Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0996 | 0.5738 | 0.9224 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0201 | 0.0982 | 0.1579 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0201 | 0.0982 | 0.1553 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0996 | 0.5738 | 0.9224 |
Echinococcus granulosus | protein kinase C gamma type | 0.0794 | 0.4531 | 0.7277 |
Brugia malayi | diacylglycerol kinase | 0.0201 | 0.0982 | 0.1579 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0285 | 0.1482 | 0.2382 |
Brugia malayi | diacylglycerol kinase | 0.0201 | 0.0982 | 0.1579 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.2063 | 0.2063 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0285 | 0.1482 | 0.1482 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0227 | 0.1136 | 0.1801 |
Onchocerca volvulus | 0.1423 | 0.8294 | 1 | |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0201 | 0.0982 | 0.1553 |
Schistosoma mansoni | unc-13 (munc13) | 0.0227 | 0.1136 | 0.1826 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0484 | 0.2672 | 0.4278 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.1076 | 0.622 | 0.622 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0982 | 0.0982 |
Entamoeba histolytica | protein kinase, putative | 0.0285 | 0.1482 | 0.4611 |
Loa Loa (eye worm) | hypothetical protein | 0.1423 | 0.8294 | 0.8294 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0082 | 0.0132 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0285 | 0.1482 | 0.2359 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0996 | 0.5738 | 0.9222 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0082 | 0.0102 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0082 | 0.0132 |
Brugia malayi | Ras association domain family 1 isoform A | 0.0201 | 0.0982 | 0.1579 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0082 | 0.0102 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0208 | 0.1019 | 0.1019 |
Brugia malayi | Protein kinase domain containing protein | 0.0285 | 0.1482 | 0.2382 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0201 | 0.0982 | 0.6584 |
Entamoeba histolytica | protein kinase, putative | 0.0285 | 0.1482 | 0.4611 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0042 | 0.0028 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1136 | 0.1136 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.0019 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0285 | 0.1482 | 0.2382 |
Schistosoma mansoni | serine/threonine kinase | 0.0285 | 0.1482 | 0.2382 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0285 | 0.1482 | 0.1482 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0982 | 0.0982 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0042 | 0.0028 | 0.0015 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0689 | 0.3901 | 0.626 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0285 | 0.1482 | 0.1482 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0484 | 0.2672 | 0.4278 |
Entamoeba histolytica | protein kinase, putative | 0.0285 | 0.1482 | 0.4611 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0484 | 0.2672 | 0.4278 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0042 | 0.0028 | 0.0015 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0285 | 0.1482 | 0.2359 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0104 | 0.0167 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0082 | 0.0102 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0279 | 0.1445 | 0.9748 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0208 | 0.1019 | 0.1019 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0019 | 0.0019 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0285 | 0.1482 | 0.2359 |
Echinococcus granulosus | protein kinase c eta type | 0.0201 | 0.0982 | 0.1553 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0996 | 0.5738 | 0.9222 |
Toxoplasma gondii | AGC kinase | 0.0285 | 0.1482 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0285 | 0.1482 | 0.2359 |
Echinococcus multilocularis | N chimaerin | 0.0201 | 0.0982 | 0.1553 |
Schistosoma mansoni | rac gtpase activating protein | 0.0201 | 0.0982 | 0.1579 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0019 | 0.5 |
Brugia malayi | RhoGAP domain containing protein | 0.0201 | 0.0982 | 0.1579 |
Loa Loa (eye worm) | hypothetical protein | 0.0685 | 0.3878 | 0.3878 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0201 | 0.0982 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0982 | 0.0982 |
Brugia malayi | Hr1 repeat family protein | 0.0285 | 0.1482 | 0.2382 |
Brugia malayi | protein kinase C3,putative | 0.0208 | 0.1019 | 0.1638 |
Echinococcus granulosus | protein kinase c epsilon type | 0.1076 | 0.622 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1423 | 0.8294 | 0.8294 |
Brugia malayi | protein kinase C II. | 0.1076 | 0.622 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.1076 | 0.622 | 1 |
Echinococcus granulosus | N chimaerin | 0.0201 | 0.0982 | 0.1553 |
Echinococcus granulosus | protein kinase c iota type | 0.0486 | 0.2688 | 0.4304 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.2672 | 0.2672 |
Brugia malayi | Protein kinase domain containing protein | 0.0285 | 0.1482 | 0.2382 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0042 | 0.0028 | 0.0015 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0201 | 0.0982 | 0.0982 |
Onchocerca volvulus | 0.0227 | 0.1136 | 0.134 | |
Brugia malayi | Inositol-1 | 0.0041 | 0.0019 | 0.003 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0285 | 0.1482 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0201 | 0.0982 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0982 | 0.0982 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0201 | 0.0982 | 0.1553 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.057 | 0.3191 | 0.5116 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0201 | 0.0982 | 0.0982 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.057 | 0.3191 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Echinococcus granulosus | myotubularin protein 13 | 0.0201 | 0.0982 | 0.1553 |
Echinococcus multilocularis | protein kinase c iota type | 0.0486 | 0.2688 | 0.4304 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0201 | 0.0982 | 0.1579 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0285 | 0.1482 | 0.1482 |
Brugia malayi | Protein kinase domain containing protein | 0.0285 | 0.1482 | 0.2382 |
Echinococcus multilocularis | solute carrier family 5 | 0.0042 | 0.0028 | 0.0015 |
