Detailed information for compound 1463225

Basic information

Technical information
  • TDR Targets ID: 1463225
  • Name: 3,5-dibromo-2-hydroxy-N-[2-(5-methyl-2-propan -2-ylphenoxy)phenyl]benzamide
  • MW: 519.226 | Formula: C23H21Br2NO3
  • H donors: 2 H acceptors: 2 LogP: 7.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1ccc(c(c1)Oc1ccccc1NC(=O)c1cc(Br)cc(c1O)Br)C(C)C
  • InChi: 1S/C23H21Br2NO3/c1-13(2)16-9-8-14(3)10-21(16)29-20-7-5-4-6-19(20)26-23(28)17-11-15(24)12-18(25)22(17)27/h4-13,27H,1-3H3,(H,26,28)
  • InChiKey: ZKIYJUYJMILJGK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,5-dibromo-2-hydroxy-N-[2-(2-isopropyl-5-methyl-phenoxy)phenyl]benzamide
  • 3,5-dibromo-2-hydroxy-N-[2-(2-isopropyl-5-methylphenoxy)phenyl]benzamide
  • 3,5-dibromo-2-hydroxy-N-[2-(5-methyl-2-propan-2-yl-phenoxy)phenyl]benzamide
  • DivK1c_003479
  • Oprea1_501133
  • STK061800
  • ZINC02323125
  • ChemDiv1_018695
  • Oprea1_870790
  • 3,5-Dibromo-2-hydroxy-N-[2-(2-isopropyl-5-methyl-phenoxy)-phenyl]-benzamide
  • BAS 00347368
  • CDS1_002439

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major oxidoreductase-like protein 0.0097 0.0213 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0012 0.0012 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Schistosoma mansoni zinc finger protein 0.0021 0.0033 0.0051
Schistosoma mansoni cpg binding protein 0.0028 0.005 0.0079
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0094 0.0207 0.0207
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.1246 0.2946 0.4467
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0028 0.1073
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0061 0.0127 0.0705
Leishmania major GTP-binding protein, putative 0.0021 0.0033 0.1002
Onchocerca volvulus 0.0097 0.0213 1
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0012 0.0012 0.002
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.002
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0028 0.1073
Echinococcus multilocularis muscleblind protein 0.0146 0.0331 0.0331
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Schistosoma mansoni ran 0.0021 0.0033 0.0051
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0008 0.0008
Schistosoma mansoni carbonyl reductase 0.0012 0.0012 0.002
Echinococcus multilocularis sodium channel protein 0.004 0.0078 0.0078
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0411 0.096 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0135
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Brugia malayi Dehydrogenases, short chain protein 2 0.0012 0.0012 0.013
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.004 0.0078 0.0078
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.0069
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0012 0.0012 0.0012
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0008 0.0008
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0023 0.0036
Brugia malayi Ets-domain containing protein 0.0071 0.0152 0.1582
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0028 0.0293
Echinococcus multilocularis protein C ets 2 0.001 0.0008 0.0008
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.1246 0.2946 0.4616
Onchocerca volvulus 0.0028 0.005 0.2347
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0084 0.0184 0.1915
Mycobacterium tuberculosis Possible oxidoreductase 0.0084 0.0184 0.027
Onchocerca volvulus 0.0012 0.0012 0.0584
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.0339
Loa Loa (eye worm) hypothetical protein 0.0146 0.0331 0.1833
Loa Loa (eye worm) X11 protein 0.0067 0.0143 0.0792
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0115 0.0351
Trypanosoma brucei ISWI complex protein 0.0015 0.0019 0.0623
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0134
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0097 0.0213 0.0316
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0411 0.096 0.1507
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.2686 0.6368 1
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Brugia malayi hypothetical protein 0.0012 0.0012 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Schistosoma mansoni amyloid beta A4 protein related 0.0067 0.0143 0.0225
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.0012 0.0012
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0084 0.0184 0.027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0084 0.0184 0.027
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Entamoeba histolytica hypothetical protein 0.0023 0.0038 0.1467
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0028 0.0779
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0028 0.1073
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0152 0.0152
Loa Loa (eye worm) glutaminase 2 0.0268 0.062 0.3431
Brugia malayi dehydrogenases, short chain protein 2 0.0012 0.0012 0.013
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0084 0.0184 0.027
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0012 0.0012
Echinococcus multilocularis snurportin 1 0.0302 0.07 0.07
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0031 0.0173
Loa Loa (eye worm) dehydrogenase 0.0012 0.0012 0.0069
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0004 0.0021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0086 0.0477
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0024 0.0038
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0012 0.0012 0.013
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0028 0.0779
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0012 0.0012 0.0584
