Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3022 | 0.3022 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0147 | 0.0147 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0147 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.2304 | 0.3471 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0147 | 0.0147 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0147 | 0.0222 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0147 | 0.0222 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0147 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3022 | 0.4552 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0147 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2304 | 0.3471 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3022 | 0.4552 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3022 | 0.4552 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1238 | 0.1864 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.2304 | 0.3471 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0147 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0147 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0147 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0147 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1238 | 0.1238 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3022 | 0.4552 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.6639 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0147 | 0.0147 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3022 | 0.3022 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3022 | 0.3022 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.6639 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3022 | 0.3022 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0147 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.6639 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0147 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.2304 | 0.3471 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0147 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3022 | 0.3022 |
Echinococcus multilocularis | geminin | 0.0171 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0147 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0147 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3022 | 0.3022 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0147 | 0.0147 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0147 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0147 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3022 | 0.3022 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0147 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3022 | 0.4552 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3022 | 0.4552 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1238 | 0.1864 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.