
Entamoeba histolytica cysteine proteinase, putative 0.0113535 0.0417957 0.405405
Echinococcus granulosus cathepsin L cysteine proteinase 0.0192923 0.103096 0.117425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192923 0.103096 0.457363
Plasmodium vivax vivapain-2 0.0192923 0.103096 1
Plasmodium vivax hypothetical protein, conserved 0.00624902 0.00238053 0.0230904
Loa Loa (eye worm) integrin beta-2 0.0709569 0.50203 0.50203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Entamoeba histolytica cysteine proteinase, putative 0.0113535 0.0417957 0.405405
Trypanosoma cruzi cysteine proteinase, putative 0.0113535 0.0417957 0.0762345
Loa Loa (eye worm) hypothetical protein 0.0138795 0.0613003 0.0613003
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0192923 0.103096 0.457363
Trypanosoma cruzi cysteine peptidase, putative 0.0192923 0.103096 0.188045
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Onchocerca volvulus 0.0192923 0.103096 0.983526
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0178264 0.0917765 0.104532
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00702284 0.00835565 0.00951698
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.00624902 0.00238053 0.0105607
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.00718473 0.00960567 0.0109407
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0192923 0.103096 0.103096
Brugia malayi Papain family cysteine protease containing protein 0.0113535 0.0417957 0.0417957
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0769428 0.548251 0.624451
Echinococcus granulosus Chromo domain 0.00624902 0.00238053 0.00271139
Schistosoma mansoni hypothetical protein 0.00699511 0.00814149 0.00927305
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.00624902 0.00238053 0.00271139
Brugia malayi Cathepsin L-like precursor 0.0192923 0.103096 0.103096
Echinococcus multilocularis cathepsin L 0.0113535 0.0417957 0.0476047
Entamoeba histolytica cysteine proteinase, putative 0.0113535 0.0417957 0.405405
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.135447 1 1
Brugia malayi chromobox protein homolog 3 0.00624902 0.00238053 0.00238053
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0351333 0.225414 0.411151
Schistosoma mansoni chromobox protein 0.00624902 0.00238053 0.00271139
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0769428 0.548251 0.624451
Schistosoma mansoni chromobox protein 0.00624902 0.00238053 0.00271139
Plasmodium falciparum cysteine proteinase falcipain 1 0.0113535 0.0417957 0.405405
Brugia malayi Peptidase family M1 containing protein 0.0153653 0.0727727 0.0727727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Loa Loa (eye worm) hypothetical protein 0.0128961 0.053707 0.053707
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0178264 0.0917765 0.104532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192923 0.103096 0.457363
Echinococcus granulosus puromycin sensitive aminopeptidase 0.00702284 0.00835565 0.00951698
Schistosoma mansoni cathepsin F (C01 family) 0.0138795 0.0613003 0.0698202
Brugia malayi CHD4 protein 0.00624902 0.00238053 0.00238053
Loa Loa (eye worm) hypothetical protein 0.00624902 0.00238053 0.00238053
Brugia malayi Tachykinin-like peptides receptor 99D 0.0385848 0.252065 0.252065
Loa Loa (eye worm) heterochromatin protein 1 0.00624902 0.00238053 0.00238053
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.00624902 0.00238053 0.0230904
Onchocerca volvulus 0.0192923 0.103096 0.983526
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.00624902 0.00238053 0.0230904
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00702284 0.00835565 0.00951698
Brugia malayi M-phase phosphoprotein, mpp8 0.00624902 0.00238053 0.00238053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113535 0.0417957 0.185418
Brugia malayi Peptidase family M1 containing protein 0.00702284 0.00835565 0.00835565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192923 0.103096 0.457363
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.00624902 0.00238053 0.0105607
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0166932 0.0830264 0.094566
Giardia lamblia Cathepsin B precursor 0.0351333 0.225414 1
Echinococcus granulosus chromobox protein 1 0.00624902 0.00238053 0.00271139
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.00624902 0.00238053 0.00271139
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.00702284 0.00835565 0.000985686
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Echinococcus multilocularis aminopeptidase N 0.0153653 0.0727727 0.0828871
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0192923 0.103096 0.117425
Echinococcus granulosus cysteine protease 0.0113535 0.0417957 0.0476047
Entamoeba histolytica hypothetical protein 0.00624902 0.00238053 0.0230904
