Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.059 | 0.5922 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.028 | 0.068 | 0.1148 |
Brugia malayi | Trypsin family protein | 0.0547 | 0.5207 | 0.8793 |
Brugia malayi | thymidylate synthase | 0.059 | 0.5922 | 1 |
Onchocerca volvulus | 0.0547 | 0.5207 | 0.6031 | |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.5207 | 0.8793 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.083 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.059 | 0.5922 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.083 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0547 | 0.5207 | 0.8793 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.059 | 0.5922 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.5207 | 0.8793 |
Trichomonas vaginalis | conserved hypothetical protein | 0.028 | 0.068 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.083 | 1 | 0.5 |
Onchocerca volvulus | 0.059 | 0.5922 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0547 | 0.5207 | 0.8793 |
Chlamydia trachomatis | dihydrofolate reductase | 0.024 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.059 | 0.5922 | 1 |
Brugia malayi | hypothetical protein | 0.028 | 0.068 | 0.1148 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.083 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.059 | 0.5922 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.083 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.059 | 0.5922 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.059 | 0.5922 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Toxicity in Saccharomyces cerevisiae after 24 hrs by microdilution method | ChEMBL. | 21109444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.