Detailed information for compound 1467339

Basic information

Technical information
  • TDR Targets ID: 1467339
  • Name: N-(1-adamantyl)-2-(propan-2-ylamino)acetamide
  • MW: 250.38 | Formula: C15H26N2O
  • H donors: 2 H acceptors: 1 LogP: 2.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NCC(=O)NC12CC3CC(C2)CC(C1)C3)C
  • InChi: 1S/C15H26N2O/c1-10(2)16-9-14(18)17-15-6-11-3-12(7-15)5-13(4-11)8-15/h10-13,16H,3-9H2,1-2H3,(H,17,18)
  • InChiKey: WOKTYNVVHGAEIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1-adamantyl)-2-(isopropylamino)acetamide
  • N-(1-adamantyl)-2-(propan-2-ylamino)ethanamide
  • STOCK1S-67437

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0719 0.0362
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0397 0.0394
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.009 0.2726 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0397 0.1445
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0719 0.2626
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0397 0.1445
Onchocerca volvulus 0.0031 0.0719 0.0436
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0397 0.0285
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.021 0.0756
Brugia malayi fructose-bisphosphate aldolase 2 0.009 0.2726 0.3823
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0719 0.2626
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0719 0.2626
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0283 0.9273 1
Echinococcus granulosus fructose bisphosphate aldolase class I 0.009 0.2726 1
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.009 0.2726 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0397 0.1445
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0901 0.3296
Schistosoma mansoni pol-related 0.0031 0.0719 0.2626
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.009 0.2726 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0397 0.1445
Echinococcus multilocularis GPCR, family 2 0.0016 0.021 0.0756
Loa Loa (eye worm) oxidoreductase 0.0031 0.0719 0.0773
Echinococcus multilocularis aldo keto reductase 0.0031 0.0719 0.2626
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.009 0.2726 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0692 0.2526
Brugia malayi SWIRM domain containing protein 0.0021 0.0397 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0719 0.0773
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0654 0.2388
Echinococcus multilocularis aldo keto reductase 0.0031 0.0719 0.2626
Loa Loa (eye worm) hypothetical protein 0.0021 0.0397 0.0285
Loa Loa (eye worm) oxidoreductase 0.0031 0.0719 0.0773
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0719 0.2626
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1376 0.1772
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.009 0.2726 1
Brugia malayi hypothetical protein 0.0123 0.3863 0.5549
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Onchocerca volvulus 0.0239 0.7777 1
Onchocerca volvulus 0.003 0.0692 0.0399
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0719 0.2626
Plasmodium vivax SET domain protein, putative 0.003 0.0692 0.2526
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0397 0.1445
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0304 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.021 0.0756
Toxoplasma gondii aldose reductase, putative 0.0031 0.0719 0.2626
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0692 0.2526
Loa Loa (eye worm) hypothetical protein 0.0021 0.0397 0.0285
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.009 0.2726 1
Onchocerca volvulus 0.0031 0.0719 0.0436
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0719 0.0773
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0397 0.1445
Schistosoma mansoni amine oxidase 0.0021 0.0397 0.1445
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0719 0.2626
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.009 0.2726 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0397 0.1445
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0719 0.2626
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0692 0.2526
Brugia malayi hypothetical protein 0.0036 0.0901 0.105
Schistosoma mansoni hypothetical protein 0.0034 0.0836 0.3057
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.0719 1
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.009 0.2726 1
Schistosoma mansoni hypothetical protein 0.0016 0.021 0.0756
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.021 0.0756
Brugia malayi Pre-SET motif family protein 0.021 0.6793 1
Brugia malayi fructose-bisphosphate aldolase 1 0.009 0.2726 0.3823
Giardia lamblia Aldose reductase 0.0031 0.0719 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.3863 0.5549
Loa Loa (eye worm) hypothetical protein 0.0021 0.0397 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0692 0.2526
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0901 0.3296
Echinococcus granulosus aldo keto reductase 0.0031 0.0719 0.2626
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Giardia lamblia Aldose reductase 0.0031 0.0719 1
Onchocerca volvulus 0.0031 0.0719 0.0436
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.009 0.2726 1
Schistosoma mansoni aldo-keto reductase 0.0031 0.0719 0.2626
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0719 0.0773
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Mycobacterium ulcerans oxidoreductase 0.0031 0.0719 0.0715
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0397 0.1445
Mycobacterium ulcerans dehydrogenase 0.0021 0.0397 0.0394
Loa Loa (eye worm) hypothetical protein 0.0021 0.0397 0.0285
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.009 0.2726 1
Loa Loa (eye worm) oxidoreductase 0.0031 0.0719 0.0773
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0719 0.2626