Echinococcus multilocularis voltage dependent calcium channel 0.0094 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.001 0.0008 0.0012
Brugia malayi transcription factor E74 isoform 0.001 0.0008 0.0079
Echinococcus granulosus cpg binding protein 0.0032 0.0058 0.0058
Echinococcus granulosus importin subunit beta 1 0.0028 0.005 0.005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Schistosoma mansoni gabp alpha 0.0071 0.0152 0.0238
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0094 0.0207 0.0325
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0028 0.1073
Schistosoma mansoni carbonyl reductase 0.0012 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Brugia malayi dehydrogenases, short chain protein 9 0.0012 0.0012 0.013
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0084 0.0184 1
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.0936 0.0936
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0012 0.0012 0.0012
Trypanosoma cruzi ISWI complex protein 0.0015 0.0019 0.0314
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0008 0.0008
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0331 0.0331
Onchocerca volvulus 0.0012 0.0012 0.0584
Echinococcus granulosus oxidoreductase 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0033 0.1002
Mycobacterium ulcerans replicative DNA helicase DnaB 0.2686 0.6368 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0028 0.1073
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0084 0.0184 0.0184
Brugia malayi oxidoreductase 0.0012 0.0012 0.013
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0012 0.0012 0.0012
Echinococcus granulosus dna polymerase eta 0.0019 0.0028 0.0028
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0084 0.0184 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0028 0.1073
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0012 0.013
Loa Loa (eye worm) fli-1 protein 0.0216 0.0495 0.2741
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0094 0.0207 0.0207
Echinococcus granulosus protein C ets 2 0.001 0.0008 0.0008
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0012 0.0012 0.0319
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0084 0.0184 0.027
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0008 0.0008
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0094 0.0207 0.2157
Brugia malayi Importin beta-1 subunit 0.0028 0.005 0.0524
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0067 0.0067
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0012 0.0012 0.0012
Echinococcus multilocularis cpg binding protein 0.0032 0.0058 0.0058
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0084 0.0184 0.027
Schistosoma mansoni Replicative DNA helicase 0.2686 0.6368 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.005 0.0277
Plasmodium vivax importin-beta 2, putative 0.0028 0.005 0.0129
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0432
Trypanosoma cruzi ISWI complex protein 0.0015 0.0019 0.0314
Brugia malayi Retinol dehydrogenase 12 0.0012 0.0012 0.013
Echinococcus multilocularis importin subunit beta 1 0.0028 0.005 0.005
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0024 0.0024
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0084 0.0184 0.027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0084 0.0184 0.027
Trypanosoma brucei oxidoreductase-like protein 0.0097 0.0213 1
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0024 0.0134
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.0401 0.0936 0.147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0084 0.0184 0.027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0084 0.0184 0.1915
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0299 0.0694 0.2323
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0084 0.0184 0.027
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.07 0.3875
Trypanosoma brucei pteridine reductase 1 0.0084 0.0184 0.8584
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0166
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0028 0.0912
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0069
Onchocerca volvulus 0.0012 0.0012 0.0584
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0084 0.0184 0.0584
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0135
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0012 0.0012 0.002
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0057 0.0119 0.5326
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0008 0.0042
Echinococcus granulosus amyloid beta A4 protein 0.0067 0.0143 0.0143
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0028 0.0044
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0084 0.0184 0.027
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0084 0.0184 0.027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0084 0.0184 0.027
Onchocerca volvulus 0.0012 0.0012 0.0584
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0008 0.0008
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0012 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.0015 0.0019 0.0314
Onchocerca volvulus 0.0012 0.0012 0.0584
Plasmodium vivax enoyl-acyl carrier protein reductase 0.1246 0.2946 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.005 0.0129
Onchocerca volvulus 0.0012 0.0012 0.0584
Brugia malayi hypothetical protein 0.0012 0.0012 0.013
Treponema pallidum replicative DNA helicase (dnaB) 0.2686 0.6368 0.5
Toxoplasma gondii transporter, cation channel family protein 0.002 0.003 0.006
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0094 0.0207 0.0325
Brugia malayi Bromodomain containing protein 0.0075 0.0162 0.1685
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0039 0.0039
