Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.2913 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2913 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2913 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0492 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2913 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0492 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2913 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2913 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0492 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0492 | 0 | 0.5 |
Onchocerca volvulus | 0.0492 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.2913 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2913 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0492 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2913 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2913 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2913 | 1 | 1 |
Onchocerca volvulus | 0.0492 | 0 | 0.5 | |
Onchocerca volvulus | 0.0492 | 0 | 0.5 | |
Onchocerca volvulus | 0.0492 | 0 | 0.5 | |
Onchocerca volvulus | 0.0492 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0492 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2913 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | < 1 % | Cytotoxicity against human HepG2 cells assessed as cell viability at 25 uM after 24 hrs by MTS assay | ChEMBL. | 21094049 |
Activity (functional) | < 1 % | Cytotoxicity against human HT-29 cells assessed as cell viability at 25 uM after 24 hrs by MTS assay | ChEMBL. | 21094049 |
Activity (functional) | < 1 % | Cytotoxicity against human MCF7 cells assessed as cell viability at 25 uM after 24 hrs by MTS assay | ChEMBL. | 21094049 |
Activity (functional) | = 100 % | Cytotoxicity against human HepG2 cells at 25 uM after 24 hrs by MTS assay | ChEMBL. | 21094049 |
Activity (functional) | = 100 % | Cytotoxicity against human HT-29 cells at 25 uM after 24 hrs by MTS assay | ChEMBL. | 21094049 |
Activity (functional) | = 100 % | Cytotoxicity against human MCF7 cells at 25 uM after 24 hrs by MTS assay | ChEMBL. | 21094049 |
IC50 (functional) | = 2.6 uM | Cytotoxicity against human HT-29 cells after 24 hrs by MTS assay | ChEMBL. | 21094049 |
IC50 (functional) | = 6 uM | Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay | ChEMBL. | 21094049 |
IC50 (functional) | = 7.1 uM | Cytotoxicity against human MCF7 cells after 24 hrs by MTS assay | ChEMBL. | 21094049 |
Inhibition (binding) | = 5.8 % | Inhibition of human recombinant DNA topoisomerase 2alpha-mediated DNA cleavage assessed as decrease in relaxation of supercoiled plasmid substrate DNA at 100 uM after 30 mins by agarose gel electrophoresis | ChEMBL. | 21094049 |
Inhibition (binding) | = 36.9 % | Inhibition of human recombinant DNA topoisomerase 1-mediated DNA cleavage assessed as decrease in relaxation of supercoiled plasmid substrate DNA at 100 uM after 30 mins by agarose gel electrophoresis | ChEMBL. | 21094049 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21094049 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.