Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0193 | 0.1509 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0193 | 0.1509 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0036 | 0.0101 | 0.0101 |
Schistosoma mansoni | acetylcholinesterase | 0.0193 | 0.1509 | 0.1509 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0193 | 0.1509 | 0.5 |
Onchocerca volvulus | 0.0193 | 0.1509 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0193 | 0.1509 | 0.1509 |
Loa Loa (eye worm) | hypothetical protein | 0.1144 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | carboxylesterase | 0.0193 | 0.1509 | 0.1509 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0036 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | carboxylesterase | 0.0193 | 0.1509 | 0.1509 |
Onchocerca volvulus | 0.0193 | 0.1509 | 0.5 | |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0036 | 0.0101 | 0.0101 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0134 | 0.098 | 0.098 |
Echinococcus granulosus | voltage gated potassium channel | 0.0036 | 0.0101 | 0.0101 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0193 | 0.1509 | 0.1509 |
Echinococcus granulosus | acetylcholinesterase | 0.1144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1509 | 0.1509 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0123 | 0.088 | 0.088 |
Echinococcus granulosus | carboxylesterase 5A | 0.1144 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1144 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1144 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1144 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0193 | 0.1509 | 0.1509 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1509 | 0.1509 |
Onchocerca volvulus | 0.0193 | 0.1509 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0193 | 0.1509 | 0.1509 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0193 | 0.1509 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1509 | 0.1509 |
Onchocerca volvulus | 0.0193 | 0.1509 | 0.5 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0193 | 0.1509 | 0.1509 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0193 | 0.1509 | 0.1509 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0193 | 0.1509 | 0.1509 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0193 | 0.1509 | 0.1509 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0115 | 0.0807 | 0.5349 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0036 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1509 | 0.1509 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0193 | 0.1509 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0193 | 0.1509 | 0.1509 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1509 | 0.1509 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0123 | 0.088 | 0.088 |
Schistosoma mansoni | gliotactin | 0.0193 | 0.1509 | 0.1509 |
Brugia malayi | Carboxylesterase family protein | 0.0193 | 0.1509 | 0.1509 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0123 | 0.088 | 0.088 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0193 | 0.1509 | 0.1509 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0193 | 0.1509 | 1 |
Brugia malayi | hypothetical protein | 0.0193 | 0.1509 | 0.1509 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0115 | 0.0807 | 0.5349 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0193 | 0.1509 | 0.1509 |
Echinococcus granulosus | acetylcholinesterase | 0.1144 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0193 | 0.1509 | 0.1509 |
Brugia malayi | Carboxylesterase family protein | 0.1144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1509 | 0.1509 |
Echinococcus multilocularis | neuroligin | 0.0193 | 0.1509 | 0.1509 |
Loa Loa (eye worm) | carboxylesterase | 0.1144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1509 | 0.1509 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0101 | 0.0101 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0193 | 0.1509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0735 | 0.0735 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0134 | 0.098 | 0.098 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1144 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0123 | 0.088 | 0.088 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0193 | 0.1509 | 0.1509 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0193 | 0.1509 | 0.1509 |
Echinococcus granulosus | neuroligin | 0.0193 | 0.1509 | 0.1509 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0101 | 0.0101 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1144 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 19.2 % | Inhibition of T-type alpha1G calcium channel expressed in HEK293 cells assessed as Kcl-induced depolarization at 10 uM | ChEMBL. | 21126876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.