Brugia malayi Muscleblind-like protein 0.0146 0.0331 0.3451
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0125 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0028 0.0779
Schistosoma mansoni hypothetical protein 0.0411 0.096 0.1507
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0012 0.0012 0.0069
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0057 0.0119 0.5475
Leishmania major importin beta-1 subunit, putative 0.0023 0.0038 0.1253
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0094 0.0207 0.0207
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0411 0.096 0.096
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.1246 0.2946 0.4616
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0008 0.0008
Echinococcus multilocularis oxidoreductase 0.0012 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0028 0.1073
Loa Loa (eye worm) oxidoreductase 0.0084 0.0184 0.1017
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0028 0.0044
Echinococcus granulosus zinc finger protein 0.0021 0.0033 0.0033
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.4214 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0411 0.096 0.1507
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0028 0.0053
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0012 0.0012 0.0584
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0084 0.0184 0.8538
Loa Loa (eye worm) dehydrogenase 0.0012 0.0012 0.0069
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.005 0.2145
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0014 0.0399
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0084 0.0184 0.027
Brugia malayi RNA, U transporter 1 0.008 0.0174 0.1815
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0014 0.0399
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0028 0.1073
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0028 0.0028
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0084 0.0184 0.027
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Mycobacterium tuberculosis Possible oxidoreductase 0.0084 0.0184 0.027
Echinococcus granulosus dnaJ subfamily B 0.0401 0.0936 0.0936
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0008 0.0008
Schistosoma mansoni ets-related 0.001 0.0008 0.0012
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0069
Echinococcus multilocularis conserved hypothetical protein 0.0012 0.0012 0.0012
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0411 0.096 0.096
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0038 0.0086
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0069
Echinococcus granulosus voltage dependent calcium channel 0.0094 0.0207 0.0207
Brugia malayi Dehydrogenases, short chain protein 30 0.0012 0.0012 0.013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Schistosoma mansoni voltage-gated cation channel 0.0094 0.0207 0.0325
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0084 0.0184 0.1017
Brugia malayi Ets-domain containing protein 0.001 0.0008 0.0079
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0028 0.1073
Schistosoma mansoni ets 0.001 0.0008 0.0012
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0008 0.0012
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0067 0.0067
Onchocerca volvulus Sepiapterin reductase homolog 0.0012 0.0012 0.0584
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0084 0.0184 0.027
Echinococcus granulosus snurportin 1 0.0302 0.07 0.07
Schistosoma mansoni elf1 0.001 0.0008 0.0012
Schistosoma mansoni cpg binding protein 0.0032 0.0058 0.0092
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.0012 0.0012
Echinococcus granulosus voltage dependent calcium channel 0.002 0.003 0.003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0028 0.0025
Schistosoma mansoni hypothetical protein 0.001 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0278
Echinococcus multilocularis dna polymerase eta 0.0019 0.0028 0.0028
Schistosoma mansoni importin beta-1 0.0028 0.005 0.0079
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Loa Loa (eye worm) apoptosis regulator protein 0.0411 0.096 0.531
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0008 0.0083
Brugia malayi glutaminase DH11.1 0.0268 0.062 0.6462
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0094 0.0207 0.0207
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0012 0.0012
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0012 0.0012 0.0319
Schistosoma mansoni apoptosis regulator bax 0.0411 0.096 0.1507
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0008 0.0042
Loa Loa (eye worm) hypothetical protein 0.0084 0.0184 0.1017
Trypanosoma brucei unspecified product 0.0013 0.0014 0.0399
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0084 0.0184 0.027
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0033 0.1289
Plasmodium falciparum enoyl-acyl carrier reductase 0.1246 0.2946 1
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0069
Onchocerca volvulus 0.0084 0.0184 0.8623
Loa Loa (eye worm) hypothetical protein 0.0065 0.0137 0.0757
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0028 0.1073
Echinococcus granulosus hypothetical protein 0.0012 0.0012 0.0012
Toxoplasma gondii hypothetical protein 0.0017 0.0024 0.0041
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0028 0.0028
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.0012 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0033 0.0069
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0069
Onchocerca volvulus 0.0012 0.0012 0.0584
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.002
