Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | NADH oxidase | 0.0056 | 0.0679 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.2893 | 0.3959 |
Brugia malayi | hypothetical protein | 0.018 | 0.2893 | 0.4162 |
Plasmodium falciparum | thioredoxin reductase | 0.0056 | 0.0679 | 0.2113 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.021 | 0.3426 | 0.3308 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0056 | 0.0679 | 0.2113 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0117 | 0.1757 | 0.2527 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.1535 | 0.2657 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0034 | 0.0285 | 0.011 |
Plasmodium falciparum | thioredoxin reductase | 0.0162 | 0.2561 | 1 |
Onchocerca volvulus | 0.018 | 0.2893 | 0.8277 | |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0056 | 0.0679 | 0.1551 |
Plasmodium falciparum | glutathione reductase | 0.0056 | 0.0679 | 0.2113 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0065 | 0.0836 | 0.0671 |
Echinococcus multilocularis | geminin | 0.058 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0034 | 0.0285 | 0.046 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0034 | 0.0285 | 0.011 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0034 | 0.0285 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0332 | 0.0229 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0056 | 0.0679 | 0.0861 |
Brugia malayi | hypothetical protein | 0.0123 | 0.1872 | 0.2693 |
Schistosoma mansoni | chromobox protein | 0.0083 | 0.1162 | 0.1003 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0034 | 0.0285 | 0.046 |
Schistosoma mansoni | glutaminase | 0.0301 | 0.5034 | 0.4945 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0642 | 0.0474 |
Trichomonas vaginalis | chromobox protein, putative | 0.005 | 0.0574 | 0.0641 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0056 | 0.0679 | 0.1551 |
Brugia malayi | MH1 domain containing protein | 0.0028 | 0.0177 | 0.0254 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.021 | 0.3426 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0642 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0642 | 0.068 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.021 | 0.3426 | 0.4928 |
Leishmania major | trypanothione reductase | 0.0162 | 0.2561 | 0.7339 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0044 | 0.0462 | 0.0884 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0642 | 0.0474 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0162 | 0.2561 | 0.2427 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0577 | 0.0408 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0056 | 0.0679 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0055 | 0.0658 | 0.2025 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0028 | 0.0177 | 0.0003 |
Trichomonas vaginalis | chromobox protein, putative | 0.0083 | 0.1162 | 0.1874 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0056 | 0.0679 | 0.0512 |
Brugia malayi | MH2 domain containing protein | 0.0028 | 0.0177 | 0.0254 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0369 | 0.625 | 0.8837 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0056 | 0.0679 | 0.0977 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.021 | 0.3426 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0072 | 0.0966 | 0.3314 |
Plasmodium vivax | glutathione reductase, putative | 0.0162 | 0.2561 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.021 | 0.3426 | 0.6625 |
Toxoplasma gondii | thioredoxin reductase | 0.0162 | 0.2561 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0162 | 0.2561 | 0.3684 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0054 | 0.0642 | 0.0923 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0171 | 0.2717 | 0.3909 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0056 | 0.0679 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0083 | 0.1162 | 0.1003 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.021 | 0.3426 | 0.3308 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0642 | 0.0474 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0082 | 0.1143 | 0.1645 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0056 | 0.0679 | 0.2113 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0054 | 0.0642 | 0.068 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0056 | 0.067 | 0.2074 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0044 | 0.0462 | 0.0884 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0162 | 0.2561 | 0.2427 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0044 | 0.0462 | 0.0406 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0056 | 0.0679 | 0.2113 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.0511 | 0.0736 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0056 | 0.0679 | 0.1551 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.041 | 0.6982 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0577 | 0.0408 |
Brugia malayi | MH2 domain containing protein | 0.0028 | 0.0177 | 0.0254 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0041 | 0.0414 | 0.0596 |
Brugia malayi | Smad1 | 0.0028 | 0.0177 | 0.0254 |
Giardia lamblia | Kinase, PLK | 0.021 | 0.3426 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0028 | 0.0177 | 0.0003 |
Echinococcus multilocularis | bloom syndrome protein | 0.0082 | 0.1143 | 0.0984 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0056 | 0.0679 | 0.2113 |
Echinococcus granulosus | bloom syndrome protein | 0.0082 | 0.1143 | 0.0984 |
Trichomonas vaginalis | chromobox protein, putative | 0.0083 | 0.1162 | 0.1874 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0056 | 0.0679 | 0.1551 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0056 | 0.0679 | 0.0861 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0056 | 0.0679 | 0.0512 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0034 | 0.0285 | 0.046 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.005 | 0.0574 | 0.0783 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0056 | 0.0679 | 0.1255 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0642 | 0.0474 |
Trichomonas vaginalis | CAMK family protein kinase | 0.021 | 0.3426 | 0.6625 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0642 | 0.0474 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0056 | 0.0679 | 0.1551 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0171 | 0.2717 | 0.3703 |
Schistosoma mansoni | hypothetical protein | 0.058 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0083 | 0.1162 | 0.1003 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0056 | 0.0679 | 0.1551 |
Loa Loa (eye worm) | Smad1 | 0.0028 | 0.0177 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.1757 | 0.1608 |
Schistosoma mansoni | DNA helicase recq5 | 0.0034 | 0.0285 | 0.011 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0369 | 0.625 | 0.8837 |
Entamoeba histolytica | hypothetical protein | 0.0123 | 0.1872 | 0.4757 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0511 | 0.058 |
Loa Loa (eye worm) | glutaminase | 0.0301 | 0.5034 | 0.7079 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0123 | 0.1872 | 0.1726 |
