Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1 | Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 80 mg/kg | ChEMBL. | 11462978 |
Activity (functional) | = 3 | Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 40 mg/kg | ChEMBL. | 11462978 |
Activity (functional) | = 13 | Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 80 mg/kg | ChEMBL. | 11462978 |
Activity (functional) | = 19 | Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 40 mg/kg | ChEMBL. | 11462978 |
Affinity (binding) | = 10 % | Binding affinity at dopamine receptor D2 from rat by spiropiperidone displacement. | ChEMBL. | 11462978 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.