Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | growth factor receptor-bound protein 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase | 0.0264 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0264 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0264 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0264 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0082 | 0.2944 | 0.2944 |
Leishmania major | hexokinase, putative | 0.0264 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0264 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0264 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3031 | 0.3031 |
Echinococcus multilocularis | hexokinase type 2 | 0.0264 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0264 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0264 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0264 | 1 | 0.5 |
Onchocerca volvulus | 0.0264 | 1 | 1 | |
Echinococcus granulosus | hexokinase | 0.0264 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0264 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0165 | 0.6192 | 0.6192 |
Leishmania major | hexokinase, putative | 0.0264 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0264 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0082 | 0.2944 | 0.2944 |
Onchocerca volvulus | 0.0264 | 1 | 1 | |
Plasmodium falciparum | hexokinase | 0.0264 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0264 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0264 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0264 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0264 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0264 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0084 | 0.3031 | 0.3031 |
Trypanosoma brucei | hexokinase | 0.0264 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0264 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.6751 | 0.6751 |
Loa Loa (eye worm) | hexokinase | 0.0165 | 0.6192 | 0.6192 |
Onchocerca volvulus | 0.0264 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3031 | 0.3031 |
Echinococcus multilocularis | hexokinase | 0.0264 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 0.45 degrees C | Binding affinity to human GRB7 SH2-apo domain expressed in Escherichia coli BL21 (DE3) assessed as change in melting temperature at 100 uM by thermofluor based melting point shift assay | ChEMBL. | 21134757 |
Delta Tm (binding) | = 1.45 degrees C | Binding affinity to human GRB7 SH2-apo domain expressed in Escherichia coli BL21 (DE3) assessed as change in melting temperature at 200 uM by thermofluor based melting point shift assay | ChEMBL. | 21134757 |
GI50 (functional) | -4.521 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.375 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.363 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.291 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.136 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Kd (binding) | = 3.06 uM | Binding affinity to human GRB7 expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry | ChEMBL. | 21134757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.