Trypanosoma brucei | polo-like protein kinase | 0.021 | 0.3426 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0162 | 0.2561 | 0.3475 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0083 | 0.1162 | 0.1438 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0577 | 0.0408 |
Schistosoma mansoni | hypothetical protein | 0.058 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0083 | 0.1162 | 0.1672 |
Schistosoma mansoni | serine/threonine protein kinase | 0.021 | 0.3426 | 0.3308 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0408 | 0.6951 | 0.9871 |
Mycobacterium tuberculosis | Probable reductase | 0.0369 | 0.625 | 0.8837 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0056 | 0.0679 | 0.1551 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0056 | 0.0679 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0369 | 0.625 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0369 | 0.625 | 0.8837 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0642 | 0.0474 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0056 | 0.0679 | 0.1551 |
Entamoeba histolytica | hypothetical protein | 0.0123 | 0.1872 | 0.4757 |
Loa Loa (eye worm) | glutathione reductase | 0.0162 | 0.2561 | 0.3475 |
Trichomonas vaginalis | chromobox protein, putative | 0.005 | 0.0574 | 0.0641 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0162 | 0.2561 | 0.2985 |
Trichomonas vaginalis | CAMK family protein kinase | 0.021 | 0.3426 | 0.6625 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.021 | 0.3426 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0056 | 0.0679 | 0.1551 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0162 | 0.2561 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.041 | 0.6982 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.2717 | 0.3703 |
Brugia malayi | MH1 domain containing protein | 0.0028 | 0.0177 | 0.0254 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0044 | 0.0462 | 0.0884 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0369 | 0.625 | 0.8837 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0577 | 0.0408 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.0642 | 0.0474 |
Trichomonas vaginalis | CAMK family protein kinase | 0.021 | 0.3426 | 0.6625 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0577 | 0.0408 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0082 | 0.1143 | 0.1834 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0511 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1757 | 0.2304 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0056 | 0.0679 | 0.1551 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.021 | 0.3426 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.021 | 0.3426 | 0.6625 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0041 | 0.0414 | 0.0596 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0162 | 0.2561 | 0.7339 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0577 | 0.0408 |
Echinococcus multilocularis | chromobox protein 1 | 0.0083 | 0.1162 | 0.1003 |
Schistosoma mansoni | DNA helicase recq1 | 0.0034 | 0.0285 | 0.011 |
Entamoeba histolytica | hypothetical protein | 0.0123 | 0.1872 | 0.4757 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0123 | 0.1872 | 0.1726 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0171 | 0.2717 | 0.3909 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.1535 | 0.2657 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0285 | 0.016 |
Plasmodium falciparum | glutathione reductase | 0.0162 | 0.2561 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0056 | 0.0679 | 0.2113 |
Mycobacterium ulcerans | glutaminase | 0.0301 | 0.5034 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.021 | 0.3426 | 0.6625 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0034 | 0.0285 | 0.016 |
Trypanosoma brucei | trypanothione reductase | 0.0162 | 0.2561 | 0.7339 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0642 | 0.0474 |
Brugia malayi | MH2 domain containing protein | 0.0408 | 0.6951 | 1 |
Schistosoma mansoni | kinase | 0.0107 | 0.1584 | 0.1433 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.1872 | 0.1726 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0056 | 0.0679 | 0.0512 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0577 | 0.083 |
Echinococcus granulosus | chromobox protein 1 | 0.0083 | 0.1162 | 0.1003 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0034 | 0.0285 | 0.011 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0082 | 0.1143 | 0.1834 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0175 | 0.0252 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0408 | 0.6951 | 0.9871 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 0.704 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.041 | 0.6982 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.041 | 0.6982 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0056 | 0.0679 | 0.1551 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0034 | 0.0285 | 0.041 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0056 | 0.0679 | 0.1551 |
Loa Loa (eye worm) | glutaminase 2 | 0.0301 | 0.5034 | 0.7079 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0056 | 0.0679 | 0.1551 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0056 | 0.0679 | 0.2113 |
Entamoeba histolytica | hypothetical protein | 0.0123 | 0.1872 | 0.4757 |
Loa Loa (eye worm) | RecQ helicase | 0.0082 | 0.1143 | 0.141 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0577 | 0.0586 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0056 | 0.0679 | 0.1551 |
Schistosoma mansoni | chromobox protein | 0.0083 | 0.1162 | 0.1003 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0034 | 0.0285 | 0.041 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0054 | 0.0642 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0511 | 0.049 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.021 | 0.3426 | 0.4736 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.021 | 0.3426 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0123 | 0.1872 | 0.1726 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0511 | 0.0509 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0056 | 0.0679 | 0.1551 |
Trichomonas vaginalis | CAMK family protein kinase | 0.021 | 0.3426 | 0.6625 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0056 | 0.0679 | 0.1551 |
Brugia malayi | glutaminase DH11.1 | 0.0301 | 0.5034 | 0.7242 |
Brugia malayi | glutathione reductase | 0.0162 | 0.2561 | 0.3684 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0056 | 0.0679 | 0.1551 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.0642 | 0.0474 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0577 | 0.0408 |
Trichomonas vaginalis | glutaminase, putative | 0.0301 | 0.5034 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K2 (binding) | = 222 M-1 min-1 | The second order rate constant of inactivation of the compound was reported | ChEMBL. | 11128643 |
K2 (binding) | = 222 M-1 min-1 | The second order rate constant of inactivation of the compound was reported | ChEMBL. | 11128643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.