TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 447.401 | Formula: C23H28Cl2N4O
H donors: 1 H acceptors: 2 LogP: 7.16 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCC(NC(=O)c1nn(c(c1C)n1cccc1)c1ccc(cc1Cl)Cl)C
InChi: 1S/C23H28Cl2N4O/c1-4-5-6-7-10-16(2)26-22(30)21-17(3)23(28-13-8-9-14-28)29(27-21)20-12-11-18(24)15-19(20)25/h8-9,11-16H,4-7,10H2,1-3H3,(H,26,30)
InChiKey: DOQRGXMYBKLLBR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Homo sapiens	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glycine receptor subunit beta	0.002	0.0167	0.0167
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0041	0.1338	0.1519
Echinococcus multilocularis	aldo keto reductase	0.0067	0.2837	0.2837
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.002	0.0167	0.0167
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0041	0.1338	0.1519
Onchocerca volvulus		0.002	0.0167	0.019
Loa Loa (eye worm)	hypothetical protein	0.003	0.0729	0.0827
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0041	0.1338	0.1338
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0024	0.035	0.0398
Onchocerca volvulus		0.002	0.0167	0.019
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0167	0.0167
Schistosoma mansoni	retinoic acid receptor RXR	0.0041	0.1338	0.1338
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0761	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1338	0.1519
Echinococcus granulosus	lamin	0.0031	0.0761	0.0761
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1338	0.1519
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0041	0.1338	0.1519
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0498	0.0565
Schistosoma mansoni	hypothetical protein	0.0193	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0067	0.2837	0.2837
Leishmania major	cytochrome p450-like protein	0.0026	0.0498	0.1391
Echinococcus granulosus	aldo keto reductase	0.0067	0.2837	0.2837
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.002	0.0167	0.019
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.002	0.0167	0.019
Trypanosoma cruzi	cytochrome P450, putative	0.0026	0.0498	0.1391
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0019	0.012	0.0136
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0067	0.2837	0.322
Brugia malayi	MH2 domain containing protein	0.0136	0.6753	0.7665
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Echinococcus granulosus	nAChR subunit	0.002	0.0167	0.0167
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0041	0.1338	0.1519
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0498	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0035	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1338	0.1519
Onchocerca volvulus		0.0031	0.0761	0.0863
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.2245	0.2548
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.002	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0761	0.0863
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.002	0.0167	0.0167
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0167	0.019
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Mycobacterium tuberculosis	Probable oxidoreductase	0.0067	0.2837	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0041	0.1338	0.1338
Schistosoma mansoni	lamin	0.0031	0.0761	0.0761
Onchocerca volvulus		0.002	0.0167	0.019
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0646	0.0734
Onchocerca volvulus		0.0075	0.3288	0.3732
Schistosoma mansoni	pol-related	0.0067	0.2837	0.2837
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.1338	0.1519
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.002	0.0167	0.0167
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0041	0.1338	0.1338
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0646	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.035	0.0398
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Onchocerca volvulus		0.002	0.0167	0.019
Brugia malayi	steroid hormone receptor	0.0041	0.1338	0.1519
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.002	0.0167	0.019
Brugia malayi	nuclear hormone receptor	0.0041	0.1338	0.1519
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0024	0.035	0.035
Echinococcus granulosus	FTZ F1 alpha	0.0041	0.1338	0.1338
Echinococcus granulosus	ecdysone induced protein 78C	0.0041	0.1338	0.1338
Loa Loa (eye worm)	cytochrome P450 family protein	0.0038	0.1167	0.1325
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.002	0.0167	0.019
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.002	0.0167	0.019
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0167	0.0167
Loa Loa (eye worm)	oxidoreductase	0.0067	0.2837	0.322
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0498	0.0565
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0024	0.035	0.035
Echinococcus multilocularis	lamin dm0	0.0031	0.0761	0.0761
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.1222	0.1387
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0041	0.1338	0.1519
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0041	0.1338	0.1338
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.2245	0.2548
Schistosoma mansoni	jun-related protein	0.0078	0.3437	0.3437
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0067	0.2837	0.2837
Loa Loa (eye worm)	MH2 domain-containing protein	0.0136	0.6753	0.7665
Echinococcus multilocularis	jun protein	0.0096	0.4457	0.4457
