Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Platelet activating factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.8478 | 0.8478 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.8478 | 0.8478 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.8478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2676 | 0.2676 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.8478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.2676 | 0.3156 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0487 | 0.0487 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.2676 | 0.2676 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.001 | 0 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.0487 | 0.0575 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.8478 | 0.8478 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0487 | 0.0575 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0487 | 0.0487 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0.0487 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0487 | 0.0575 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0149 | 1 | 1 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.001 | 0 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0487 | 0.0487 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0487 | 0.0575 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0487 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0487 | 0.0575 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.2676 | 0.3156 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.2676 | 0.3156 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.8478 | 0.8478 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.2676 | 0.3156 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0487 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.2676 | 0.2676 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.7943 | 0.7943 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0487 | 1 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.2676 | 0.3156 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0487 | 1 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.2676 | 0.3156 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.8478 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.2676 | 0.3156 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0.0487 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.2676 | 0.2676 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0487 | 0.0575 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.8478 | 1 |
Entamoeba histolytica | hypothetical protein | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0487 | 0.0575 |
Chlamydia trachomatis | DNA ligase | 0.001 | 0 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0.0487 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.661 | 0.661 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.8478 | 0.8478 |
Brugia malayi | RNA binding protein | 0.0128 | 0.8478 | 0.8478 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.8478 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.8478 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.8478 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0.0487 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.2676 | 0.3156 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.2676 | 0.3156 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0102 | 0.661 | 0.661 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.7943 | 0.7943 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0 | 0.5 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.7943 | 0.7943 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0149 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0.0487 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0487 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.661 | 0.7796 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.2676 | 0.3156 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 uM | In vitro inhibitory activity against PAF receptor using [3H]-PAF as radioligand in rabbit platelets | ChEMBL. | 9651167 |
IC50 (binding) | = 1.6 uM | In vitro inhibitory activity against PAF receptor using [3H]-PAF as radioligand in rabbit platelets | ChEMBL. | 9651167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.