Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | 0.0047 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0184 | 1 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0101 | 0.3933 | 0.3933 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0101 | 0.3933 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.049 | 0.049 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0101 | 0.3933 | 0.3933 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0047 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0101 | 0.3933 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0047 | 0 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0047 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0101 | 0.3933 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0047 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0101 | 0.3933 | 0.3933 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0101 | 0.3933 | 0.3933 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0101 | 0.3933 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0101 | 0.3933 | 0.3933 |
Trypanosoma brucei | cytochrome P450, putative | 0.0101 | 0.3933 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0047 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 5 | Binding affinity to human recombinant PR by competition ligand binding fluorescence polarization assay | ChEMBL. | 21129964 |
EC50 (binding) | > 5 | Antagonist activity at human MR ligand binding domain transfected in CHO cells co-transfected with MMTV-luciferase gene assessed as inhibition of cortisol-induced luciferase activity | ChEMBL. | 21129964 |
EC50 (binding) | = 7 | Antagonist activity at human GR DNA binding domain transfected in CHO cells co-transfected with MMTV-luciferase gene assessed as inhibition of cortisol-induced luciferase activity | ChEMBL. | 21129964 |
EC50 (binding) | = 7.9 | Binding affinity to human recombinant GR by competition ligand binding fluorescence polarization assay | ChEMBL. | 21129964 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.