Detailed information for compound 1466574

Basic information

Technical information
  • TDR Targets ID: 1466574
  • Name: 2-(2,5-dioxopyrrol-1-yl)-4,5,6,7-tetrahydro-1 -benzothiophene-3-carbonitrile
  • MW: 258.296 | Formula: C13H10N2O2S
  • H donors: 0 H acceptors: 3 LogP: 2 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(sc2c1CCCC2)N1C(=O)C=CC1=O
  • InChi: 1S/C13H10N2O2S/c14-7-9-8-3-1-2-4-10(8)18-13(9)15-11(16)5-6-12(15)17/h5-6H,1-4H2
  • InChiKey: FSAPLHALRWHHII-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2,5-dioxopyrrol-1-yl)-4,5,6,7-tetrahydrobenzothiophene-3-carbonitrile
  • 2-(2,5-dioxo-1-pyrrolyl)-4,5,6,7-tetrahydrobenzothiophene-3-carbonitrile
  • 2-maleimido-4,5,6,7-tetrahydrobenzothiophene-3-carbonitrile
  • ST5323443
  • ZINC00558889

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0525 0.0443
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0183 0.1027
Echinococcus granulosus GPCR family 2 0.0015 0.0172 0.0087
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.1079 0.1002
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.1079 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0952 0.6071
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0086 0.0498
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0337 0.027
Schistosoma mansoni hypothetical protein 0.0015 0.0172 0.0153
Loa Loa (eye worm) hypothetical protein 0.0034 0.1037 0.0975
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0069 0.034
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1079 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0337 0.2905
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.1072 0.0995
Loa Loa (eye worm) hypothetical protein 0.0034 0.1037 0.0975
Leishmania major DNA polymerase kappa, putative 0.0019 0.0337 0.198
Schistosoma mansoni hypothetical protein 0.0015 0.0172 0.0153
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.1568 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1568 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0086 0.0017
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.1079 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0337 0.027
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0337 0.1698
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.1568 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0069 0.034
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1617 0.1559
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.1037 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1079 1
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.6725 0.6697
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.1568 1
Schistosoma mansoni alpha-glucosidase 0.0137 0.5715 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0086 0.0498
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.1568 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.1079 0.6816
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0069 0.034
Brugia malayi hypothetical protein 0.0035 0.1072 0.1009
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.1079 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.1037 1
Entamoeba histolytica hypothetical protein 0.0035 0.1072 0.6766
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0068 0.033
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1568 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.1037 0.5
Onchocerca volvulus 0.0014 0.0086 0.0046
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0086 0.0546
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0337 0.2905
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1689 0.1632
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0337 0.1698
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0337 0.0254
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.6725 0.6702
Loa Loa (eye worm) hypothetical protein 0.0034 0.1037 0.0975
Loa Loa (eye worm) hypothetical protein 0.0046 0.1568 0.1509
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0086 0.0017
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0069 0.034
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0069 0.034
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.1568 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0086 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1568 0.1509
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0086 0.0017
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0172 0.0104
Loa Loa (eye worm) hypothetical protein 0.0117 0.4784 0.4747
Trypanosoma brucei unspecified product 0.0013 0.0068 0.033
Loa Loa (eye worm) hypothetical protein 0.0085 0.3345 0.3299
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0086 0.034
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1079 1
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1568 0.1509
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1568 1
Schistosoma mansoni alpha-glucosidase 0.0137 0.5715 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.1072 0.1752
Onchocerca volvulus 0.0014 0.0086 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0952 0.6071
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0337 0.2905
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.1072 0.0995
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.5076 0.5042
Echinococcus granulosus dna polymerase eta 0.0019 0.0337 0.0254
Schistosoma mansoni DNA polymerase eta 0.0019 0.0337 0.0447
Loa Loa (eye worm) oxidoreductase 0.0014 0.0086 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0123 0.5076 0.8866
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0086 0.034
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.1568 1
Echinococcus multilocularis survival motor neuron protein 1 0.0232 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0069 0.034
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0175 0.0898
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0337 0.198
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1079 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0086 0.0498
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.1568 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1568 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.6725 0.6697
Loa Loa (eye worm) TAR-binding protein 0.0123 0.5076 0.5042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0172 0.0087
Echinococcus multilocularis tar DNA binding protein 0.0123 0.5076 0.5034
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0086 0.034
Entamoeba histolytica hypothetical protein 0.0035 0.1072 0.6766
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.1079 0.1017
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0086 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0086 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Entamoeba histolytica hypothetical protein 0.0035 0.1072 0.6766
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.1568 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.5076 0.5042
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0086 0.0546
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.1037 0.6617
Loa Loa (eye worm) hypothetical protein 0.0014 0.0086 0.0017
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0086 0.034
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1568 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0337 0.0254
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0337 0.2905