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Echinococcus granulosus cathepsin L cysteine protease 0.0113535 0.0417957 0.0476047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113535 0.0417957 0.15406
Loa Loa (eye worm) matrixin family protein 0.0111013 0.0398477 0.0398477
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0113535 0.0417957 0.0476047
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.00624902 0.00238053 0.00271139
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.00624902 0.00238053 0.00271139
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Toxoplasma gondii kringle domain-containing protein 0.00699511 0.00814149 0.036118
Brugia malayi Angiotensin-converting enzyme family protein 0.135447 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0351333 0.225414 1
Entamoeba histolytica aminopeptidase, putative 0.00702284 0.00835565 0.0810473
Schistosoma mansoni chromodomain helicase DNA binding protein 0.00624902 0.00238053 0.00271139
Trypanosoma cruzi aminopeptidase, putative 0.00702284 0.00835565 0.0152406
Plasmodium vivax cysteine repeat modular protein 1, putative 0.00699511 0.00814149 0.07897
Echinococcus granulosus puromycin sensitive aminopeptidase 0.00702284 0.00835565 0.00951698
Onchocerca volvulus Cathepsin L homolog 0.0192923 0.103096 0.983526
Echinococcus multilocularis cathepsin L cysteine protease 0.0192923 0.103096 0.117425
Echinococcus multilocularis cysteine protease 0.0192923 0.103096 0.117425
Toxoplasma gondii cathepsin CPL 0.0192923 0.103096 0.457363
Plasmodium vivax heterochromatin protein 1, putative 0.00624902 0.00238053 0.0230904
Loa Loa (eye worm) hypothetical protein 0.00624902 0.00238053 0.00238053
Schistosoma mansoni chromobox protein 0.00624902 0.00238053 0.00271139
Onchocerca volvulus 0.0192923 0.103096 0.983526
Echinococcus granulosus puromycin sensitive aminopeptidase 0.00702284 0.00835565 0.00951698
Echinococcus multilocularis cathepsin b 0.0769428 0.548251 0.624451
Loa Loa (eye worm) hypothetical protein 0.0111405 0.0401511 0.0401511
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Schistosoma mansoni hypothetical protein 0.00624902 0.00238053 0.00271139
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.00624902 0.00238053 0.00271139
Brugia malayi SET domain containing protein 0.00624902 0.00238053 0.00238053
Entamoeba histolytica cysteine proteinase 2 0.0113535 0.0417957 0.405405
Brugia malayi Integrin beta pat-3 precursor 0.0709569 0.50203 0.50203
Brugia malayi hypothetical protein 0.0111405 0.0401511 0.0401511
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.00624902 0.00238053 0.0105607
Onchocerca volvulus Matrilysin homolog 0.0101832 0.0327587 0.312514
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.00799842 0.0158887 0.018097
Entamoeba histolytica cysteine proteinase, putative 0.0192923 0.103096 1
Loa Loa (eye worm) hypothetical protein 0.0192923 0.103096 0.103096
Trichomonas vaginalis chromobox protein, putative 0.00624902 0.00238053 0.0105607
Echinococcus granulosus tissue type plasminogen activator 0.00699511 0.00814149 0.00927305
Leishmania major cathepsin L-like protease 0.0192923 0.103096 0.43703
Brugia malayi Cathepsin L-like precursor 0.0192923 0.103096 0.103096
Onchocerca volvulus 0.0138795 0.0613003 0.584799
Plasmodium vivax hypothetical protein, conserved 0.00624902 0.00238053 0.0230904
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.00702284 0.00835565 0.0370681
Onchocerca volvulus 0.0192923 0.103096 0.983526
Onchocerca volvulus 0.0153653 0.0727727 0.694244
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.00624902 0.00238053 0.00271139
Trypanosoma brucei cysteine peptidase C (CPC) 0.0351333 0.225414 1
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Brugia malayi Cathepsin L-like precursor 0.0138795 0.0613003 0.0613003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Onchocerca volvulus 0.019516 0.104823 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113535 0.0417957 0.15406
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.00624902 0.00238053 0.0105607
Brugia malayi Glutamate receptor 1 precursor 0.00671045 0.00594349 0.00594349
Leishmania major cathepsin L-like protease 0.0192923 0.103096 0.43703
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192923 0.103096 0.457363
Brugia malayi Kelch motif family protein 0.0111405 0.0401511 0.0401511
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0192923 0.103096 1
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Loa Loa (eye worm) hypothetical protein 0.0385848 0.252065 0.252065
Onchocerca volvulus 0.00651 0.00439568 0.0419344
Leishmania major cathepsin L-like protease 0.0192923 0.103096 0.43703
Entamoeba histolytica cysteine proteinase, putative 0.0138795 0.0613003 0.594595
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.00624902 0.00238053 0.0230904
Onchocerca volvulus 0.00624902 0.00238053 0.02271
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Trichomonas vaginalis chromobox protein, putative 0.00624902 0.00238053 0.0105607
