Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Metabotropic glutamate receptor 2 | 872 aa | 774 aa | 20.4 % | |
Onchocerca volvulus | Cell death abnormality protein 8 homolog | Metabotropic glutamate receptor 2 | 872 aa | 883 aa | 43.3 % |
Onchocerca volvulus | Golgi-associated plant pathogenesis-related protein 1 homolog | Metabotropic glutamate receptor 2 | 872 aa | 884 aa | 35.3 % |
Schistosoma mansoni | metabotropic glutamate receptor | Metabotropic glutamate receptor 2 | 872 aa | 892 aa | 26.9 % |
Loa Loa (eye worm) | hypothetical protein | Metabotropic glutamate receptor 2 | 872 aa | 822 aa | 21.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.1408 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0963 | 0.6809 | 0.6691 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0065 | 0.0356 | 1 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.1408 | 1 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0061 | 0.0327 | 0.917 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.1408 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0963 | 0.6809 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0024 | 0.006 | 0.0217 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0073 | 0.041 | 0.0056 |
Loa Loa (eye worm) | glutamate receptor | 0.0061 | 0.0327 | 0.1176 |
Onchocerca volvulus | 0.0073 | 0.041 | 1 | |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0963 | 0.6809 | 0.6691 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0073 | 0.041 | 0.0084 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0065 | 0.0356 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0073 | 0.041 | 0.0056 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0963 | 0.6809 | 0.6691 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0073 | 0.041 | 0.0056 |
Plasmodium vivax | multidrug resistance-associated protein 1, putative | 0.0297 | 0.2023 | 0.2583 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0069 | 0.0387 | 0.0288 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0073 | 0.041 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0963 | 0.6809 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.0255 | 0.0155 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0963 | 0.6809 | 0.6691 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0073 | 0.041 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0055 | 0.0285 | 0.801 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0065 | 0.0356 | 0.1283 |
Leishmania major | pteridine reductase 1 | 0.0073 | 0.041 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0963 | 0.6809 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0065 | 0.0356 | 0.0257 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0065 | 0.0356 | 0.5838 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0356 | 0.1283 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.1408 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0075 | 0.0428 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0075 | 0.0428 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0073 | 0.041 | 0.0056 |
Leishmania major | oxidoreductase-like protein | 0.0073 | 0.041 | 1 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.1408 | 1 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0065 | 0.0356 | 0.5838 |
Schistosoma mansoni | Replicative DNA helicase | 0.1408 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0963 | 0.6809 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0065 | 0.0356 | 0.1283 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0428 | 0.1542 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0065 | 0.0356 | 0.0257 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0073 | 0.041 | 0.0056 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.003 | 0.0101 | 0.2849 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0065 | 0.0356 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0065 | 0.0356 | 0.1283 |
Loa Loa (eye worm) | twinkle helicase | 0.0402 | 0.2777 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0963 | 0.6809 | 0.6691 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.014 uM | Partial displacement of [3H]LY354740 from recombinant rat mGluR2 | ChEMBL. | 20971004 |
IC50 (functional) | = 0.16 uM | Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP production | ChEMBL. | 20971004 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.