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Entamoeba histolytica aldose reductase, putative 0.0031 0.0719 0.7967
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.009 0.2726 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.3863 0.4696
Onchocerca volvulus 0.0031 0.0719 0.0436
Loa Loa (eye worm) hypothetical protein 0.005 0.1376 0.1772
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0415 0.0548
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0836 0.0952
Plasmodium falciparum fructose-bisphosphate aldolase 0.009 0.2726 1
Brugia malayi Pre-SET motif family protein 0.003 0.0692 0.0732
Echinococcus granulosus aldo keto reductase 0.0031 0.0719 0.2626
Schistosoma mansoni hypothetical protein 0.0016 0.021 0.0756
Leishmania major fructose-1,6-bisphosphate aldolase 0.009 0.2726 1
Brugia malayi hypothetical protein 0.0021 0.0397 0.0285
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.009 0.2726 1
Echinococcus multilocularis 0.0021 0.0397 0.1445
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.009 0.2726 0.3823
Loa Loa (eye worm) hypothetical protein 0.003 0.0692 0.0732
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0719 0.0773
Echinococcus granulosus GPCR family 2 0.0016 0.021 0.0756
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0719 0.2626
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0397 0.1445
Schistosoma mansoni hypothetical protein 0.0016 0.021 0.0756
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0719 0.0773
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.009 0.2726 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Leishmania major prostaglandin f synthase, putative 0.0031 0.0719 0.2626
Entamoeba histolytica hypothetical protein 0.0036 0.0901 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0692 0.2526
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1376 0.1772
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0397 0.1445
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Echinococcus granulosus aldehyde reductase 0.0022 0.0415 0.151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0901 0.3296
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Leishmania major aldo-keto reductase-like protein 0.0031 0.0719 0.2626
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0397 0.1445
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.0719 0.2626
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0397 0.5
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0397 0.1445
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.6793 1
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.009 0.2726 1
Leishmania major UDP-galactopyranose mutase 0.0021 0.0397 0.1445
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0021 0.0397 0.1445
Loa Loa (eye worm) hypothetical protein 0.0034 0.0836 0.0952
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0719 0.2626
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0719 0.2626
Loa Loa (eye worm) oxidoreductase 0.0031 0.0719 0.0773
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.021 0.0756
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.009 0.2726 1
Schistosoma mansoni aldo-keto reductase 0.0031 0.0719 0.2626
Onchocerca volvulus 0.0031 0.0719 0.0436
Mycobacterium ulcerans oxidoreductase 0.0021 0.0397 0.0394
Echinococcus granulosus aldo keto reductase 0.0031 0.0719 0.2626
Echinococcus granulosus hypothetical protein 0.0031 0.0719 0.2626
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0692 0.2526
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.009 0.2726 0.3823
Trypanosoma brucei prostaglandin f synthase 0.0031 0.0719 0.2626
Schistosoma mansoni amine oxidase 0.0021 0.0397 0.1445
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0692 0.2526
Onchocerca volvulus 0.0031 0.0719 0.0436
Schistosoma mansoni hypothetical protein 0.0036 0.0901 0.3296
Entamoeba histolytica hypothetical protein 0.0036 0.0901 1
Entamoeba histolytica hypothetical protein 0.0036 0.0901 1
Entamoeba histolytica aldose reductase, putative 0.0031 0.0719 0.7967
Loa Loa (eye worm) hypothetical protein 0.0021 0.0397 0.0285
Entamoeba histolytica hypothetical protein 0.0036 0.0901 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0719 0.2626
Entamoeba histolytica aldose reductase, putative 0.0031 0.0719 0.7967
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0397 0.1445
Loa Loa (eye worm) hypothetical protein 0.0123 0.3863 0.5549
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0397 0.1445
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.009 0.2726 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0397 0.1445
Echinococcus multilocularis aldo keto reductase 0.0031 0.0719 0.2626
Echinococcus multilocularis aldehyde reductase 0.0022 0.0415 0.151
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0692 0.2526
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.009 0.2726 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.021 0.0756
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.009 0.2726 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0719 0.2626
Echinococcus multilocularis aldo keto reductase 0.0031 0.0719 0.2626
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1376 0.1772
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0397 0.1445
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0397 0.0394
Onchocerca volvulus Huntingtin homolog 0.0123 0.3863 0.4696
Loa Loa (eye worm) hypothetical protein 0.0021 0.0397 0.0285
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0719 0.2626
Loa Loa (eye worm) oxidoreductase 0.0031 0.0719 0.0773
Trichomonas vaginalis set domain proteins, putative 0.0239 0.7777 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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