Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Butyrylcholinesterase | 602 aa | 554 aa | 35.9 % |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Onchocerca volvulus | Putative nuclear protein | Butyrylcholinesterase | 602 aa | 573 aa | 41.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 551 aa | 30.1 % | |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 578 aa | 25.4 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0028 | 0.1024 | 1 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0028 | 0.1024 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.1024 | 0.011 |
Brugia malayi | hypothetical protein | 0.0028 | 0.1024 | 0.0912 |
Onchocerca volvulus | 0.0028 | 0.1024 | 1 | |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0924 | 0.0895 |
Echinococcus granulosus | neuroligin | 0.0028 | 0.1024 | 0.0996 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.1024 | 0.011 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0028 | 0.1024 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0924 | 0.0924 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2125 | 0.21 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.0924 | 0.0895 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1024 | 0.1024 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1024 | 0.1024 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.1024 | 0.0912 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2125 | 0.1323 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0028 | 0.1024 | 0.5 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0924 | 0.0895 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3251 | 0.2564 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0924 | 0.0924 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2125 | 0.21 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3251 | 0.2564 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.3251 | 0.323 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.1024 | 0.0912 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.1024 | 0.011 |
Onchocerca volvulus | 0.0028 | 0.1024 | 1 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2125 | 0.2125 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0028 | 0.1024 | 0.011 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2125 | 0.1323 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.3251 | 0.3251 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0893 | 0.0893 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.1024 | 0.1024 |
Schistosoma mansoni | gliotactin | 0.0028 | 0.1024 | 0.011 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.1024 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0028 | 0.1024 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1024 | 0.1024 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3251 | 0.2564 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.1024 | 0.1024 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0924 | 0.0895 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0028 | 0.1024 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.3251 | 0.3251 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0924 | 0.0895 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1024 | 0.1024 |
Echinococcus multilocularis | neuroligin | 0.0028 | 0.1024 | 0.0996 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2125 | 0.2027 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3251 | 0.2564 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2125 | 0.21 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.1024 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1024 | 0.1024 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.3251 | 0.3167 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1024 | 0.1024 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0028 | 0.1024 | 0.0996 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0924 | 0.0811 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0123 | 0.0123 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0028 | 0.1024 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.1024 | 0.0912 |
Schistosoma mansoni | acetylcholinesterase | 0.0028 | 0.1024 | 0.011 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2125 | 0.21 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0924 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1024 | 0.1024 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0924 | 0.0895 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0028 | 0.1024 | 0.0996 |
Onchocerca volvulus | 0.0028 | 0.1024 | 1 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.3251 | 0.3167 |
Onchocerca volvulus | 0.0028 | 0.1024 | 1 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0028 | 0.1024 | 0.0996 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.3251 | 0.3251 |
Brugia malayi | RNA binding protein | 0.0061 | 0.3251 | 0.3167 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0028 | 0.1024 | 0.0996 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3251 | 0.2564 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.1024 | 0.0912 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0924 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0032 | 0.0032 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0028 | 0.1024 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2125 | 0.1323 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.3251 | 0.323 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.