Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0865 | 0.0997 |
Brugia malayi | Pyridoxal-phosphate dependent enzyme family protein | 0.0073 | 0.8669 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0177 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0073 | 0.8669 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 1 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0865 | 1 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0073 | 0.8669 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0865 | 0.0152 |
Schistosoma mansoni | cysteine synthase | 0.0073 | 0.8669 | 1 |
Mycobacterium tuberculosis | Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) | 0.0073 | 0.8669 | 1 |
Trypanosoma brucei | threonine synthase, putative | 0.0018 | 0.0724 | 0.0835 |
Leishmania major | cysteine synthase | 0.0073 | 0.8669 | 1 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0073 | 0.8669 | 1 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0073 | 0.8669 | 0.8565 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0177 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0997 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0073 | 0.8669 | 1 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0073 | 0.8669 | 1 |
Mycobacterium leprae | PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) | 0.0073 | 0.8669 | 1 |
Mycobacterium tuberculosis | Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) | 0.0073 | 0.8669 | 1 |
Trypanosoma brucei | cystathionine beta-synthase, putative | 0.0073 | 0.8669 | 1 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0073 | 0.8669 | 0.8565 |
Toxoplasma gondii | pyridoxal-phosphate dependent superfamily protein | 0.0073 | 0.8669 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0997 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0865 | 0.0177 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0865 | 0.0997 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0865 | 0.0177 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0073 | 0.8669 | 1 |
Brugia malayi | cbs-prov protein | 0.0073 | 0.8669 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0997 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0073 | 0.8669 | 1 |
Onchocerca volvulus | Serine racemase homolog | 0.0018 | 0.0724 | 0.5 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0083 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0865 | 0.0177 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0997 |
Mycobacterium ulcerans | cysteine synthase a CysK1 | 0.0073 | 0.8669 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0177 |
Trichomonas vaginalis | threonine synthase, putative | 0.0073 | 0.8669 | 1 |
Chlamydia trachomatis | tryptophan synthase subunit beta | 0.0018 | 0.0724 | 0.5 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0073 | 0.8669 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0865 | 0.0152 |
Schistosoma mansoni | cysteine synthase | 0.0073 | 0.8669 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0865 | 0.0177 |
Mycobacterium tuberculosis | Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) | 0.0073 | 0.8669 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0865 | 1 |
Trichomonas vaginalis | threonine synthase, putative | 0.0073 | 0.8669 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0865 | 0.0177 |
Mycobacterium leprae | Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) | 0.0073 | 0.8669 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0177 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0865 | 0.0177 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0865 | 1 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0073 | 0.8669 | 1 |
Toxoplasma gondii | CBS family protein | 0.0073 | 0.8669 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0865 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0865 | 0.0177 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0073 | 0.8669 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0865 | 0.0177 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0073 | 0.8669 | 1 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0073 | 0.8669 | 0.8565 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0865 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0865 | 0.0997 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0997 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0073 | 0.8669 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0865 | 0.0997 |
Leishmania major | cystathionine beta-synthase | 0.0073 | 0.8669 | 1 |
Mycobacterium ulcerans | cystathionine beta-synthase | 0.0073 | 0.8669 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0865 | 0.0177 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0997 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0865 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0997 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0177 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0865 | 0.0177 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0073 | 0.8669 | 1 |
Trypanosoma cruzi | cysteine synthase, putative | 0.0073 | 0.8669 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0997 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0865 | 0.0152 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0865 | 1 |
Trypanosoma cruzi | cysteine synthase, putative | 0.0073 | 0.8669 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0865 | 0.0177 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0865 | 0.0177 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0073 | 0.8669 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0997 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0865 | 0.0997 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0073 | 0.8669 | 1 |
Onchocerca volvulus | 0.0018 | 0.0724 | 0.5 | |
Trichomonas vaginalis | cysteine synthase, putative | 0.0073 | 0.8669 | 1 |
Mycobacterium ulcerans | cysteine synthase B | 0.0073 | 0.8669 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0865 | 0.0177 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0865 | 0.0177 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0865 | 0.0997 |
Loa Loa (eye worm) | cbs-prov protein | 0.0073 | 0.8669 | 0.8565 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 5.49 uM | Growth inhibition of human OVCAR4 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 36.8 uM | Growth inhibition of human OVCAR5 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 63.8 uM | Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human MDA-MB-231cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human MDA-N cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human BT549 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human IGROV1 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human OVCAR8 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
LD50 (ADMET) | = 452.81 mg kg-1 | Acute toxicity in mouse after 24 hrs | ChEMBL. | 20950898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.