Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | pyridoxal-phosphate dependent superfamily protein | 0.0136 | 0.4136 | 1 |
Schistosoma mansoni | threonine dehydratase/deaminase | 0.0034 | 0.0615 | 0.0256 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0831 | 0.0613 |
Loa Loa (eye worm) | cbs-prov protein | 0.0136 | 0.4136 | 0.4136 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0594 | 0.0594 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0136 | 0.4136 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0594 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0831 | 0.0831 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0136 | 0.4136 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0136 | 0.4136 | 0.4424 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0831 | 1 |
Giardia lamblia | Threonine dehydratase lateral transfer candidate | 0.0034 | 0.0615 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0831 | 0.0831 |
Chlamydia trachomatis | tryptophan synthase subunit beta | 0.0034 | 0.0615 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0831 | 0.028 |
Echinococcus granulosus | l serine dehydratase:l threonine deaminase | 0.0034 | 0.0615 | 0.0195 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0136 | 0.4136 | 0.4424 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0464 | 0.0464 |
Schistosoma mansoni | integrin beta subunit | 0.018 | 0.566 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0232 | 0.7464 | 0.7464 |
Echinococcus multilocularis | integrin beta 2 | 0.0227 | 0.7264 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0257 | 0.8308 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0831 | 0.0613 |
Brugia malayi | beta-lactamase | 0.004 | 0.0831 | 0.0831 |
Onchocerca volvulus | 0.004 | 0.0831 | 0.0431 | |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0831 | 0.028 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0831 | 0.0271 |
Onchocerca volvulus | 0.004 | 0.0831 | 0.0431 | |
Schistosoma mansoni | cysteine synthase | 0.0136 | 0.4136 | 0.7056 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0831 | 0.028 |
Schistosoma mansoni | cysteine synthase | 0.0136 | 0.4136 | 0.7056 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0594 | 0.0164 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0831 | 0.0271 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0136 | 0.4136 | 0.4424 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0831 | 0.0831 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0831 | 0.0613 |
Mycobacterium tuberculosis | Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) | 0.0136 | 0.4136 | 0.4576 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0831 | 0.0831 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0831 | 0.0271 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0136 | 0.4136 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0136 | 0.4136 | 0.4424 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0831 | 0.0831 |
Trypanosoma cruzi | cysteine synthase, putative | 0.0136 | 0.4136 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0483 | 0.0483 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0831 | 0.0271 |
Mycobacterium leprae | Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) | 0.0136 | 0.4136 | 1 |
Brugia malayi | Pyridoxal-phosphate dependent enzyme family protein | 0.0136 | 0.4136 | 0.4136 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0232 | 0.7464 | 0.7464 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0136 | 0.4136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1047 | 0.1047 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0594 | 0.0164 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0831 | 0.0613 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0136 | 0.4136 | 1 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0046 | 0.1047 | 0.1047 |
Brugia malayi | cbs-prov protein | 0.0136 | 0.4136 | 0.4136 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0831 | 0.0831 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0594 | 0.0215 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0594 | 0.0215 |
Onchocerca volvulus | 0.0033 | 0.0594 | 0.0137 | |
Mycobacterium leprae | PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) | 0.0136 | 0.4136 | 1 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0136 | 0.4136 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0136 | 0.4136 | 0.4424 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0831 | 0.0613 |
Onchocerca volvulus | 0.0264 | 0.8572 | 1 | |
Trichomonas vaginalis | cysteine synthase, putative | 0.0136 | 0.4136 | 0.4424 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0831 | 0.0831 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0136 | 0.4136 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0831 | 0.0613 |
Mycobacterium ulcerans | cysteine synthase a CysK1 | 0.0136 | 0.4136 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0831 | 0.0613 |
Mycobacterium ulcerans | cysteine synthase B | 0.0136 | 0.4136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | integrin beta-2 | 0.0306 | 1 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0831 | 0.0831 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0483 | 0.0483 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0831 | 0.0669 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0136 | 0.4136 | 1 |
Leishmania major | cystathionine beta-synthase | 0.0136 | 0.4136 | 1 |
Schistosoma mansoni | threonine dehydratase | 0.0034 | 0.0615 | 0.0256 |
Brugia malayi | Pyridoxal-phosphate dependent enzyme family protein | 0.0034 | 0.0615 | 0.0615 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0831 | 0.028 |
Toxoplasma gondii | O-acetylserine (thiol) lyase 2, putative | 0.0034 | 0.0615 | 0.006 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0831 | 0.0673 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0831 | 0.0613 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0831 | 0.0271 |
Onchocerca volvulus | 0.0034 | 0.0615 | 0.0164 | |
Trypanosoma cruzi | cysteine synthase, putative | 0.0136 | 0.4136 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0227 | 0.7264 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0594 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0483 | 0.0483 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0831 | 0.028 |
Loa Loa (eye worm) | pyridoxal-phosphate dependent enzyme family protein | 0.0034 | 0.0615 | 0.0615 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0831 | 0.0831 |
Mycobacterium tuberculosis | Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) | 0.0136 | 0.4136 | 0.4576 |
Echinococcus multilocularis | l serine dehydratase:l threonine deaminase | 0.0034 | 0.0615 | 0.0195 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0831 | 0.0271 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0831 | 0.0613 |
Brugia malayi | Kelch motif family protein | 0.0046 | 0.1047 | 0.1047 |
Leishmania major | cysteine synthase | 0.0136 | 0.4136 | 1 |
Brugia malayi | hypothetical protein | 0.0046 | 0.1047 | 0.1047 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0136 | 0.4136 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0831 | 0.028 |
Trichomonas vaginalis | threonine synthase, putative | 0.0136 | 0.4136 | 0.4424 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0831 | 0.0514 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0594 | 0.0215 |
Mycobacterium ulcerans | cystathionine beta-synthase | 0.0136 | 0.4136 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0831 | 0.0514 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0483 | 0.0483 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0831 | 0.0831 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0594 | 0.0215 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0136 | 0.4136 | 1 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0136 | 0.4136 | 1 |
Toxoplasma gondii | CBS family protein | 0.0136 | 0.4136 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0551 | 0.0101 |
Trichomonas vaginalis | threonine synthase, putative | 0.0136 | 0.4136 | 0.4424 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0831 | 0.0613 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0831 | 0.028 |
Onchocerca volvulus | Serine racemase homolog | 0.0034 | 0.0615 | 0.0164 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0483 | 0.0483 |
Brugia malayi | Pyridoxal-phosphate dependent enzyme family protein | 0.0034 | 0.0615 | 0.0615 |
Onchocerca volvulus | 0.004 | 0.0831 | 0.0431 | |
Trypanosoma brucei | cystathionine beta-synthase, putative | 0.0136 | 0.4136 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0264 | 0.8572 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0831 | 0.028 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0831 | 0.028 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0831 | 0.0613 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0136 | 0.4136 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0831 | 0.0673 |
Mycobacterium tuberculosis | Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) | 0.0136 | 0.4136 | 0.4576 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0831 | 0.028 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0136 | 0.4136 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of recombinant CDK2 at 10 uM by Z'-LYTE kinase assay kit method | ChEMBL. | 21082766 | |
Inhibition (binding) | = 49.4 % | Inhibition of recombinant GSK3-beta at 10 uM by Z'-LYTE kinase assay kit method | ChEMBL. | 21082766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.