Trichomonas vaginalis chromobox protein, putative 0.00624902 0.00238053 0.0105607
Brugia malayi Kringle domain containing protein 0.00699511 0.00814149 0.00814149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192923 0.103096 0.457363
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0111405 0.0401511 0.0401511
Echinococcus multilocularis chromobox protein 1 0.00624902 0.00238053 0.00271139
Onchocerca volvulus 0.00624902 0.00238053 0.02271
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.00702284 0.00835565 0.00951698
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Echinococcus granulosus aminopeptidase N 0.0153653 0.0727727 0.0828871
Schistosoma mansoni cathepsin F (C01 family) 0.0192923 0.103096 0.117425
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00702284 0.00835565 0.00951698
Trypanosoma cruzi cysteine peptidase, putative 0.0192923 0.103096 0.188045
Schistosoma mansoni cathepsin F (C01 family) 0.0192923 0.103096 0.117425
Leishmania major cathepsin L-like protease 0.0192923 0.103096 0.43703
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.00702284 0.00835565 0.0152406
Brugia malayi Papain family cysteine protease containing protein 0.0113535 0.0417957 0.0417957
Echinococcus granulosus lysine specific histone demethylase 1A 0.0178264 0.0917765 0.104532
Schistosoma mansoni hypothetical protein 0.00651 0.00439568 0.00500662
Loa Loa (eye worm) hypothetical protein 0.0769428 0.548251 0.548251
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0351333 0.225414 1
Entamoeba histolytica hypothetical protein 0.00624902 0.00238053 0.0230904
Giardia lamblia Cathepsin B precursor 0.0351333 0.225414 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0108115 0.0376106 0.0376106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.00624902 0.00238053 0.0105607
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Brugia malayi Associated with TFs and helicases family protein 0.00624902 0.00238053 0.00238053
Trypanosoma cruzi hypothetical protein, conserved 0.00699511 0.00814149 0.0148499
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0192923 0.103096 0.117425
Echinococcus multilocularis glutamate receptor 2 0.00671045 0.00594349 0.00676955
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.00624902 0.00238053 0.0105607
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Trichomonas vaginalis chromobox protein, putative 0.00624902 0.00238053 0.0105607
Echinococcus granulosus puromycin sensitive aminopeptidase 0.00702284 0.00835565 0.00951698
Brugia malayi cathepsin B-like cysteine proteinase 0.0769428 0.548251 0.548251
Echinococcus granulosus cathepsin l1 0.0192923 0.103096 0.117425
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.00624902 0.00238053 0.0105607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138795 0.0613003 0.271946
Plasmodium falciparum cysteine repeat modular protein 1 0.00699511 0.00814149 0.07897
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0769428 0.548251 0.624451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192923 0.103096 0.457363
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00702284 0.00835565 0.00951698
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Onchocerca volvulus Heterochromatin protein 1 homolog 0.00624902 0.00238053 0.02271
Brugia malayi hypothetical protein 0.00702284 0.00835565 0.00835565
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0113535 0.0417957 0.0476047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Trichomonas vaginalis chromobox protein, putative 0.00624902 0.00238053 0.0105607
Loa Loa (eye worm) hypothetical protein 0.00624902 0.00238053 0.00238053
Trypanosoma cruzi cruzipain precursor, putative 0.0192923 0.103096 0.188045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Onchocerca volvulus 0.0192923 0.103096 0.983526
Leishmania major cathepsin L-like protease 0.0192923 0.103096 0.43703
Onchocerca volvulus 0.00624902 0.00238053 0.02271
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0192923 0.103096 0.103096
Brugia malayi Valyl-tRNA synthetase 0.00624902 0.00238053 0.00238053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.00718473 0.00960567 0.0109407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0769428 0.548251 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0769428 0.548251 0.624451
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.00624902 0.00238053 0.00271139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Brugia malayi Cathepsin L-like precursor 0.0192923 0.103096 0.103096
Brugia malayi cathepsin L-like precursor 0.0138795 0.0613003 0.0613003
Brugia malayi Cathepsin L-like precursor 0.0192923 0.103096 0.103096
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0166932 0.0830264 0.094566
Onchocerca volvulus 0.00702284 0.00835565 0.0797121