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0067	0.2837	0.322
Schistosoma mansoni	lamin	0.0031	0.0761	0.0761
Trypanosoma brucei	prostaglandin f synthase	0.0067	0.2837	1
Brugia malayi	Steroid receptor seven-up type 2	0.0041	0.1338	0.1519
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0041	0.1338	0.1338
Trypanosoma cruzi	aldo-keto reductase	0.0067	0.2837	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0167	0.019
Loa Loa (eye worm)	transcription factor SMAD2	0.0136	0.6753	0.7665
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0035	0.0039
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0024	0.035	0.035
Onchocerca volvulus		0.0067	0.2837	0.322
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.002	0.0167	0.0167
Brugia malayi	bZIP transcription factor family protein	0.0096	0.4457	0.5059
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.035	0.0398
Loa Loa (eye worm)	ACC-1 protein	0.002	0.0167	0.019
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.1338	0.1519
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.1338	0.1338
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0026	0.0498	0.1391
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0035	0.0035
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.002	0.0167	0.0167
Brugia malayi	Cation transporter family protein	0.002	0.0167	0.019
Echinococcus multilocularis	aldo keto reductase	0.0067	0.2837	0.2837
Schistosoma mansoni	nAChR subunit	0.002	0.0167	0.0167
Echinococcus multilocularis	lamin	0.0031	0.0761	0.0761
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0761	0.0863
Trypanosoma cruzi	aldo/keto reductase, putative	0.0067	0.2837	1
Echinococcus multilocularis	geminin	0.0193	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0067	0.2837	0.2837
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1338	0.1519
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0041	0.1338	0.1338
Loa Loa (eye worm)	oxidoreductase	0.0067	0.2837	0.322
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0041	0.1338	0.1338
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.002	0.0167	0.0167
Brugia malayi	hypothetical protein	0.0019	0.0067	0.0076
Mycobacterium leprae	Conserved hypothetical protein	0.0048	0.1729	0.5922
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4308	0.489
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0041	0.1338	0.1338
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0761	0.0761
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0067	0.2837	0.2837
Giardia lamblia	Aldose reductase	0.0067	0.2837	0.5
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.002	0.0167	0.019
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.1338	0.1338
Echinococcus granulosus	jun protein	0.0096	0.4457	0.4457
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.002	0.0167	0.019
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0067	0.2837	1
Onchocerca volvulus		0.002	0.0167	0.019
Echinococcus granulosus	aldo keto reductase	0.0067	0.2837	0.2837
Schistosoma mansoni	aldo-keto reductase	0.0067	0.2837	0.2837
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0067	0.2837	0.322
Echinococcus granulosus	glycine receptor subunit beta	0.002	0.0167	0.0167
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0167	0.019
Echinococcus granulosus	glycine receptor subunit beta	0.002	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0024	0.035	0.0398
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0019	0.012	0.0136
Trichomonas vaginalis	aldo/keto reductase, putative	0.0067	0.2837	1
Schistosoma mansoni	hypothetical protein	0.0193	1	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0646	0.1937
Schistosoma mansoni	nAChR subunit	0.002	0.0167	0.0167
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0035	0.0035
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.002	0.0167	0.0167
Schistosoma mansoni	nAChR subunit	0.002	0.0167	0.0167
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0067	0.2837	1
Loa Loa (eye worm)	oxidoreductase	0.0067	0.2837	0.322
Brugia malayi	hypothetical protein	0.0029	0.0646	0.0734
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.002	0.0167	0.019
Schistosoma mansoni	hypothetical protein	0.0018	0.0035	0.0035
Loa Loa (eye worm)	CYP4Cod1	0.0026	0.0498	0.0565
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0067	0.2837	0.322
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0498	0.0565
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0646	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0067	0.2837	0.322
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Echinococcus multilocularis	aldehyde reductase	0.0048	0.1729	0.1729
Echinococcus multilocularis	aldo keto reductase	0.0067	0.2837	0.2837
Schistosoma mansoni	nuclear hormone receptor	0.0041	0.1338	0.1338
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1338	0.1519
Trypanosoma cruzi	cytochrome P450, putative	0.0026	0.0498	0.1391
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.002	0.0167	0.019
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Entamoeba histolytica	aldose reductase, putative	0.0067	0.2837	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0067	0.2837	1
Brugia malayi	ecdysteroid receptor	0.0119	0.5776	0.6555
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0041	0.1338	0.1519
Schistosoma mansoni	nAChR subunit	0.002	0.0167	0.0167
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.002	0.0167	0.019
