Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0166 | 0.4624 | 1 |
Trichomonas vaginalis | threonine synthase, putative | 0.0166 | 0.4624 | 1 |
Mycobacterium tuberculosis | Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) | 0.0166 | 0.4624 | 0.5 |
Trypanosoma brucei | cystathionine beta-synthase, putative | 0.0166 | 0.4624 | 1 |
Trypanosoma cruzi | cysteine synthase, putative | 0.0166 | 0.4624 | 1 |
Schistosoma mansoni | cysteine synthase | 0.0166 | 0.4624 | 0.9028 |
Mycobacterium ulcerans | cystathionine beta-synthase | 0.0166 | 0.4624 | 0.5 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0166 | 0.4624 | 1 |
Mycobacterium tuberculosis | Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) | 0.0166 | 0.4624 | 0.5 |
Brugia malayi | cbs-prov protein | 0.0166 | 0.4624 | 0.4624 |
Leishmania major | cysteine synthase | 0.0166 | 0.4624 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0048 | 0 | 0.5 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0166 | 0.4624 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0166 | 0.4624 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0166 | 0.4624 | 1 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0166 | 0.4624 | 1 |
Brugia malayi | Pyridoxal-phosphate dependent enzyme family protein | 0.0166 | 0.4624 | 0.4624 |
Giardia lamblia | Kinase, CMGC GSK | 0.0048 | 0 | 0.5 |
Mycobacterium ulcerans | cysteine synthase B | 0.0166 | 0.4624 | 0.5 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0166 | 0.4624 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0166 | 0.4624 | 1 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0166 | 0.4624 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.6925 | 1 |
Mycobacterium leprae | Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) | 0.0166 | 0.4624 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0303 | 1 | 1 |
Mycobacterium leprae | PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) | 0.0166 | 0.4624 | 0.5 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0166 | 0.4624 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0166 | 0.4624 | 1 |
Toxoplasma gondii | CBS family protein | 0.0166 | 0.4624 | 1 |
Trypanosoma cruzi | cysteine synthase, putative | 0.0166 | 0.4624 | 1 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0166 | 0.4624 | 1 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0166 | 0.4624 | 1 |
Schistosoma mansoni | cysteine synthase | 0.0166 | 0.4624 | 0.9028 |
Mycobacterium tuberculosis | Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) | 0.0166 | 0.4624 | 0.5 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0166 | 0.4624 | 1 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0166 | 0.4624 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.5122 | 1 |
Mycobacterium ulcerans | cysteine synthase a CysK1 | 0.0166 | 0.4624 | 0.5 |
Toxoplasma gondii | pyridoxal-phosphate dependent superfamily protein | 0.0166 | 0.4624 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0048 | 0 | 0.5 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0166 | 0.4624 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.6925 | 1 |
Trichomonas vaginalis | threonine synthase, putative | 0.0166 | 0.4624 | 1 |
Loa Loa (eye worm) | cbs-prov protein | 0.0166 | 0.4624 | 0.4624 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Entamoeba histolytica | cysteine synthase A, putative | 0.0166 | 0.4624 | 1 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0048 | 0 | 0.5 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0166 | 0.4624 | 1 |
Leishmania major | cystathionine beta-synthase | 0.0166 | 0.4624 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0166 | 0.4624 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 8.84 uM | Growth inhibition of human MDA-MB-231cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 9.53 uM | Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 21.8 uM | Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 21.8 uM | Growth inhibition of human BT549 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 31.2 uM | Growth inhibition of human MDA-N cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 31.8 uM | Growth inhibition of human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 32.8 uM | Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 63 uM | Growth inhibition of human OVCAR4 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 68 uM | Growth inhibition of human OVCAR8 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 93.8 uM | Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | = 94.8 uM | Growth inhibition of human IGROV1 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
GI50 (functional) | > 100 uM | Growth inhibition of human OVCAR5 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20950898 |
LD50 (ADMET) | = 131.9 mg kg-1 | Acute toxicity in mouse after 24 hrs | ChEMBL. | 20950898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.