Detailed information for compound 1467947

Basic information

Technical information
  • TDR Targets ID: 1467947
  • Name: N-ethyl-2-fluoro-N-[2-oxo-2-(thiophen-2-ylmet hylamino)ethyl]benzamide
  • MW: 320.382 | Formula: C16H17FN2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1ccccc1F)CC(=O)NCc1cccs1
  • InChi: 1S/C16H17FN2O2S/c1-2-19(16(21)13-7-3-4-8-14(13)17)11-15(20)18-10-12-6-5-9-22-12/h3-9H,2,10-11H2,1H3,(H,18,20)
  • InChiKey: DRBHTTMSSXFIIQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-ethyl-2-fluoro-N-[2-oxo-2-(2-thienylmethylamino)ethyl]benzamide
  • N-ethyl-2-fluoro-N-[2-keto-2-(2-thienylmethylamino)ethyl]benzamide
  • T5336763
  • MLS001007402
  • SMR000384563

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni notch 0.0071 0.1005 0.0741
Onchocerca volvulus 0.0071 0.1005 0.0741
Toxoplasma gondii EGF family domain-containing protein 0.0071 0.1005 1
Onchocerca volvulus 0.0071 0.1005 0.0741
Brugia malayi hypothetical protein 0.002 0.0042 0.0042
Giardia lamblia High cysteine protein 0.0071 0.1005 0.5
Brugia malayi Calcium binding EGF domain containing protein 0.0071 0.1005 0.1005
Onchocerca volvulus Slit protein homolog 0.0071 0.1005 0.0741
Trichomonas vaginalis AGC family protein kinase 0.0097 0.1506 0.5
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Echinococcus granulosus protein jagged 1 0.0071 0.1005 0.0741
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0245 0.5
Echinococcus multilocularis fat cadherin tumor suppressor 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Brugia malayi EGF-like domain containing protein 0.0071 0.1005 0.1005
Brugia malayi hypothetical protein 0.003 0.0245 0.0245
Echinococcus granulosus protein jagged 2 0.0071 0.1005 0.0741
Echinococcus multilocularis neurogenic locus notch protein 0.0071 0.1005 0.0741
Echinococcus granulosus geminin 0.0205 0.3523 0.3334
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Schistosoma mansoni notch 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Brugia malayi Animal haem peroxidase family protein 0.0549 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.3523 0.3334
Schistosoma mansoni notch 0.0071 0.1005 0.0741
Schistosoma mansoni notch 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Echinococcus multilocularis neural cadherin 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.2544 0.2544
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0071 0.1005 0.0741
Schistosoma mansoni single-minded 0.0049 0.06 0.0324
Echinococcus multilocularis peroxidasin 0.0549 1 1
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0359 0.0076
Loa Loa (eye worm) hypothetical protein 0.0033 0.0285 0.0285
Onchocerca volvulus 0.0549 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Schistosoma mansoni hypothetical protein 0.0071 0.1005 0.0741
Brugia malayi EGF-like domain containing protein 0.0071 0.1005 0.1005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0711 0.0439
Onchocerca volvulus 0.0071 0.1005 0.0741
Onchocerca volvulus Peroxidasin homolog 0.0549 1 1
Entamoeba histolytica protein kinase, putative 0.0097 0.1506 0.5
Brugia malayi intermediate filament protein 0.0033 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Schistosoma mansoni laminin gamma-3 chain 0.0071 0.1005 0.0741
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0097 0.1506 0.1506
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Brugia malayi GCC2 and GCC3 family protein 0.0071 0.1005 0.1005
Brugia malayi Cadherin domain containing protein 0.0071 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Schistosoma mansoni cell polarity protein 0.0071 0.1005 0.0741
Schistosoma mansoni septate junction protein 0.0071 0.1005 0.0741
Loa Loa (eye worm) animal heme peroxidase 0.0549 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.0071 0.1005 0.1005
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0097 0.1506 0.1257
Echinococcus granulosus neurogenic locus notch protein 4 0.0071 0.1005 0.0741
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0245 0.5
Brugia malayi Delta serrate ligand family protein 0.0071 0.1005 0.1005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0711 0.0711
Brugia malayi phosphoinositide-dependent protein kinase I 0.0097 0.1506 0.1506
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Loa Loa (eye worm) notch protein 0.0071 0.1005 0.1005
Schistosoma mansoni peroxidasin 0.0549 1 1
Onchocerca volvulus Chorion peroxidase homolog 0.0549 1 1
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0549 1 1
Echinococcus granulosus neural cadherin 0.0071 0.1005 0.0741
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.8571 0.8529
Leishmania major hypothetical protein, conserved 0.003 0.0245 0.5
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Echinococcus granulosus protein jagged 2 0.0071 0.1005 0.0741
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0711 0.0439
Trichomonas vaginalis AGC family protein kinase 0.0097 0.1506 0.5
Echinococcus multilocularis neurogenic locus protein delta 0.0071 0.1005 0.0741
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0285 0.0285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0711 0.0439
Brugia malayi EGF-like domain containing protein 0.0071 0.1005 0.1005
Brugia malayi Peroxidasin 0.0549 1 1
Loa Loa (eye worm) Notch2 0.0071 0.1005 0.1005
Echinococcus granulosus fibropellin Ia 0.0071 0.1005 0.0741
Echinococcus granulosus protein jagged 1 0.0071 0.1005 0.0741
Echinococcus multilocularis protein jagged 1 0.0071 0.1005 0.0741
Brugia malayi Animal haem peroxidase family protein 0.0549 1 1
Onchocerca volvulus 0.0036 0.0359 0.0076
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0097 0.1506 0.1257
Echinococcus granulosus peroxidasin 0.0549 1 1
Echinococcus multilocularis notch 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0171 0.0171
Onchocerca volvulus Peroxidase homolog 0.0549 1 1
