Detailed information for compound 1465027

Basic information

Technical information
  • TDR Targets ID: 1465027
  • Name: N-[di(phenyl)methyl]-2-[4-(phenylmethyl)piper azin-1-yl]acetamide
  • MW: 399.528 | Formula: C26H29N3O
  • H donors: 1 H acceptors: 1 LogP: 4.1 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(c1ccccc1)c1ccccc1)CN1CCN(CC1)Cc1ccccc1
  • InChi: 1S/C26H29N3O/c30-25(21-29-18-16-28(17-19-29)20-22-10-4-1-5-11-22)27-26(23-12-6-2-7-13-23)24-14-8-3-9-15-24/h1-15,26H,16-21H2,(H,27,30)
  • InChiKey: XLUJQEGUCVZQST-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[di(phenyl)methyl]-2-[4-(phenylmethyl)-1-piperazinyl]acetamide
  • 2-[4-(benzyl)piperazin-1-yl]-N-[di(phenyl)methyl]acetamide
  • N-[di(phenyl)methyl]-2-[4-(phenylmethyl)piperazin-1-yl]ethanamide
  • T5272195
  • BAS 06976852
  • N-Benzhydryl-2-(4-benzyl-piperazin-1-yl)-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0037 0.0082 0.0078
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0097 0.034 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Echinococcus multilocularis GPCR, family 3, C terminal 0.0034 0.0071 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0204 0.0963
Onchocerca volvulus 0.0046 0.0124 0.0551
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0184 0.018
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0247 0.0243
Brugia malayi Guanylyl cyclase protein 23 0.002 0.001 0.0006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0075 0.007
Echinococcus granulosus nmda type glutamate receptor 0.002 0.001 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0008 0.0003
Schistosoma mansoni hypothetical protein 0.0035 0.0075 0.007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.025 0.0246
Schistosoma mansoni tyrosine kinase 0.002 0.001 0.0006
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0008 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.0271 0.0267
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.034 0.0336
Brugia malayi metabotropic GABA-B receptor subtype 2 0.002 0.001 0.0006
Schistosoma mansoni cpg binding protein 0.0035 0.0074 0.007
Onchocerca volvulus 0.0265 0.1056 0.5067
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0239 0.0235
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0013 0.0009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0003
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0076 0.0072
Schistosoma mansoni metabotropic glutamate receptor 0.0175 0.0674 0.067
Brugia malayi Bromodomain containing protein 0.0075 0.0248 0.0244
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.001 0.001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0075 0.007
Echinococcus granulosus sodium:myo inositol cotransporter 0.0046 0.0124 0.012
Loa Loa (eye worm) hypothetical protein 0.0265 0.1056 0.1056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0162 0.0162
Echinococcus granulosus high affinity choline transporter 1 0.042 0.1719 0.1715
Echinococcus granulosus sodium:glucose cotransporter 0.0046 0.0124 0.012
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.0124 0.012
Loa Loa (eye worm) hypothetical protein 0.0054 0.0155 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0037 0.0158
Brugia malayi PHD-finger family protein 0.0026 0.0039 0.0034
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0005 0.0005
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0065 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0065 0.0292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0271 0.0267
Schistosoma mansoni metabotropic glutamate receptor 0.0102 0.0361 0.0357
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0173 0.0816
Echinococcus granulosus tyrosine kinase 0.002 0.001 0.0006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0076 0.025 0.025
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.0124 0.012
Schistosoma mansoni hypothetical protein 0.0494 0.2036 0.2032
Schistosoma mansoni protein kinase 0.002 0.001 0.0006
Echinococcus granulosus GPCR family 3 C terminal 0.0034 0.0071 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0158
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0097 0.034 0.0336
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0097 0.034 0.0336
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 0.5
Echinococcus multilocularis nmda type glutamate receptor 0.002 0.001 0.0006
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0149 0.07
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0877 0.3672 0.367
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0257 0.1025 0.1021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0195 0.092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.034 0.1621
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0038 0.1085
Echinococcus granulosus glutamate receptor 2 0.002 0.001 0.0006
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2324
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4108 0.4106
Loa Loa (eye worm) hypothetical protein 0.0257 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.0044 0.0113 0.0113
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0162 0.0158
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.2311 0.2308
Schistosoma mansoni fructose-16-bisphosphatase-related 0.2359 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0038 0.0088 0.0083
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0046 0.0124 0.012
Leishmania major extracellular receptor, putative 0.002 0.001 0.0002
Plasmodium vivax SET domain protein, putative 0.0064 0.02 0.6902
Echinococcus granulosus sodium:glucose cotransporter 2 0.0046 0.0124 0.012
Brugia malayi hypothetical protein 0.002 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Echinococcus multilocularis cpg binding protein 0.0039 0.0091 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Leishmania major 0.2359 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0255 0.1212
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0008 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0171 0.0805
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0162 0.0158
Loa Loa (eye worm) glutamate receptor 0.0209 0.0819 0.0819
Echinococcus granulosus tumor protein p63 0.1808 0.7646 0.7645
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0029 0.0024
Echinococcus multilocularis receptor type guanylyl cyclase 0.002 0.001 0.0006
Schistosoma mansoni hypothetical protein 0.0034 0.0071 0.0067
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0075 0.007
Plasmodium vivax ataxin-2 like protein, putative 0.0084 0.0286 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0209 0.0819 0.0814
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0097 0.034 0.0336
Brugia malayi CXXC zinc finger family protein 0.0035 0.0074 0.007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0396 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0149 0.07
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0097 0.034 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0072 0.0234 0.023