Trypanosoma cruzi cysteine peptidase, putative 0.0113535 0.0417957 0.0762345
Onchocerca volvulus Cathepsin L homolog 0.0192923 0.103096 0.983526
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.00624902 0.00238053 0.0105607
Schistosoma mansoni integrin beta subunit 0.0408119 0.269262 0.306686
Trichomonas vaginalis chromobox protein, putative 0.00624902 0.00238053 0.0105607
Echinococcus granulosus chromobox protein 2 0.119644 0.877974 1
Brugia malayi Protein kinase domain containing protein 0.00699511 0.00814149 0.00814149
Echinococcus multilocularis glutamate receptor 2 0.00718473 0.00960567 0.0109407
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Mycobacterium ulcerans aminopeptidase N PepN 0.00702284 0.00835565 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0192923 0.103096 0.188045
Loa Loa (eye worm) ctsf protein 0.0192923 0.103096 0.103096
Echinococcus granulosus chromobox protein 1 0.00624902 0.00238053 0.00271139
Brugia malayi Heterochromatin protein 1 0.00624902 0.00238053 0.00238053
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Brugia malayi Type III restriction enzyme, res subunit family protein 0.00624902 0.00238053 0.00238053
Echinococcus multilocularis glutamate receptor 2 0.00625957 0.00246195 0.00280413
Trypanosoma cruzi cysteine protease, putative 0.0113535 0.0417957 0.0762345
Brugia malayi Cathepsin L-like cysteine proteinase 0.0138795 0.0613003 0.0613003
Plasmodium vivax vivapain-2 0.0192923 0.103096 1
Trichomonas vaginalis chromobox protein, putative 0.00624902 0.00238053 0.0105607
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.00624902 0.00238053 0.0105607
Trichomonas vaginalis Heterochromatin protein, putative 0.00624902 0.00238053 0.0105607
Entamoeba histolytica cysteine proteinase, putative 0.0113535 0.0417957 0.405405
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.00702284 0.00835565 0.00951698
Loa Loa (eye worm) hypothetical protein 0.019516 0.104823 0.104823
Echinococcus multilocularis tissue type plasminogen activator 0.00699511 0.00814149 0.00927305
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Onchocerca volvulus 0.00699511 0.00814149 0.077669
Schistosoma mansoni chromodomain helicase DNA binding protein 0.00624902 0.00238053 0.00271139
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Echinococcus granulosus integrin beta 2 0.0519524 0.355285 0.404665
Leishmania major cysteine peptidase A (CPA) 0.0192923 0.103096 0.43703
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00702284 0.00835565 0.00951698
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192923 0.103096 0.436474
Brugia malayi Matrixin family protein 0.0111013 0.0398477 0.0398477
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0192923 0.103096 1
Toxoplasma gondii cathepsin B 0.0351333 0.225414 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.00624902 0.00238053 0.0105607
Echinococcus granulosus Chromobox protein 3 0.00624902 0.00238053 0.00271139
Schistosoma mansoni memapsin-2 (A01 family) 0.0852971 0.612761 0.697926
Trypanosoma cruzi cysteine proteinase, putative 0.0113535 0.0417957 0.0762345
Entamoeba histolytica cysteine protease, putative 0.0113535 0.0417957 0.405405
Leishmania major cathepsin L-like protease 0.0192923 0.103096 0.43703
Echinococcus multilocularis Chromobox protein 3 0.00624902 0.00238053 0.00271139
Loa Loa (eye worm) fibroinase 0.0192923 0.103096 0.103096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113535 0.0417957 0.185418
Trichomonas vaginalis conserved hypothetical protein 0.00624902 0.00238053 0.0105607
Onchocerca volvulus Cathepsin F homolog 0.0192923 0.103096 0.983526
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.00702284 0.00835565 0.0370681
Loa Loa (eye worm) CHromoDomain protein family member 0.00624902 0.00238053 0.00238053
Loa Loa (eye worm) cysteine protease 0.0192923 0.103096 0.103096
Onchocerca volvulus Matrix metalloproteinase homolog 0.0101832 0.0327587 0.312514
Plasmodium vivax vivapain-1 0.0113535 0.0417957 0.405405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192923 0.103096 0.457363
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.00624902 0.00238053 0.0230904

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antiparasitic activity against Trypanosoma cruzi T2 epimastigotes assessed as growth inhibition at 25 uM after 5 days ChEMBL. 20889239
IC50 (functional) = 2.7 uM Antichagasic activity against Trypanosoma cruzi Tulahuen 2 ChEMBL. 21550147
Inhibition (binding) = 57 % Inhibition of Trypanosoma cruzi triosephosphate isomerase at 100 uM after 2 hrs ChEMBL. 20889239
Inhibition (binding) = 85 % Inhibition of Trypanosoma cruzi triosephosphate isomerase at 400 uM after 2 hrs ChEMBL. 20889239

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma cruzi ChEMBL23 21550147

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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