Brugia malayi Muscle positioning protein 4 0.0071 0.1005 0.1005
Onchocerca volvulus Putative cubilin 0.0071 0.1005 0.0741
Brugia malayi PAS domain containing protein 0.0049 0.06 0.06
Brugia malayi Animal haem peroxidase family protein 0.0549 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0245 0.5
Onchocerca volvulus Peroxidasin homolog 0.0549 1 1
Schistosoma mansoni hypothetical protein 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.003 0.0245 0.0245
Echinococcus granulosus slit 2 protein 0.0071 0.1005 0.0741
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0245 0.5
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0285 0.0285
Onchocerca volvulus 0.0549 1 1
Echinococcus multilocularis neurogenic locus notch protein 0.0071 0.1005 0.0741
Onchocerca volvulus 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Loa Loa (eye worm) blistered cuticle protein 3 0.0549 1 1
Brugia malayi follicle stimulating hormone receptor 0.024 0.4182 0.4182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0711 0.0439
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Echinococcus multilocularis geminin 0.0205 0.3523 0.3334
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.1506 0.1257
Echinococcus granulosus notch 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Brugia malayi Cytochrome P450 family protein 0.0027 0.0171 0.0171
Loa Loa (eye worm) animal heme peroxidase 0.0549 1 1
Echinococcus granulosus delta-like protein 1 0.0071 0.1005 0.0741
Brugia malayi notch-like transmembrane receptor 0.0071 0.1005 0.1005
Echinococcus multilocularis protein jagged 2 0.0071 0.1005 0.0741
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0711 0.0439
Brugia malayi Protein kinase domain containing protein 0.0097 0.1506 0.1506
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0359 0.5
Brugia malayi hypoxia-induced factor 1 0.0153 0.2544 0.2544
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Brugia malayi Animal haem peroxidase family protein 0.0549 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0245 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Onchocerca volvulus 0.0549 1 1
Brugia malayi EGF-like domain containing protein 0.0071 0.1005 0.1005
Echinococcus multilocularis slit 2 protein 0.0071 0.1005 0.0741
Echinococcus multilocularis neurogenic locus protein delta 0.0071 0.1005 0.0741
Onchocerca volvulus Neurogenic locus notch homolog 0.0071 0.1005 0.0741
Schistosoma mansoni hypothetical protein 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Brugia malayi EGF-like domain containing protein 0.0071 0.1005 0.1005
Schistosoma mansoni hypothetical protein 0.0205 0.3523 0.3334
Onchocerca volvulus 0.0071 0.1005 0.0741
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.8571 0.8529
Brugia malayi EGF-like domain containing protein 0.0071 0.1005 0.1005
Schistosoma mansoni peroxidasin 0.0549 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Echinococcus granulosus neurogenic locus notch protein 0.0071 0.1005 0.0741
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0071 0.1005 0.1005
Brugia malayi hypothetical protein 0.0165 0.2786 0.2786
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Schistosoma mansoni hypothetical protein 0.0071 0.1005 0.0741
Echinococcus granulosus neurogenic locus notch protein 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Onchocerca volvulus Peroxidase homolog 0.0549 1 1
Schistosoma mansoni slit 0.0071 0.1005 0.0741
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0711 0.0711
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0273 0.0273
Schistosoma mansoni hypothetical protein 0.0071 0.1005 0.0741
Brugia malayi Cadherin domain containing protein 0.0071 0.1005 0.1005
Schistosoma mansoni notch 0.0071 0.1005 0.0741
Echinococcus granulosus neuropeptide s receptor 0.0473 0.8571 0.8529
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Schistosoma mansoni notch 0.0071 0.1005 0.0741
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0711 0.0439
Brugia malayi Animal haem peroxidase family protein 0.0549 1 1
Echinococcus granulosus neurogenic locus protein delta 0.0071 0.1005 0.0741
Schistosoma mansoni hypothetical protein 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0245 0.5
Echinococcus granulosus single minded 2 0.0036 0.0359 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0097 0.1506 0.5
Echinococcus multilocularis neurogenic locus notch protein 4 0.0071 0.1005 0.0741
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.06 0.0324
Schistosoma mansoni hypothetical protein 0.0071 0.1005 0.0741
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0071 0.1005 0.0741
Echinococcus multilocularis protein jagged 1 0.0071 0.1005 0.0741
Loa Loa (eye worm) hypothetical protein 0.0549 1 1
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0097 0.1506 0.1506
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Loa Loa (eye worm) animal heme peroxidase 0.0549 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2786 0.2786
Loa Loa (eye worm) hypothetical protein 0.0071 0.1005 0.1005
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.8571 0.8529
Onchocerca volvulus Dual oxidase homolog 0.0549 1 1
Brugia malayi EGF-like domain containing protein 0.0071 0.1005 0.1005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0711 0.0439
Echinococcus multilocularis fibropellin Ia 0.0071 0.1005 0.0741
Brugia malayi Calcium binding EGF domain containing protein 0.0071 0.1005 0.1005
Brugia malayi Blistered cuticle protein 3 0.0549 1 1
Loa Loa (eye worm) hypothetical protein 0.0549 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0168 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.0178 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.1735 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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