Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine sulfhydrylase | 0.0139 | 0.459 | 1 |
Mycobacterium ulcerans | cysteine synthase a CysK1 | 0.0139 | 0.459 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0139 | 0.459 | 1 |
Trypanosoma cruzi | cysteine synthase, putative | 0.0139 | 0.459 | 1 |
Schistosoma mansoni | cysteine synthase | 0.0139 | 0.459 | 1 |
Toxoplasma gondii | pyridoxal-phosphate dependent superfamily protein | 0.0139 | 0.459 | 1 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0139 | 0.459 | 1 |
Brugia malayi | cbs-prov protein | 0.0139 | 0.459 | 1 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0139 | 0.459 | 1 |
Mycobacterium ulcerans | cystathionine beta-synthase | 0.0139 | 0.459 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0139 | 0.459 | 1 |
Brugia malayi | Pyridoxal-phosphate dependent enzyme family protein | 0.0139 | 0.459 | 1 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Mycobacterium tuberculosis | Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) | 0.0139 | 0.459 | 0.459 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0139 | 0.459 | 0.5 |
Trichomonas vaginalis | threonine synthase, putative | 0.0139 | 0.459 | 1 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0139 | 0.459 | 1 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0139 | 0.459 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0 | 0.5 |
Mycobacterium ulcerans | cysteine synthase B | 0.0139 | 0.459 | 1 |
Mycobacterium tuberculosis | Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) | 0.0139 | 0.459 | 0.459 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0139 | 0.459 | 1 |
Leishmania major | cysteine synthase | 0.0139 | 0.459 | 1 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0139 | 0.459 | 1 |
Mycobacterium leprae | Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) | 0.0139 | 0.459 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0139 | 0.459 | 1 |
Trypanosoma cruzi | cysteine synthase, putative | 0.0139 | 0.459 | 1 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Schistosoma mansoni | cysteine synthase | 0.0139 | 0.459 | 1 |
Mycobacterium tuberculosis | Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) | 0.0139 | 0.459 | 0.459 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0139 | 0.459 | 1 |
Loa Loa (eye worm) | cbs-prov protein | 0.0139 | 0.459 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0139 | 0.459 | 1 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0139 | 0.459 | 0.5 |
Trichomonas vaginalis | threonine synthase, putative | 0.0139 | 0.459 | 1 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0139 | 0.459 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0139 | 0.459 | 1 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0139 | 0.459 | 1 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0139 | 0.459 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) | 0.0139 | 0.459 | 1 |
Toxoplasma gondii | CBS family protein | 0.0139 | 0.459 | 1 |
Trypanosoma brucei | cystathionine beta-synthase, putative | 0.0139 | 0.459 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0139 | 0.459 | 1 |
Leishmania major | cystathionine beta-synthase | 0.0139 | 0.459 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 44 uM | Inhibition of human recombinant furin by fluorescence plate reader analysis | ChEMBL. | 21168329 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.