Detailed information for compound 146477

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 244.268 | Formula: C9H12N2O4S
  • H donors: 3 H acceptors: 4 LogP: -2.56 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@@H](CS(=O)(=O)c1ccccc1N)N
  • InChi: 1S/C9H12N2O4S/c10-6-3-1-2-4-8(6)16(14,15)5-7(11)9(12)13/h1-4,7H,5,10-11H2,(H,12,13)/t7-/m1/s1
  • InChiKey: JJUXYMMPJKOKBD-SSDOTTSWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kynureninase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Pyridoxal phosphate dependent transferase, major region, subdomain 1 Get druggable targets OG5_129469 All targets in OG5_129469
Trypanosoma cruzi kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Trypanosoma congolense kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Loa Loa (eye worm) kynureninase Get druggable targets OG5_129469 All targets in OG5_129469
Trypanosoma brucei kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Candida albicans possible L-kynurenine hydrolase Get druggable targets OG5_129469 All targets in OG5_129469
Schistosoma japonicum ko:K01556 kynureninase [EC3.7.1.3], putative Get druggable targets OG5_129469 All targets in OG5_129469
Leishmania braziliensis kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Trypanosoma cruzi kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Candida albicans possible L-kynurenine hydrolase Get druggable targets OG5_129469 All targets in OG5_129469
Echinococcus granulosus Pyridoxal phosphate dependent transferase major region subdomain 1 Get druggable targets OG5_129469 All targets in OG5_129469
Leishmania mexicana kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Brugia malayi hypothetical protein Get druggable targets OG5_129469 All targets in OG5_129469
Trypanosoma brucei gambiense kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Leishmania major kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Brugia malayi kynureninase family protein Get druggable targets OG5_129469 All targets in OG5_129469
Brugia malayi FLYWCH zinc finger domain containing protein Get druggable targets OG5_129469 All targets in OG5_129469
Leishmania infantum kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129469 All targets in OG5_129469
Leishmania donovani kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Trypanosoma brucei kynureninase, putative Get druggable targets OG5_129469 All targets in OG5_129469
Schistosoma mansoni 3-hydroxy-kinureninase Get druggable targets OG5_129469 All targets in OG5_129469
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0321 0.0741 0.0739
Echinococcus multilocularis lamin dm0 0.0028 0.0024 0.0022
Onchocerca volvulus 0.0028 0.0024 0.0355
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0043 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0203 0.0201
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0024 0.0022
Echinococcus granulosus lamin dm0 0.0028 0.0024 0.0022
Onchocerca volvulus 0.0036 0.0043 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0038 0.0082
Echinococcus multilocularis sterol regulatory element binding protein 0.1688 0.4091 0.409
Echinococcus granulosus microtubule associated protein 2 0.2211 0.5372 0.5371
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0024 0.0022
Schistosoma mansoni hypothetical protein 0.0148 0.0319 0.0317
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0148 0.0319 0.0317
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0047 0.0072 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.0203 0.0201
Loa Loa (eye worm) hypothetical protein 0.0148 0.0319 0.0317
Schistosoma mansoni cpg binding protein 0.0158 0.0342 0.034
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0043 0.0041
Brugia malayi MH1 domain containing protein 0.0024 0.0014 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0038 0.0082
Brugia malayi Pre-SET motif family protein 0.0037 0.0045 0.0043
Mycobacterium leprae Probable lipase LipE 0.0036 0.0043 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0038 0.0049 0.0047
Brugia malayi Smad1 0.0043 0.0061 0.0059
Brugia malayi hypothetical protein 0.0152 0.0327 0.0325
Brugia malayi MH1 domain containing protein 0.0043 0.0061 0.0059
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0208 0.0206
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0049 0.0047
Brugia malayi beta-lactamase family protein 0.0036 0.0043 0.0041
Schistosoma mansoni smad1 5 8 and 0.0043 0.0061 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0038 0.0082
Brugia malayi Calcitonin receptor-like protein seb-1 0.0469 0.1104 0.1102
Echinococcus granulosus geminin 0.0171 0.0373 0.0371
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0045 0.0666
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0061 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0045 0.0043
Echinococcus multilocularis musashi 0.0028 0.0024 0.0022
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.4101 1 1
Echinococcus multilocularis lamin 0.0028 0.0024 0.0022
Schistosoma mansoni hypothetical protein 0.0171 0.0373 0.0371
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0469 0.1104 0.1102
Echinococcus multilocularis protein patched 0.1688 0.4091 0.409
Mycobacterium tuberculosis Conserved protein 0.0036 0.0043 0.0796
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.0203 0.0201
Brugia malayi MH2 domain containing protein 0.0633 0.1505 0.1504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0045 0.0043
Echinococcus granulosus smad 0.0043 0.0061 0.0059
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.0533 0.0531
Schistosoma mansoni hypothetical protein 0.0148 0.0319 0.0317
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0038 0.0082
Trypanosoma brucei kynureninase, putative 0.0179 0.0394 0.0392
Schistosoma mansoni lamin 0.0028 0.0024 0.0022
Onchocerca volvulus 0.0103 0.0208 0.3376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.0203 0.0201
Onchocerca volvulus 0.0152 0.0327 0.5319
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0041 0.0039
Echinococcus multilocularis Pyridoxal phosphate dependent transferase, major region, subdomain 1 0.0176 0.0386 0.0384
Onchocerca volvulus 0.0268 0.0612 1
