Detailed information for compound 1467104

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 438.491 | Formula: C25H27FN2O4
  • H donors: 0 H acceptors: 1 LogP: 3.9 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)OCCOc1ccn(c(=O)c1)c1ccc(cc1)OCCN1CCCC1
  • InChi: 1S/C25H27FN2O4/c26-20-3-7-22(8-4-20)31-17-18-32-24-11-14-28(25(29)19-24)21-5-9-23(10-6-21)30-16-15-27-12-1-2-13-27/h3-11,14,19H,1-2,12-13,15-18H2
  • InChiKey: BMCQCQBJDOTTHX-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0012 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0012 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0012 0.5 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0012 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0012 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0012 0.5 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0012 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0012 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Leishmania major dehydrogenase-like protein 0.0012 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0012 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0012 0.5 0.5
Mycobacterium ulcerans carveol-like dehydrogenase 0.0012 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0012 0.5 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0012 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0012 0.5 0.5
Brugia malayi oxidoreductase 0.0012 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0012 0.5 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0012 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0012 0.5 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0012 0.5 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0012 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Brugia malayi Retinol dehydrogenase 12 0.0012 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0012 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.5 0.5
Leishmania major oxidoreductase-like protein 0.0012 0.5 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0012 0.5 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0012 0.5 0.5
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Schistosoma mansoni retinal dehydrogenase 0.0012 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0012 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0012 0.5 0.5
Brugia malayi hypothetical protein 0.0012 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.0012 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0012 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0012 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0012 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0012 0.5 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Echinococcus granulosus steroid dehydrogenase 0.0012 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.5 0.5
Brugia malayi hypothetical protein 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0012 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0012 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0012 0.5 0.5
Mycobacterium leprae Probable oxidoreductase 0.0012 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0012 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Echinococcus granulosus oxidoreductase 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0012 0.5 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Giardia lamblia Hypothetical protein 0.0012 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0012 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.5 0.5
Leishmania major pteridine reductase 1 0.0012 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0012 0.5 0.5
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0012 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0012 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.5 0.5
Mycobacterium ulcerans dehydrogenase/reductase 0.0012 0.5 0.5
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0012 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0012 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0012 0.5 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0012 0.5 0.5
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0012 0.5 0.5
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0012 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0012 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.0012 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.5 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0012 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.5 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0012 0.5 0.5
Mycobacterium ulcerans dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0012 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0012 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0012 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 2 0.0012 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.5 0.5
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.5 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Echinococcus multilocularis oxidoreductase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Plasmodium vivax hypothetical protein, conserved 0.0012 0.5 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0012 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.5 0.5
Giardia lamblia Reductase, putative 0.0012 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.5 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.5 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.5 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.5 0.5
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0012 0.5 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0012 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Onchocerca volvulus Sepiapterin reductase homolog 0.0012 0.5 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0012 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0012 0.5 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0012 0.5 0.5
Echinococcus multilocularis conserved hypothetical protein 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0012 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0012 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Leishmania major short chain dehydrogenase-like protein 0.0012 0.5 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0012 0.5 0.5
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0012 0.5 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0012 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0012 0.5 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0012 0.5 0.5
Trypanosoma brucei oxidoreductase-like protein 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0012 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0012 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0012 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0012 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0012 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0012 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0012 0.5 0.5
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0012 0.5 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0012 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0012 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.5 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0012 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.5 0.5
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 9 0.0012 0.5 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0012 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.5 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0012 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.5 0.5
Onchocerca volvulus 0.0012 0.5 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced intracellular calcium release by FLIPR assay ChEMBL. 21190859
IC50 (binding) = 150 nM Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay ChEMBL. 21190859

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.