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0041	0.1338	0.1338
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.5776	0.6555
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0035	0.0039
Schistosoma mansoni	potassium channel beta	0.0019	0.012	0.012
Echinococcus multilocularis	FTZ F1 alpha	0.0041	0.1338	0.1338
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0041	0.1338	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0172	0.8811	1
Brugia malayi	hypothetical protein	0.0024	0.035	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0024	0.035	0.0398
Onchocerca volvulus		0.0172	0.8811	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0035	0.0035
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0167	0.0167
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0035	0.0035
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.002	0.0167	0.019
Schistosoma mansoni	hypothetical protein	0.0018	0.0035	0.0035
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0167	0.019
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0019	0.012	0.012
Schistosoma mansoni	RAR-like nuclear receptor	0.0041	0.1338	0.1338
Schistosoma mansoni	hypothetical protein	0.0039	0.1222	0.1222
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0167	0.019
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Schistosoma mansoni	hypothetical protein	0.0018	0.0035	0.0035
Loa Loa (eye worm)	oxidoreductase	0.0067	0.2837	0.322
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.002	0.0167	0.0167
Leishmania major	aldo-keto reductase-like protein	0.0067	0.2837	1
Schistosoma mansoni	hypothetical protein	0.0078	0.3437	0.3437
Echinococcus granulosus	GPCR family 2	0.0018	0.0035	0.0035
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0067	0.2837	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.1338	0.1519
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.1338	0.1338
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0646	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2245	0.2548
Echinococcus granulosus	aldehyde reductase	0.0048	0.1729	0.1729
Brugia malayi	hypothetical protein	0.0075	0.3288	0.3732
Brugia malayi	Cation transporter family protein	0.002	0.0167	0.019
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0646	0.1937
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0067	0.2837	0.2837
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0167	0.0167
Schistosoma mansoni	aldo-keto reductase	0.0067	0.2837	0.2837
Loa Loa (eye worm)	LGC-31 protein	0.002	0.0167	0.019
Brugia malayi	excitatory GABA receptor EXP-1A	0.002	0.0167	0.019
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.002	0.0167	0.0167
Trichomonas vaginalis	aldo/keto reductase, putative	0.0067	0.2837	1
Onchocerca volvulus		0.0067	0.2837	0.322
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0041	0.1338	0.1519
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0041	0.1338	0.1338
Giardia lamblia	Aldose reductase	0.0067	0.2837	0.5
Onchocerca volvulus		0.0067	0.2837	0.322
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0041	0.1338	0.1338
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0096	0.4457	0.4457
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Leishmania major	hypothetical protein, conserved	0.0029	0.0646	0.1937
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.1338	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0024	0.035	0.0398
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.002	0.0167	0.0167
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.002	0.0167	0.0167
Trypanosoma brucei	cytochrome P450, putative	0.0026	0.0498	0.1391
Brugia malayi	intermediate filament protein	0.0031	0.0761	0.0863
Loa Loa (eye worm)	oxidoreductase	0.0067	0.2837	0.322
Loa Loa (eye worm)	ACC-1 protein	0.002	0.0167	0.019
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0646	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0041	0.1338	0.1519
Onchocerca volvulus		0.0067	0.2837	0.322
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0041	0.1338	0.1338
Echinococcus granulosus	aldo keto reductase	0.0067	0.2837	0.2837
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.002	0.0167	0.019
Brugia malayi	nuclear receptor NHR-88	0.0041	0.1338	0.1519
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0067	0.2837	0.2837
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0041	0.1338	0.1519
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Entamoeba histolytica	aldose reductase, putative	0.0067	0.2837	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.035	0.0398
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0167	0.0167
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0167	0.0167
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.002	0.0167	0.0167
Entamoeba histolytica	aldose reductase, putative	0.0067	0.2837	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Echinococcus granulosus	lamin dm0	0.0031	0.0761	0.0761
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.1338	0.1338
Schistosoma mansoni	nAChR subunit	0.002	0.0167	0.0167
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0067	0.2837	0.2837
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0041	0.1338	0.1519
Onchocerca volvulus		0.002	0.0167	0.019
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0041	0.1338	0.1338
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.002	0.0167	0.0167
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.1338	0.1519