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0028 0.0025
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0411 0.096 0.1507
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0028 0.0025
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.002
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.1246 0.2946 1
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0012 0.0012 0.0319
Schistosoma mansoni carbonyl reductase 0.0012 0.0012 0.002
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0084 0.0184 0.0584
Echinococcus granulosus steroid dehydrogenase 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0146 0.0331 0.1833
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Echinococcus multilocularis voltage dependent calcium channel 0.0094 0.0207 0.0207
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.005 0.2145
Trichomonas vaginalis ran, putative 0.0021 0.0033 0.0069
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0152 0.084
Chlamydia trachomatis replicative DNA helicase 0.2686 0.6368 1
Schistosoma mansoni hypothetical protein 0.002 0.0031 0.0049
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0097 0.0213 0.0684
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0084 0.0184 0.027
Echinococcus multilocularis zinc finger protein 0.0021 0.0033 0.0033
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0008 0.0008
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0008 0.0008
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.002
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0069
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0012 0.0012
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.0012 0.0012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0097 0.0213 0.0316
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0097 0.0213 1
Schistosoma mansoni cpg binding protein 0.0032 0.0058 0.0092
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0012 0.0319
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.0012 0.0012
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0084 0.0184 0.027
Schistosoma mansoni zinc finger protein 0.0015 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0094 0.0207 0.1146
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0008 0.0042
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0084 0.0184 0.8538
Echinococcus granulosus dna polymerase kappa 0.0019 0.0028 0.0028
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.002
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0023 0.0023
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.0012 0.0012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0084 0.0184 0.027
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0012 0.0012 0.002
Schistosoma mansoni dihydropteridine reductase 0.0084 0.0184 0.0289
Schistosoma mansoni ran 0.0021 0.0033 0.0051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0084 0.0184 0.8538
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0084 0.0184 0.8538
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.0012 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.003 0.0166
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.0012 0.0012
Brugia malayi CXXC zinc finger family protein 0.0028 0.005 0.0521
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0012 0.0319
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0069
Trypanosoma brucei unspecified product 0.0013 0.0014 0.0399
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0152 0.0152
Brugia malayi PHD-finger family protein 0.0026 0.0045 0.0469
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0024 0.0024
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0084 0.0184 0.0584
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.2686 0.6368 1
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Brugia malayi hypothetical protein 0.0065 0.0137 0.1426
Schistosoma mansoni bromodomain containing protein 0.0064 0.0134 0.0211
Onchocerca volvulus 0.0012 0.0012 0.0584
Entamoeba histolytica Ran family GTPase 0.0021 0.0033 0.1174
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0042
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0008 0.0008
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0012 0.0319
Schistosoma mansoni DNA polymerase eta 0.0019 0.0028 0.0044
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0023 0.0036
Trichomonas vaginalis hypothetical protein 0.1246 0.2946 1
Schistosoma mansoni ets-related 0.0216 0.0495 0.0778
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0094 0.0207 0.0207
Loa Loa (eye worm) calcium channel 0.0094 0.0207 0.1146
Giardia lamblia DINP protein human, muc B family 0.0019 0.0028 0.7771
Brugia malayi Fli-1 protein 0.0216 0.0495 0.5163
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.002
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Leishmania major DNA polymerase kappa, putative 0.0019 0.0028 0.0779
Leishmania major DNA polymerase eta, putative 0.0019 0.0028 0.0779
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0084 0.0184 0.027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0097 0.0213 0.0316
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0012 0.0012 0.0319
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0126 0.0126
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0028 0.0293
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0069
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0094 0.0207 0.0207
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0012 0.0319
Trichomonas vaginalis glutaminase, putative 0.0268 0.062 0.2071
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0023 0.0023