Entamoeba histolytica hypothetical protein 0.0104 0.0209 0.2087
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1924 0.4668 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0003 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0633 0.1505 0.1504
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0038 0.0082
Schistosoma mansoni Smad4 0.0019 0.0003 0.0001
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0002 0.5
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.4101 1 1
Trypanosoma cruzi kynureninase, putative 0.0179 0.0394 0.0392
Echinococcus granulosus Niemann Pick C1 protein 0.1688 0.4091 0.409
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0038 0.0082
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0045 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0038 0.0082
Onchocerca volvulus 0.0036 0.0043 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0038 0.0082
Echinococcus granulosus neuropeptide s receptor 0.0449 0.1054 0.1052
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0061 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0043 0.9384
Loa Loa (eye worm) histone methyltransferase 0.0047 0.0072 0.007
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.1054 0.1052
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0038 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0045 0.0043
Echinococcus multilocularis smad 0.0043 0.0061 0.0059
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0043 0.0041
Schistosoma mansoni intermediate filament proteins 0.0028 0.0024 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0038 0.0082
Echinococcus multilocularis microtubule associated protein 2 0.2211 0.5372 0.5371
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1924 0.4668 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0041
Schistosoma mansoni cpg binding protein 0.0149 0.0321 0.0319
Echinococcus multilocularis Niemann Pick C1 protein 0.1688 0.4091 0.409
Loa Loa (eye worm) CXXC zinc finger family protein 0.0149 0.0321 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0038 0.0082
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0043 0.0796
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0034 0.0032
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0043 0.0796
Onchocerca volvulus 0.0037 0.0045 0.0697
Schistosoma mansoni hypothetical protein 0.0171 0.0373 0.0371
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0024 0.0022
Brugia malayi MH1 domain containing protein 0.0043 0.0061 0.0059
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.4101 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.1688 0.4091 0.409
Schistosoma mansoni microtubule-associated protein tau 0.2211 0.5372 0.5371
Schistosoma mansoni Smad4 0.0043 0.0061 0.0059
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0104 0.0209 0.2087
Schistosoma mansoni smad1 5 8 and 0.0043 0.0061 0.0059
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0148 0.0319 0.0317
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0003 0.0001
Echinococcus granulosus tumor protein p63 0.0705 0.1683 0.1681
Schistosoma mansoni smad1 5 8 and 0.0043 0.0061 0.0059
Brugia malayi intermediate filament protein 0.0028 0.0024 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0633 0.1505 0.1504
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.1688 0.4091 0.409
Echinococcus multilocularis Smad4 0.0043 0.0061 0.0059
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.0043
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.4101 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0148 0.0319 0.0317
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.4101 1 1
Trichomonas vaginalis set domain proteins, putative 0.0268 0.0612 0.1311
Onchocerca volvulus 0.0149 0.0321 0.5225
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0043 0.0796
Echinococcus granulosus Smad4 0.0043 0.0061 0.0059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0318 0.0734 0.0732
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0045 0.0043
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0061 0.0059
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0047 0.0072 0.007
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0043 0.5
Schistosoma mansoni Smad4 0.0019 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0469 0.1104 0.1102
Schistosoma mansoni cpg binding protein 0.0158 0.0342 0.034
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.4101 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0203 0.0201
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0045 0.0043
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0061 0.0059
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0038 0.0082
Echinococcus multilocularis tumor protein p63 0.0705 0.1683 0.1681
Schistosoma mansoni patched 1 0.1688 0.4091 0.409
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0148 0.0319 0.0317
Loa Loa (eye worm) hypothetical protein 0.4101 1 1
Loa Loa (eye worm) nuclear factor I 0.0024 0.0014 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0038 0.0082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0041
Brugia malayi MH1 domain containing protein 0.0024 0.0014 0.0012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0043 0.0796
Schistosoma mansoni lamin 0.0028 0.0024 0.0022
Echinococcus granulosus intermediate filament protein 0.0028 0.0024 0.0022
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0003 0.0001
Loa Loa (eye worm) beta-lactamase 0.0036 0.0043 0.0041
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0043 0.0796
Echinococcus granulosus lamin 0.0028 0.0024 0.0022
Echinococcus multilocularis GPCR, family 2 0.0148 0.0319 0.0317
Echinococcus granulosus Protein patched homolog 1 0.1688 0.4091 0.409
Loa Loa (eye worm) hypothetical protein 0.0103 0.0208 0.0206
Brugia malayi MH2 domain containing protein 0.0043 0.0061 0.0059
Echinococcus multilocularis protein dispatched 1 0.1688 0.4091 0.409
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0038 0.0049 0.0047
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1603 0.388 0.3879
Leishmania major kynureninase, putative 0.0179 0.0394 0.0392
