Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3 uM | Antiproliferative activity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 20933308 |
IC50 (functional) | = 3.1 uM | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | ChEMBL. | 20933308 |
IC50 (functional) | = 3.1 uM | Antiproliferative activity against human K562 cells after 72 hrs by MTT assay | ChEMBL. | 20933308 |
IC50 (functional) | = 3.5 uM | Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay | ChEMBL. | 20933308 |
IC50 (functional) | = 4.1 uM | Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay | ChEMBL. | 20933308 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20933308 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.