Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin alpha | 0.0442 | 0.6808 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0335 | 0.4756 | 0.6985 |
Echinococcus granulosus | acetylcholinesterase | 0.0335 | 0.4756 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0131 | 0.0805 | 0.1693 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0335 | 0.4756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.4756 | 0.4756 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0805 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1524 | 0.1524 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0335 | 0.4756 | 0.6985 |
Echinococcus multilocularis | integrin alpha ps | 0.0273 | 0.3557 | 0.7479 |
Echinococcus multilocularis | integrin alpha 3 | 0.0299 | 0.4057 | 0.853 |
Echinococcus granulosus | carboxylesterase 5A | 0.0335 | 0.4756 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0335 | 0.4756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1023 | 0.1023 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0296 | 0.3997 | 0.5871 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0805 | 0.1182 |
Schistosoma mansoni | integrin alpha-ps | 0.0273 | 0.3557 | 0.5224 |
Echinococcus granulosus | acetylcholinesterase | 0.0335 | 0.4756 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0142 | 0.1023 | 0.1503 |
Echinococcus multilocularis | integrin alpha ps | 0.0273 | 0.3557 | 0.7479 |
Echinococcus granulosus | integrin alpha 3 | 0.0299 | 0.4057 | 0.853 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0442 | 0.6808 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.4756 | 0.4756 |
Echinococcus multilocularis | acetylcholinesterase | 0.0335 | 0.4756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.3997 | 0.3997 |
Echinococcus multilocularis | integrin alpha ps | 0.0131 | 0.0805 | 0.1693 |
Loa Loa (eye worm) | carboxylesterase | 0.0335 | 0.4756 | 0.4756 |
Echinococcus granulosus | integrin alpha ps | 0.0273 | 0.3557 | 0.7479 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.4275 | 0.4275 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0335 | 0.4756 | 0.4756 |
Brugia malayi | Carboxylesterase family protein | 0.0335 | 0.4756 | 0.6985 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 1.3 % | Reactivation of DEP-mediated inactive human recombinant AChE at 10 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 3.1 % | Reactivation of DEP-mediated inactive human recombinant AChE at 100 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 8.9 % | Reactivation of GA-mediated inactive human recombinant AChE at 10 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 9.6 % | Reactivation of GA-mediated inactive human recombinant AChE at 100 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 37.2 % | Reactivation of MePOX-mediated inactive human recombinant AChE at 100 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 38.9 % | Reactivation of POX-mediated inactive human recombinant AChE at 10 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 52.2 % | Reactivation of MePOX-mediated inactive human recombinant AChE at 10 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 72.2 % | Reactivation of POX-mediated inactive human recombinant AChE at 100 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
IC50 (binding) | = 291 uM | Inhibition of human recombinant AChE by modified Ellman's method | ChEMBL. | 21215642 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.