Schistosoma mansoni hypothetical protein 0.0035 0.0041 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0148 0.0319 0.0317
Trypanosoma brucei kynureninase, putative 0.0179 0.0394 0.0392
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0148 0.0319 0.0317
Trichomonas vaginalis helicase, putative 0.0034 0.0038 0.0082
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.1054 0.1052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0045 0.0043
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0043 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0043 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0011 0.0009
Schistosoma mansoni smad 0.0019 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0038 0.0082
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0061 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0021
Echinococcus multilocularis cpg binding protein 0.0158 0.0342 0.034
Brugia malayi CXXC zinc finger family protein 0.0149 0.0321 0.0319
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0061 0.0059
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0061 0.0059
Echinococcus granulosus cpg binding protein 0.0158 0.0342 0.034
Brugia malayi Pre-SET motif family protein 0.0236 0.0533 0.0531
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0043 0.0091
Schistosoma mansoni hypothetical protein 0.2125 0.516 0.5159
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0043 0.0041
Brugia malayi beta-lactamase family protein 0.0036 0.0043 0.0041
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.1054 0.1052
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.4101 1 1
Echinococcus granulosus Pyridoxal phosphate dependent transferase major region subdomain 1 0.0176 0.0386 0.0384
Schistosoma mansoni niemann-pick C1 (NPC1) 0.1688 0.4091 0.409
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0043 0.0041
Plasmodium vivax SET domain protein, putative 0.0037 0.0045 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0148 0.0319 0.0317
Trichomonas vaginalis esterase, putative 0.0036 0.0043 0.0091
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0003 0.0001
Trypanosoma cruzi kynureninase, putative 0.0179 0.0394 0.0392
Brugia malayi hypothetical protein 0.0176 0.0386 0.0384
Echinococcus granulosus GPCR family 2 0.0148 0.0319 0.0317
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0041 0.0039
Brugia malayi hypothetical protein 0.0035 0.0041 0.0039
Brugia malayi kynureninase family protein 0.0176 0.0386 0.0384
Brugia malayi beta-lactamase 0.0036 0.0043 0.0041
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0003 0.0001
Loa Loa (eye worm) Smad1 0.0043 0.0061 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0038 0.0082
Echinococcus granulosus sterol regulatory element binding protein 0.1688 0.4091 0.409
Loa Loa (eye worm) hypothetical protein 0.0152 0.0327 0.0325
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.0203 0.0201
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0511 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.0203 0.0201
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0041
Leishmania major hypothetical protein, conserved 0.0036 0.0043 0.0041
Mycobacterium tuberculosis Conserved protein 0.0036 0.0043 0.0796
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0043 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.0203 0.0201
Echinococcus multilocularis geminin 0.0171 0.0373 0.0371
Echinococcus granulosus mixed lineage leukemia protein mll 0.0038 0.0049 0.0047
Schistosoma mansoni hypothetical protein 0.0148 0.0319 0.0317
Schistosoma mansoni smad 0.0043 0.0061 0.0059
Brugia malayi CHE-14 protein 0.1688 0.4091 0.409
Echinococcus multilocularis dnaJ subfamily B 0.2125 0.516 0.5159
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.4101 1 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.0386 0.0384
Schistosoma mansoni hypothetical protein 0.0321 0.0741 0.0739
Brugia malayi MH2 domain containing protein 0.0043 0.0061 0.0059
Schistosoma mansoni 3-hydroxy-kinureninase 0.0179 0.0394 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.1688 0.4091 0.8764
Toxoplasma gondii ABC1 family protein 0.0036 0.0043 0.0625
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.1924 0.4668 1
Brugia malayi F/Y-rich N-terminus family protein 0.0047 0.007 0.0068
Onchocerca volvulus 0.0036 0.0043 0.0654
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0364 0.0847 1
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1924 0.4668 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.0741 0.0739
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0469 0.1104 0.1102
Brugia malayi MH2 domain containing protein 0.0019 0.0003 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0043 0.0091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0043 0.0041
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0043 0.0796
Echinococcus granulosus dnaJ subfamily B 0.2125 0.516 0.5159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0203 0.0201
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0038 0.0082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0041
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0003 0.0001
Onchocerca volvulus 0.0028 0.0024 0.0355
Schistosoma mansoni hypothetical protein 0.0148 0.0319 0.0317
Loa Loa (eye worm) kynureninase 0.0179 0.0394 0.0392
Loa Loa (eye worm) hypothetical protein 0.0024 0.0014 0.0012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0284 0.0651 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0043 0.0041
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0038 0.0049 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0038 0.0082
Mycobacterium tuberculosis Conserved protein 0.0036 0.0043 0.0796
Brugia malayi FLYWCH zinc finger domain containing protein 0.0176 0.0386 0.0384
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0043 0.0796
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0003 0.0001

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 70 nm Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence ChEMBL. No reference
Ki (binding) = 70 nm Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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