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1689 0.1632
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0987 0.0924
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0069 0.034
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0337 0.2905
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0086 0.0546
Schistosoma mansoni tar DNA-binding protein 0.0123 0.5076 0.8866
Loa Loa (eye worm) hypothetical protein 0.0014 0.0086 0.0017
Echinococcus granulosus survival motor neuron protein 1 0.0232 1 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0397 0.3272
Giardia lamblia DINP protein human, muc B family 0.0019 0.0337 0.5
Onchocerca volvulus 0.0047 0.1617 0.4305
Schistosoma mansoni tar DNA-binding protein 0.0123 0.5076 0.8866
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0068 0.033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0337 0.2152
Onchocerca volvulus 0.0014 0.0086 0.0046
Trypanosoma brucei unspecified product 0.0013 0.0068 0.033
Schistosoma mansoni hypothetical protein 0.0033 0.0987 0.1601
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.1568 1
Echinococcus granulosus bloom syndrome protein 0.0023 0.0525 0.0443
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0337 0.027
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0525 0.4701
Schistosoma mansoni hypothetical protein 0.0015 0.0172 0.0153
Schistosoma mansoni survival motor neuron protein 0.0047 0.1617 0.2721
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.1079 0.1017
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1079 1
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0069 0.0232
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0086 0.0546
Loa Loa (eye worm) hypothetical protein 0.0085 0.3345 0.3299
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0069 0.0232
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0086 0.0498
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.1037 0.6421
Leishmania major DNA polymerase eta, putative 0.0019 0.0337 0.198
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.1079 0.1002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.1568 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.1079 0.6816
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0086 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0068 0.033
Loa Loa (eye worm) RecQ helicase 0.0023 0.0525 0.0459
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0337 0.198
Echinococcus multilocularis GPCR, family 2 0.0015 0.0172 0.0087
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0525 0.4701
Onchocerca volvulus 0.0014 0.0086 0.0046
Entamoeba histolytica hypothetical protein 0.0035 0.1072 0.6766
Schistosoma mansoni alpha glucosidase 0.0035 0.1079 0.1766
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1568 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0337 0.027
Loa Loa (eye worm) hypothetical protein 0.0046 0.1568 0.1509
Trypanosoma brucei unspecified product 0.0019 0.0337 0.2905
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0337 0.2905
Echinococcus multilocularis dna polymerase eta 0.0019 0.0337 0.0254
Schistosoma mansoni eyes absent homolog 0.0085 0.3345 0.579
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0086 0.0498
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0069 0.034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0987 0.0924
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0337 0.0254
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1689 0.1632
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0086 0.0017
Onchocerca volvulus 0.0046 0.1568 0.4167
Loa Loa (eye worm) RNA binding protein 0.0123 0.5076 0.5042
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.6725 0.6702
Brugia malayi TAR-binding protein 0.0123 0.5076 0.5042
Schistosoma mansoni hypothetical protein 0.0047 0.1617 0.2721
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0069 0.034
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.1079 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1568 0.1509
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0952 0.6071
Loa Loa (eye worm) hypothetical protein 0.0034 0.1037 0.0975
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0172 0.0087
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0337 0.0447
Loa Loa (eye worm) hypothetical protein 0.0232 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1079 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0172 0.0104
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0337 0.0447
Schistosoma mansoni hypothetical protein 0.0015 0.0172 0.0153
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1079 1
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1568 0.1509
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0086 0.0546
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0172 0.0104
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0172 0.0087
Brugia malayi RNA binding protein 0.0123 0.5076 0.5042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0172 0.0087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0086 0.0546
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0086 0.0546
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0337 0.0254
Schistosoma mansoni tar DNA-binding protein 0.0123 0.5076 0.8866
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.1568 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0086 0.0017
Mycobacterium ulcerans hypothetical protein 0.0046 0.1568 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0086 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0086 0.0546
Trypanosoma brucei glucosidase, putative 0.0035 0.1079 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.6725 0.6697
Schistosoma mansoni hypothetical protein 0.0035 0.1072 0.1752
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0069 0.034
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0086 0.0017
Onchocerca volvulus 0.0092 0.3666 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0337 0.2905
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0069 0.034
Schistosoma mansoni tar DNA-binding protein 0.0123 0.5076 0.8866
Echinococcus granulosus tar DNA binding protein 0.0123 0.5076 0.5034
Brugia malayi hypothetical protein 0.0085 0.3345 0.3299
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0086 0.0546
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.1079 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0952 0.6071
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0337 0.2905
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0086 0.0546
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0086 0.0546
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0337 0.2152
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0303 0.0386
Loa Loa (eye worm) hypothetical protein 0.0049 0.1689 0.1632
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0525 0.0459
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.1079 0.6816
Loa Loa (eye worm) hypothetical protein 0.0034 0.1037 0.0975
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0172 0.0104

Activities

Activity type Activity value Assay description Source Reference
Ratio (functional) = 3 Antianxiety activity in ip dosed Albino mouse assessed as increase in locomotor activity after 30 mins relative to Diazepam ChEMBL. 20950897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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