Loa Loa (eye worm) | raf kinase | 0.0201 | 0.0982 | 0.0982 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0285 | 0.1482 | 0.2382 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0285 | 0.1482 | 0.2382 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0208 | 0.1019 | 0.1612 |
Onchocerca volvulus | 0.0201 | 0.0982 | 0.1154 | |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0285 | 0.1482 | 0.2382 |
Schistosoma mansoni | unc-13 (munc13) | 0.0227 | 0.1136 | 0.1826 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0019 | 0.003 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0285 | 0.1482 | 0.2359 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0285 | 0.1482 | 0.2359 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0982 | 0.0982 |
Brugia malayi | Pleckstrin Homology Domain | 0.0201 | 0.0982 | 0.1579 |
Brugia malayi | C1-like domain containing protein | 0.0208 | 0.1019 | 0.1638 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.0019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1423 | 0.8294 | 0.8294 |
Schistosoma mansoni | sodium/solute symporter | 0.0042 | 0.0028 | 0.0045 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0019 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.0042 | 0.0028 | 0.0045 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0382 | 0.2063 | 0.3297 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0982 | 0.0982 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0201 | 0.0982 | 0.3036 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0382 | 0.2063 | 0.3297 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0285 | 0.1482 | 0.1482 |
Brugia malayi | Sodium:solute symporter family protein | 0.0042 | 0.0028 | 0.0045 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0516 | 0.2862 | 0.2862 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0201 | 0.0982 | 0.1553 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0082 | 0.0102 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0201 | 0.0982 | 0.1579 |
Schistosoma mansoni | atypical protein kinase C | 0.0486 | 0.2688 | 0.4321 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0982 | 0.0982 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0208 | 0.1019 | 0.1638 |
Schistosoma mansoni | high-affinity choline transporter | 0.0382 | 0.2063 | 0.3317 |
Entamoeba histolytica | protein kinase, putative | 0.0285 | 0.1482 | 0.4611 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Brugia malayi | RhoGAP domain containing protein | 0.0201 | 0.0982 | 0.1579 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0201 | 0.0982 | 0.0982 |
Schistosoma mansoni | protein kinase C mu | 0.0201 | 0.0982 | 0.1579 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0082 | 0.0132 |
Schistosoma mansoni | protein kinase C | 0.0227 | 0.1136 | 0.1826 |
Schistosoma mansoni | vav2 | 0.0201 | 0.0982 | 0.1579 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0849 | 0.486 | 0.7807 |
Brugia malayi | GH02984p | 0.0382 | 0.2063 | 0.3317 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0208 | 0.1019 | 0.1638 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0982 | 0.0982 |
Brugia malayi | RhoGEF domain containing protein | 0.0201 | 0.0982 | 0.1579 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0201 | 0.0982 | 0.1579 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0042 | 0.0028 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0982 | 0.0982 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0201 | 0.0982 | 0.3036 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0227 | 0.1136 | 0.1801 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0208 | 0.1019 | 0.1612 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0104 | 0.0167 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0042 | 0.0028 | 0.0015 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0019 | 0.003 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0285 | 0.1482 | 0.1482 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0019 | 0.5 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0285 | 0.1482 | 0.1482 |
Echinococcus granulosus | solute carrier family 5 | 0.0042 | 0.0028 | 0.0015 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0201 | 0.0982 | 0.1579 |
Echinococcus multilocularis | protein kinase c eta type | 0.0201 | 0.0982 | 0.1553 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0042 | 0.0028 | 0.0015 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1076 | 0.622 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0104 | 0.0104 |
Onchocerca volvulus | 0.0201 | 0.0982 | 0.1154 | |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0201 | 0.0982 | 0.3036 |
Schistosoma mansoni | protein kinase C mu | 0.0208 | 0.1019 | 0.1638 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0227 | 0.1136 | 0.1801 |
Brugia malayi | Protein kinase domain containing protein | 0.0208 | 0.1019 | 0.1638 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0201 | 0.0982 | 0.1553 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0201 | 0.0982 | 0.1553 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0201 | 0.0982 | 0.0982 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0208 | 0.1019 | 0.1638 |
Schistosoma mansoni | inositol transporter | 0.0042 | 0.0028 | 0.0045 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0042 | 0.0028 | 0.0063 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0794 | 0.4531 | 0.7277 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0285 | 0.1482 | 0.2359 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0082 | 0.0132 |
Brugia malayi | Protein kinase c protein 2 | 0.0717 | 0.4068 | 0.6541 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0285 | 0.1482 | 0.2359 |
Echinococcus granulosus | NDR protein kinase | 0.0285 | 0.1482 | 0.2359 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0201 | 0.0982 | 0.1553 |
Schistosoma mansoni | hypothetical protein | 0.0201 | 0.0982 | 0.1579 |
Trichomonas vaginalis | AGC family protein kinase | 0.0285 | 0.1482 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1624 | 0.95 | 0.95 |
Echinococcus granulosus | unc 13 munc13 | 0.0227 | 0.1136 | 0.1801 |
Brugia malayi | Variant SH3 domain containing protein | 0.0201 | 0.0982 | 0.1579 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0285 | 0.1482 | 0.2359 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 88.5 % | Cytotoxicity against human MRC5 cells assessed as metabolic active cells at 100 uM after 72 hrs by XTT assay relative to control | ChEMBL. | 21106378 |
Activity (ADMET) | = 94.9 % | Cytotoxicity against human MRC5 cells assessed as metabolic active cells at 30 uM after 72 hrs by XTT assay relative to control | ChEMBL. | 21106378 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.