TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 398.457 | Formula: C24H22N4O2
H donors: 0 H acceptors: 3 LogP: 3.16 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1C#Cc1ccccc1)C(=O)N1CCN(CC1)c1cnccn1
InChi: 1S/C24H22N4O2/c1-30-22-10-9-21(17-20(22)8-7-19-5-3-2-4-6-19)24(29)28-15-13-27(14-16-28)23-18-25-11-12-26-23/h2-6,9-12,17-18H,13-16H2,1H3
InChiKey: TXOGQEKHNHEKSN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Metabotropic glutamate receptor 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0076	1	1
Brugia malayi	Cathepsin L-like precursor	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.5175	0.5061
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.3303	0.3303
Onchocerca volvulus		0.0076	1	1
Loa Loa (eye worm)	glutamate receptor	0.0049	0.4833	0.4712
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0041	0.3303	0.0537
Leishmania major	cathepsin L-like protease	0.0076	1	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0076	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0076	1	1
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0229	0.0229
Echinococcus multilocularis	cathepsin L cysteine protease	0.0076	1	1
Onchocerca volvulus		0.0076	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0039	0.2923	0.2923
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0051	0.5175	0.5175
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0076	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.2923	0.2923
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.0229	0.0229
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0051	0.5175	0.5175
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0044	0.3947	0.3947
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.2923	0.2923
Plasmodium vivax	vivapain-2	0.0076	1	1
Plasmodium vivax	vivapain-3	0.0039	0.2923	0.2757
Onchocerca volvulus		0.0076	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Brugia malayi	cathepsin L-like precursor	0.0051	0.5175	0.5175
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0076	1	1
Loa Loa (eye worm)	ctsf protein	0.0076	1	1
Echinococcus granulosus	cathepsin l1	0.0076	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.5175	0.5061
Brugia malayi	Papain family cysteine protease containing protein	0.0076	1	1
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0049	0.4833	0.4833
Onchocerca volvulus		0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.5175	0.5061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0076	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0076	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0039	0.2923	0.2757
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	1	1
Echinococcus multilocularis	cysteine protease	0.0076	1	1
Onchocerca volvulus		0.0076	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0039	0.2923	0.2757
Leishmania major	cathepsin L-like protease	0.0076	1	0.5
Schistosoma mansoni	cathepsin s	0.0025	0.0229	0.0229
Trypanosoma cruzi	cysteine peptidase, putative	0.0039	0.2923	0.2757
Plasmodium vivax	unspecified product	0.0039	0.2923	0.2757
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	1	1
Echinococcus multilocularis	cysteine protease	0.0076	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0076	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0051	0.5175	0.5061
Echinococcus granulosus	metabotropic glutamate receptor 5	0.006	0.7012	0.5778
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0076	1	1
Leishmania major	cathepsin L-like protease	0.0076	1	0.5
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0025	0.0229	0.0229
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Brugia malayi	Cathepsin L-like precursor	0.0076	1	1
Brugia malayi	Cathepsin L-like precursor	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	1	1
Brugia malayi	Cathepsin L-like precursor	0.0051	0.5175	0.5175
Leishmania major	cathepsin L-like protease	0.0076	1	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0076	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	1	1
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0056	0.6125	0.6125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0039	0.2923	0.2923
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.7012	0.6942
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Loa Loa (eye worm)	cysteine protease	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0051	0.5175	0.3182
Trypanosoma cruzi	cysteine protease, putative	0.0039	0.2923	0.2757
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Echinococcus granulosus	cathepsin l1	0.0051	0.5175	0.3182
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0041	0.3303	0.0537
Toxoplasma gondii	cathepsin CPL	0.0076	1	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0039	0.2923	0.2757
Onchocerca volvulus	Cathepsin F homolog	0.0076	1	1
Onchocerca volvulus		0.0076	1	1
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.006	0.7012	0.5778
Brugia malayi	Cathepsin L-like precursor	0.0051	0.5175	0.5175
Brugia malayi	Cathepsin L-like precursor	0.0076	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0076	1	0.5
Loa Loa (eye worm)	fibroinase	0.0076	1	1
Onchocerca volvulus		0.0076	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	1	1
Leishmania major	cathepsin L-like protease	0.0076	1	0.5
Brugia malayi	Cathepsin L-like precursor	0.0076	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0051	0.5175	0.3182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0076	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Plasmodium vivax	vivapain-2	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Plasmodium vivax	vivapain-1	0.0039	0.2923	0.2757
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0051	0.5175	0.3182
Entamoeba histolytica	cysteine protease, putative	0.0076	1	1
Leishmania major	cathepsin L-like protease	0.0076	1	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.2923	0.2923
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1
Leishmania major	cathepsin L-like protease	0.0076	1	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0076	1	1
Leishmania major	cathepsin L-like protease	0.0076	1	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)		Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assay	ChEMBL.	21126874
Inhibition (ADMET)	= 7 %	Inhibition of CYP2D6 at 3 uM	ChEMBL.	21126874
Inhibition (ADMET)	= 34 %	Inhibition of CYP2C9 at 3 uM	ChEMBL.	21126874
Inhibition (ADMET)	= 62 %	Inhibition of CYP3A4 at 3 uM	ChEMBL.	21126874
Ki (binding)	= 27 nM	Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cells	ChEMBL.	21126874

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1645013

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1464088