Onchocerca volvulus		0.0067	0.2837	0.322
Onchocerca volvulus	Bile acid receptor homolog	0.0119	0.5776	0.6555
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0067	0.2837	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0067	0.2837	0.2837
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0019	0.012	0.012
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0167	0.019
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1338	0.1519
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.002	0.0167	0.0167
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0035	0.0039
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Schistosoma mansoni	nAChR subunit	0.002	0.0167	0.0167
Brugia malayi	nuclear receptor RXR	0.0024	0.035	0.0398
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0041	0.1338	0.1338
Toxoplasma gondii	aldose reductase, putative	0.0067	0.2837	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Echinococcus multilocularis	aldo keto reductase	0.0067	0.2837	0.2837
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0067	0.2837	0.2837
Trichomonas vaginalis	aldo/keto reductase, putative	0.0067	0.2837	1
Loa Loa (eye worm)	steroid hormone receptor	0.0041	0.1338	0.1519
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0041	0.1338	0.1519
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0167	0.019
Echinococcus multilocularis	nAChR subunit	0.002	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Onchocerca volvulus		0.0041	0.1338	0.1519
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0035	0.0035
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0167	0.019
Brugia malayi	photoreceptor-specific nuclear receptor	0.0041	0.1338	0.1519
Trypanosoma brucei	aldo-keto reductase, putative	0.0067	0.2837	1
Echinococcus multilocularis	musashi	0.0031	0.0761	0.0761
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.2245	0.2548
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0167	0.0167
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0761	0.0863
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0041	0.1338	0.1519
Brugia malayi	Cation transporter family protein	0.002	0.0167	0.019
Schistosoma mansoni	nAChR subunit	0.002	0.0167	0.0167
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1222	0.1387
Brugia malayi	Cytochrome P450 family protein	0.0038	0.1167	0.1325
Schistosoma mansoni	thyroid hormone receptor	0.0041	0.1338	0.1338
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.002	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0024	0.035	0.0398
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.035	0.035
Onchocerca volvulus	Putative nachr subunit	0.002	0.0167	0.019
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0646	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.002	0.0167	0.019
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.002	0.0167	0.0167
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0096	0.4457	0.4457
Echinococcus multilocularis	ecdysone induced protein 78C	0.0041	0.1338	0.1338
Schistosoma mansoni	thyroid hormone receptor	0.0041	0.1338	0.1338
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0041	0.1338	0.1338
Brugia malayi	hypothetical protein	0.0024	0.035	0.0398
Mycobacterium ulcerans	oxidoreductase	0.0067	0.2837	1
Echinococcus multilocularis	glycine receptor subunit beta	0.002	0.0167	0.0167
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.002	0.0167	0.0167
Onchocerca volvulus	Protein ultraspiracle homolog	0.0041	0.1338	0.1519
Brugia malayi	NADH-dependent xylose reductase	0.0019	0.012	0.0136
Schistosoma mansoni	coup transcription factor	0.0041	0.1338	0.1338
Leishmania major	prostaglandin f synthase, putative	0.0067	0.2837	1
Echinococcus granulosus	voltage gated potassium channel subunit	0.0019	0.012	0.012
Brugia malayi	hypothetical protein	0.0172	0.8811	1
Onchocerca volvulus		0.0031	0.0761	0.0863
Onchocerca volvulus		0.0019	0.012	0.0136
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0041	0.1338	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1338	0.1519
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Echinococcus granulosus	intermediate filament protein	0.0031	0.0761	0.0761
Onchocerca volvulus		0.0067	0.2837	0.322
Trichomonas vaginalis	aldo-keto reductase, putative	0.0067	0.2837	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0167	0.019
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.1338	0.1519
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0041	0.1338	0.1519
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0041	0.1338	0.1338
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.002	0.0167	0.019
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0041	0.1338	0.1519
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0067	0.2837	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0067	0.2837	0.2837
Echinococcus granulosus	hypothetical protein	0.0067	0.2837	0.2837
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.1338	0.1519

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 157.5 nM	Displacement of [3H]CP-55,940 from recombinant human CB1 receptor transfected in HEK cells	ChEMBL.	20943290
Ki (binding)	= 237.3 nM	Displacement of [3H]CP-55,940 from recombinant human CB2 receptor transfected in HEK cells	ChEMBL.	20943290

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1631295

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1465256