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.1246 0.2946 0.4616
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0024 0.0038
Brugia malayi Bromodomain containing protein 0.0038 0.0072 0.0754
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0028 0.0155
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0213 0.0316
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0008 0.0042
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Brugia malayi Ets-domain containing protein 0.0071 0.0152 0.1582
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.2686 0.6368 1
Loa Loa (eye worm) twinkle helicase 0.0767 0.1807 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0126 0.0126
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0038 0.0086
Loa Loa (eye worm) glutaminase 0.0268 0.062 0.3431
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.1246 0.2946 0.4616
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0033 0.0033
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.018
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0012 0.0012
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0039 0.0039
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0012 0.0012 0.0319
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0039 0.0062
Schistosoma mansoni hypothetical protein 0.0302 0.07 0.11
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0028 0.1073
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0401
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0028 0.0779
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0028 0.1073
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Echinococcus multilocularis amyloid beta A4 protein 0.0067 0.0143 0.0143
Echinococcus multilocularis retinol dehydrogenase 13 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0155
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0084 0.0184 0.0184
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0012 0.0012 0.002
Echinococcus granulosus hypothetical protein 0.0012 0.0012 0.0012
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0033 0.0069
Mycobacterium ulcerans short chain dehydrogenase 0.0097 0.0213 0.0316
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0038 0.1253
Loa Loa (eye worm) hypothetical protein 0.0411 0.096 0.531
Echinococcus granulosus WW domain containing oxidoreductase 0.0012 0.0012 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0028 0.1073
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0084 0.0184 0.0289
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0012 0.0012 0.0584
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0084 0.0184 0.027
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0012 0.0012
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0028 0.0779
Schistosoma mansoni retinal dehydrogenase 0.0012 0.0012 0.002
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0012 0.0319
Schistosoma mansoni glutaminase 0.0268 0.062 0.0974
Echinococcus granulosus muscleblind protein 0.0146 0.0331 0.0331
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0028 0.0025
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0084 0.0184 0.8538
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Onchocerca volvulus 0.0012 0.0012 0.0584
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0084 0.0184 0.8584
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0012 0.0012 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0028 0.0779
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0028 0.0028
Onchocerca volvulus 0.0012 0.0012 0.0584
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.006 0.0126 0.1316
Plasmodium falciparum importin beta, putative 0.0028 0.005 0.0129
Mycobacterium ulcerans glutaminase 0.0268 0.062 0.0956
Mycobacterium ulcerans oxidoreductase 0.0084 0.0184 0.027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Mycobacterium ulcerans short chain dehydrogenase 0.0084 0.0184 0.027
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0028 0.0053
Echinococcus multilocularis ets variant gene 4 0.001 0.0008 0.0008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0033 0.1002
Leishmania major pteridine reductase 1 0.0097 0.0213 1
Echinococcus multilocularis transient receptor potential cation channel 0.0012 0.0012 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Trypanosoma brucei unspecified product 0.0019 0.0028 0.1073
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.013
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0038 0.0086
Loa Loa (eye worm) retinol dehydrogenase 12 0.0084 0.0184 0.1017
Loa Loa (eye worm) hypothetical protein 0.0069 0.0148 0.0818
Onchocerca volvulus 0.0012 0.0012 0.0584
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0012 0.0012 0.0012
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0008 0.0008
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.002
Onchocerca volvulus 0.0012 0.0012 0.0584
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0069
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0094 0.0207 0.0207
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0084 0.0184 0.0584
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0084 0.0184 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0028 0.1073
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0014 0.0399

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 8 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 29213 after 18 to 24 hrs by alamar blue assay ChEMBL. 21075637

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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