Schistosoma mansoni glutamate receptor NMDA 0.002 0.001 0.0006
Trypanosoma brucei PAB1-binding protein , putative 0.0084 0.0286 0.0282
Echinococcus multilocularis glutamate receptor 2 0.002 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0081 0.0271 0.0271
Brugia malayi Probable ClpP-like protease 0.0076 0.025 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0065 0.0292
Schistosoma mansoni bromodomain containing protein 0.0064 0.0199 0.0195
Schistosoma mansoni hypothetical protein 0.0035 0.0075 0.007
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 0.8719
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0008 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0239 0.0235
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.025 0.0246
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0082 0.0078
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.002 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0084 0.0286 0.0286
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0076 0.0072
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0877 0.3672 0.367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.034 0.1621
Echinococcus granulosus metabotropic glutamate receptor 2 0.0175 0.0674 0.067
Echinococcus granulosus cpg binding protein 0.0039 0.0091 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.02 0.0195
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0046 0.0122 0.0117
Schistosoma mansoni hypothetical protein 0.0038 0.0088 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0255 0.1212
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.2359 1 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0097 0.034 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0075 0.007
Echinococcus granulosus atrial natriuretic peptide receptor 0.002 0.001 0.0006
Echinococcus granulosus receptor type guanylyl cyclase 0.002 0.001 0.0006
Schistosoma mansoni cellular tumor antigen P53 0.0265 0.1056 0.1052
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0003
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0097 0.034 0.0333
Loa Loa (eye worm) hypothetical protein 0.0069 0.0222 0.0222
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.004 0.0098 0.0094
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0877 0.3672 0.367
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0239 0.0235
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.001 0.001
Onchocerca volvulus 0.0503 0.2074 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.025 0.8719
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0082 0.0078
Entamoeba histolytica hypothetical protein 0.002 0.001 0.0168
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0075 0.007
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0008 0.0003
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.0065 0.0061
Schistosoma mansoni zinc finger protein 0.0021 0.0016 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0171 0.0805
Schistosoma mansoni hypothetical protein 0.0035 0.0075 0.007
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2036 0.2032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0097 0.034 0.0336
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.034 0.1621
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0227 0.0222
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.015 0.0701
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.025 0.0246
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0065 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0149 0.07
Loa Loa (eye worm) transcription factor SMAD2 0.027 0.1078 0.1078
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0139 0.5654
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0065 0.0061
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0046 0.0124 0.012
Brugia malayi Pre-SET motif family protein 0.0442 0.1814 0.181
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0038 0.1085
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0075 0.007
Echinococcus granulosus neuropeptide s receptor 0.0558 0.2311 0.2308
Onchocerca volvulus Poor gastrulation protein homolog 0.0034 0.0071 0.0295
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.001 0.0006
Toxoplasma gondii fructose-bisphospatase II 0.2359 1 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0247 0.0247
Schistosoma mansoni cpg binding protein 0.0039 0.0091 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0065 0.0292
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0008 0.0003
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0034 0.0071 0.0067
Brugia malayi Pre-SET motif family protein 0.0064 0.02 0.0195
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0065 0.0065
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.002 0.001 0.001
Echinococcus multilocularis solute carrier family 5 0.0046 0.0124 0.012
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Schistosoma mansoni tyrosine kinase 0.002 0.001 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0005 0.0005
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.001 0.0006
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0082 0.0078
Loa Loa (eye worm) hypothetical protein 0.0034 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Brugia malayi Sodium:solute symporter family protein 0.0046 0.0124 0.012
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.2311 0.2308
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.025 0.0246
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0239 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Schistosoma mansoni high-affinity choline transporter 0.042 0.1719 0.1715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0065 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0173 0.0816
Echinococcus multilocularis glutamate receptor 2 0.002 0.001 0.0006
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0077 0.0256 0.0251
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0255 0.1212
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.02 0.0195
Loa Loa (eye worm) hypothetical protein 0.0046 0.0124 0.0124
Echinococcus granulosus fructose 16 bisphosphatase 1 0.2359 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0084 0.0286 1
Onchocerca volvulus 0.0035 0.0074 0.0311
Schistosoma mansoni cpg binding protein 0.0039 0.0091 0.0086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0396 0.0392
Toxoplasma gondii fructose-bisphospatase I 0.0877 0.3672 0.367
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Schistosoma mansoni inositol transporter 0.0046 0.0124 0.012
Echinococcus granulosus solute carrier family 5 0.0046 0.0124 0.012
Toxoplasma gondii LsmAD domain-containing protein 0.0084 0.0286 0.0282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0162 0.0158
Echinococcus multilocularis tumor protein p63 0.1808 0.7646 0.7645
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0442 0.1814 0.1814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0158
Echinococcus multilocularis GPCR, family 2 0.0035 0.0075 0.007
