Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Golgi-associated plant pathogenesis-related protein 1 homolog | Metabotropic glutamate receptor 2 | 872 aa | 884 aa | 35.3 % |
Schistosoma mansoni | metabotropic glutamate receptor | Metabotropic glutamate receptor 2 | 872 aa | 892 aa | 26.9 % |
Onchocerca volvulus | Cell death abnormality protein 8 homolog | Metabotropic glutamate receptor 2 | 872 aa | 883 aa | 43.3 % |
Loa Loa (eye worm) | hypothetical protein | Metabotropic glutamate receptor 2 | 872 aa | 822 aa | 21.2 % |
Onchocerca volvulus | Metabotropic glutamate receptor 2 | 872 aa | 774 aa | 20.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0075 | 0.0305 | 0.0258 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0055 | 0.0172 | 0.0268 |
Mycobacterium ulcerans | thymidylate synthase | 0.0985 | 0.6414 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0069 | 0.0267 | 0.0416 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0181 | 0.1018 | 0.1394 |
Loa Loa (eye worm) | thymidylate synthase | 0.0985 | 0.6414 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0181 | 0.1018 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1518 | 1 | 1 |
Onchocerca volvulus | 0.0985 | 0.6414 | 1 | |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0181 | 0.1018 | 0.1587 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0985 | 0.6414 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0748 | 0.4823 | 0.5 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0181 | 0.1018 | 0.1587 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1518 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0061 | 0.021 | 0.0328 |
Echinococcus granulosus | thymidylate synthase | 0.0985 | 0.6414 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0985 | 0.6414 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0985 | 0.6414 | 1 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0113 | 0.0561 | 0.167 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1518 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0985 | 0.6414 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0748 | 0.4823 | 0.7464 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0113 | 0.0561 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0305 | 0.0352 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1518 | 1 | 0.5 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0042 | 0.0083 | 0.0129 |
Brugia malayi | hypothetical protein | 0.0468 | 0.2946 | 0.4594 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0181 | 0.1018 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0181 | 0.1018 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0985 | 0.6414 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0468 | 0.2946 | 1 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0181 | 0.1018 | 0.1394 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0042 | 0.0083 | 0.0129 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0075 | 0.0305 | 0.0258 |
Loa Loa (eye worm) | glutamate receptor | 0.0061 | 0.021 | 0.0202 |
Echinococcus granulosus | beta hexosaminidase subunit alpha | 0.0113 | 0.0561 | 0.0665 |
Brugia malayi | dihydrofolate reductase family protein | 0.0748 | 0.4823 | 0.752 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0113 | 0.0561 | 0.167 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0113 | 0.0561 | 0.167 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0181 | 0.1018 | 0.1587 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0748 | 0.4823 | 0.7488 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1518 | 1 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.0144 | 0.0224 |
Brugia malayi | Dihydrofolate reductase | 0.0748 | 0.4823 | 0.752 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.0181 | 0.1018 | 0.1477 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0181 | 0.1018 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0748 | 0.4823 | 0.752 |
Echinococcus multilocularis | beta hexosaminidase subunit alpha | 0.0113 | 0.0561 | 0.0665 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0748 | 0.4823 | 0.5414 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0748 | 0.4823 | 0.7464 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.002 uM | Partial displacement of [3H]LY354740 from recombinant rat mGluR2 | ChEMBL. | 20971004 |
IC50 (functional) | = 0.004 uM | Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP production | ChEMBL. | 20971004 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.