Trichomonas vaginalis set domain proteins, putative 0.0503 0.2074 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.015 0.0701
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0139 0.0134
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0097 0.034 0.0336
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.2359 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.015 0.0701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0008 0.0008
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0077 0.0256 0.0248
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0139 0.4744
Brugia malayi hypothetical protein 0.0054 0.0158 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0043
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0139 0.0134
Schistosoma mansoni sodium/solute symporter 0.0046 0.0124 0.012
Echinococcus granulosus glutamate receptor 2 0.002 0.001 0.0006
Brugia malayi GH02984p 0.042 0.1719 0.1715
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0004 0.000000011328
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0239 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Echinococcus multilocularis atrial natriuretic peptide receptor 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Leishmania major hypothetical protein, conserved 0.0084 0.0286 0.0279
Echinococcus granulosus zinc finger protein 0.0021 0.0016 0.0012
Loa Loa (eye worm) phosphatidylinositol 3 0.0097 0.034 0.034
Plasmodium falciparum ataxin-2 like protein, putative 0.0084 0.0286 1
Brugia malayi hypothetical protein 0.0084 0.0286 0.0282
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0008 0.0003
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.002 0.001 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0239 0.0235
Echinococcus multilocularis high affinity choline transporter 1 0.042 0.1719 0.1715
Loa Loa (eye worm) MH2 domain-containing protein 0.027 0.1078 0.1078
Loa Loa (eye worm) hypothetical protein 0.0035 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0035 0.0075 0.007
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.025 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.0065 0.0057
Echinococcus multilocularis tyrosine kinase 0.002 0.001 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0396 0.0392
Schistosoma mansoni hypothetical protein 0.002 0.0012 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.042 0.1719 0.1719
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0239 0.0232
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2359 1 1
Brugia malayi Bromodomain containing protein 0.0037 0.0086 0.0082
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0012 0.0012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.0271 0.0267
Echinococcus granulosus GPCR family 2 0.0035 0.0075 0.007
Toxoplasma gondii hypothetical protein 0.0026 0.0038 0.0033
Trypanosoma cruzi target of rapamycin kinase 3 0.0077 0.0256 0.0251
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0097 0.034 0.0336
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0238 0.0941 0.0937
Loa Loa (eye worm) glutamate receptor 0.0082 0.0277 0.0277
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0065 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0065 0.0292
Loa Loa (eye worm) hypothetical protein 0.004 0.0096 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0173 0.0816
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0271 0.0267
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.025 0.0246
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0008 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0255 0.1212
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.001 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0075 0.0075
Brugia malayi MH2 domain containing protein 0.027 0.1078 0.1074
Echinococcus granulosus metabotropic glutamate receptor 5 0.0257 0.1025 0.1021
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0065 0.0061
Onchocerca volvulus 0.0064 0.02 0.0919
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0097 0.034 0.0336
Brugia malayi isocitrate dehydrogenase 0.0019 0.0008 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.015 0.0701
Brugia malayi Receptor family ligand binding region containing protein 0.0054 0.0155 0.0151
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.001 0.0006
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0065 0.0061
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.02 0.0195
Trypanosoma cruzi PAB1-binding protein , putative 0.0084 0.0286 0.0282
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0139 0.5654
Trypanosoma cruzi extracellular receptor, putative 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0255 0.1212
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0054 0.0155 0.0155
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2324
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.0124 0.012
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0877 0.3672 0.367
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.025 0.0246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.02 0.0195
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0187 0.0182
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0034 0.0071 0.0295
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0184 0.018
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0175 0.0674 0.067
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.001 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0162 0.0158
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0086
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2359 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.2311 0.2308
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0029 0.0024
Brugia malayi metabotropic glutamate receptor type 2 0.0102 0.0361 0.0357
Schistosoma mansoni inositol transporter 0.0046 0.0124 0.012
Trypanosoma brucei fructose-1,6-bisphosphatase 0.2359 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0084 0.0286 0.0282
Giardia lamblia GTOR 0.0097 0.034 0.5
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0162 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.028 0.1329
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0065 0.0057
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0008 0.0003
Schistosoma mansoni hypothetical protein 0.0075 0.0247 0.0243
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0189 0.0735 0.073
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.0065 0.0061
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0038 0.0088 0.0083
Loa Loa (eye worm) hypothetical protein 0.011 0.0396 0.0396
Brugia malayi hypothetical protein 0.0037 0.0082 0.0078
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2036 0.2032
Echinococcus multilocularis zinc finger protein 0.0021 0.0016 0.0012
Loa Loa (eye worm) Smad1 0.0018 0.0005 0.0005
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0054 0.0155 0.0155

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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